Review
Cell Biology
Iason Psilopatis, Kleio Vrettou, Florian Nima Fleckenstein, Stamatios Theocharis
Summary: Endometriosis is a chronic disorder that affects many women globally. Histone deacetylases (HDACs) play a role in gene transcription by regulating chromatin relaxation. This comprehensive review examines the impact of histone modifications and therapeutic targeting, specifically focusing on HDACs and their inhibitors in endometriosis. The five most studied HDAC enzymes, HDAC1, HDAC2, HDAC3, Sirtuin 1, and Sirtuin 3, have been found to influence the pathophysiology of endometriosis. Both established and novel HDACIs show promise as effective anti-endometriotic drugs. Overall, histone modifications and therapeutic targeting have a significant impact on endometriosis.
Review
Pharmacology & Pharmacy
Hae Jin Kee, Inkyeom Kim, Myung Ho Jeong
Summary: This article provides an overview of the pathogenesis of hypertension, current anti-hypertensive drugs, and the need for novel drugs. It focuses on the role and regulatory mechanisms of HDACs in hypertension and discusses the progress in developing HDAC inhibitors as potential therapeutic targets.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Martina Mazzocchi, Susan R. Goulding, Noelia Morales-Prieto, Tara Foley, Louise M. Collins, Aideen M. Sullivan, Gerard W. O'Keeffe
Summary: The peripheral administration of Class IIa-specific HDIs may have neuroprotective effects in Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Svetlana Demyanenko, Valentina Dzreyan, Svetlana Sharifulina
Summary: Cerebral ischemia is the second leading cause of death worldwide, requiring multimodal stroke therapy. Histone deacetylase inhibitors have shown to be effective in protecting the brain from ischemic damage by inducing neurogenesis and angiogenesis in damaged brain areas, promoting functional recovery after stroke.
Article
Agricultural Engineering
Xuefeng Lu, Tae Kyung Hyun
Summary: Post-translational histone modifications, such as histone acetylation, play key roles in regulating gene expression in plant growth, development, and stress responses. The research found that HDAC inhibitors led to hyperacetylation of histone H3, enhancing MeJA-induced ginsenoside production in ginseng adventitious roots. Additionally, the study identified specific PgHDACs that may serve as crucial factors in controlling MeJA-induced ginsenoside production.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Review
Oncology
Amandine Badie, Christian Gaiddon, Georg Mellitzer
Summary: Our understanding of the identity of many cancers has greatly increased in recent years, leading to progress in early detection and treatment options. However, gastric cancer remains poorly treated with low survival rates. The lack of possibilities for early detection and the variations between tumors of gastric cancer patients are major challenges. Histone Deacetylases (HDACs) have been identified to be potentially related to gastric cancer. In this review, we summarize the current knowledge on the role of HDACs in gastric cancer development and their potential as early detection markers and targets for new treatment options.
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daria Oleinichenko, Soyon Ahn, Ru Song, Terrance P. Snutch, Anthony G. Phillips
Summary: Effective pain control is crucial for opioid detoxification, lacking of which poses a significant barrier to success. l-Tetrahydropalmatine (l-THP) has powerful analgesic properties and has been used in Vietnam for treating opioid withdrawal syndrome. In this study, l-THP significantly improves pain tolerance scores in rats undergoing morphine treatment and attenuates hyperalgesia during withdrawal. This non-opioid treatment may be a valuable addition to the limited options for opioid detoxification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Robert Jenke, Nina Ressing, Finn K. Hansen, Achim Aigner, Thomas Buch
Summary: Epigenetic changes can drive cancer malignancy, while histone deacetylase inhibitors (HDACis) hold promise as anticancer drugs due to their ability to target multiple pathways relevant to the disease.
Review
Oncology
Jason Lin, Shang-Chuen Wu
Summary: This review examines the role of protein serotonylation in transcriptional regulation, its potential impact on the epigenetic landscape, and its implications in lung and other types of cancer. The review discusses the mechanistic details of serotonylation and its connections to the epigenome, as well as the role of transglutaminase 2, in order to guide the development of optimized histone deacetylase inhibitor designs or combination therapies for cancer treatment.
Article
Agronomy
Sasipriya Sasikumar, Banur Marulasiddappa Dushyanthakumar, Shankarappa Sridhara, Nagarajappa Adivappar, Harish Babu Bheemanapalli Nagraja, Ahmed M. El-Shehawi, Salman Aloufi, Mohammed Alqurashi, Hosam O. Elansary, Khalid M. Elhindi, Eman A. Mahmoud
Summary: This study investigated the effects of Trichostatin A (TSA) on the morphological variations in okra. The results showed that TSA treatment had a negative impact on the growth and development of okra, including inhibited seedling emergence, malformed plants, abnormal flower development, and pollen sterility. However, under specific doses and incubation periods, TSA treatment can induce epigenetic variations in okra without significantly compromising its growth and vigor parameters.
