Review
Engineering, Environmental
Sanjeeb Mohapatra, Lin Yutao, Shin Giek Goh, Charmaine Ng, You Luhua, Ngoc Han Tran, Karina Yew-Hoong Gin
Summary: Amplified hygiene and precautionary measures are necessary to control COVID-19, but may lead to increased use and discharge of disinfectants, particularly quaternary ammonium compounds (QACs). This review discusses the classification and mechanism of disinfectants, with a focus on QACs, and highlights the occurrence, fate, toxicity, and antimicrobial resistance associated with QACs. Evidence shows a significant rise in the mass load of QACs at wastewater treatment plants and higher concentrations in residential dust during the pandemic, posing potential risks to human health and the environment.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Engineering, Environmental
Yuhan Mai, Zhiyou Wang, Yang Zhou, Guodong Wang, Jingyi Chen, Yuxin Lin, Panpan Ji, Wei Zhang, Qian Jing, Liyun Chen, Zheng Chen, Haili Lin, Longguang Jiang, Cai Yuan, Peng Xu, Mingdong Huang
Summary: This study presents a new series of QACs, PACs, which enhance the biosafety and antimicrobial efficacy of QACs by substituting the alkyl chain with a phthalocyanine moiety. PACs demonstrate superior selectivity and antibacterial activity, and show promising therapeutic effects in a mouse model. This study provides a new strategy to improve the application range of QACs.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Kai Jansen, Christian Mohr, Katrin Luegger, Christian Heller, Jan Siemens, Ines Mulder
Summary: Quaternary alkylammonium compounds (QAACs) are widely used as surfactants and disinfectants in various industries. Studies suggest that QAACs may contribute to the spread of antibiotic resistance in the environment. A comprehensive study conducted in German soils found QAACs in 97% of the samples, with long-chain DADMACs being the most abundant.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Chemistry, Medicinal
Wenjia Dan, Jixiang Gao, Xiaohui Qi, Junru Wang, Jiangkun Dai
Summary: This review summarizes the chemical diversity, structure-activity relationships, and antibacterial mechanisms of quaternary ammonium compounds (QACs) reported over the past decade. The review aims to provide sufficient information for medicinal chemists to discover new generation antibacterial agents based on QACs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Entomology
Ya-Ling Wang, Qi-Nian Jin, Xiang-Ping Wang
Summary: Delaying mating has negative effects on the reproduction and population life table parameters of Henosepilachna vigintioctopunctata, leading to reduced preoviposition and oviposition periods in adults, decreased mating success rate, fecundity, fertility, and proportion of hatching eggs, as well as increased population doubling time. This study provides important information for potential pest control strategies in the future.
Review
Toxicology
Yuchong He, Ruocheng Yin
Summary: Microplastics and nanoplastics are widely distributed in the environment and have effects on the reproductive capacity and transgenerational toxicity on mammals, especially on humans. For males, microplastics cause abnormalities in testicular and sperm structure, decreased sperm vitality, and endocrine disruption. For females, microplastics cause abnormalities in ovary and uterus structure and endocrine disruption. Transgenerational toxicity studies show that exposure to microplastics can result in premature mortality and various disorders in offspring. Further research is needed to assess the threat of microplastics and nanoplastics to human fertility and reproductive health risks.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Entomology
Lvquan Zhao, Zheng Liu, Yuqun Lin, Shouzhu Liu
Summary: Mating disruption is an effective method for pest management, but delayed mating has limited impact on the reproductive fitness of the willow leaf beetle Plagiodera versicolora Laicharting. Additionally, mating age is an important factor affecting mating selection, sexual performance, and fecundity in P. versicolora.
Article
Biochemistry & Molecular Biology
Marta W. Chroszcz, Izabela M. Barszczewska-Rybarek
Summary: Six novel urethane-dimethacrylate analogues (QAUDMAs) were synthesized and characterized, with potential antibacterial effects for dental applications. They showed satisfactory physicochemical properties and will be further researched for dental composites development. The synthesis of QAUDMAs involved three stages, and their characteristics including density, viscosity, refractive index, glass transition temperature, polymerization shrinkage, and degree of conversion were determined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Entomology
Qin Lu, Jiale Lv, Endong Wang, Xuenong Xu
Summary: This study investigated the reproductive investment of N. californicus males under limited prey availability. The results showed that males could still mate after a 36-hour fast, but the mating duration increased. If the daily food availability was below 20% of demand, males could mate until the end of their lives, but their fertility decreased gradually.
EXPERIMENTAL AND APPLIED ACAROLOGY
(2022)
Review
Green & Sustainable Science & Technology
Guodong Wang, Ling Yang, Libin Jiang, Jingyi Chen, Qian Jing, Yuhan Mai, Lina Deng, Yuxin Lin, Liyun Chen, Zheng Chen, Peng Xu, Longguang Jiang, Cai Yuan, Mingdong Huang
Summary: A new type of disinfectant containing zinc phthalocyanine (ZnPc) was synthesized and showed higher antimicrobial effect against bacteria compared to traditional quaternary ammonium compounds (QACs). The disinfectant exhibited enhanced bactericidal toxicity at nanomolar concentrations when combined with specific light wavelengths. Furthermore, it was safe for mammalian cells and environmentally friendly due to its degradation under sunlight illumination.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Multidisciplinary Sciences
Matthew Etterson, Nathan Schumaker, Kristina Garber, Steven Lennartz, Andrew Kanarek, Jennifer Connolly
Summary: A novel integrated modeling system was developed to evaluate the impacts of pesticides on bird populations, with a case study focusing on the California Gnatcatcher population. Results showed varying effects from different pesticides on gnatcatcher abundance and distribution.
