Article
Acoustics
Antria Filippou, Christakis Damianou
Summary: Experimental measurements of acoustic attenuation and propagation speed were conducted on three surgically excised malignant canine mammary tumours. The results showed that both attenuation and propagation speed of CMTs were higher than normal canine tissues, indicating potential applications of ultrasound in CMTs diagnosis and treatment.
Article
Veterinary Sciences
Yufan Zhu, Baochun Lu, Juye Wu, Shoujun Li, Kun Jia
Summary: This study analyzed the expression profile of circRNAs in canine mammary tumors and identified potential circRNAs that could be used as biomarkers for molecular diagnosis.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Jose Rodriguez, Angelo Santana, Pedro Herraez, David R. Killick, Antonio Espinosa de los Monteros
Summary: This study provides an insight into the changing epidemiology of canine mammary cancer in the Canary Archipelago, showing a high prevalence of malignant tumors. Neutering was negatively associated with epithelial mammary gland tumors, and native breeds in the region had a lower risk of mammary tumors. Further analysis of environmental, socioeconomic, and management factors will enhance understanding of mammary gland tumor epidemiology in both canine and human populations.
BMC VETERINARY RESEARCH
(2022)
Article
Medicine, General & Internal
Ciprian Roi, Pusa Nela Gaje, Raluca Amalia Ceausu, Alexandra Roi, Laura Cristina Rusu, Eugen Radu Boia, Simina Boia, Ruxandra Elena Luca, Mircea Rivis
Summary: Gingivitis is a common oral disease that can progress to periodontitis if left untreated. Inflammation of the gingiva is associated with pathological angiogenesis and changes in blood vessel morphology. The severity of gingival lesions is correlated with increased microvessel density.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Veterinary Sciences
Giada Giambrone, Stefania Di Giorgio, Cecilia Vullo, Gabriele Marino, Roberto Puleio, Francesca Mariotti, Giuseppe Mazzullo, Alessandra Sfacteria
Summary: This study demonstrates the existence of TLSs in canine mammary simple carcinomas, where some inflammatory infiltrates assume a follicle-like organization, especially in high-grade carcinomas. The role of TLSs in tumors is controversial, but their presence in aggressive tumor subtypes suggests their importance in tumor progression.
VETERINARY SCIENCES
(2022)
Article
Veterinary Sciences
Penggang Liu, Yurong Lu, Yang Yang, Xueli Chen, Wenbing Xiong, Jing Sun
Summary: This study investigates the distribution and expression of the tumor transcription factor GLI1 and the downstream proteins, Bmi1 and Sox2, in canine mammary tumors and paracancerous tissues. The results suggest that GLI1 and related proteins play an important role in regulating the proliferation and differentiation of tumors.
VETERINARY MEDICINE AND SCIENCE
(2022)
Article
Veterinary Sciences
Francesca Parisi, Matteo Tesi, Francesca Millanta, Marzia Gnocchi, Alessandro Poli
Summary: This study quantified TAMs in 60 canine malignant mammary tumors and found that the presence of M2-polarized TAMs was associated with tumor development and disease progression. CD204 expression may serve as a potential prognostic factor for these tumors.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Hyuk Jang, Jawun Choi, Jeong-Ki Park, Gayeon Won, Jae-Won Seol
Summary: Fucoxanthin, a carotenoid from brown algae, exhibits anticancer activity by inducing apoptosis and inhibiting angiogenesis in canine mammary tumor cells. It also suppresses tube formation and cell migration in human umbilical vein endothelial cells. These findings suggest that fucoxanthin has promise as a therapeutic agent for canine mammary gland tumors.
Review
Agriculture, Dairy & Animal Science
Guilherme Henrique Tamarindo, Adriana Alonso Novais, Luiz Gustavo Almeida Chuffa, Debora Aparecida Pires Campos Zuccari
Summary: Metabolic reprogramming in canine mammary tumors presents a therapeutic opportunity. Alterations in carbohydrate metabolism, amino acid metabolism, lipid metabolism, and mitochondrial functions have been observed in these tumors. Targeting metabolic vulnerabilities may improve the outcome of canine mammary tumors.
Article
Biochemistry & Molecular Biology
Yutian Zhang, Kang Hu, Ziyi Qu, Zhihong Xie, Fei Tian
Summary: ADAMTS8 inhibits lung cancer progression by suppressing VEGFA and is associated with overall survival rate of patients.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Veterinary Sciences
Seulji Lee, Sungin Lee, Wan Hee Kim
Summary: The study found that TRPM7 is expressed in canine mammary gland tumors and is associated with tumor malignancy, Ki-67 index, and metastasis. High TRPM7 expression is significantly associated with poor disease-free and overall survival in malignant CMTs.