Article
Biochemistry & Molecular Biology
Yiming Chen, Lihui Zhang, Lin Zhang, Qixiao Jiang, Lei Zhang
Summary: Through structural modification, a HDAC inhibitor (I13) with high anticancer activity was discovered, showing promising inhibitory and antiproliferative potencies in in vitro investigations and cancer cell screenings. The compound also demonstrated potential for inhibiting tumor growth in animal models.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Review
Cell Biology
Bingyi Zhou, Deliang Liu, Yuyong Tan
Summary: Cancer is the second leading cause of death worldwide, with digestive system cancers being a primary contributor. Acetylation and deacetylation play crucial roles in cancer development, with HDAC6 being a widely studied enzyme that is upregulated in various tumors and associated with clinicopathological characteristics. There is ongoing research on HDAC6 inhibitors and their potential in inhibiting tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jianglei Li, Meihong Yu, Shifeng Fu, Deliang Liu, Yuyong Tan
Summary: This review summarizes the research progress and underlying mechanism of ACY-1215 in cancer and other human diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Anuhya Kommalapati, Tawee Tanvetyanon
Summary: Immunotherapy with checkpoint inhibitors has replaced chemotherapy in some settings, allowing many patients to live longer with fewer side effects, but only works for about one-fifth of unselected patients. Important cofactors within the tumor microenvironment, such as T-cells and chemokines, can impact the efficacy of immunotherapy through epigenetic modulation.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Obstetrics & Gynecology
Chenyu Mao, Xishi Liu, Sun-Wei Guo
Summary: This study investigated the role of glycolysis in endometrial repair and heavy menstrual bleeding (HMB). Through mouse experiments and analysis of human endometrial samples, it was found that glycolysis plays an important role in endometrial repair, and its suppression delays the repair process and increases menstrual blood loss. Additionally, glycolysis suppression affects the proliferative and migratory capability of endometrial cells.
REPRODUCTIVE SCIENCES
(2023)
Review
Medicine, General & Internal
Sun-Wei Guo
Summary: Adenomyosis is a common gynecological disease with unclear causes and mechanisms. Bleeding and tissue repair play a crucial role in its progression, with platelets leading the tissue repair process. This repeated tissue injury and repair can lead to fibrosis and various complications, such as heavy menstrual bleeding and an enlarged uterus. This review focuses on the role of platelets in the pathogenesis, progression, and complications of adenomyosis, and discusses the therapeutic implications. The concept of repeated tissue injury and repair provides a framework to better understand the disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Sun-Wei Guo, Giuseppe Benagiano, Marc Bazot
Summary: Adenomyosis is a complicated gynecological disease that is poorly understood. The diagnosis used to rely solely on histology after hysterectomy, but now imaging techniques like transvaginal ultrasound and MRI are increasingly used. However, the lack of a consensus on a classification system makes it difficult to relate imaging findings with disease severity or histopathological features, which hampers patient and clinician communication and comparative studies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Fengyi Xiao, Xishi Liu, Sun-Wei Guo
Summary: In endometriosis, Tregs produce increased amounts of effector cytokines under the influence of lesion-derived IL-33, promoting fibrogenesis in the disease.
Article
Obstetrics & Gynecology
Sun-Wei Guo
Summary: Currently, hormonal drugs are the main treatment for endometriosis or adenomyosis, but their lack of innovation and failure to target specific areas is concerning. The failure to understand the natural history of the ectopic endometrium has led to many unsuccessful nonhormonal drug research projects. This review aims to explore new concepts in the progression of ectopic endometrium and provide insights for better therapeutic options.
FERTILITY AND STERILITY
(2023)
Editorial Material
Obstetrics & Gynecology
Michel Canis, Sun-Wei Guo
Summary: Endometriosis-associated pain can be managed through either surgery or hormonal therapy, with the final decision dependent on efficacy, complications, recurrence risk, and patient preferences. However, choosing the right treatment involves weighing irrational fears against scientific evidence. Pros and cons of both treatment options should be thoroughly discussed with patients, considering the known irrationality of human beings.
HUMAN REPRODUCTION
(2023)
Review
Biochemistry & Molecular Biology
Sun-Wei Guo, Marwan Habiba, Giuseppe Benagiano
Summary: Practically unknown outside of China, the endometrial determinism theory proposes a causal and phylogenetic relationship between endometrial aberrations and endometriosis. However, all available evidence of endometrial defect is post hoc and may be secondary to induced endometriosis. While endometriosis is likely a consequence of retrograde menstruation, the case for molecular aberrations as a sole or necessary determinant remains unproven. Root treatment is currently a far-fetched ambition.
