Article
Veterinary Sciences
Meric Kocaturk, Fernando Tecles, Ebru Yalcin, Huseyin Cihan, Merve Tural, Pinar Levent, Mehmet Cansev, Jose J. Ceron, Zeki Yilmaz
Summary: This study found that salivary Ch levels were higher in dogs with CP and positively correlated with CRP, indicating that salivary Ch could potentially serve as a biomarker for the severity of CP.
RESEARCH IN VETERINARY SCIENCE
(2021)
Article
Nutrition & Dietetics
Jessica A. Baker, Kristen R. Breit, Tamara S. Bodnar, Joanne Weinberg, Jennifer D. Thomas
Summary: Prenatal alcohol exposure can disrupt the development of the immune system, but choline supplementation can mitigate these effects. The study found that early choline supplementation can reduce the impact of alcohol exposure on hippocampal inflammation and improve hippocampal function.
Article
Agriculture, Multidisciplinary
Jiabao Zhang, Mengke Wang, Jinying Liu, Yuntai Lv, Xingguang Su
Summary: In this study, a label-free ratiometric fluorescence biosensing strategy was developed for the determination of BChE activity and OPs concentration. The strategy involved the hydrolysis of BTCh by BChE, releasing ssDNA which triggered target recycling amplification and produced G-quadruplex. The addition of OPs inhibited the hydrolysis, resulting in the absence of fluorescence signal.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Dominik Szwajgier, Ewa Baranowska-Wojcik, Anna Winiarska-Mieczan, Dorota Gajowniczek-Alasa
Summary: Alzheimer's disease is a progressive neurodegenerative disease characterized by low levels of acetylcholine, oxidative stress, and inflammation. The current treatment involves the use of acetylcholinesterase inhibitors, but prevention can be achieved by consuming the right inhibitors through food. This study found that different types of honey contain cholinesterase inhibitors, which may play a significant role in Alzheimer's disease.
Article
Multidisciplinary Sciences
Kalhari Bandara Goonewardene, Naama Karu, Khawaja Ashfaque Ahmed, Shelly Popowich, Betty Chow-Lockerbie, Lisanework E. Ayalew, Ruwani Karunarathna, Thushari Gunawardana, Mengying Liu, Suresh K. Tikoo, Marianna Foldvari, Philip Willson, Rupasri Mandal, David S. Wishart, Susantha Gomis
Summary: Synthetic CpG-ODNs can enhance antimicrobial immunity in neonatal chicks by altering metabolic pathways and supporting immune cell function through changes in nutrient uptake and cell proliferation triggered by the innate immune response. The study highlights the potential of CpG-ODNs to modulate immunometabolic interactions in establishing immunity against pathogens in chicks.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Urna Kansakar, Valentina Trimarco, Pasquale Mone, Fahimeh Varzideh, Angela Lombardi, Gaetano Santulli
Summary: This comprehensive review examines the effects of various choline supplements, such as choline alfoscerate, choline bitartrate, lecithin, and citicoline, on cognitive function. These supplements have been extensively used as food supplements and have shown to be effective in enhancing memory and cognitive function.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Medicinal
Tingkai Chen, Shenghu Sang, Yuqing Wei, Yujie Ge, Jisheng Jin, Yaoyao Bian, Yuqiong Pei, Nianguang Li, Haopeng Sun, Yao Chen
Summary: A series of tetrahydrothienopyridine derivatives were designed, synthesized, and evaluated as selective BChE inhibitors. The compounds were analyzed using HRMS, 1H NMR, and 13C NMR. The most potent and selective inhibitor against BChE was found to be 6n.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Neurosciences
Hanna Carmon, Evan C. Haley, Vinay Parikh, Natalie C. Tronson, Martin Sarter
Summary: Sign-tracking rats have higher levels of cytokines and poly-ubiquitinated CHTs in the brain compared to goal-trackers. Activation of the immune system increases cytokines and ubiquitinated CHTs only in goal-trackers, indicating a connection between immune modulator signaling and addiction vulnerability.
