Journal
REPRODUCTIVE SCIENCES
Volume 20, Issue 3, Pages 234-237Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719112446081
Keywords
hemopexin activity; angiotensin II receptor; vascular expansion; protease-like activity; ATP
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Funding
- Dutch Kidney Foundation [C08-2266]
- Technology Foundation-NWO (Netherlands Organisation for Scientific Research) [10704]
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This brief review focuses on the functional activities of plasma hemopexin recently recognized by several authors. In particular, the protease-like activity of hemopexin in vitro is linked with downregulation of the vascular angiotensin II receptor in vivo, leading to vascular expansion. Also a potential mechanism of inhibition of hemopexin activity by extracellular adenosine triphosphate is considered.
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