Article
Biology
Md. Eftakhar Jahan Bhuiyan, Md. Golzar Hossain, Amit Saha, Md. Kamrul Islam, Farida Yeasmin Bari, Md. Abu Hadi Noor Ali Khan, Sharmin Akter
Summary: The study aimed to investigate the protective effects of vitamin C and 5-ASA against ACR-induced reproductive toxicity. The results showed that vitamin C and 5-ASA potentially mitigated the negative effects of ACR on male reproduction, and the combined application was recommended for better performance.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Chemistry, Organic
Caroline Paula Assuncao de Oliveira, Alice Arantes Carneiro, Luiz Otavio Guimaraes Ervilha, Mariana Machado-Neves, Ana Claudia Ferreira Souza, Renner Philipe Rodrigues Carvalho
Summary: Due to environmental contamination, exposure to pollutants in polluted environments can cause reproductive damages in male vertebrate animals, including reduced fertility and population decline. The effects include a reduction in androgen levels, impaired spermatogenesis, morphological damage to reproductive organs, and decreased sperm quality. Wild animals are mainly exposed to endocrine-disrupting compounds, toxic metals, and radiation. Further studies are needed to better understand the effects of environmental contaminants on male reproduction in naturally exposed animals.
Review
Endocrinology & Metabolism
Larissa Berloffa Belardin, Keliane Brochu, Christine Legare, Maria Agustina Battistone, Sylvie Breton
Summary: Purinergic receptors are widely expressed throughout the body and play a role in regulating cell function. They activate specific receptors and trigger different signaling pathways to regulate various cellular responses. Purinergic signaling is important for the physiological and pathophysiological processes in the male reproductive system, but our understanding of this is limited.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Rongyu Yao, Tingting Lu, Jiamei Liu, Wanhong Li, Xiuiu Weng, Xiangpeng Yue, Fadi Li
Summary: ADP-dependent glucokinase (ADPGK) plays a significant role in regulating energy metabolism and promoting testis development and spermatogenesis. The mutation in ADPGK gene was found to be associated with testis traits and spermatogenesis in Hu sheep, with TC genotype individuals showing increased gene expression and reproductive advantages. The SNP identified may serve as an effective DNA molecular marker for marker-assisted selection in Hu sheep breeding programs.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yun Liang, Xinshuang Huang, Li Fang, Mingjie Wang, Chunxiao Yu, Qingbo Guan
Summary: This study found that exposure to Iodoacetic acid (IAA) can negatively affect spermatogenesis and testosterone synthesis in the testis by inducing DNA damage and reducing lipid droplet transport.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Andrology
Akanksha Singh, Debarshi Sarkar, Shio Kumar Singh
Summary: Treatment with fenugreek seed extract had adverse effects on male reproductive health and pregnancy outcome in mice, including degenerative changes in the testis, alterations in sperm parameters and fertility indices.
Review
Environmental Sciences
Maingredy Rodrigues Souza, Renata Mazaro-Costa, Thiago Lopes Rocha
Summary: A bibliometric and systematic review on the toxic effects of different types of NMs on the male reproductive system in mammalian models revealed that NMs have the ability to cross the blood-testis barrier and bioaccumulate in several organs. The reproductive toxicity of NMs is mainly related to ROS production, oxidative stress, DNA damage and apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Pharmacology & Pharmacy
Farah Hanan Fathihah Jaffar, Khairul Osman, Chua Kien Hui, Aini Farzana Zulkefli, Siti Fatimah Ibrahim
Summary: The study found that supplementation with 250 mg/kg BW/d of EBN showed a significant increase in sperm concentration, sperm motility, FSH, and LH levels compared to the group receiving 10 mg/kg BW/d. There was a dose-dependent increase in testosterone level, but it was not significant between groups. In conclusion, EBN was found to have significant effects on male reproductive parameters.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yanping Huang, Xiangping Li, Xiangzhou Sun, Jiahui Yao, Fengxin Gao, Zhenqing Wang, Jiaying Hu, Zhu Wang, Bin Ouyang, Xiangan Tu, Xuenong Zou, Wei Liu, Mujun Lu, Chunhua Deng, Qiyun Yang, Yun Xie
Summary: This study investigates the phenotypes and transcriptomes of different regions of the male mouse reproductive tract to explore the mechanisms underlying reproductive aging. It identifies region-specific genes and highlights the role of immune response-associated factors in male reproductive aging. The findings contribute to our understanding of male reproductive aging and infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gerile Naren, Jiaojiao Guo, Qiujuan Bai, Na Fan, Buhe Nashun
Summary: Chemotherapeutic agent 5-fluorouracil has adverse effects on reproduction, causing developmental block, malformation, and ovarian damage in females. However, studies suggest that the toxicity is reversible and certain drugs used in combination can protect the reproductive system from damage.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Review
Reproductive Biology
Mariana Feijo, Roberta V. L. Martins, Silvia Socorro, Luisa Pereira, Sara Correia
Summary: Endocrine-disrupting chemical Vinclozolin was found to decrease sperm quality parameters and testicular/epididymal weight in exposed animals. Exposure length, dose, and time point influenced the results, with overall robustness observed in sensitivity analysis despite moderate/high heterogeneity. Studies included were of good quality, with data supporting the disruption of spermatogenic output and male fertility by Vinclozolin exposure.