Article
Chemistry, Medicinal
Milena Mlakic, Tena Cadez, Danijela Baric, Ivana Pucek, Ana Ratkovic, Zeljko Marinic, Kornelija Lasic, Zrinka Kovarik, Irena Skoric
Summary: Novel uncharged thienostilbene oximes were synthesized as reactivators for nerve-agent-inhibited AChE and BChE, with four derivatives showing potential to reactivate BChE up to 70% and promising for further development in treating OP poisoning.
Article
Agriculture, Multidisciplinary
Hui Huang, Donghui Song, Wenjing Zhang, Shuaizhen Fang, Qianxi Zhou, Haoyu Zhang, Zheng Liang, Yongxin Li
Summary: A sensor strategy based on a metal-organic framework is developed for one-step cascade detection of choline. This method exhibits excellent catalytic activity and stability, allowing for efficient detection of choline across a wide concentration range.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Analytical
Wenxin Kang, Mo Ma, Lanlan Xu, Shuai Tang, Jingkang Li, Pinyi Ma, Daqian Song, Ying Sun
Summary: In this study, we developed a fluorescent probe named Kang-BChE for rapid and accurate detection of BChE in thyroid cancer cells. The probe exhibited low cytotoxicity, high stability, and good specificity, completely eliminating interference from AChE. Furthermore, we observed a positive correlation between BChE activity and H2O2 concentration in Tpc1 cells.
ANALYTICA CHIMICA ACTA
(2023)
Article
Biochemistry & Molecular Biology
Hai Duc Nguyen, Min-Sun Kim
Summary: This study aimed to explore the relationship between heterocyclic molecules and their biological activities for AChE and BChE enzymes. A dataset of 36 heterocycles was used to predict the activity of AChE and BChE inhibitors. Four different models were generated for quantitative structure-activity relationship (QSAR) analysis, and four models were statistically acceptable. Five selected molecules showed high pIC50 values for AChE and BChE enzymes. Docking scores between the receptors and candidates were within a specific range. The selected compounds exhibited pharmacokinetics, biological activities, and physicochemical properties that supported their potential as AD protective agents.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Medicinal
Xin Lu, Nan Qin, Yijun Liu, Chenxi Du, Feng Feng, Wenyuan Liu, Yao Chen, Haopeng Sun
Summary: This study identified compounds 17c and 19c as potential drugs with selective inhibition of BChE, good blood brain barrier permeation, and cellular safety. The experimental results also showed that 17c and 19c were able to protect cells from AD-related damage and restore cognitive function in vivo.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
E. Baris, O. Simsek, H. Efe, S. Oncu, A. Gelal, E. Hamurtekin, M. Tosun, S. Ozbal, Z. Yuce, M. A. Arici
Summary: CDP-choline and choline reduced LPS-induced COX-2 enzyme expression and prostaglandin levels in rats by increasing serum and brain total choline levels in the endotoxemia model.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2021)
Review
Neurosciences
Proshanta Roy, Daniele Tomassoni, Giulio Nittari, Enea Traini, Francesco Amenta
Summary: This study analyzes the roles of choline and choline-containing phospholipids (CCPLs) in maintaining and progressing the integrity of the neurovascular unit (NVU). The loss of CCPLs contributes to the development of neurodegenerative diseases. Some CCPLs, particularly alpha-GPC, show promising results and may be reconsidered as potential therapeutic compounds in larger controlled studies. This study also highlights the importance of defining the role of the NVU in brain disorders characterized by vascular impairment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Lukasz Grzeskowiak, Eva-Maria Saliu, Anna Grete Wessels, Beatriz Martinez-Vallespin, Klaus Maenner, Jose Joaquin Ceron, Wilfried Vahjen, Juergen Zentek
Summary: Maternal dietary factors have no significant influence on the colonization of Clostridioides difficile in the neonatal piglets' intestines, regardless of whether the sows were fed diets supplemented with high-fermentable sugar beet pulp or low-fermentable lignocellulose. This study provides insights into the relationship between maternal diet and neonatal piglet gut microbiota colonization.
