Article
Environmental Sciences
Andrew Nagel, Chad W. W. Cuss, Greg G. G. Goss, William Shotyk, Chris N. N. Glover
Summary: The accumulation and tissue distribution of thallium (Tl) in rainbow trout after acute and subchronic waterborne exposures were investigated. Tl accumulated in the gill in a dose-dependent manner, while plasma Tl was rapidly mobilized to tissues and only accumulated at higher exposure concentrations. Muscle Tl concentrations at 28 days were lower than those at 96 hours, indicating mechanisms that reduce Tl accumulation over time. However, muscle Tl concentrations after acute exposure exceeded acceptable daily intake values, posing a risk to human health.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Biochemical Research Methods
Qian Li, Lu Mu, Xuebing Yang, Ge Wang, Jing Liang, Shaolin Wang, Hua Zhang, Zhen Li
Summary: We developed an efficient and simplified workflow for single-cell proteomics analysis, allowing us to profile the proteome at the individual oocyte level. By using this workflow, we constructed a comprehensive proteome library during oocyte maturation, identifying and quantifying more than 4000 protein groups from only 15 oocytes. Our analysis revealed significant variations in abundance for marker proteins and highlighted the importance of maternal mRNA degradation during oocyte maturation. Furthermore, our findings shed light on the factors affecting oocyte quality during ovary aging, including changes in antioxidant factors, maternal factors, mRNA stabilization, and energy metabolism. This study lays the foundation for future advancements in assisted reproduction techniques.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Cell Biology
Ping-Shuang Lu, Lan-Ping Xie, Xiao-Han Kong, Yi Xu, Shao-Chen Sun
Summary: In this study, exposure to POD significantly reduced the developmental competence of mouse oocytes, affecting the distribution and function of organelles such as endoplasmic reticulum and Golgi apparatus. This exposure induced vesicle-based protein transport disorder and aberrant accumulation of lysosomes, as well as disruption of the perinuclear distribution of mitochondria.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Long Jin, Hai-Ying Zhu, Xiang-Jin Kang, Li-Ping Lin, Pu-Yao Zhang, Tao Tan, Yang Yu, Yong Fan
Summary: Oxybenzone, a common UV filter in sunscreens and cosmetics, has been found to have negative effects on oocyte maturation, but melatonin shows protective effects against these detrimental effects.
Article
Reproductive Biology
Qiaochu Wang, Karla J. Hutt
Summary: Cisplatin can decrease mitochondrial membrane potential in oocytes, leading to cell death. Five weeks after treatment, the number of mature oocytes harvested from cisplatin treated mice was significantly lower, but the surviving oocytes had normal mitochondrial parameters.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Cell Biology
Chao-Ying Zhao, Lin-Lin Hu, Chun-Hua Xing, Xiang Lu, Shao-Chen Sun, Yu-Xia Wei, Yan-Ping Ren
Summary: Acrylamide exposure disrupts the distribution and functions of organelles in mouse oocytes, leading to reduced developmental competence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Yang Gai, Man-Yu Zhang, Peng-Yuan Ji, Rong-Jing You, Zhao-Jia Ge, Wei Shen, Qing-Yuan Sun, Shen Yin
Summary: Diazinon has detrimental effects on the maturation and quality of mouse oocytes, resulting in mitochondrial dysfunction, early apoptosis, and impaired sperm binding. Melatonin can restore these abnormalities and improve oocyte quality.
Article
Pharmacology & Pharmacy
Si-Cheng Zhao, Feng-Xin Qiao, Ming-Xin Sun, Yue-Cen Liu, Hai-Long Wang, Zhi-Ran Xu, Yu Liu
Summary: This study found that cobalt chloride treatment affects ovary function, leading to decreased oocyte quality, impaired follicular growth, disrupted spindle assembly, and mitochondrial dysfunction.
Article
Multidisciplinary Sciences
Yan-Zhe Zhang, Qian-Han Zhao, Hong-Wei Duan, Yuan-Jing Zou, Shao-Chen Sun, Lin-Lin Hu
Summary: Our study found that exposure to AFB1 had toxic effects on the distribution of mouse oocyte organelles, leading to a decline in oocyte quality.
