Journal
REPRODUCTIVE TOXICOLOGY
Volume 49, Issue -, Pages 219-225Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2014.09.006
Keywords
Methylmercury; Daphnia pulex; Early life; Nutrition; Reproduction; Survivorship
Categories
Funding
- International Life Sciences Institute, North America (ILSI N.A.) through the Future Leader Award
- NIH [T32 HL072757]
Ask authors/readers for more resources
As a well-known eco-toxicological model organism, Daphnia pulex may also offer advantages in human health research for assessing long-term effects of early life exposures to coupled stressors. Here, we examine consequences of early life exposure to methylmercury (MeHg) under standard and reduced food ration. We exposed Daphnia for 24 h in early life to varying concentrations of methylmercury(II) chloride (0, 200, 400, 800 and 1600 ng/L) and thereafter kept Daphnia on either a standard or a reduced food ration. The data suggests an additive effect of MeHg concentration and food ration on decreasing lifespan, although MeHg concentration does not affect survival linearly. Food ration and MeHg concentration were predictive of reduced reproduction, and there is some evidence of an interaction (p = 0.048). Multi-stressor work in alternative model systems may be useful for prioritizing research, taking into account potential antagonistic, additive or synergistic effects that nutritional status may have on chemical toxicity. (C) 2014 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available