Article
Entomology
Mst Shahrima Tasnin, Bianca Jayde Kay, Thelma Peek, Katharina Merkel, Anthony R. Clarke
Summary: The study evaluated the impact of age and mating partner age on the reproductive potential of Bactrocera tryoni. Results showed that increasing age significantly reduced the fecundity and fertility of female flies, while males' fertility was influenced by both their own age and the age of their mating partner. Old females demonstrate reduced fecundity but are still capable of starting a new season's generation, while old males have the potential to contribute to the rapid population growth observed in the field when mating with new generation females.
JOURNAL OF INSECT PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Doris Crncevic, Lucija Krce, Linda Mastelic, Ana Maravic, Barbara Soldo, Ivica Aviani, Ines Primozic, Renata Odzak, Matilda Sprung
Summary: Quaternary ammonium compounds (QACs) are antimicrobial agents with broad spectrum activity targeting bacterial membrane. In this study, QACs based on imidazole derivative N-benzylimidazole showed potent antimicrobial activity against pathogenic bacteria, especially against bacterial biofilms. The most promising compound, N-tetradecyl derivative (BnI-14), demonstrated low toxicity to healthy human cells, suggesting potential as a new antimicrobial agent.
BIOORGANIC CHEMISTRY
(2021)
Article
Environmental Sciences
Elizabeth DiBona, Carol Haley, Simon Geist, Frauke Seemann
Summary: Microplastic pollution is a potential threat to environmental and human health. This study reveals that microplastics are present in all ecosystems and can contaminate food and water sources. Exposure to polyethylene fibers during the development stage of Japanese medaka fish results in delayed hatching and adverse effects at the molecular and organismal levels. These findings suggest a potential risk of polyethylene fiber exposure for wild fish during reproductive development.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Anderson Tadeu de Araujo-Ramos, Marcella Tapias Passoni, Marco Aurelio Romano, Renata Marino Romano, Anderson Joel Martino-Andrade
Summary: Glyphosate-based herbicides are widely used but controversial for their potential impacts on human health. While regulatory guideline studies suggest glyphosate lacks endocrine disrupting properties, in vivo and in vitro studies indicate GBHs may disrupt hormonal pathways.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Letter
Reproductive Biology
Patricia Hunt, Terry C. Hrubec
REPRODUCTIVE TOXICOLOGY
(2015)
Article
Reproductive Biology
Vanessa E. Melin, Travis E. Melin, Brian J. Dessify, Christina T. Nguyen, Caroline S. Shea, Terry C. Hrubec
REPRODUCTIVE TOXICOLOGY
(2016)
Article
Veterinary Sciences
Oscar A. Galagarza, David D. Kuhn, Stephen A. Smith, Terry C. Hrubec
VETERINARY CLINICAL PATHOLOGY
(2017)
Article
Developmental Biology
Terry C. Hrubec, Vanessa E. Melin, Caroline S. Shea, Elizabeth E. Ferguson, Craig Garofola, Claire M. Repine, Tyler W. Chapman, Hiral R. Patel, Reza M. Razvi, Jesse E. Sugrue, Haritha Potineni, Geraldine Magnin-Bissel, Patricia A. Hunt
BIRTH DEFECTS RESEARCH
(2017)
Letter
Developmental Biology
Terry C. Hrubec, Patricia A. Hunt
BIRTH DEFECTS RESEARCH
(2018)
Article
Anatomy & Morphology
Terry C. Hrubec, Kimberly A. Toops, Steven D. Holladay
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2009)
Article
Oncology
Mural Mallela, Theresa Hrubec
BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY
(2012)
Article
Environmental Sciences
Vanessa E. Melin, David W. Johnstone, Felicia A. Etzkorn, Terry C. Hrubec
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2014)
Article
Environmental Sciences
Murali K. Mallela, Stephen R. Werre, Terry C. Hrubec
ENVIRONMENTAL TOXICOLOGY
(2011)
Article
Parasitology
David Goodwin, Terry C. Hrubec, Bradley G. Klein, Jeannine S. Strobl, Stephen R. Werre, Qian Han, Anne M. Zajac, David S. Lindsay
JOURNAL OF PARASITOLOGY
(2012)
Review
Public, Environmental & Occupational Health
T. C. Hrubec, M. R. Prater, M. K. Mallela, R. M. Gogal, T. L. Guo, S. D. Holladay
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2012)
Article
Toxicology
Terry C. Hrubec, Ryan P. Seguin, Libin Xu, Gino A. Cortopassi, Sandipan Datta, Alexandra L. Hanlon, Alicia J. Lozano, Valerie A. McDonald, Claire A. Healy, Tyler C. Anderson, Najaha A. Musse, Richard T. Williams
Summary: This study found that 80% of study participants contained QACs in their blood; and that markers of inflammation, mitochondrial function, and sterol homeostasis varied with blood QAC concentration.
TOXICOLOGY REPORTS
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Murali K. Mallela, Juan Claudio Gutierrez, Terry C. Hrubec
Article
Developmental Biology
J. Claudio Gutierrez, Terry C. Hrubec, M. Renee Prater, Bonnie J. Smith, Larry E. Freeman, Steven D. Holladay
BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY
(2007)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)