Article
Psychiatry
Yiyue Yang, Kaiqi Gu, Changyang Meng, Jia Li, Qiao Lu, Xiaobo Zhou, Deping Yan, Dongxiao Li, Changzhen Pei, Yue Lu, Shenglan Ran, Jing Li
Summary: There is a relationship between sleep and inflammatory factors, and the quality of sleep in MDD patients is associated with specific inflammatory factors. Poor sleep quality is negatively correlated with IL-2 and IL-8 levels, and positively correlated with IL-6, IL-10, CRP, TNF-alpha, CXCL-1, CXCL-2, and IFN-gamma levels.
PSYCHIATRY RESEARCH
(2023)
Article
Multidisciplinary Sciences
Junhel Dalanon, Sachiko Chikahisa, Tetsuya Shiuchi, Noriyuki Shimizu, Parimal Chavan, Yoshitaka Suzuki, Kazuo Okura, Hiroyoshi Sei, Yoshizo Matsuka
Summary: The study revealed that predictable chronic mild stress influences sleep-wake states and pain threshold, leading to decreased slow-wave activity, intensified mechanical and thermal hyperalgesia, and elevated plasma corticosterone levels.
SCIENTIFIC REPORTS
(2021)
Review
Pediatrics
Marton Szabados, Erika Kolumban, Gergely Agocs, Szilvia Kiss-Dala, Marie Anne Engh, Mark Hernadfoi, Kata Takacs, Eszter Tuboly, Andrea Parniczky, Peter Hegyi, Miklos Garami
Summary: This study evaluated the association between the location of brain tumors and the development of depression and anxiety in childhood cancer survivors. The results showed that survivors of infratentorial brain tumors had higher levels of anxiety and depression.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2023)
Article
Oncology
Moran Yang, Jiaqi Lu, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Congjian Xu, Haiou Liu
Summary: This study reveals the critical role of CXCL13 in shaping the antitumor microenvironment by facilitating the maintenance of CXCR5(+)CD8(+) T cells in TLSs, and supports a clinical investigation for a combination of CXCL13 and PD-1 blockade therapy in HGSC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Zoi Diamantopoulou, Francesc Castro-Giner, Fabienne Dominique Schwab, Christiane Foerster, Massimo Saini, Selina Budinjas, Karin Strittmatter, Ilona Krol, Bettina Seifert, Viola Heinzelmann-Schwarz, Christian Kurzeder, Christoph Rochlitz, Marcus Vetter, Walter Paul Weber, Nicola Aceto
Summary: The generation of circulating tumor cells (CTCs) with metastatic ability is concentrated during the rest phase, and CTCs generated during the active phase lack metastatic ability. Mechanistically, the upregulation of mitotic genes during the rest phase enables CTCs' metastasis proficiency. Circadian rhythm hormones such as melatonin, testosterone and glucocorticoids dictate the generation dynamics of CTCs, and insulin promotes tumor cell proliferation in a time-dependent manner.
Article
Oncology
Yoonjoo Kim, Heejung Kim, Sang-Yeon Suh, Hyunki Park, Hyangkyu Lee
Summary: Caregivers of cancer patients experience psychological distress that is negatively correlated with inflammatory cytokine levels. High levels of fatigue and depression, along with increased days of care provided per week, are associated with lower levels of inflammatory cytokines. Interventions to support caregivers and manage their distress are necessary to improve their caregiving experience.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Clinical Neurology
Sarah L. Martindale, Sagar S. Lad, Anna S. Ord, Kristina A. Nagy, Cameron D. Crawford, Katherine H. Taber, Jared A. Rowland
Summary: Sleep quality plays an independent role in affecting health outcomes in post-deployment veterans, beyond mild traumatic brain injury (TBI) and PTSD diagnosis. It not only contributes to PTSD and neurobehavioral symptoms, but also moderates the effects of PTSD diagnosis on neurobehavioral symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Oncology
Moloud Sooreshjani, Shashwat Tripathi, Corey Dussold, Hinda Najem, John de Groot, Rimas V. Lukas, Amy B. Heimberger
Summary: Glioblastoma, a highly infiltrative tumor, often recurs despite multi-modal treatment. Novel strategies incorporating cytokines as potential therapeutic options, including virotherapy, systemic cytokine therapy, and cellular and gene therapy, are being explored to improve treatment outcomes in glioblastoma patients.