Article
Cell Biology
Wen Gao, Chen Zhang, Bichun Li, Jeong Su Oh
Summary: Azoxystrobin (AZO), a widely used fungicide in agriculture, has been found to impair mouse oocyte maturation by disturbing spindle formation, chromosome alignment, mitochondrial distribution, and increasing oxidative stress. The toxicity of AZO to oocytes can be relieved by melatonin supplementation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Meng-Hao Pan, Yu-Ke Wu, Bi-Yun Liao, Hui Zhang, Chan Li, Jun-Li Wang, Lin-Lin Hu, Baohua Ma
Summary: The study showed that different concentrations of BPA can be toxic to the organelles of mouse oocytes, leading to mitochondrial dysfunction, abnormal distribution of the endoplasmic reticulum, and abnormal structure of the Golgi apparatus. The exposure to BPA also resulted in damage to lysosomes, indicating a negative impact on the normal function of the organelles.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Environmental Sciences
Cai-feng Fei, Shi-meng Guo, Ying Yin, Ximiao He, Li-quan Zhou
Summary: N,N-dimethylformamide (DMF) is a widely-used solvent with diverse applications, but its biological toxicity on mammalian reproduction has not been thoroughly explored. Our study found that DMF exposure inhibited oocyte maturation and fertilization ability. It caused mitochondrial dysfunction, abnormal aggregation of mitochondria, and decreased mitochondrial membrane potential in mouse oocytes. Additionally, DMF exposure led to abnormal distribution of Golgi apparatus and endoplasmic reticulum, oxidative stress, disordered spindle, chromosome abnormality, and reduced histone modification levels in oocytes.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Pharmacology & Pharmacy
Haoya Chang, Jian Li, Chunhui Zhang, Weiping Qian
Summary: This study investigated the impacts of Octocrylene (OCL) on mouse oocyte maturation and quality. The results showed that OCL exposure disrupted oocyte meiotic maturation, reduced oocyte quality, damaged mitochondrial function, and led to overproduction of reactive oxygen species (ROS) and apoptosis.
Article
Food Science & Technology
Cong Ma, Zhuonan Yang, Shouxin Zhang, Xueke Zhang, Siyuan Wang, Huiru Cheng, Yang Liu, Hongzhen Ruan, Zuying Xu, Chunmei Liang, Dan Liang, Zhiming Ding, Yajing Liu, Yunxia Cao
Summary: CBZ exposure negatively affects the maturation of mouse oocytes, leading to disruptions in polar body extrusion, cell cycle distribution, spindle assembly, chromosomal alignment, and kinetochore microtubule attachment.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Lei Liu, Jinwu Chen, Fang Liu, Wencheng Song, Yubing Sun
Summary: The study investigated the bioaccumulation of hexavalent uranium on Candida utilis and its biological effects, showing that C. utilis has high adsorption capacity and enhanced activity of intracellular antioxidants under U(VI) stress, making it an ideal biosorbent for radionuclide removal in environmental remediation.
ENVIRONMENTAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mira Kuzmic, Helene Javot, Jean-Marc Bonzom, Catherine Lecomte-Pradines, Miroslav Radman, Jacqueline Garnier-Laplace, Sandrine Frelon
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Biochemistry & Molecular Biology
S. Pyr Dit Ruys, J. -M. Bonzom, S. Frelon
FREE RADICAL BIOLOGY AND MEDICINE
(2016)
Article
Plant Sciences
Laure Genies, Daniel Orjollet, Loic Carasco, Virginie Camilleri, Sandrine Frelon, Alain Vavasseur, Nathalie Leonhardt, Pascale Henner
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2017)
Article
Biochemistry & Molecular Biology
Y. Eb-Levadoux, S. Frelon, O. Simon, C. Arnaudguilhem, R. Lobinski, S. Mounicou
Article
Multidisciplinary Sciences
Cecile Dubois, Catherine Lecomte, Sebastien Pyr Dit Ruys, Mira Kuzmic, Claire Della-Vedova, Nicolas Dubourg, Simon Galas, Sandrine Frelon
SCIENTIFIC REPORTS
(2018)
Article
Environmental Sciences
Olivier Simon, Beatrice Gagnaire, Vivien Sommard, Sylvie Pierrisnard, Virginie Camilleri, Loic Carasco, Rodolphe Gilbin, Sandrine Frelon
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Mira Kuzmic, Myriam Richaud, Pierre Cuq, Sandrine Frelon, Simon Galas
Article
Biochemistry & Molecular Biology
Mira Kuzmic, Simon Galas, Catherine Lecomte-Pradines, Cecile Dubois, Nicolas Dubourg, Sandrine Frelon
