Review
Medicine, General & Internal
Luigi Pannone, Giulio Falasconi, Lorenzo Cianfanelli, Luca Baldetti, Francesco Moroni, Roberto Spoladore, Pasquale Vergara
Summary: Sudden cardiac death is a major cause of mortality in patients with certain heart diseases, with ongoing research focused on improving risk stratification to identify patients who would benefit from ICD implantation. Despite high levels of available data, there are currently no clear recommendations to reduce the risk of sudden cardiac death in these patient populations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Kevin Willy, Julia Kobe, Florian Reinke, Benjamin Rath, Christian Ellermann, Julian Wolfes, Felix K. Wegner, Patrick R. Leitz, Philipp S. Lange, Lars Eckardt, Gerrit Frommeyer
Summary: This study aimed to evaluate the usefulness of the MADIT-ICD benefit score in primary prevention. The results showed that the score was effective for patients with ischemic cardiomyopathy, but not for patients without structural heart disease or with left ventricular ejection fraction below 35%. Non-arrhythmic death could be predicted by a proposed non-arrhythmic mortality score. Future research should assess the performance of the score in different subgroups and compare it to other risk scores.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Christian Steinberg, Nicolas Dognin, Amit Sodhi, Catherine Champagne, John A. Staples, Jean Champagne, Zachary W. Laksman, Jean-Francois Sarrazin, Matthew T. Bennett, Benoit Plourde, Marc W. Deyell, Jason G. Andrade, Karine Roy, John A. Yeung-Lai-Wah, Nathaniel M. Hawkins, Blandine Mondesert, Louis Blier, Isabelle Nault, Gilles O'Hara, Andrew D. Krahn, Francois Philippon, Santabhanu Chakrabarti
Summary: This study assessed the incidence rate of appropriate device therapies in patients with secondary prevention ICD implants. The results showed that the risk of recurrent ventricular arrhythmia was highest in the first 3 months after device insertion and decreased over time. The cumulative incidence of arrhythmic syncope resulting in sudden cardiac incapacitation was highest within the first 90 days and subsequently dropped. Therefore, lowering the driving restrictions period to 3 months seems to be safe.
Article
Cardiac & Cardiovascular Systems
Rune Boas, Nikolay Sappler, Lukas von Stuelpnagel, Mathias Klemm, Ulrik Dixen, Jens Jakob Thune, Steen Pehrson, Lars Kober, Jens C. Nielsen, Lars Videbaek, Jens Haarbo, Eva Korup, Niels Eske Bruun, Axel Brandes, Hans Eiskjaer, Anna M. Thogersen, Berit T. Philbert, Jesper Hastrup Svendsen, Jacob Tfelt-Hansen, Axel Bauer, Konstantinos D. Rizas
Summary: Through a post hoc analysis of the DANISH study, researchers found that periodic repolarization dynamics can help identify patients with nonischemic cardiomyopathy who will benefit from prophylactic ICD implantation. PRD was significantly associated with mortality, with patients having higher PRD values experiencing greater mortality reduction after ICD implantation.
Article
Cardiac & Cardiovascular Systems
Amr Abdin, Suleman Aktaa
Summary: Implantable cardioverter defibrillators (ICDs) are effective in reducing the risk of sudden cardiac death, but transvenous implantation carries high risk. Subcutaneous ICDs (S-ICDs) offer a safer alternative for select patients.
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Badder Kattih, Felix Operhalski, Felicitas Boeckling, Florian Hecker, Felix Michael, Mate Vamos, Stefan H. Hohnloser, Julia W. Erath
Summary: This study evaluated the clinical outcomes of subcutaneous implantable cardioverter-defibrillator (S-ICD) and single-chamber transvenous (TV-ICD) in an all-comers population and found no significant differences in the composite endpoint, including survival, freedom of hospitalization, and device-associated events, between the two.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Gherardo Finocchiaro, Davide Radaelli, Stefano D'Errico, Michael Papadakis, Elijah R. Behr, Sanjay Sharma, Joseph Westaby, Mary N. Sheppard
Summary: This study investigated the causes of sudden cardiac death (SCD) in adolescents and found that the most common autopsy finding was structurally normal heart, indicative of sudden arrhythmic death syndrome. Among young athletes, arrhythmogenic cardiomyopathy, coronary artery anomalies, and commotio cordis were more common causes of SCD.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Health Care Sciences & Services
Henrik Eckert, Ibrahim El-Battrawy, Michael Veith, Gretje Roterberg, Jacqueline Kowitz, Siegfried Lang, Xiaobo Zhou, Ibrahim Akin, Andreas Muegge, Assem Aweimer
Summary: This study compared the complications of transvenous and subcutaneous implantable cardioverter-defibrillators (ICDs). The results showed that subcutaneous ICDs (S-ICDs) have certain advantages over transvenous ICDs (T-ICDs) in terms of lead-related complications. However, S-ICDs still have issues with inappropriate shocks and other ICD-related complications. Therefore, a case-by-case decision is recommended, but the continuous improvement of S-ICDs may make them an overall advantageous therapy option in the future.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Junichi Sugita, Katsuhito Fujiu, Yukiteru Nakayama, Takumi Matsubara, Jun Matsuda, Tsukasa Oshima, Yuxiang Liu, Yujin Maru, Eriko Hasumi, Toshiya Kojima, Hiroshi Seno, Keisuke Asano, Ayumu Ishijima, Naoki Tomii, Masatoshi Yamazaki, Fujimi Kudo, Ichiro Sakuma, Ryozo Nagai, Ichiro Manabe, Issei Komuro
Summary: It has been demonstrated that cardiac resident macrophages are crucial regulators of cardiac impulse conduction through the production of Amphiregulin, contributing significantly to the prevention of sudden death.
