Article
Neurosciences
Kyle Pemberton, Martina Rosato, Cass Dedert, Chelsea DeLeon, Christopher Arnatt, Fenglian Xu
Summary: Estrogen plays important roles in nervous system development and function. The activation of GPER has differential effects on rat hippocampal and cortical neurons, with a stronger response observed in hippocampal neurons. The GPER-mediated increase in Ca2+ in hippocampal neurons involves both the release of intracellular Ca2+ stores and the entry of extracellular Ca2+ through Ca2+ channels.
Article
Biochemistry & Molecular Biology
Chelsea DeLeon, Kyle Pemberton, Michael Green, Vanja Kalajdzic, Martina Rosato, Fenglian Xu, Christopher Arnatt
Summary: This study identified 10 novel compounds with neuroprotective effects, among which one called CIFTA significantly promoted axonal and dendritic growth in neurons. Results from treating E18 hippocampal neurons showed that neurite outgrowth in response to G-1 and CIFTA originated from GPER activation.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Oncology
Ting Xu, Ding Ma, Sheng Chen, Rui Tang, Jianling Yang, Chunhui Meng, Yang Feng, Li Liu, Jiangfen Wang, Haojun Luo, Keda Yu
Summary: GPER has been found to mediate estrogenic actions in TNBC and is correlated with clinical variables, survival, and metastasis. High GPER expression is associated with high-risk TNBC subtype and poor prognosis, providing new insights and potential strategies for endocrine therapy in TNBC.
Article
Cell Biology
Francesca Cirillo, Marianna Talia, Maria Francesca Santolla, Michele Pellegrino, Domenica Scordamaglia, Asia Spinelli, Salvatore De Rosis, Francesca Giordano, Lucia Muglia, Azzurra Zicarelli, Marika Di Dio, Damiano Cosimo Rigiracciolo, Anna Maria Miglietta, Gianfranco Filippelli, Ernestina Marianna De Francesco, Antonino Belfiore, Rosamaria Lappano, Marcello Maggiolini
Summary: In this study, the researchers used CRISPR/Cas9 technology to knock out GPER expression in TNBC cells and made new mechanistic and biological discoveries. They found that GPER KO led to anti-proliferative and pro-apoptotic effects in TNBC cells, as well as impairments in migratory effects in cancer-associated fibroblasts. These findings suggest that GPER may be a valuable target for comprehensive therapeutic approaches in halting TNBC progression.
CELL DEATH DISCOVERY
(2023)
Article
Environmental Sciences
Ignacio Babiloni-Chust, Reinaldo S. dos Santos, Regla M. Medina-Gali, Atenea A. Perez-Serna, Jose-Antonio Encinar, Juan Martinez-Pinna, Jan-Ake Gustafsson, Laura Marroqui, Angel Nadal
Summary: 17 beta-estradiol protects pancreatic beta-cells from apoptosis via estrogen receptors ER alpha, ER beta, and GPER. Conversely, the endocrine disruptor bisphenol-A (BPA) increases basal apoptosis in the same cell type through the same estrogen receptors. The molecular events that trigger these opposite actions have not been identified yet.
ENVIRONMENT INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Antonio Mercorio, Pierluigi Giampaolino, Andrea Romano, Patrick Dallenbach, Nicola Pluchino
Summary: This article reviews the endocrine issues and related enzymatic pathways in endometriosis. The clinical role of these enzymes is still controversial and lacks sufficient clinical data. Research on new drug targets is ongoing, but there are challenges, such as evaluating enzyme expression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Hui-Hui Shen, Tao Zhang, Hui-Li Yang, Zhen-Zhen Lai, Wen-Jie Zhou, Jie Mei, Jia-Wei Shi, Rui Zhu, Feng-Yuan Xu, Jin Li, Jiang-Feng Ye, Ming-Qing Li
Summary: Menstruation is a cyclic physiological phenomenon controlled by ovarian hormones, and a proper understanding of normal endometrial physiology is crucial for regulating menstrual disorders. Autophagy in the endometrium, regulated by ovarian hormones, plays a key role in immune cell infiltration, tissue repair, and infection prevention during menstruation. Abnormal autophagy levels and dysregulated immune system function are associated with the pathogenesis and progression of endometriosis, suggesting the potential value of autophagy as a target for the treatment of menstrual-related and endometrium-related disorders.
Article
Obstetrics & Gynecology
Essam R. Othman, Ahmad Abo Markeb, Maha Y. Khashbah, Ibrahim I. Abdelaal, Tarek T. ElMelegy, Ahmed N. Fetih, Lisette E. Van der Houwen, Cornelis B. Lambalk, Velja Mijatovic
Summary: The study found that endometriosis patients' eutopic endometrial tissue contained higher levels of certain estrogen metabolites, and the concentration of one metabolite was also higher in urine. This suggests that endometriosis patients preferentially metabolize estrogen through specific pathways.