VETERINARY AND COMPARATIVE ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haijun Zhao, Yanhui He
Summary: Increasing evidence suggests that lysophosphatidylcholine (LPC) is closely related to endothelial dysfunction. This study aimed to investigate the mechanism of LPC in inhibiting pro-angiogenesis and vascular inflammation in human endothelial progenitor cells (EPCs) derived from CD34(+) hematopoietic stem cells. LPC was found to suppress the expression of certain inflammatory cytokines and genes associated with angiogenesis in EPCs, while promoting the activation of the PKC signaling pathway. Additionally, LPC treatment inhibited the angiogenesis-promoting effect of EPCs on human umbilical vein endothelial cells (HUVECs).
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Driele B. Santos, Geysson J. J. Fernandez, Luciana M. C. Pardini, Maria Ines M. C. Pardini, Adriana C. C. Ferrasi
Summary: Studying the transcriptome of canine mammary ductal carcinoma can help identify genes and pathways related to human breast cancer, leading to the discovery of biomarkers and therapeutic targets. This study identified 633 downregulated and 573 upregulated genes in carcinoma tissue compared to normal tissue, indicating deregulation in inflammatory, cell differentiation and adhesion, and extracellular matrix maintenance pathways. The differentially expressed genes may indicate disease aggressiveness and prognosis. The canine transcriptome serves as an excellent model for oncology research in both humans and animals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ozge Turna, Aslihan Baykal, Elif Sozen Kucukkara, Asuman Deveci Ozkan, Gamze Guney Eskiler, Funda Yildirim
Summary: The therapeutic effect of curcumin on canine mammary gland tumors (CMGTs) was evaluated, and it was found that curcumin can inhibit the growth of tumor cells and induce cell death through apoptosis, suggesting its potential as a treatment option.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Agriculture, Dairy & Animal Science
Giada Giambrone, Cecilia Vullo, Roberto Puleio, Claudia Rifici, Stefania Di Giorgio, Alessandra Sfacteria
Summary: This study identified hemosiderin-laden macrophages (HLMs) in canine mammary carcinoma and revealed their potential role in cancer progression and cell protection from hypoxia.
Article
Veterinary Sciences
Leonor Delgado, Paula Brilhante-Simoes, Justina Prada, Luis Monteiro
Summary: This study analyzed the frequency and clinical-pathological characteristics of oral lesions in Portuguese dogs. The gingiva was the most frequently affected site, with oral melanoma being the most common malignant tumor and fibromatous epulis of periodontal ligament origin being the most common benign tumor.
JOURNAL OF VETERINARY DENTISTRY
(2023)
Article
Agronomy
Adriano Fernandes Ferreira, Grasiene Meneses Silva, Ana Cristina Silvestre-Ferreira, Felisbina Luisa Queiroga
Summary: This study established reference intervals for biochemical variables and the proteinogram of the Sapajus libidinosus, a near threatened primate species in Brazil. The study found significant differences in certain biochemical markers and protein levels between different age and sex categories. These findings provide valuable reference values for assessing the health status of this species and contribute to its conservation efforts.
Article
Agriculture, Dairy & Animal Science
Salome Azevedo, Bairbre O'Malley, Claire Greene, Helena Moran, Tomas Rodrigues Magalhaes, Felisbina Luisa Queiroga
Summary: The clinical records of guinea pigs diagnosed with lower urinary tract disease in a veterinary hospital over a 14-year period were retrospectively searched. The most common diagnosis was urolithiasis, followed by cystitis/UTI. Female guinea pigs were more likely to have a family history of urinary disease, abnormal micturition signs, and recurrence. Males were more prone to urolithiasis, while females were more prone to cystitis/UTI. The use of potassium citrate and urethrotomy showed a better therapeutic response. Further studies are needed to confirm these findings in larger populations of guinea pigs.
