Editorial Material
Biochemistry & Molecular Biology
Borja Quiroga
Summary: BPA, a common component of plastics worldwide, has been shown to act as an endocrine disruptor with some hormonal functions. High levels of BPA are related to cardiovascular events and carcinogenesis pathways, and CKD patients have higher serum concentrations of BPA due to impaired renal function. Efforts to reduce BPA levels in these patients include developing BPA-free dialysis filters and other techniques.
Article
Multidisciplinary Sciences
Xiaohui Liu, Keitaro Suyama, Takeru Nose, Miki Shimohigashi, Yasuyuki Shimohigashi
Summary: The study reports the dual action of bisphenol compounds on ER alpha and ER beta receptors, with the bisphenol E analogs exhibiting enhanced agonist/antagonist activities due to an electrostatic halogen bond. Bisphenol C (BPC) is found to be a bifunctional ER alpha-agonist and ER beta-antagonist, with high ER alpha activity and inhibitory activity against ER beta. The intensified receptor interaction of BPC is attributed to the presence of an n-pi-pi-n conjugation system mediated through the >C = CCl2 double bond.
Article
Biochemistry & Molecular Biology
Laura Maria Daian, Gabriela Tanko, Andrei Mircea Vacaru, Luiza Ghila, Simona Chera, Ana-Maria Vacaru
Summary: Diabetes, affecting nearly half a billion people worldwide, is linked to dysfunction of beta-cells. Exposure to endocrine-disrupting chemicals, such as bisphenol A (BPA), has been correlated with increased diabetes incidence. This study explores the activation of unfolded protein response (UPR) pathways in beta-cells under BPA treatment and the potential recovery of endoplasmic reticulum (ER) homeostasis. The findings suggest that modulators of UPR, like the chemical chaperone TUDCA, could be used as therapeutic interventions to restore beta-cell function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Julia de Morais Farias, Natascha Krepsky
Summary: This study reviewed the research on bacterial degradation of bisphenol analogues, finding that bacteria can degrade bisphenol analogues, especially bisphenol A. Sphingomonas, Sphingobium, and Cupriavidus are common degradation strains. The research is important for selecting suitable microorganisms for the bioremediation of bisphenol analogue pollution.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Xiaoyun Wu, Xiaowen Yang, Yuchai Tian, Pengchong Xu, Huifeng Yue, Nan Sang
Summary: The study found that BPB and BPAF, analogs of BPA, have adverse effects on uterine health, causing endometrial contraction, decreased epithelial height, and increased gland numbers. Bioinformatics analysis revealed that both BPB and BPAF disrupt the immune landscape of the uterus. Furthermore, eight genes associated with BPB and BPAF exposure were found to be related to uterine corpus endometrial carcinoma (UCEC), and high expression of Srd5a1 was significantly correlated with poor prognosis in patients.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Environmental Sciences
Tijana Vasiljevic, Tom Harner
Summary: BPA and its analogues are widely used in plastic synthesis, potentially disrupting the hormonal structure of living organisms. Reports on BPA levels in air are limited, mainly due to anthropogenic activities. China reported the highest outdoor air levels of BPA near a low-tech e-waste recycling site, and indoor dust also revealed bisphenol analogues used in BPA-free products.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Endocrinology & Metabolism
Giada Frenzilli, Joan Martorell-Ribera, Margherita Bernardeschi, Vittoria Scarcelli, Elisabeth Jonsson, Nadia Diano, Martina Moggio, Patrizia Guidi, Joachim Sturve, Noomi Asker
Summary: The study shows that both bisphenol A and its alternative bisphenol S can cause endocrine disrupting and genotoxic effects in brown trout, indicating two different mechanisms of damage underlying the activities of bisphenol A and bisphenol S. Bisphenol A primarily increases micronuclei frequency in fish erythrocytes, while bisphenol S may cause damage through other mechanisms.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marcelino Perez-Bermejo, Irene Mas-Perez, Maria Teresa Murillo-Llorente
Summary: Bisphenol A, a common endocrine disruptor found in daily products, is linked to obesity and diabetes due to its ability to mimic natural estrogen. This compound can stimulate adipocyte hypertrophy and alter the endocrine system. Despite some countries implementing policies, there is a lack of international agreement on the regulation of Bisphenol A exposure.
Article
Environmental Sciences
Yiwen Xu, Ailun Hu, Yiren Li, Yan He, Jianming Xu, Zhijiang Lu
Summary: A robust method was developed to accurately and quickly detect bisphenol A and 13 analogs in soil. The method was applied to 29 soil samples from 21 provinces in China, revealing 12 bisphenols with notably high concentrations, particularly bisphenol P which was at least ten times higher than in other environmental matrices. The results indicate hot spots of bisphenol pollution in soil, calling for further investigations.