Article
Immunology
Marinela Contreras, Joaquin Vicente, Jose Joaquin Ceron, Silvia Martinez Subiela, Jose Miguel Urra, Francisco J. Rodriguez-del-Rio, Elisa Ferreras-Colino, Rita Vaz-Rodrigues, Isabel G. de Fernandez G. de Mera, Sandra Antunes, Ana Domingos, Christian Gortazar, Jose de la Fuente
Summary: This study identified potential diagnostic, prognostic, and protective antibody binding epitopes for SARS-CoV-2. The results provide new tools for COVID-19 surveillance and risk evaluation in hospitalized patients, as well as potential insights for the development of new vaccines.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Maria Botia, Damian Escribano, Silvia Martinez-Subiela, Asta Tvarijonaviciute, Fernando Tecles, Marina Lopez-Arjona, Jose J. Ceron
Summary: The main glucocorticoids involved in the stress response, such as cortisol, cortisone, and corticosterone, are widely used as biomarkers for evaluating physiological response to stress. Measurement of total glucocorticoids, which encompasses various types of glucocorticoids, is commonly performed using immunoassays. This review explores the characteristics of these glucocorticoids, techniques for their quantification, and the importance of measuring multiple types of glucocorticoids in assessing welfare.
Article
Veterinary Sciences
Laura Miguel-Pastor, Katy Satue, Deborah Chicharro, Pau Pelaez, Marta Torres-Torrillas, Jose M. Carrillo, Jose J. Ceron, Joaquin J. Sopena, Monica Rubio
Summary: Feline leukemia virus (FeLV) is a chronic disease that weakens a cat's immune system. Platelet-rich plasma (PRP) and growth factors (GFs) determination offer potential alternative treatment for improving quality of life in FeLV cats. This study aimed to determine the concentration of platelets, red blood cells, white blood cells, and growth factors in whole blood, PRP, and platelet-poor plasma fractions using a standardized protocol.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Veterinary Sciences
M. Botia, M. Lopez-Arjona, D. Escribano, M. D. Contreras-Aguilar, P. J. Vallejo-Mateo, J. J. Ceron, S. Martinez-Subiela
Summary: In recent years, saliva has been increasingly used as a non-invasive matrix for measuring biomarkers of health and welfare. This study aimed to develop and validate an assay based on luminescent amplification for measuring Hp in bovine saliva, and to examine the changes in inflammatory situations such as the peripartum period and lameness.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alba Ortin-Bustillo, Damian Escribano, Silvia Martinez-Subiela, Asta Tvarijonaviciute, Alberto Munoz-Prieto, Marina Lopez-Arjona, Jose J. Ceron, Fernando Tecles
Summary: The objective of this study was to evaluate the changes of zinc, copper, iron, and ferritin in pigs during the fattening cycle and at different sampling times. The presence of pen contaminants and storage stability were also assessed. The analytes showed variation throughout the cycle, with higher values in the initial phases. The measurements of zinc and copper also varied at different sampling times. The addition of feces or feed increased the values of all analytes, especially at higher concentrations.
Article
Biochemistry & Molecular Biology
Vitoldo Antonio Kozlowski Neto, Elizabeth Moreira dos Santos Schmidt, Camila Peres Rubio, Naiara Mirelly Marinho da Silva, Renata Tardivo, Ciniro Costa, Paulo Roberto de Lima Meirelles, Jose Joaquin Ceron, Asta Tvarijonaviciute, Alessandro Francisco Talamini do Amarante
Summary: The trial aimed to evaluate the levels of oxidative stress biomarkers and biochemical analytes in crossbred lambs during the rearing phase in an integrated crop-livestock system (ICLS) for controlling gastrointestinal parasites. 36 crossbred lambs were divided into two groups, with one group supplemented with whole cottonseed (WCS) and the other serving as controls. The results showed that the inclusion of WCS was beneficial in controlling infection and increasing antioxidants while reducing oxidants in lambs naturally infected by gastrointestinal parasites. The combination of WCS and ICLS could effectively control gastrointestinal parasite infection without affecting production performance.