REPRODUCTIVE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shafi Ullah Khan, Nafees Ahemad, Lay-Hong Chuah, Rakesh Naidu, Thet Thet Htar
Summary: Cancer ranks second among the cause of death worldwide. In this study, a combination of virtual screening techniques and molecular dynamics simulations were used to identify potential GPER modulators with novel structures, which could be used as the core for the development of new anticancer drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Medicine, Research & Experimental
Carlotta Boscaro, Giovanni Eugenio Ramaschi, Lucia Trevisi, Andrea Cignarella, Chiara Bolego
Summary: miR-206 can interfere with GPER-mediated signaling and cell motility, and has the potential to act as pathway-selective antagonists in estrogen-dependent EOC.
Article
Cell Biology
Yuri Park, Yeon Jean Cho, Nuri Sung, Mi Jin Park, Xiaoming Guan, William E. Gibbons, Bert W. O'Malley, Sang Jun Han
Summary: In this study, researchers identified a natural product called oleuropein that selectively inhibits ER beta activity without affecting ER alpha activity, thus suppressing the progression of endometriosis and improving fertility in patients.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Sylvia C. Hewitt, San-pin Wu, Tianyuan Wang, Madhumita Ray, Marja Brolinson, Steven L. Young, Thomas E. Spencer, Alan DeCherney, Francesco J. DeMayo
Summary: This study investigates the molecular processes underlying estrogen responses and their effects on endometrial health. By analyzing the ESR1 cistromes and transcriptomes of endometrial biopsies and organoids, the study identifies candidate ESR1 target genes and reveals differences in the distribution and regulation of ESR1 binding sites between different stages of the menstrual cycle. The findings provide valuable resources for understanding how estrogen affects endometrial function and health.
Review
Endocrinology & Metabolism
Kun Yu, Zheng-Yuan Huang, Xue-Ling Xu, Jun Li, Xiang-Wei Fu, Shou-Long Deng
Summary: This article discusses the role of estrogen in the female endometrium and its regulatory role through nuclear and membrane-associated receptors. The importance of ERs in maintaining endometrial function is emphasized, and references for treating endometrial diseases are provided.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Nicolas Chevalier, Charlotte Hinault, Stephan Clavel, Rachel Paul-Bellon, Patrick Fenichel
Summary: GPER/GPR30, a novel estrogen-binding protein structurally distinct from classic estrogen receptors, is involved in male germ cell proliferation in testicular germ cell cancers. Overexpression of GPER/GPR30 in seminomas, potentially linked to genetic variations, suggests it as a therapeutic target.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Xin-Jun Wu, Marcus Jermaul Williams, Kimberly Ann Kew, Aubrey Converse, Peter Thomas, Yong Zhu
Summary: The study on a gper zebrafish mutant line suggests that Gper is involved in the control of ovarian follicle development through regulation of vitellogenesis and Egfr expression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Shannon Pretzel, Katherine Kuhn, Lubna Pal, Alex Polotsky, Hugh S. Taylor, Heping Zhang, Jared Robins, Steven L. Young, Nanette Santoro
Summary: Recruitment for an endometriosis clinical trial using an electronic medical record (EMR)-based strategy is feasible, although the overall yield of participants is low. Delays in treatment due to COVID-19 did not appear to overly influence potential recruitment.
REPRODUCTIVE SCIENCES
(2022)
Article
Reproductive Biology
Yeon Jeong Hwang, Gi-Jun Sung, Ryan Marquardt, Steven L. Young, Bruce A. Lessey, Tae Hoon Kim, Yong-Pil Cheon, Jae-Wook Jeong
Summary: This study reveals the temporal expression pattern of SIRT1 in the mouse uterus and demonstrates its important role in uterine function, decidualization, and key molecules involved in implantation.
BIOLOGY OF REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Tae Hoon Kim, Steven L. Young, Tsutomu Sasaki, Jeffrey L. Deaton, David P. Schammel, Wilder Alberto Palomino, Jae-Wook Jeong, Bruce A. Lessey
Summary: The study revealed that SIRT1 expression in the endometrium is associated with progesterone resistance and normal endometrial function, while aberrant SIRT1 expression may contribute to progesterone resistance and the pathophysiology of endometriosis. SIRT1 serves as a novel and targetable protein for the diagnosis and treatment of endometriosis and infertility associated with this disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Jung-Yoon Yoo, Tae Hoon Kim, Jung-Ho Shin, Ryan M. Marquardt, Ulrich Muller, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Ho-Geun Yoon, Jae-Wook Jeong
Summary: Progesterone-induced MIG-6 reduction in the endometrium is associated with endometriosis-related infertility, and Erbb2 is identified as the key mediator of Mig-6 loss in this context.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Sylvia C. Hewitt, San-Pin Wu, Tianyuan Wang, Steven L. Young, Thomas E. Spencer, Francesco J. DeMayo
Summary: The study demonstrates that uterine cells respond to estrogen and progesterone through their nuclear receptors ESR1 and PGR, with the involvement of chromatin structures. The organoids model provides insights into the regulatory mechanisms of hormone responsiveness.
