Article
Environmental Sciences
Pai Liu, Yeming Zhao, Sheng Wang, Hao Xing, Wen-Fei Dong
Summary: The study found that SiNPs and CdCl2 have synergistic adverse effects on zebrafish ovaries, leading to changes in ovarian structure and function, reduced number of mature oocytes, and malformed offspring. Deep-sequencing analysis indicated that lipid metabolism, estrogen metabolism, and oocyte development processes were significantly affected by the exposure.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Naira da Silva Mansano, Henrique Rodrigues Vieira, Roberta Araujo-Lopes, Raphael Escorsim Szawka, Jose Donato Jr, Renata Frazao
Summary: This study found that acute fasting can modulate the activity of the HPG axis and has gender-specific effects on Kisspeptin neurons. In female mice, fasting reduces the levels of luteinizing hormone and prolactin, while increasing follicle-stimulating hormone levels. Fasting also reduces Kisspeptin gene expression. Additionally, GABAergic transmission and the effects of neuropeptide Y on ARHKisspeptin neurons show gender differences.
Article
Reproductive Biology
Suellen Ribeiro da Silva Scarton, Felipe Tsuzuki, Marina Trevizan Guerra, Dayane Priscila dos Santos, Aldair Casagrande dos Santos, Ana Tereza Bittencourt Guimaraes, Andrea Name Colado Simao, Celia Cristina Leme Beu, Glaura Scantamburlo Alves Fernades
Summary: This study investigated the reproductive effects of cyantraniliprole on adult female rats. Results indicate that cyantraniliprole could act as an endocrine disruptor, causing negative changes in the morphology and redox system of the uterus and ovaries.
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Reproductive Biology
Svenja Claassen, Joerg Aurich, Ingrid Walter, Camille Gautier, Christine Aurich
Summary: This study analyzed the relationship between anti-Mullerian hormone (AMH) concentration in blood and ovarian tissue in female cats. The results showed that AMH protein was expressed in all endocrine structures of the cat ovary, but its usefulness for assessing individual cat ovarian function is limited.
Article
Cell Biology
Yiran Zhou, Han Yan, Wenjun Liu, Chengqing Hu, Yuan Zhou, Ruya Sun, Yida Tang, Chao Zheng, Jichun Yang, Qinghua Cui
Summary: This study provides a comprehensive transcriptomic landscape of female mice during different phases of the reproductive cycle, revealing the widespread regulation of neuro-functions, immune functions, and blood coagulation. The study also identifies key transcription factors and pathways involved in the estrous cycle. Moreover, the study demonstrates the significant impact of the estrous cycle on the cardiovascular system and highlights the enhanced efficacy of certain hypotensive drugs during the estrus phase. Overall, this research contributes valuable insights for investigating the reproductive cycle and precision medicine.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
I. Rajesh, M. Gobikrushanth, J. E. Carrelli, M. Oba, D. J. Ambrose
Summary: The study aimed to determine the repeatability of anogenital distance (AGD) in different physiological states in cows. The results showed that AGD had high repeatability during the estrous cycle, gestation, and lactation, except during late gestation.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Nutrition & Dietetics
Yaxue Cao, Min Yang, Jie Song, Xuemei Jiang, Shengyu Xu, Lianqiang Che, Zhengfeng Fang, Yan Lin, Chao Jin, Bin Feng, De Wu, Lun Hua, Yong Zhuo
Summary: FGF21, a hormone released in the liver, has been identified as an important endocrine signal for dietary protein intake. This study investigated the role of FGF21 and hypothalamic changes in controlling estrous cyclicity by dietary protein intake. The research found that severe dietary protein restriction resulted in the cessation of estrous cyclicity and ovarian follicle development, and hepatic FGF21 and hypothalamic Kiss-1 were partially required for this process.
Article
Biology
Sara Pagliarani, Chiara Palmieri, Michael McGowan, Frank Carrick, Jackson Boyd, Stephen D. Johnston, Dongbao Chen
Summary: The koala has recently been listed as an endangered species due to challenges associated with habitat fragmentation, climate change, and disease. This article presents the findings of two PhD theses, providing a detailed description of the female koala reproductive anatomy and histology. The research focuses on artificial insemination and the histopathological changes in the urogenital system caused by Chlamydia spp. infections.