Review
Biology
Jose Joaquin Ceron, Alba Ortin-Bustillo, Maria Jose Lopez-Martinez, Silvia Martinez-Subiela, Peter David Eckersall, Fernando Tecles, Asta Tvarijonaviciute, Alberto Munoz-Prieto
Summary: S100 proteins are a group of calcium-binding proteins with similar molecular mass and amino acid sequence, which have diverse biological functions. The calgranulins family, including S100A8, S100A9, and S100A12, have potential value as biomarkers in veterinary science. The heterodimer calprotectin can be formed by SA100A8 and SA100A9 proteins. This review will enhance understanding of S100 proteins and their potential use as biomarkers in the veterinary field.
Article
Oncology
Pia Lopez-Jornet, Aitana Olmo-Monedero, Camila Peres-Rubio, Eduardo Pons-Fuster, Asta Tvarijonaviciute
Summary: Early diagnosis of potentially malignant oral disorders is crucial for reducing oral cancer mortality. This study analyzed a panel of salivary markers and found that ferritin and total proteins may serve as potential salivary biomarkers for diagnosis. Additionally, saliva tests are reliable and non-invasive diagnostic tools that offer an interesting alternative for screening large populations.
Article
Food Science & Technology
Jose Enrique de la Rubia Orti, Jose Luis Platero Armero, Maria Cuerda-Ballester, Claudia Emmanuela Sanchis-Sanchis, Esther Navarro-Illana, Jose Maria Lajara-Romance, Maria Benlloch, Jose Joaquin Ceron, Asta Tvarijonaviciute, Belen Proano
Summary: Dyslipidemia in multiple sclerosis (MS) patients is not associated with dietary habits. Administration of epigallocatechin gallate (EGCG) and coconut oil can lower blood triglyceride (TG) levels and potentially improve functional disability.
Article
Veterinary Sciences
Lorena Franco-Martinez, Luis Pardo-Marin, Laura Sanchez-Mateos, Alberto Munoz-Prieto, Juan Diego Garcia-Martinez, Jose J. Ceron, Silvia Martinez-Subiela, Camila P. Rubio, Asta Tvarijonaviciute
Summary: The study found higher levels of ferritin in overweight/obese dogs compared to lean/normal weight dogs, which may indicate tissue hypoxia. Additionally, obese dogs exhibited higher haematocrit and erythrocyte mean corpuscular volume. These findings contribute to our understanding of the mechanisms causing complications in obese dogs.
VETERINARY SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Carlos E. Iglesias-Aguirre, Antonio Gonzalez-Sarrias, Adrian Cortes-Martin, Maria Romo-Vaquero, Leire Osuna-Galisteo, Jose Joaquin Ceron, Juan Carlos Espin, Maria Victoria Selma
Summary: The capacity to produce urolithin varies among individuals due to differences in gut bacterial ecology. In this study, two urolithin-producing bacterial consortia were administered to rats, successfully colonizing their guts and transferring the ability to produce urolithins. The bacterial strains were well-tolerated and did not have adverse effects on gut bacteria, blood parameters, or biochemical parameters, making them potential probiotics for individuals who cannot produce bioactive urolithins.
Article
Veterinary Sciences
Diana Rammal, Christos K. K. Koutinas, Labrini V. V. Athanasiou, Melpomeni Tangalidi, Camila P. P. Rubio, Jose J. Ceron, Androniki Tamvakis, Michael N. N. Patsikas, Zoe S. S. Polizopoulou
Summary: The study aimed to measure the concentration of Paraoxonase-1 (PON-1) and N-terminal-prohormone-B-type natriuretic peptide (NT-proBNP) in dogs with mitral valve disease and determine their association with clinical stage and specific clinico-pathologic and echocardiographic findings. The results showed that PON-1 was not correlated with clinical stage, gender, or concurrent conditions. NT-proBNP, on the other hand, was correlated with clinical stage and echocardiographic indices of cardiomegaly and heart failure. These findings suggest that PON-1 is an insensitive marker for the severity of mitral valve disease and its utility may be hindered by confounding factors.