Article
Environmental Sciences
Junjie Ao, Yongjie Liu, Weifeng Tang, Jun Zhang
Summary: This study investigates the potential effects and mechanisms of bisphenol S (BPS) exposure on human colon mucosal epithelial cells. The results show that BPS exposure increases the production of pro-inflammatory cytokines, destroys the tight junctions of the cells, and affects neurotransmitters. These findings suggest that BPS exposure may disrupt the balance of the gut-brain axis, leading to inflammatory cytokine production and tight junction destruction.
Article
Environmental Sciences
Chalana M. Sol, Charissa Van Zwol-Janssens, Elise M. Philips, Alexandros G. Asimakopoulos, Maria-Pilar Martinez-Moral, Kurunthachalam Kannan, Vincent W. V. Jaddoe, Leonardo Trasande, Susana Santos
Summary: Higher maternal bisphenol S urine concentrations, especially in the first trimester, seem to be associated with larger fetal head circumference, higher weight, and a lower risk of being small size for gestational age at birth. Other bisphenols were not consistently associated with fetal growth outcomes.
ENVIRONMENTAL HEALTH
(2021)
Article
Chemistry, Multidisciplinary
Eujung Kim, Minjung Song, Adam Gopal Ramu, Dongjin Choi
Summary: Bisphenol A (BPA), a common chemical used in plastic production, has emerged as a serious environmental concern due to its potential toxicity to plants. This study aimed to investigate the mechanism of BPA-induced root cells by examining the effects of BPA on the ultrastructure and function of soybean plant root tip cells. Changes in plant root cell tissues after BPA exposure were observed, and the accumulation of BPA in different plant parts was analyzed. The findings provide insight into how BPA can alter plant root growth.
Article
Marine & Freshwater Biology
Kaiqi Lai, Libin Zhang, Jialei Xu
Summary: In this study, metabolomics was used to investigate the metabolic response of sea cucumber exposed to BPAF, a type of bisphenol analogue. The results showed changes in lipid metabolism, glycerophospholipid metabolism, and amino acid synthesis following BPAF treatment. Sea cucumbers upregulated glycerophospholipid metabolism to repair intestinal cellular homeostasis destruction. Six metabolites were identified as potential biomarkers for BPAF exposure. This study provides theoretical support for assessing the risk of bisphenol analogues on economically important echinoderms such as A. japonicus.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Laura Marroqui, Juan Martinez-Pinna, Manuel Castellano-Munoz, Reinaldo S. dos Santos, Regla M. Medina-Gali, Sergi Soriano, Ivan Quesada, Jan-Ake Gustafsson, Jose A. Encinar, Angel Nadal
Summary: The study investigated the effects of BPS and BPF on insulin secretion and ion channel activity in pancreatic beta-cells using WT and BERKO mice. Results showed that both compounds enhance insulin release by affecting ion channel activity, with the involvement of the ER beta pathway. Molecular dynamics simulations indicated differences in ER beta ligand-binding domain among different bisphenols and PaPE-1.
Article
Chemistry, Analytical
Anna Raysyan, Rudolf J. Schneider
Summary: Bisphenol A is a crucial chemical in polymer plastics and coatings production. To address concerns about BPA toxicity, a latex microparticle-based lateral flow immunoassay method was developed for rapid on-site screening. The method showed high sensitivity and efficiency in detecting BPA.
Article
Environmental Sciences
T. C. Guillette, James McCord, Matthew Guillette, M. E. Polera, Kyle T. Rachels, Clint Morgeson, Nadine Kotlarz, Detlef R. U. Knappe, Benjamin J. Reading, Mark Strynar, Scott M. Belcher
ENVIRONMENT INTERNATIONAL
(2020)
Article
Neurosciences
Thomas W. Jackson, Gabriel A. Bendfeldt, Kelby A. Beam, Kylie D. Rock, Scott M. Belcher
NEUROTOXICOLOGY AND TERATOLOGY
(2020)
Article
Reproductive Biology
Jerrold J. Heindel, Scott Belcher, Jodi A. Flaws, Gail S. Prins, Shuk-Mei Ho, Jiude Mao, Heather B. Patisaul, William Ricke, Cheryl S. Rosenfeld, Ana M. Soto, Frederick S. vom Saal, R. Thomas Zoeller
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Engineering, Environmental
Thomas W. Jackson, Chris M. Scheibly, M. E. Polera, Scott M. Belcher
Summary: This study optimized a novel thermal denaturation assay to evaluate the thermal stability changes of HSA in the presence of various PFAS, revealing the protein-binding properties of most PFAS and providing a new method for understanding the structure and protein-binding properties of these chemicals.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Kaylie Kirkwood, Jonathon Fleming, Helen Nguyen, David M. Reif, Erin S. Baker, Scott M. Belcher
Summary: As concerns over exposure to PFAS continue to rise, novel monitoring methods are needed. This study used pine needles as passive samplers and a multidimensional analytical method to detect over 70 PFAS in the needles. The results provide critical insights into PFAS transport, contamination, and reduction efforts over the past six decades.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Toxicology
Thomas W. Jackson, Oliver Baars, Scott M. Belcher
Summary: This study found that gestational exposure to cadmium can cause hepatic insulin resistance, metabolic disruption, and obesity in female mice. Additionally, it was discovered that cadmium can preferentially cross the female placenta, accumulate in the liver, and lead to lifelong dysregulation of metal ion concentrations.