BIOLOGY OF REPRODUCTION
(2021)
Article
Agriculture, Dairy & Animal Science
Nicola Mirabella, Alessandra Pelagalli, Giovanna Liguori, Mohammad Alam Rashedul, Caterina Squillacioti
Summary: Aquaporins (AQPs) are transmembrane proteins facilitating transport of water and small solutes between cells. This study found that AQP3 and AQP5 have different distribution patterns in reproductive tissues of dogs and may be involved in spermatogenesis and sperm maturation. Investigating testicular and epididymal function is important for understanding male fertility.
ANIMAL REPRODUCTION SCIENCE
(2021)
Article
Cell Biology
Xue Zhang, Yong Zuo, Jianhua Zhang, Di Zhang, Muhammad Naeem, Yanzhong Chang, Zhenhua Shi
Summary: Sevoflurane, a commonly used inhalation anesthetic, has a detrimental effect on spermatogenesis and fertilization in male animals. This study explores the mechanism behind this impact, suggesting that Sev disrupts iron metabolism in the testis and epididymis, leading to inhibited sperm production. The damaging effects of Sev on fertility can be ameliorated through iron supplementation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Plant Sciences
Adam Shepherd, Oliver Brunckhorst, Kamran Ahmed, Qihe Xu
Summary: This scoping review examines the clinical evidence on the effects of botanicals on testicular functions and male fertility. The study reveals that different botanicals can have both beneficial and detrimental effects on the testis and male fertility. However, more research is needed to determine the specific botanicals that can be safely and effectively used.
Article
Agriculture, Dairy & Animal Science
Fahad Al-Yahyaey, Cyril Stephen, Yasir Al-Shukaili, Samir Al-Bulushi, Ihab Shaat, Russell Bush
Summary: This study aimed to investigate the impact of Spirulina platensis supplementation on the reproductive characteristics of Sahrawi and Jabbali bucks. The findings demonstrated that the addition of Spirulina platensis had a notable positive effect on reproductive parameters, offering valuable insights for livestock management practices.
Article
Nutrition & Dietetics
Fernanda Lambert de Andrade Freire, Raquel Costa Silva Dantas-Komatsu, Niethia Regina Dantas de Lira, Rosiane Viana Zuza Diniz, Severina Carla Vieira Cunha Lima, Fernando Barbosa Jr, Lucia Fatima Campos Pedrosa, Karine Cavalcanti Mauricio Sena-Evangelista
Summary: This study found that biomarkers of zinc and copper in patients with heart failure did not seem to be affected by differences in intake, but factors related to oxidative stress and inflammation should be monitored in clinical practice.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Article
Chemistry, Multidisciplinary
Jorge Willian Franco de Barros, Patricia Villela e Silva, Gustavo Venancio da Silva, Katiussia Pinho da Silva, Cibele dos Santos Borges, Andre Mueller, Lethicia Valencise, Andre Sampaio Pupo, Wilma De Grava Kempinas
Summary: Rosuvastatin, a third-generation statin, does not exhibit estrogenic or antiestrogenic effects on uterine tissue in rats, but is associated with alterations in uterine basal contraction pattern. In vivo and ex vivo exposures to rosuvastatin potentially modulate the action of uterine contraction inducers, indicating a pleiotropic effect on uterine physiology. Further studies are needed to determine the precise mechanism of action of rosuvastatin on female reproductive function.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Cell Biology
Franciely A. V. D. Leal, Gessica D. Goncalves, Joao Gabriel M. Soncini, Larissa A. Staurengo-Ferrari, Victor R. Fattori, Waldiceu A. Verri, Wellerson R. Scarano, Glaura S. A. Fernandes
Summary: This study suggests that exposure to aluminium chloride during the peripubertal period can have detrimental effects on prostate development in rats, including decreased body weight and reorganization of tissue compartments.