VETERINARY SCIENCES
(2023)
Article
Veterinary Sciences
R. Mischke, K. Rumstedt, S. O. Hungerbuehler, K. Rohn, M. Schmicke
Summary: Contrast-enhanced ultrasound (CEUS) can provide an additional tool for the diagnosis of hypothyroidism in dogs and support its differentiation from non-thyroidal illness. Sedation has limited impact on CEUS results.
RESEARCH IN VETERINARY SCIENCE
(2024)
Review
Veterinary Sciences
Lucas Petitemberte de Souza, William Borges Domingues, Eduardo Bierhals Blodorn, Leandro da Silva Nunes, Hadassa Gabriela Ortiz, Eliza Rossi Komninou, Vinicius Farias Campos
Summary: This study performed a systematic review of the differential expression of sperm microRNAs in bulls related to fertility. A total of 182 unique differentially expressed miRNAs were identified, among which 49 miRNAs were found in common between at least two studies. The results suggest that miRNAs such as miR-10a, -10b, -103, -15b, -122, -125b, -126-5p, -151-5p, -193a-5p, -196a, -27a-5p, and -99b may serve as potential universal biomarkers for assessing the reproductive potential of males.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Wonhee Cha, Katinca Fungbrant, Giulio Grandi, Ylva Persson
Summary: This study investigated the prevalence and development of hair loss in outdoor cattle in Sweden. It found a relatively high hair loss rate, with the occurrence of hair loss increasing over time during winters, suggesting a contagious etiology. The study also identified preventative delousing before November, keeping animals clean, and maintaining small group sizes as effective measures to reduce the risk of hair loss, while older age and access to bedding materials increased the risk.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Sheeba Thomas, David Francis Lappin, David Bennett, Christopher Nile, Marcello Pasquale Riggio
Summary: This study found that Feline odontoclastic resorptive lesion (FORL) can be divided into two subgroups, with FORL-1 subgroup having a less diverse oral microbiome and higher levels of proinflammatory cytokines and chemokines, which may be associated with the severity and activity of the disease.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
S. L. Gayathri, M. Bhakat, T. K. Mohanty
Summary: This study used infrared thermography (IRT) to identify mastitis in Sahiwal cows. The results showed significant differences in the mean values of udder and teat surface temperature between healthy, subclinical mastitis (SCM), and clinical mastitis (CM) cases during different seasons. IRT is an efficient tool for the early identification of subclinical mastitis.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Zeynep Ozdemir Kutahya, Busra Aslan Akyol, Kubra Deliklitas, Cengiz Gokbulut
Summary: In this study, the pharmacokinetic behavior of Eprinomectin was studied in two different goat breeds. The results showed no significant differences in plasma concentration between the breeds, but the clearance from the body may vary. High concentration of Eprinomectin in feces is beneficial against gastrointestinal parasites but poses an ecotoxicological risk to the environment.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Mohammad Ashrafzadeh-Shiraz, Mousa Tavassoli, Bahram Dalir-Naghadeh, Alireza Sazmand
Summary: This study evaluated the efficacy of fenbendazole and ivermectin on strongyles and Parascaris sp. infecting adult riding horses in different regions of Iran. The results demonstrated varying degrees of resistance of these parasites to both anthelminthics. It emphasizes the urgency of educating horse owners about the importance of a test-and-treatment strategy and suggests evaluating the efficacy of different anthelminthics to choose the most effective treatment in each region.
RESEARCH IN VETERINARY SCIENCE
(2024)
Article
Veterinary Sciences
Moises Gonzalvez, Clara Munoz-Hernandez
Summary: The study evaluated the use of R software in research articles addressing the study of wildlife, showing an increasing trend in the number of publications over time and a wide geographical distribution globally.
RESEARCH IN VETERINARY SCIENCE
(2024)
