Article
Developmental Biology
Valerie J. Robert, Matthieu Caron, Loic Gely, Annie Adrait, Victoria Pakulska, Yohann Coute, Manon Chevalier, Christian G. Riedel, Cecile Bedet, Francesca Palladino
Summary: The transcriptional co-regulator SIN3 plays a crucial role in regulating the germline transcriptome in Caenorhabditis elegans. Loss of SIN3 leads to maternal-effect sterility and de-silencing of X-linked genes. Different SIN3 complexes are identified, and SIN3 is found to be involved in silencing the X chromosome.
Review
Biochemistry & Molecular Biology
Sweta Kumari, Ayushi Rehman, Pratap Chandra, Kusum K. Singh
Summary: SAP18 is a conserved protein associated with Sin3 and exon junction complex (EJC), playing roles in transcriptional regulation and mRNA splicing. Recent studies have highlighted its involvement in cancer and potential therapeutic targeting, particularly in myeloid malignancies.
CELL BIOCHEMISTRY AND FUNCTION
(2023)
Article
Biochemistry & Molecular Biology
Sakthidasan Jayaprakash, Le T. M. Le, Bjoern Sander, Monika M. Golas
Summary: The REST/NRSF-SIN3 transcriptional corepressor complex regulates gene expression through binding to RE1/NRSE sites, with protein complexes including multiple subunits and a druggable histone deacetylase. It is a critical transcriptional repressor complex for biomedical research and potential drug testing.
MOLECULAR BIOTECHNOLOGY
(2021)
Article
Microbiology
Chaoxiang Lin, Xue Cao, Ziwei Qu, Shulin Zhang, Naweed I. Naqvi, Yi Zhen Deng
Summary: This study identified and characterized two histone deacetylase genes, MoRPD3 and MoHST4, in the rice blast fungus Magnaporthe oryzae. MoHst4 is essential for proper mycelial growth and pathogenicity, while overproduction of MoRpd3 leads to loss of pathogenicity by inhibiting conidial cell death. The different roles of MoRpd3 and MoHst4 in regulating vegetative growth, asexual development, and pathogenesis expand our understanding of fungal pathobiology.
Article
Biochemistry & Molecular Biology
Zhouyan Guo, Chen Chu, Yichen Lu, Xiaofeng Zhang, Yihang Xiao, Mingxuan Wu, Shuaixin Gao, Catherine C. L. Wong, Xiechao Zhan, Chengcheng Wang
Summary: This study presents the cryo-EM structure of the yeast SIN3-HDAC complex Rpd3L, revealing a distinctive organization mechanism compared with other class I HDAC complexes. The structure shows two distinct arms that interact with different subunits, resulting in an asymmetric architecture of Rpd3L.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Katrine Bugge, Lasse Staby, Edoardo Salladini, Rasmus G. Falbe-Hansen, Birthe B. Kragelund, Karen Skriver
Summary: Hub proteins are essential in protein-protein interaction networks, with alpha alpha-hubs being a newly defined group of folded hub domains. They play a crucial role in organizing disordered transcriptional regulators and membrane scaffolds, showcasing multifaceted protein-protein interaction properties facilitated by the alpha alpha-hub fold.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
N. Connor Payne, Ralph Mazitschek
Summary: Histone deacetylase paralogs HDAC1/2/3 and their corepressor complexes are key regulators of chromatin function. Over the past decades, extensive research has been conducted on using HDACs as pharmacological targets and developing small molecule drugs. This study investigates the dynamic processes that regulate HDAC complexes and their impact on the selectivity of HDAC inhibitors. The findings suggest the need for a comprehensive reinterpretation of previous studies that utilized these compounds for studying epigenetic and cellular processes.