Article
Engineering, Biomedical
Fernanda Gomes Leite, Juliana Fonzar Marana, Luiza Fernandes Tavares de Sa, Thais Francine Ribeiro Alves de Almeida, Helison Rafael Pereira do Carmo, Marco Vinicius Chaud, Denise Grotto, Lindemberg da Mota Silveira-Filho
Summary: The study found that the combination of polyaniline (PANi) with collagen and silk-fibroin (COL-SF) patches can safely promote improvement in left ventricular remodeling in a myocardial infarct rat model. These patches showed better performance in reducing infarct size and increasing left ventricular thickness compared to the control group, and did not cause worsening of echocardiographic measurements. However, the use of PANi may lead to signs of hepatotoxicity and pro-oxidant effects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bruno A. Rocha, Cibele A. Cesila, Airton C. Martins, Marilia C. O. Souza, Fernando Barbosa Jr
Summary: A study established a method for detecting five commonly used parabens in sports supplements, revealing that almost all samples contained at least one paraben, with ethylparaben and methylparaben being the most frequently detected. Propylparaben, butylparaben, and benzylparaben, which are forbidden in food samples, were also found in some samples.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Oncology
Wilmer Ramirez-Carmona, Beatriz Diaz-Fabregat, Andreia Yuri Yoshigae, Ariana Musa de Aquino, Wellerson Rodrigo Scarano, Anthony Cesar de Souza Castilho, Juliane Avansini Marsicano, Rosana Leal do Prado, Juliano Pelim Pessan, Leonardo de Oliveira Mendes
Summary: The systematic review found that SF levels were higher in patients with cancer, especially in head and neck cancer, lung cancer, pancreatic cancer, and renal cell carcinoma patients. In advanced stages of tumors, ferritin levels were significantly higher than in healthy adults. SF acts as a sensitive biomarker for the detection of advanced stages of cancer.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Environmental Sciences
Ana Carolina Cavalheiro Paulelli, Cibele Aparecida Cesila, Paula Picoli Devoz, Silvana Ruella de Oliveira, Joao Paulo Bianchi Ximenez, Walter dos Reis Pedreira Filho, Fernando Barbosa Jr
Summary: The study conducted in communities directly affected by the disaster revealed high levels of exposure to toxic metals such as aluminum, arsenic, mercury, and nickel. Factors such as community, drinking water, fish and seafood consumption, and smoking habits were found to be associated with metal/metalloid levels in their body. Well and tap water intake were identified as important sources of exposure to aluminum and nickel. The findings represent health risks to the groups living in the areas affected by the tailings dam failure, calling for further studies to evaluate the potential health effects of high exposure to metals and remediation actions from public health Brazilian authorities.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Physical
Natalia A. D'Angelo, Mayra C. C. Camara, Mariana A. Noronha, Denise Grotto, Marlus Chorilli, Felipe R. Lourenco, Carlota De O. Rangel-Yagui, Andre M. Lopes
Summary: This study investigates the co-encapsulation of chemotherapeutic drugs using nanostructures to improve treatment efficacy and reduce the risk of drug resistance. The researchers found that poly(ethylene glycol)-block-poly(epsilon-caprolactone) (PEG-PCL)-based polymersomes (Ps) can enhance the bioavailability and cellular uptake of drugs, as well as increase their solubility. The study also examines the influence of various conditions on the nanostructures and provides optimal parameters for their production.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Cell Biology
Marilia Martins Cavariani, Talita de Mello Santos, Luiz Gustavo de Almeida Chuffa, Patricia Fernanda Felipe Pinheiro, Wellerson Rodrigo Scarano, Raquel Fantin Domeniconi
