Journal
REPRODUCTIVE SCIENCES
Volume 22, Issue 2, Pages 235-241Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719114537713
Keywords
preeclampsia; mass spectrometry; biomarkers; fetal sex; ADAM12
Categories
Funding
- New Zealand: New Enterprise Research Fund, Foundation for Research Science and Technology
- Health Research Council [04/198]
- Evelyn Bond Fund, Auckland District Health Board Charitable Trust
- Australia: Premier's Science and Research Fund, South Australian Government
- London: Guy's and St Thomas' Charity, United Kingdom
- London: Tommy's the Baby Charity
- Manchester: UK Biotechnology and Biological Sciences Research Council [GT084]
- Manchester: UK National Health Services NEAT Grant [FSD025]
- Manchester: University of Manchester Proof of Concept Funding
- Manchester: Tommy's the Baby Charity
- Manchester: NIHR
- Leeds: Cerebra, UK
- Cork, Ireland: Health Research Board, Ireland [CSA/2007/2]
- Action Medical Research Endowment Fund
- NIHR Manchester Biomedical Research Centre
- Pronota, Zwijnaarde, Belgium
- National Institute for Health Research [NIHR-CS-011-020] Funding Source: researchfish
- National Institutes of Health Research (NIHR) [FSD025] Funding Source: National Institutes of Health Research (NIHR)
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An overrepresentation of adverse pregnancy outcomes has been observed in pregnancies associated with a male fetus. We investigated the association between fetal gender and candidate biomarkers for preeclampsia. Proteins were quantified in samples taken at 20 weeks from women recruited to the SCreening fOr Pregnancy Endpoints (SCOPE) study (preeclampsia n = 150; no preeclampsia n = 450). In contrast to placental growth factor, soluble endoglin, and insulin-like growth factor acid labile subunit, levels of metallopeptidase domain 12 (ADAM12) at 20 weeks were dependent on fetal gender in pregnancies complicated by preeclampsia, for male (n = 73) fetuses the multiples of the median (MoM; interquartile range [IQR] 1.1-1.5) was 1.3, whereas for female fetuses (n = 75) MoM was 1.1 (1.0-1.3); P < .01. Prediction of preeclampsia using ADAM12 levels was improved for pregnancies associated with a male fetus (area under receiver-operator curve [AUC] 0.73 [95% confidence interval [CI] 0.67-0.80]) than that of a female fetus (AUC 0.62 [0.55-0.70]); P = .03. The data presented here fit a contemporary hypothesis that there is a difference between the genders in response to an adverse maternal environment and suggest that an alteration in ADAM12 may reflect an altered placental response in pregnancies subsequently complicated by preeclampsia.
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