Article
Medicine, General & Internal
Ying Liang, Haoyan Jiao, Lingbo Qu, Hao Liu
Summary: This study found that hormone replacement therapy (HRT) use is associated with an increased risk of endometrial cancer (EC). Different types/methods of HRT use are associated with EC risk, and this risk varies within different body mass index (BMI) groups.
FRONTIERS IN MEDICINE
(2022)
Article
Oncology
Tai-Han Lin, Hong-Wei Gao, Guo-Shiou Liao, Jyh-Cherng Yu, Ming-Shen Dai, Jar-Yi Ho, Cheng-Ping Yu
Summary: Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death of women worldwide. This retrospective study aimed to propose better prognostic cut-off levels for ER and PgR, and found that patients with PgR expression <= 50% or an Allred score <= 5 exhibited a poor prognosis, needing more attention during follow-up.
Review
Endocrinology & Metabolism
Jaya Mehta, Juliana M. Kling, JoAnn E. Manson
Summary: Prescribing practices for menopausal hormone therapy have evolved in recent decades based on changing understanding of the treatment's risks and benefits. Recent research suggests that the risks of HT are low for healthy women under 60 or within ten years of menopause, while the benefits may outweigh the risks for those experiencing bothersome vasomotor symptoms. HT also plays a role in preventing osteoporosis for appropriate candidates.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
D. Grassi, M. Marraudino, L. M. Garcia-Segura, G. C. Panzica
Summary: This article reviews the roles of estradiol and hypothalamic paraventricular nucleus (PVN) in coordinating reproduction, body physiology, growth, and metabolism. The authors discuss the cyto- and chemo-architecture, connectivity, and function of PVN, as well as the sex-specific regulation exerted by estradiol on PVN neurons and the expression of neurotransmitters, neuromodulators, neuropeptides, and neurohormones in PVN. The study also highlights the importance of classical and non-classical estrogen receptors (ERs) in modulating body homeostasis through PVN.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Anna Sjostrom, Simona Chisalita, Charlotte Hoybye
Summary: Growth hormone treatment increases copeptin levels, potentially compensating for the anti-natriuretic effect of the treatment. It also has an impact on body composition and water balance.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Lovlesh Thakur, Sunil Thakur
Summary: This review summarizes the role of miRNAs in endometrial cancer regulated by sex steroid hormone pathways. Dysregulation of miRNAs has been linked to abnormal sex steroid hormone signaling and the development of endometrial cancer. Various miRNAs have been identified as modulators of estrogen and progesterone receptor expression, and the miRNA expression profile has been shown to be a predictor of response to hormone therapy. Future studies should focus on elucidating the functional roles of specific miRNAs in sex steroid hormone signaling and identifying novel miRNA targets for hormone therapy in endometrial cancer management.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Yutong Xing, Fan Xuan, Kaixi Wang, Huifeng Zhang
Summary: Aging is a biological process that leads to a progressive decline in physiological function due to interaction between the environment and the body. It can result in dysfunction of vital organ systems and the onset of age-related diseases that significantly impact quality of life. The endocrine system plays a role in coordinating cellular interactions, metabolism, growth, and aging through hormones and related functional factors. This paper explores the mechanisms of growth hormone, thyroid hormone, and estrogen in the aging process, offering insights into endocrine mechanisms associated with aging.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Emanuele Varaldo, Fabio Bioletto, Daniela Cuboni, Nunzia Prencipe, Chiara Bona, Marco Barale, Ezio Ghigo, Silvia Grottoli, Alessandro Maria Berton, Valentina Gasco
Summary: This study aimed to investigate the potential use of intranasal glucagon as a stimulus test for the evaluation of pituitary function. The results showed that intranasal glucagon administration is not effective for pituitary secretion and can lead to hypokalemia as a complication.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Medicine, General & Internal
Akimasa Adachi, Tetsuya Honda
Summary: Psoriasis is a chronic inflammatory skin disease associated with the interleukin-23/interleukin-17 axis, and female sex hormones, specifically estrogens, play a significant role in its development by suppressing the production of psoriasis-related cytokines.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Fengyuan Xu, Ialu Shi, Xueyun Qin, Zimeng Zheng, Min Chen, Zhi Lin, Jiangfeng Ye, Mingqing Li
Summary: Endocrine-related cancers and hormones are closely linked, with hormones playing a crucial role in tumor induction and progression. The role of glutamine metabolism in mediating tumorigenesis and development, as well as the regulation of glutamine metabolism by hormones such as estrogen, progesterone, androgen, prostaglandin, thyroid hormone, and insulin, have been extensively studied. However, the relationship between these three factors still needs to be further elucidated. This review provides an updated overview of glutamine metabolism traits and its influence on endocrine oncology, as well as its upstream hormonal regulation. The hormone/glutamine metabolism axis may serve as a potential target for novel therapeutic strategies in endocrine-related cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Jun Ma, Yi-Hsien Chen, Chien-Ping Chiang, Wei-Ming Wang, Chi-Hsiang Chung, Chang-Huei Tsao, Zi-Xeng Weng, Chih-Tsung Hung, Wu-Chien Chien
Summary: A population-based retrospective cohort study in Taiwan found no significant correlation between hormone replacement therapy (HRT) and risk of melanoma. Estrogen plus progesterone combined therapy was associated with a lower risk of melanoma.
JOURNAL OF DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yichao Ou, Mingfeng Zhou, Mengjie Che, Haodong Gong, Guangsen Wu, Junjie Peng, Kai Li, Runwei Yang, Xingqin Wang, Xian Zhang, Yawei Liu, Zhanpeng Feng, Songtao Qi
Summary: Body fluid homeostasis is critical to survival, and the hypothalamus plays a key role in regulating this process. This study shows that neurogenesis in the adult hypothalamus is involved in the structural reconstruction of the AVP release circuit, leading to the restoration of body fluid metabolic homeostasis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Peik M. A. Brundin, Britt-Marie Landgren, Peter Fjallstrom, Mohamed M. M. Shamekh, Jan-Ake Gustafsson, Anders F. F. Johansson, Ivan Nalvarte
Summary: The study reveals the expression patterns of sex hormone receptors in different immune cells and the lack of significant correlation between sex hormone levels and expression of SHR or immune response genes. However, there is a positive correlation between sex hormone-binding globulin and the expression of certain genes. Additionally, immune response genes show significant differences in expression between different phases of the menstrual cycle, suggesting a potential role for sex hormones in immune response.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Pharmacology & Pharmacy
Guiyun Song, Daniel Banov, Hui Song, Yi Liu, Kendice Ip, August S. Bassani, Benigno C. Valdez
Summary: This study evaluated the safety and efficacy of a newly developed anhydrous permeation-enhancing base (APEB) for delivering hormones through the skin. Results showed that APEB had mild to non-irritating properties and did not cause adverse reactions on the skin. It also facilitated the percutaneous absorption of progesterone, testosterone, estriol, and estradiol, making it a potential vehicle for hormone replacement therapy.
Review
Clinical Neurology
Annika Haufe, Fiona C. Baker, Brigitte Leeners
Summary: Sleep disturbances are common among women during the menopausal transition. The decline in estrogen and progesterone levels contributes to these disturbances, and timely hormone therapy can improve overall sleep quality.
SLEEP MEDICINE REVIEWS
(2022)