Summary: Nutrition is an important environmental factor for the interactions between fetus and mother. This study investigated the effects of maternal protein restriction on the morphology and development of the epididymis in rat offspring. The results showed that maternal protein restriction altered the structure and functioning of the epididymis during important periods of postnatal development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Helga Caputo Nunes, Samara Costa Tavares, Heloisa Vicente Garcia, Maira Smaniotto Cucielo, Sergio Alexandre Alcantara dos Santos, Mirian Carolini Esgoti Aal, Marjorie Assis de Golim, Luis Antonio Justulin Jr, Amanda Oliveira Ribeiro, Elenice Deffune, Wellerson Rodrigo Scarano, Flavia Karina Delella
Summary: Chemical contamination is an important factor to consider in cell therapy strategy design. This study found that BPA and TCDD can significantly reduce cell viability and affect adipogenic differentiation and DNA damage.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Toxicology
Suyane da Silva Moreira, Beatriz de Matos Manoel, Joao Pedro Gaspar Inacio, Carolina Gabrielli de Souza, Ana Carolina Casali Reis, Barbara Campos Jorge, Ariana Musa de Aquino, Wellerson Rodrigo Scarano, Claudia Andrea Lima Cardoso, Arielle Cristina Arena
Summary: Exposure to venlafaxine during lactation can lead to changes in play behavior, sperm quality, and hypothalamic androgen receptor content in male offspring. This study highlights the importance of evaluating the potential effects of antidepressant use during lactation.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Toxicology
Ana Flavia Quiarato Lozano, Bruna Marques Tavares, Patricia Villela E. Silva, Jorge Willian Franco de Barros, Wilma De Grava Kempinas
Summary: This study investigated the impact of stress and sertraline on the reproductive development of male rats. The results showed that prenatal exposure to sertraline affects the cell count in fetal testes and the nuclear volume of Leydig cells in adult rats, as well as the morphology and motility of sperm.
TOXICOLOGICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Veronyca Goncalves Paula, Yuri Karen Sinzato, Franciane Quintanilha Gallego, Larissa Lopes Cruz, Ariana Musa de Aquino, Wellerson Rodrigo Scarano, Jose Eduardo Corrente, Gustavo Tadeu Volpato, Debora Cristina Damasceno
Summary: This study analyzed the effects of maternal hyperglycemia and post-weaning consumption of a high-fat diet on the mitochondrial function and ovarian development in adult pups of diabetic rats. The results showed that maternal diabetes and high-fat diet led to impaired ovarian function and mitochondrial dysfunction in adult offspring.
Article
Environmental Sciences
Thaina Cavalleri Sousa, Leticia Pereira de Souza, Maria Luiza Silva Ricardo, Andreia Yuri Yoshigae, Karianne Delalibera Hinokuma, Ana Beatriz Ratto Gorzoni, Ariana Musa de Aquino, Wellerson Rodrigo Scarano, Anthony Cesar de Sousa Castillho, Maria Eduarda Almeida Tavares, Alice Santos Cruz Veras, Giovana Rampazzo Teixeira, Gisele Alborghetti Nai, Leonardo de Oliveira Mendes
Summary: Endocrine disruptors (ED) are compounds that can modify hormone biosynthesis, affecting hormone-dependent organs. Previous studies have mainly focused on evaluating the effects of single or small amounts of ED on humans, with short durations, without fully revealing human exposure. This study characterized the prostate histoarchitecture of rats exposed to an ED mixture (ED Mix) mimicking human exposure. The results showed that the ED Mix could cause alterations in the prostatic histoarchitecture and induce the appearance of preneoplastic lesions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Bruna Jardim Pereira Lima, Gabriel Rodrigues Leal de Oliveira, Thaina Cavalleri Sousa, Ariana Musa de Aquino, Karianne Delalibera Hinokuma, Maria Luiza Silva Ricardo, Wellerson Rodrigo Scarano, Anthony Cesar de Souza Castilho, Francis Lopes Pacagnelli, Francisco Eduardo Martinez, Leonardo de Oliveira Mendes
Summary: This study analyzes the importance of fractal analysis as a useful tool to identify and quantify tissue remodeling in rats submitted to ethanol consumption and hormone therapy with testosterone. The findings suggest that alcohol consumption leads to tissue disorganization in the prostate of rats and androgen therapy can mitigate these changes. Fractal analysis can be used to quantify these tissue changes.
ANIMAL REPRODUCTION
(2023)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