Review
Biochemistry & Molecular Biology
Marwan Habiba, Giuseppe Benagiano, Sun-Wei Guo
Summary: Due to the complex nature of endometriosis and adenomyosis, the understanding of their pathogenesis remains unclear. A tissue injury and repair theory suggests that both diseases originate from the same abnormalities within the uterus, but this theory has faced criticism for its lack of confirmatory evidence and epidemiological support. The theory also fails to explain why only a small percentage of women develop these conditions. Further research and evidence are necessary to validate this theory.
Review
Pharmacology & Pharmacy
Zheng Ying, Na Ye, Qilian Ma, Fan Chen, Ningning Li, Xuechu Zhen
Summary: Significant evidences show that sub-cellular organelle dynamics play a critical role in physiological and pathological events, making them attractive drug targets. However, drug development in this field is still limited despite extensive studies on the biological mechanisms. This review explores the potential of targeting organelle dynamics in the central nervous system, specifically mitochondrial dynamics and ER-organelle membrane contact dynamics, for treating neurodegenerative diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Giuseppe Benagiano, Salvatore Mancuso, Sun-Wei Guo, Gian Carlo Di Renzo
Summary: This article highlights the significant number of early embryo losses during the pre-implantation period and the importance of the maternal-embryonic dialogue in the formation of placenta and completion of pregnancy. Several factors and molecules have been identified to play a role in this process, including Chorionic Gonadotrophin, Early Pregnancy Factor, Pre-Implantation Factor, and Embryo-Derived Platelet-activating Factor. The implantation process is guided by signals from various types of cells in the decidualized endometrium, and immune cells also play a role. The distinction between the first two weeks after fertilization and the rest of gestation is proposed, with the former period being named gestation and the latter period being named pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xishi Liu, Ding Ding, Minhong Shen, Dingmin Yan, Sun-Wei Guo
Summary: This study investigated the association between anogenital distance (AGD) and adenomyosis, endometriosis, and uterine leiomyomas (UL). The results showed that women with ovarian endometrioma (OE) and adenomyosis had significantly shorter AGD from the posterior fourchette to the center of the anus (AGDAF), but not from the anterior clitoral surface or the tip of the clitoris. The findings suggest that reduced prenatal exposure to androgens may increase the risk of developing endometriosis and adenomyosis, but other factors may also contribute to the pathogenesis of these conditions.
Article
Obstetrics & Gynecology
Tasuku Harada, Fuminori Taniguchi, Sun-Wei Guo, Young Min Choi, Kutay Omer Biberoglu, Shaw-Jenq Sean Tsai, Saeed Alborzi, Moamar Al-Jefout, Amphan Chalermchokcharoenkit, Angela G. Sison-Aguilar, Yoke-Fai Fong, Hemantha Senanayake, Alexander Popov, Andon Hestiantoro, Yuval Kaufman
Summary: This is the first guideline for adenomyosis from the Asian Society of Endometriosis and Adenomyosis.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Hanxi Zheng, Xishi Liu, Sun-Wei Guo
Summary: This study aimed to screen Zn2+-dependent histone deacetylase 1-11 (HDAC) in endometriotic cells and evaluate their expression in ovarian endometrioma (OE) and deep endometriosis (DE) lesions. The therapeutic potential of HDAC8 inhibition was also assessed in mice.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Hanxi Zheng, Xishi Liu, Sun-Wei Guo
Summary: The study evaluated the staining changes of Class I HDACs and Hdac6 in serially harvested lesion samples in mice with induced endometriosis. The results showed a progressive increase in staining of Hdac1, Hdac8, and Hdac6 during the course of lesional progression, while Hdac2 staining gradually decreased and Hdac3 staining was consistently reduced. Hdac8 activation accelerated the progression and fibrogenesis of endometriotic lesions, while inhibition of Hdac8 or Hdac6 hindered lesional progression and fibrogenesis, especially Hdac8 inhibition. Further investigation of epigenetic aberrations of endometriosis and HDACs is warranted.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2023)
Article
Obstetrics & Gynecology
Chenyu Mao, Xishi Liu, Sun-Wei Guo
Summary: This study explores the role of histone deacetylase 3 (HDAC3) in adenomyosis-associated heavy menstrual bleeding (HMB). The researchers found that reduced expression of HDAC3 is associated with HMB in women with adenomyosis. Higher stiffness and fibrosis in the adenomyotic lesions and neighboring endometrial-myometrial interface were observed in women with excessive bleeding compared to those with moderate/heavy bleeding. Inhibition of HDAC3 resulted in disrupted NF-KB signaling, inflammation, and increased bleeding in mice with induced adenomyosis. Overall, this study highlights the importance of HDAC3 in the pathogenesis of adenomyosis-associated HMB.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)