Article
Biochemistry & Molecular Biology
Jorge C. Pereira, Nuno Goncalves-Anjo, Leonor Orge, Maria A. Pires, Sara Rocha, Luis Figueira, Ana C. Matos, Joao Silva, Paula Mendonca, Paulo Carvalho, Paula Tavares, Carla Lima, Anabela Alves, Alexandra Esteves, Maria L. Pinto, Isabel Pires, Adelina Gama, Roberto Sargo, Filipe Silva, Fernanda Seixas, Madalena Vieira-Pinto, Estela Bastos
Summary: Chronic wasting disease (CWD) in cervids has become a rising concern in Europe since the first case was detected in Norway in 2016. A total of 34 cases have been described in Norway, Sweden, and Finland until June 2022. Diagnosis of CWD is confirmed through post-mortem examination of the brain and lymph nodes, using rapid tests, immunohistochemistry, and Western immunoblotting. The study analyzed PRNP gene exon 3 of 143 samples from red deer and fallow deer in Portugal, finding three single nucleotide polymorphisms (SNPs) in red deer and no sequence variation in fallow deer. The genetic diversity observed is consistent with previous studies in Europe, and further research is needed to evaluate susceptibility of the deer populations to CWD.
Article
Oncology
Felisbina Queiroga, Bruno Cogliati
Article
Agriculture, Dairy & Animal Science
Sofia Rosa, Ana C. Silvestre-Ferreira, Roberto Sargo, Filipe Silva, Felisbina Luisa Queiroga
Summary: The Western European hedgehog can serve as a bioindicator and host for zoonotic agents, making it relevant for environmental pollution and One Health studies. It is important to deepen our understanding of this species by calculating reference intervals for hematological and biochemical parameters. Age differences were found in this study, highlighting the need for further investigations.
Review
Neurosciences
Rui Alvites, Abby Caine, Giunio Bruto Cherubini, Justina Prada, Artur Severo P. Varejao, Ana Colette Mauricio
Summary: The Olfactory Bulb plays a crucial role in the olfactory system, integrating and transmitting olfactory information to the cerebral cortex. Changes in the Olfactory Bulb can lead to olfactory abnormalities and have been linked to aging, neurodegenerative diseases, head trauma, and infectious diseases. However, there is a lack of quantitative assessment and research in veterinary sciences on olfactory acuity in animals.
Article
Agriculture, Dairy & Animal Science
Maria Francisca Ferreira, Emma Fabrega, Isabel Pires, Maria Madalena Vieira-Pinto
Summary: This study aimed to evaluate the use of agonic aspiration of blood (AAB) as an indicator of electrical stunning ineffectiveness during pig slaughter. The findings indicate that AAB might not be a reliable indicator and further research is needed to understand the causes of blood aspiration and its relation to slaughter techniques.
Article
Agriculture, Dairy & Animal Science
Grasiene Silva, Felisbina Queiroga, Madalena Ferreira, Daniela Andrade, Ana C. Silvestre-Ferreira
Summary: The Miranda donkey is an endangered Portuguese breed, and research has been conducted to help preserve them. Understanding hematological reference intervals is crucial for characterizing the breed, identifying animal health, and aiding in disease diagnosis. This study aimed to determine reference intervals for healthy Miranda donkeys and evaluate the influence of sex and age. Only age affected the hematological values, and the results can be used to assess animal health, diagnose diseases, and select healthy animals for reproduction, contributing to breed preservation.
Review
Agriculture, Dairy & Animal Science
Eliza Vazquez, Yulia Lipovka, Alejandro Cervantes-Arias, Adriana Garibay-Escobar, Michelle M. Haby, Felisbina Luisa Queiroga, Carlos Velazquez
Summary: Mammary tumors are a common cancer in female dogs and humans. Canine mammary tumors share many similarities with human breast cancers. This review provides a detailed description of the histological, molecular, and clinical aspects of mammary cancer in dogs, as well as discussing risk factors and available treatment options. There are still challenges and unanswered questions, including the need for standardization of clinical study protocols and the development of new therapies.
Article
Agriculture, Dairy & Animal Science
Andreia Garces, Isabel Pires, Roberto Sargo, Luis Sousa, Justina Prada, Filipe Silva
Summary: This study investigates the causes, outcomes, and mortality of vultures admitted to a wildlife rehabilitation center and necropsy service in Northern Portugal. Over 17 years, 84 vultures were admitted, with the main causes being unknown, debilitation, vehicle collision, captivity, gunshot, and electrocution. Most admissions occurred in summer and autumn, and 73% of the animals that arrived alive could be rehabilitated and released. This study provides valuable information about these vulture populations in Portugal, especially for endangered species.