TOXICOLOGICAL SCIENCES
(2022)
Article
Ecology
Scott M. Belcher, Matthew P. Guillette, Frank Robb, Kylie D. Rock
Summary: The study found that blood mercury concentrations were particularly high in American alligators at Lake Waccamaw in North Carolina, while concentrations were lower at the Wilmington site. The bioaccumulation of mercury in alligators is greatly influenced by local environmental factors.
Article
Toxicology
Sierra D. Riegl, Cassie Starnes, Dereje D. Jima, Marine Baptissart, Anna Mae Diehl, Scott M. Belcher, Michael Cowley
Summary: Cadmium (Cd) exposure in adulthood is associated with nonalcoholic fatty liver disease (NAFLD). This study reveals that developmental Cd exposure may also play a significant role in the programming of NAFLD. The Imprinted Gene Network (IGN) and its regulator Zac1 are identified as key factors in the programming of NAFLD during Cd exposure.
TOXICOLOGICAL SCIENCES
(2023)
Article
Engineering, Environmental
Kylie D. Rock, Madison E. Polera, Theresa C. Guillette, Hannah M. Starnes, Kentley Dean, Mike Watters, Debra Stevens-Stewart, Scott M. Belcher
Summary: In this study, serum PFAS concentrations were determined for 31 dogs and 32 horses in Gray's Creek NC. PFAS were detected in every sample, with higher concentrations found in dogs compared to horses. The study suggests that long-term PFAS exposures may affect the renal and hepatic health of domestic animals.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Jane Muncke, Anna-Maria Andersson, Thomas Backhaus, Scott M. Belcher, Justin M. Boucher, Bethanie Carney Almroth, Terrence J. Collins, Birgit Geueke, Ksenia J. Groh, Jerrold J. Heindel, Frank A. von Hippel, Juliette Legler, Maricel V. Maffini, Olwenn V. Martin, John Peterson Myers, Angel Nadal, Cristina Nerin, Ana M. Soto, Leonardo Trasande, Laura N. Vandenberg, Martin Wagner, Lisa Zimmermann, R. Thomas Zoeller, Martin Scheringer
Summary: Food contact materials and articles are widely used in the global food system, but current regulations do not adequately protect public health from harmful chemicals that migrate from these materials. To address this issue, we propose testing the migration of finished food contact articles and expanding toxicological testing to improve the safety of these materials.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Toxicology
T. C. Guillette, Thomas W. Jackson, Matthew Guillette, James McCord, Scott M. Belcher
Summary: The surface and groundwater of the Cape Fear River basin in North Carolina is contaminated with high levels of PFAS, which have been found to have immune toxicant effects. This study evaluated the exposure of American alligators in the Cape Fear River to PFAS and found an association between increased PFAS exposure, disrupted immune functions, and autoimmune-like pathology in the alligator population.
FRONTIERS IN TOXICOLOGY
(2022)
Review
Toxicology
Hannah M. M. Starnes, Kylie D. D. Rock, Thomas W. W. Jackson, Scott M. M. Belcher
Summary: PFAS are a class of synthetic organic chemicals that are chemically stable, persistent in the environment, and have been globally contaminating built and natural environments. Studies show that PFAS accumulate in the brain of humans and wildlife, potentially causing neurotoxic effects, especially with exposures during development. There is limited research on short-chain PFAS, and most studies focus on high dose exposures to single PFAS congeners rather than chronic low-dose mixtures, highlighting the need for further analysis on the neurodevelopmental effects of environmentally relevant concentrations and complex mixtures of PFAS.
FRONTIERS IN TOXICOLOGY
(2022)
Article
Environmental Sciences
Lars Lind, Jesus A. Araujo, Aaron Barchowsky, Scott Belcher, Brian R. Berridge, Nipavan Chiamvimonvat, Weihsueh A. Chiu, Vincent J. Cogliano, Sarah Elmore, Aimen K. Farraj, Aldrin V. Gomes, Cliona M. McHale, Kathleen B. Meyer-Tamaki, Nikki Gillum Posnack, Hugo M. Vargas, Xi Yang, Lauren Zeise, Changcheng Zhou, Martyn T. Smith
Summary: The concept of key characteristics (KCs) has been developed to identify carcinogenic hazards and has now been applied to identify cardiovascular (CV) toxicants. This study identified 12 KCs of CV toxicants, divided into those affecting cardiac tissue, the vascular system, or both. These KCs can be used to identify potential CV toxicants and evaluate CV toxicity in a more comprehensive and standardized manner.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Toxicology
Thomas W. Jackson, Garret L. Ryherd, Chris M. Scheibly, Aubrey L. Sasser, T. C. Guillette, Scott M. Belcher
TOXICOLOGICAL SCIENCES
(2020)
Article
Pediatrics
P. Sorrow, R. Maguire, S. K. Murphy, S. M. Belcher, C. Hoyo
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