FREE RADICAL BIOLOGY AND MEDICINE
(2019)
Article
Environmental Sciences
Cecile Dubois, Matthieu Pophillat, Stephane Audebert, Patrick Fourquet, Catherine Lecomte, Nicolas Dubourg, Simon Galas, Luc Camoin, Sandrine Frelon
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Environmental Sciences
Noemie Guirandy, Beatrice Gagnaire, Sandrine Frelon, Thomas Munch, Nicolas Dubourg, Virginie Camilleri, Isabelle Cavalie, Magali Floriani, Caroline Arcanjo, Sophia Murat El Houdigui, Olivier Armant, Christelle Adam-Guillermin, Patrice Gonzalez, Olivier Simon
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2019)
Article
Environmental Sciences
S. Mounicou, S. Frelon, A. Le Guernic, Y. Eb-Levadoux, V. Camilleri, L. Fevrier, S. Pierrisnard, L. Carasco, R. Gilbin, K. Mahe, H. Tabouret, G. Bareille, O. Simon
SCIENCE OF THE TOTAL ENVIRONMENT
(2019)
Article
Multidisciplinary Sciences
Sophia Murat El Houdigui, Christelle Adam-Guillermin, Giovanna Loro, Caroline Arcanjo, Sandrine Frelon, Magali Floriani, Nicolas Dubourg, Emilie Baudelet, Stephane Audebert, Luc Camoin, Olivier Armant
SCIENTIFIC REPORTS
(2019)
Article
Environmental Sciences
Sandrine Frelon, Olivier Simon, Yvan Eb-Levadoux, Sandra Mounicou
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2020)
Article
Biochemistry & Molecular Biology
Elizabeth Dufourcq-Sekatcheff, Stephan Cuine, Yonghua Li-Beisson, Loic Quevarec, Myriam Richaud, Simon Galas, Sandrine Frelon
Summary: This study investigated the impact of radiation on reproduction decrease in the roundworm C. elegans using a life stage dependent approach. The results showed that reproductive defects are life stage dependent, lipids are differently regulated according to the exposure, and a proposed conceptual model of lipid signaling after radiation stress was provided.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Caroline Arcanjo, Sandrine Frelon, Olivier Armant, Luc Camoin, Stephane Audebert, Virginie Camilleri, Isabelle Cavalie, Christelle Adam-Guillermin, Beatrice Gagnaire
Summary: In this study, the effects of tritiated water (HTO) on zebrafish larvae were investigated. Transcriptomic and proteomic analyses revealed similar impacts on biological pathways such as defence response, muscle integrity and contraction, and potential visual alterations. Interestingly, these effects partly overlapped with those induced by gamma irradiation, suggesting potential common modes of action. This study provides evidence of the molecular-level effects of HTO on zebrafish larvae, and further research could explore whether these effects persist in adult organisms.
JOURNAL OF ENVIRONMENTAL RADIOACTIVITY
(2023)
Article
Reproductive Biology
Lei Gong, Siyi Jiang, Jia Tian, Yong Li, Wansu Yu, Lubo Zhang, Daliao Xiao
Summary: Exposure to gestational diabetes mellitus during pregnancy can lead to the development of a neonatal brain hypoxia/ischemia-sensitive phenotype. The PTEN/AKT/mTOR/autophagy signaling pathway plays a role in this process.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Sudipta Dutta, Kirthiram K. Sivakumar, John W. Erwin, Jone A. Stanley, Joe A. Arosh, Robert J. Taylor, Sakhila K. Banu
Summary: This study found that exposure to hexavalent chromium disrupts follicle development and causes apoptosis by altering epigenetic marks in the ovary.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Yuxin Li, Xianzhi He, Bin Sun, Nannan Hu, Jiamin Li, Ruolan You, Feiyan Tao, Lei Fang, Yuanyuan Li, Qingfeng Zhai
Summary: This study investigated the toxic effects and mechanism of beta-CYP and EMB on the reproductive system of female rats. The results showed that exposure to these pesticides led to changes in hormone and gene expression in the hypothalamic-pituitary-ovarian axis, as well as alterations in oxidative damage indicators. The findings support the evaluation of the adverse effects of pesticide exposure on reproductive health in greenhouse operations.
REPRODUCTIVE TOXICOLOGY
(2024)
Article
Reproductive Biology
Ran Lee, Won-Young Lee, Hyun-Jung Park
Summary: This study investigates the toxicity of diuron on fetal mouse testes and finds that diuron has a negative impact on the development of fetal Leydig cells, while not affecting germ cells and Sertoli cells.
REPRODUCTIVE TOXICOLOGY
(2024)