Letter
Otorhinolaryngology
Ana Teresa Lima Vieira, Maria Silva, Filipe Silva, Justina Prada, Isabel Pires
EGYPTIAN JOURNAL OF OTOLARYNGOLOGY
(2023)
Article
Veterinary Sciences
Alexandra Monteiro, Leonor Delgado, Luis Monteiro, Isabel Pires, Justina Prada, Teresa Raposo
Summary: The expression of CTEN was evaluated in oral and cutaneous squamous cell carcinoma samples from dogs, and a higher level of expression was found in higher-grade tumors. This study demonstrates the clinical significance of CTEN in canine squamous cell carcinoma for the first time. CTEN, as a member of the tensin family, plays oncological functions in various types of cancer.
VETERINARY SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ana Cristina Rodrigues, Ligia Costa, Ricardo Silva-Carvalho, Renato Mota, Sara Duarte-Silva, Andreia Teixeira-Castro, Nuno Lamas, Goncalo N. P. Oliveira, Yizao Wan, Fernando Dourado, Miguel Gama
Summary: In this study, it was found that BNC nanofibers are not absorbed at the intestine after oral administration in Wistar rats, suggesting that BNC can be considered a safe food additive.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Veterinary Sciences
R. Mischke, K. Rumstedt, S. O. Hungerbuehler, K. Rohn, M. Schmicke
Summary: Contrast-enhanced ultrasound (CEUS) can provide an additional tool for the diagnosis of hypothyroidism in dogs and support its differentiation from non-thyroidal illness. Sedation has limited impact on CEUS results.
RESEARCH IN VETERINARY SCIENCE
(2024)
Review
Veterinary Sciences
Lucas Petitemberte de Souza, William Borges Domingues, Eduardo Bierhals Blodorn, Leandro da Silva Nunes, Hadassa Gabriela Ortiz, Eliza Rossi Komninou, Vinicius Farias Campos
Summary: This study performed a systematic review of the differential expression of sperm microRNAs in bulls related to fertility. A total of 182 unique differentially expressed miRNAs were identified, among which 49 miRNAs were found in common between at least two studies. The results suggest that miRNAs such as miR-10a, -10b, -103, -15b, -122, -125b, -126-5p, -151-5p, -193a-5p, -196a, -27a-5p, and -99b may serve as potential universal biomarkers for assessing the reproductive potential of males.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Wonhee Cha, Katinca Fungbrant, Giulio Grandi, Ylva Persson
Summary: This study investigated the prevalence and development of hair loss in outdoor cattle in Sweden. It found a relatively high hair loss rate, with the occurrence of hair loss increasing over time during winters, suggesting a contagious etiology. The study also identified preventative delousing before November, keeping animals clean, and maintaining small group sizes as effective measures to reduce the risk of hair loss, while older age and access to bedding materials increased the risk.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Sheeba Thomas, David Francis Lappin, David Bennett, Christopher Nile, Marcello Pasquale Riggio
Summary: This study found that Feline odontoclastic resorptive lesion (FORL) can be divided into two subgroups, with FORL-1 subgroup having a less diverse oral microbiome and higher levels of proinflammatory cytokines and chemokines, which may be associated with the severity and activity of the disease.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
S. L. Gayathri, M. Bhakat, T. K. Mohanty
Summary: This study used infrared thermography (IRT) to identify mastitis in Sahiwal cows. The results showed significant differences in the mean values of udder and teat surface temperature between healthy, subclinical mastitis (SCM), and clinical mastitis (CM) cases during different seasons. IRT is an efficient tool for the early identification of subclinical mastitis.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Zeynep Ozdemir Kutahya, Busra Aslan Akyol, Kubra Deliklitas, Cengiz Gokbulut
Summary: In this study, the pharmacokinetic behavior of Eprinomectin was studied in two different goat breeds. The results showed no significant differences in plasma concentration between the breeds, but the clearance from the body may vary. High concentration of Eprinomectin in feces is beneficial against gastrointestinal parasites but poses an ecotoxicological risk to the environment.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Mohammad Ashrafzadeh-Shiraz, Mousa Tavassoli, Bahram Dalir-Naghadeh, Alireza Sazmand
Summary: This study evaluated the efficacy of fenbendazole and ivermectin on strongyles and Parascaris sp. infecting adult riding horses in different regions of Iran. The results demonstrated varying degrees of resistance of these parasites to both anthelminthics. It emphasizes the urgency of educating horse owners about the importance of a test-and-treatment strategy and suggests evaluating the efficacy of different anthelminthics to choose the most effective treatment in each region.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Moises Gonzalvez, Clara Munoz-Hernandez
Summary: The study evaluated the use of R software in research articles addressing the study of wildlife, showing an increasing trend in the number of publications over time and a wide geographical distribution globally.
RESEARCH IN VETERINARY SCIENCE
(2024)