CELL CHEMICAL BIOLOGY
(2022)
Article
Oncology
Yize Li, Yongmei Zhao, Hongyan Peng, Jing Zhang, Lun Bo, Lei Wen, Wenchao Liu, Wendong Bai, Hongmei Zhang
Summary: Inhibitors of histone deacetylases (HDACi) have shown promising effects in preclinical applications for the treatment of many diseases. However, the effects of the HDACi trichostatin A (TSA) on angiogenesis vary among different diseases. This study investigated the direct effects of TSA on endothelial cells and identified novel mechanisms underlying its effects on angiogenesis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Analytical
Thangapandi Kalyani, Amalesh Nanda, Saikat Kumar Jana
Summary: Endometriosis is a major issue affecting women worldwide, and the use of an immunosensor to detect the GLY biomarker presents a new possibility for diagnosis, offering a sensitive and accurate alternative method.
ANALYTICA CHIMICA ACTA
(2021)
Article
Infectious Diseases
Thomas Mouveaux, Dante Rotili, Tom Boissavy, Emmanuel Roger, Christine Pierrot, Antonello Mai, Mathieu Gissot
Summary: This study identified a potent HDAC inhibitor compound, MC1742, which showed activity in inhibiting the growth of Toxoplasma gondii in vitro and preventing the consequences of the acute disease in vivo. The compound induced hyper-acetylation of histones and changed the parasite's gene expression program, leading to parasite death.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Chemistry, Analytical
Sarita Yadav, Preeti Kumari, Shikha Sharma, Shatrughan Aafria, Bhawna Batra, Minakshi Sharma
Summary: Glycodelin is a glycoprotein expressed in amniotic fluid, secretory endometrium, and pregnancy decidua. It has been identified as a potential biomarker for various reproductive disorders and malignancies. This review article summarizes the methods developed for the detection of glycodelin biomarker and highlights the need for miniaturization of detection devices.
MICROCHEMICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Yicun Wang, Jinhui Wu, Hui Chen, Yang Yang, Chengwu Xiao, Xiaoming Yi, Changjie Shi, Ke Zhong, Haowei He, Yaoming Li, Zhenjie Wu, Guangxin Zhou, Qiu Rao, Xiaoxia Wang, Xiaodie Zhou, Gwen Lomberk, Bing Liu, Jianning Zhao, Jingping Ge, Wenquan Zhou, Xiaoyuan Chu, Cheng Chen, Xuhui Zhou, Linhui Wang, Kunliang Guan, Le Qu
Summary: The study identified KLF11 as a negative regulator in sarcoma cancer stem cells, forming a negative feedback loop with YAP/TEAD. Epigenetic silencing of KLF11 in CSCs leads to sustained YAP activation, which is associated with poor prognosis and chemotherapy response in sarcoma patients. Pharmacological activation of KLF11 effectively restored chemotherapy response.
Article
Oncology
Christian Mayr, Tobias Kiesslich, Sara Erber, Dino Bekric, Heidemarie Dobias, Marlena Beyreis, Markus Ritter, Tarkan Jaeger, Bettina Neumayer, Paul Winkelmann, Eckhard Klieser, Daniel Neureiter
Summary: HDAC class I inhibitor romidepsin shows promising anti-cancer effects in BTC cells, inducing apoptosis, reducing HDAC activity, and enhancing the cytotoxic effect of cisplatin. Patients with high expression of HDAC-2 in their tumors have significantly shorter survival.
Article
Obstetrics & Gynecology
Amelia M. Schaub, Margareta D. Pisarska, Kelly N. Wright
Summary: Limited knowledge exists about the long-term reproductive effects of pelvic infection with a levonorgestrel-releasing intrauterine device (LNG-IUD) in situ. This case study highlighted the successful conception after adhesion lysis, but further studies and counseling may be needed to explore potential consequences affecting the intrauterine milieu.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Oncology
Vanda Salutari, Viola Ghizzoni, Maria Vittoria Carbone, Elena Giudice, Serena Cappuccio, Francesco Fanfani, Giovanni Scambia, Domenica Lorusso
Summary: This study analyzes the clinical relevance of NGS testing in endometrial carcinoma management by assessing the clinical benefit of NGS-driven targeted therapies. The results show that NGS-driven targeted therapies have clinical benefits for endometrial carcinoma patients.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)