Article
Endocrinology & Metabolism
Klaudia Barabas, Gergely Kovacs, Viola Vertes, Erzsebet Kovesdi, Peter Faludi, Ildiko Udvaracz, Daniel Pham, Dora Reglodi, Istvan M. Abraham, Zsuzsanna Nagy
Summary: This study found that embryonic deletion of PACAP significantly alters the structure and function of the GnRH-kisspeptin neuronal network, leading to changes in fertility. Specifically, PACAP KO mice experienced altered estrous cycles with longer periods of diestrus and decreased time in estrus. Furthermore, the number of kisspeptin neurons decreased in the ARC region, while ERα expression levels showed differential changes in different brain regions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Neurosciences
Cathryn A. Cutia, Leanna K. Leverton, Xiyu Ge, Rana Youssef, Lori T. Raetzman, Catherine A. Christian-Hinman
Summary: Clinical evidence suggests that there are differential outcomes of comorbid conditions in patients with temporal lobe epilepsy (TLE) based on the lateralization of the seizure focus. This study evaluated the effects of targeting left or right dorsal hippocampus in a model of TLE, and found that it produced different outcomes in granule cell dispersion, body weight gain, and reproductive endocrine dysfunction in female mice. The findings suggest that lateralization of the epileptogenic insult may contribute to similar reproductive endocrine outcomes.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Food Science & Technology
Maria Rosa Ramos Nieto, Marianela Lasagna, Gabriel Cao, Gloria Alvarez, Clarisa Santamaria, Maria Eugenia Rodriguez Girault, Nadia Bourguignon, Noelia Di Giorgio, Clara Ventura, Mariana Mardirosian, Horacio Rodriguez, Victoria Lux-Llantos, Claudia Cocca, Mariel Nunez
Summary: The study found that chronic exposure to low concentrations of CPF affects ovarian steroid synthesis in female rats, leading to changes in the estrous cycle of animals, as well as proliferative changes in the uterus.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Environmental Sciences
Laura Yesenia Castillo, Jorge Rios-Carrillo, Juan Carlos Gonzalez-Orozco, Ignacio Camacho-Arroyo, Jean-Pascal Morin, Rossana C. Zepeda, Gabriel Roldan-Roldan
Summary: This study found that male rats are more susceptible to anxiety induced by BPA exposure during puberty compared to female rats, as evidenced by an increase in passive-coping behaviors and changes in brain gene expression. These findings highlight the importance of considering sex differences in peripubertal behavioral toxicology studies.
Article
Behavioral Sciences
Gabriel Guillen-Ruiz, Jonathan Cueto-Escobedo, Fabiola Hernandez-Lopez, Lina E. Rivera-Aburto, Emma Herrera-Huerta, Juan Francisco Rodriguez-Landa
Summary: The study found that the effects of caffeine intake vary during different stages of the ovarian cycle in rats. In female rats during metestrus-diestrus, all doses of caffeine increased anxiety-like behavior, while during proestrus-estrus, only high doses had a slight increase in anxiety behavior. The observed effects may be associated with the naturally occurring low and high concentrations of steroid hormones during these phases.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Environmental Sciences
Yanhua Wang, Lu Lv, Chao Xu, Dou Wang, Guiling Yang, Xinquan Wang, Hongbiao Weng, Qiang Wang
Summary: The study found that the mixture of thiophanate-methyl and fenvalerate showed higher toxicity to zebrafish embryos compared to individual chemicals, and had a greater impact on the expression of related genes in zebrafish. Therefore, future environmental risk assessments need to consider the effects of pesticide mixtures on aquatic ecosystems.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Medicine, Research & Experimental
Lucas Silva Cortes, Henrique Spaulonci Silveira, Luiz Antonio Lupi, Talita de Mello Santos, Marilia Martins Cavariani, Raquel Fantin Domeniconi, Leticia Barbosa Gaiotte, Diego Augusto de Morais Oliveira, Luis Antonio Justulin, Luiz Gustavo de Almeida Chuffa
Summary: Maternal low protein diet significantly affects the nutritional parameters, estrous cycle, ovarian histomorphometry, and reproductive health of offspring, without altering the levels of intracellular regulatory molecules in adulthood.