Article
Endocrinology & Metabolism
Sylvia C. Hewitt, San-pin Wu, Tianyuan Wang, Madhumita Ray, Marja Brolinson, Steven L. Young, Thomas E. Spencer, Alan DeCherney, Francesco J. DeMayo
Summary: This study investigates the molecular processes underlying estrogen responses and their effects on endometrial health. By analyzing the ESR1 cistromes and transcriptomes of endometrial biopsies and organoids, the study identifies candidate ESR1 target genes and reveals differences in the distribution and regulation of ESR1 binding sites between different stages of the menstrual cycle. The findings provide valuable resources for understanding how estrogen affects endometrial function and health.
Article
Medicine, General & Internal
Hugh Taylor, Howard J. Li, Sandra Carson, Valerie Flores, Lubna Pal, Jared Robbins, Nanette F. Santoro, James H. Segars, David Seifer, Hao Huang, Steven Young, Heping Zhang
Summary: This is a prospective study on the efficacy of GnRH antagonist pretreatment for women with endometriosis undergoing IVF. The study aims to recruit 814 patients who will be randomly assigned to receive either GnRH antagonist or placebo treatment for 8 weeks before undergoing IVF. The primary outcome is live birth, and secondary outcomes include oocyte number, fertilisation rate, embryo morphology, implantation rates, and endometriosis-related obstetrical outcomes.
Article
Immunology
Alison McCallion, Yasmin Nasirzadeh, Harshavardhan Lingegowda, Jessica E. Miller, Kasra Khalaj, SooHyun Ahn, Stephany P. Monsanto, Mallikarjun Bidarimath, Danielle J. Sisnett, Andrew W. Craig, Steven L. Young, Bruce A. Lessey, Madhuri Koti, Chandrakant Tayade
Summary: This study found that mast cell numbers significantly increase in endometriotic lesions, and the microenvironment within these lesions promotes the recruitment and differentiation of mast cells. There is cross-talk between mast cells and endocrine and immune factors, which may contribute to the pathophysiology of endometriosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychiatry
Tory A. Eisenlohr-Moul, Savannah M. Bowers, Mitchell J. Prinstein, Katja M. Schmalenberger, Erin C. Walsh, Steven L. Young, David R. Rubinow, Susan S. Girdler
Summary: Female suicide attempts peak peri-menstrually, potentially due to withdrawal of estradiol and progesterone. Experimental administration of these hormones can reduce perimenstrual exacerbation of suicidal ideation and related symptoms, while delayed withdrawal leads to symptom relapse.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Obstetrics & Gynecology
Eduardo Hariton, Ruben Alvero, Micah J. Hill, Jennifer E. Mersereau, Shana Perman, David Sable, Fiona Wang, Geoffrey David Adamson, Christos Coutifaris, LaTasha B. Craig, Pardis Hosseinzadeh, Anthony N. Imudia, Erica B. Johnstone, Ruth B. Lathi, Paul C. Lin, Erica E. Marsh, Michele Munch, Gloria Richard-Davis, Lauren W. Roth, Amy K. Schutt, Kim Thornton, Lauren Verrilli, Rachel S. Weinerman, Steven L. Young, Kate Devine
Summary: The field of reproductive endocrinology and infertility faces a mismatch between demand and availability of care. It is recommended to increase the number of qualified physicians and non-REI providers to address the physician shortage problem and improve clinical efficiency through technological improvements.
FERTILITY AND STERILITY
(2023)
Meeting Abstract
Obstetrics & Gynecology
Anthony Bui, Audrey Garneau, Steven L. Young, Genevieve S. Neal-Perry
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Audrey Garneau, Anthony Bui, Steven L. Young, Melissa Paczkowski, Caitlin Boylan
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Audrey Garneau, Anthony Bui, Douglas Timmons, Caitlin Boylan, Steven L. Young
FERTILITY AND STERILITY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Aydogan B. Mathyk, F. Alvarado, S. L. Young, A. Beheshti, A. M. Quaas
FERTILITY AND STERILITY
(2022)
Review
Obstetrics & Gynecology
Anthony H. Bui, Douglas B. Timmons, Steven L. Young
Summary: This review succinctly examines the mechanisms of implantation and luteal phase endometrial differentiation, the causes of impaired endometrial function and receptivity, and the current methods for evaluating and treating impaired endometrial receptivity. Although there is an understanding of some mechanisms of impaired endometrial receptivity, treatment options remain limited.
CURRENT OPINION IN OBSTETRICS & GYNECOLOGY
(2022)