Article
Oncology
Sarah Ellen Braun, Farah J. Aslanzadeh, Leroy Thacker, Ashlee R. Loughan
Summary: The study found that caregivers of brain tumor patients reported higher levels of fear of cancer recurrence (FCR) than patients themselves, and caregiver FCR may be higher at the time of diagnosis and decrease over time. Psychological distress, including depressive symptoms, generalized anxiety, and death anxiety, exerted a significant impact on FCR among both patients and caregivers. Dyadic effects of a brain tumor diagnosis were demonstrated, emphasizing the importance of including caregivers in psychotherapy for neuro-oncology patients.
Review
Oncology
Rachel M. Morris, Toni O. Mortimer, Kim L. O'Neill
Summary: Cytokines play a crucial role in cancer development, influencing immune function, inflammation, and tumor cell survival. They also have a significant impact on the molecular biology and microbiology of the tumor microenvironment. Therefore, cytokines have become attractive targets for cancer treatment.
Review
Immunology
Anil Kumar, Adeleh Taghi Khani, Ashly Sanchez Ortiz, Srividya Swaminathan
Summary: GM-CSF is a cytokine that drives the generation of myeloid cell subsets in response to stress, infections, and cancers. The levels of GM-CSF can either promote or inhibit cancer aggressiveness, depending on the specific conditions. The impact of GM-CSF signaling on cancer progression varies depending on the levels of GM-CSF, the cancer type, and the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Meiyan Zhang, Huiting Zhang, Shuxian Hu, Man Zhang, Yu Fang, Junjie Hu, Jianxiang Liao
Summary: This study surveyed 308 caregivers of children with epilepsy aged 0-12 years. The results showed that 65.6% of caregivers were in a depression status, 41.9% were in an anxiety status, 49.0% had poor sleep quality, and the proportion of unhealthy family functioning was 45.1%-96.1%, with unhealthy behavior control function accounting for 96.1%.
FRONTIERS IN NEUROLOGY
(2021)
Review
Oncology
Jawad Fares, Alex Cordero, Deepak Kanojia, Maciej S. Lesniak
Summary: Cytokines play a crucial role in brain metastases by regulating tumor metastasis and influencing therapeutic outcomes. Understanding the interactions between cytokines and cancer cells is essential for improving diagnostics and treatments in the context of brain metastases.
Article
Health Care Sciences & Services
Yuan He, Li-Yue Sun, Kun-Wei Peng, Man-Jun Luo, Ling Deng, Tao Tang, Chang-Xuan You
Summary: This study investigates the clinical implications of sleep quality, anxiety, and depression in patients with advanced lung cancer and their family caregivers. The results show high prevalence rates of poor sleep quality, anxiety, and depression in patients. There is a significant correlation between the sleep quality and anxiety/depression levels of patients and their caregivers.
BMJ SUPPORTIVE & PALLIATIVE CARE
(2022)
Article
Oncology
Leonie K. de Klerk, Anuj K. Patel, Sarah Derks, Eirini Pectasides, Jeremy Augustin, Mohamed Uduman, Nihal Raman, Fahire G. Akarca, Nadine J. McCleary, James M. Cleary, Douglas A. Rubinson, Jeffrey W. Clark, Bridget Fitzpatrick, Lauren K. Brais, Megan E. Cavanaugh, Amanda J. Rode, Melissa G. Jean, Patrick H. Lizotte, Matthew J. Nazzaro, Mariano Severgnini, Hui Zheng, Charles S. Fuchs, Peter C. Enzinger, Adam J. Bass
Summary: This study indicates that single-agent pembrolizumab has limited efficacy in patients with esophageal cancer, but circulating CXCL10 at baseline appears to be a robust predictor of response. Upregulation of other T cell exhaustion markers in PD-L1-positive patients suggests that immunotherapy combinations may hold promise in refractory esophageal cancer treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