NATURE COMMUNICATIONS
(2021)
Review
Genetics & Heredity
Li Fan, Ping Yin, Zuojun Xu
Summary: Sudden death in young adults can result from genetic and environmental factors, requiring an understanding of genetic etiology for prevention. The causes of sudden death are complex and varied, with genetic risk factors playing a significant role.
Article
Cardiac & Cardiovascular Systems
Hanna-Kaisa Nordenswan, Pauli Poyhonen, Jukka Lehtonen, Kaj Ekstrom, Valtteri Uusitalo, Meri Niemela, Tapani Vihinen, Kari Kaikkonen, Petri Haataja, Tuomas Kerola, Tuomas T. Rissanen, Aleksi Alatalo, Paivi Pietila-Effati, Markku Kupari
Summary: Current guidelines for ICD implantation in patients with clinically manifest CS do not effectively distinguish a truly low-risk group, as the 5-year risk of SCD approaches 5% even in the absence of ICD indications. Further research is needed to investigate prognostic factors, including the role of diagnostic histology. In the meantime, all patients with CS presenting with clinical cardiac manifestations should be considered for ICD implantation.
Article
Multidisciplinary Sciences
Andrew E. Radbill, Lucy Y. Lei, Sachin Y. Paranjape, Daniel J. Blackwell, Robert L. Abraham, Derek S. Chew, Satish R. Raj, Bjorn C. Knollmann
Summary: This study aimed to assess rate-dependence of clinical surrogates of contractility and repolarization in humans with hypertrophic cardiomyopathy. Findings show that rapid pacing trains triggered ventricular ectopy in hypertrophic cardiomyopathy patients, but not controls. However, there were no significant differences observed in surrogate measures for cardiac contractility, suggesting that altered length-dependent myofilament activation may not have significant clinical implications in these patients.
Review
Cardiac & Cardiovascular Systems
Cicely Anne Dye, Erica Engelstein, Sean Swearingen, Jeanine Murphy, Timothy Larsen, Annabelle Santos Volgman
Summary: Arrhythmias and sudden cardiac death with sexual activity are rare, but recent studies suggest that these events are occurring in younger individuals, with a higher proportion of female decedents than previously described. Open dialogue between the cardiovascular team and the cardiac patient is necessary to provide education and reassurance for safe sexual activity participation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Andreea Maria Ursaru, Antoniu Octavian Petris, Irina Iuliana Costache, Nicolae Dan Tesloianu
Summary: This single-center study focused on the cardiovascular outcomes in ischemic and non-ischemic heart failure patients who received ICD therapy for the prevention of sudden cardiac death. The results showed similar rates of cardiovascular and all-cause mortality between ICMP and NICMP patients, as well as comparable rates of recurrent ventricular tachyarrhythmias and appropriate ICD therapies.
Article
Cardiac & Cardiovascular Systems
Juan P. Hernandez del Rincon, Mari C. Olmo Conesa, Ana Rodriguez Serrano, Helena Garcia Pulgar, David Lopez Cuenca, Carmen Munoz Esparza, Marina Navarro Penalver, Juan Jose Santos Mateo, Elisa Nicolas Rocamora, Cristina Gil Ortuno, Maria Sabater-Molina, Juan Ramon Gimeno Blanes, Francisco Pastor Quirante
Summary: Inherited cardiovascular diseases are a major cause of sudden cardiac death, but the prevention rate remains low at 35.6%. Among resuscitated cases, female sex and channelopathies were more prevalent, with 60.4% of patients achieving good neurological recovery.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