Article
Biochemistry & Molecular Biology
Jorge Willian Franco de Barros, Cibele dos Santos Borges, Gabriela Missassi, Taina Louise Pacheco, Wilma De Grava Kempinas
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Article
Food Science & Technology
Gabriel Adan Araujo Leite, Thamiris Moreira Figueiredo, Marina Trevizan Guerra, Cibele dos Santos Borges, Fabio Henrique Fernandes, Janete Aparecida Anselmo-Franci, Wilma De Grava Kempinas
FOOD AND CHEMICAL TOXICOLOGY
(2018)
Article
Toxicology
Gabriel Adan Araujo Leite, Marciana Sanabria, Marilia Martins Cavariani, Janete Aparecida Anselmo-Franci, Patricia Fernanda Felipe Pinheiro, Raquel Fantin Domeniconi, Wilma De Grava Kempinas
JOURNAL OF APPLIED TOXICOLOGY
(2018)
Article
Toxicology
Gabriel Adan Araujo Leite, Jorge Willian Franco de Barros, Airton da Cunha Martins, Janete Aparecida Anselmo-Franci, Fernando Barbosa, Wilma De Grava Kempinas
JOURNAL OF APPLIED TOXICOLOGY
(2019)
Article
Environmental Sciences
Gabriel Adan Araujo Leite, Thamiris Moreira Figueiredo, Taina Louise Pacheco, Marina Trevizan Guerra, Janete Aparecida Anselmo-Franci, Wilma De Grava Kempinas
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2018)
Article
Andrology
W. G. Kempinas, C. S. Borges, G. A. A. Leite, T. M. Figueiredo, M. Gregory, D. G. Cyr
Article
Toxicology
Patricia Villela e Silva, Cibele dos Santos Borges, Josiane de Lima Rosa, Taina Louise Pacheco, Thamiris Moreira Figueiredo, Gabriel Adan Araujo Leite, Marina Trevizan Guerra, Janete Aparecida Anselmo-Franci, Gary Robert Klinefelter, Wilma De Grava Kempinas
JOURNAL OF APPLIED TOXICOLOGY
(2020)
Article
Urology & Nephrology
Luiz Ricardo de Almeida Kiguti, Taina Louise Pacheco, Edson Antunes, Wilma de Grava Kempinas
JOURNAL OF SEXUAL MEDICINE
(2020)
Article
Pharmacology & Pharmacy
Cibele S. Borges, Patricia V. Silva, Ana Flavia Q. Lozano, Gabriela Missassi, Raquel F. Silva, Janete A. Anselmo-Franci, Wilma G. Kempinas
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Jorge Willian Franco de Barros, Patricia Villela e Silva, Gustavo Venancio da Silva, Katiussia Pinho da Silva, Cibele dos Santos Borges, Andre Mueller, Lethicia Valencise, Andre Sampaio Pupo, Wilma De Grava Kempinas
Summary: Rosuvastatin, a third-generation statin, does not exhibit estrogenic or antiestrogenic effects on uterine tissue in rats, but is associated with alterations in uterine basal contraction pattern. In vivo and ex vivo exposures to rosuvastatin potentially modulate the action of uterine contraction inducers, indicating a pleiotropic effect on uterine physiology. Further studies are needed to determine the precise mechanism of action of rosuvastatin on female reproductive function.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Ana Flavia Quiarato Lozano, Mayara Silva Moura, Bruna Marques Tavares, Wilma De Grava Kempinas
Summary: The study found that exposure to sertraline during pregnancy affected the somatic, reflex, and neurobehavioral development of offspring, with delays in teeth eruption and fur development, as well as reduced exploratory behavior compared to control groups.
Article
Toxicology
Ana Flavia Quiarato Lozano, Bruna Marques Tavares, Patricia Villela E. Silva, Jorge Willian Franco de Barros, Wilma De Grava Kempinas
Summary: This study investigated the impact of stress and sertraline on the reproductive development of male rats. The results showed that prenatal exposure to sertraline affects the cell count in fetal testes and the nuclear volume of Leydig cells in adult rats, as well as the morphology and motility of sperm.
TOXICOLOGICAL SCIENCES
(2022)
Editorial Material
Reproductive Biology
Daniel G. Cyr, Wilma G. Kempinas, Cibele S. Borges
REPRODUCTIVE TOXICOLOGY
(2022)
Article
Toxicology
Jorge W. F. Barros, Karolina S. Tonon, Cibele S. Borges, Patricia Silva, Ana F. Q. Lozano, Taina L. Pacheco, Janete A. Anselmo-Franci, Wilma G. Kempinas
CURRENT RESEARCH IN TOXICOLOGY
(2020)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)
