Journal
REPRODUCTIVE TOXICOLOGY
Volume 81, Issue -, Pages 108-114Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2018.07.078
Keywords
Fluoride; Development exposure; Memory; Nicotinic receptor; Oxidative stress; Rat offspring
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Funding
- Secretaria General de Ciencia y Tecnologia from the Universidad Nacional del Sur (UNS) [PGI 24/B223]
- National Research Council (CONICET) [PIP 11220130100393CO]
- National Agency for the Promotion of Science and Technology of Argentina (ANPCyT) [PICT 2013 939, PICT 2015 0941]
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Daily exposure to fluoride (F) depends mainly on the intake of this element with drinking water. When administered during gestation and lactation, F has been associated with cognitive deficits in the offspring. However, the mechanisms underlying the neurotoxicity of F remain obscure. In the current study, we investigated the effects of oral exposure to low levels of F during the gestational and lactation periods, on the memory of adult female rat offspring. We also considered a possible underlying neurotoxic mechanism. Our results showed that this exposure reduced step-down latency in the inhibitory avoidance task, and decreased both mRNA expression of the alpha 7 nicotinic receptor (nAChR) and catalase activity in hippocampus. Our data indicates that low F concentrations administrated during gestation and lactation decrease the memory of 90-day-old female offspring. This suggests that the mechanism might be connected with an alpha 7 nAChR deficit in the hippocampus, induced by oxidative stress.
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