Journal
REPRODUCTIVE SCIENCES
Volume 17, Issue 1, Pages 29-39Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719109345288
Keywords
Circulating factors; plasma; cerebrovasculature; vasodilator
Categories
Funding
- Preeclampsia Foundation Vision [NINDS NS045940, AHA EI 0540082]
- NIH [RO1 HL 71.944]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL071944] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS045940] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Using a rat model, we investigated the effects circulating factors in pregnancy on cerebrovascular and systemic vascular function by comparing myogenic reactivity, tone, and endothelial vasodilator production of the posterior cerebral artery (PCA) and mesenteric artery (MS) of nonpregnant (NP) animals perfused with nonpregnant and pregnant human plasma. Arteries from late pregnant (LP) animals were then perfused similarly to evaluate a potential adaptive effect of pregnant on vessel function. A 3-hour exposure to pregnant plasma caused increased myogenic reactivity and tone in vessels from NP animals and produced a decreased endothelium-derived hyperpolarizing factor response in NP PCAs, findings that were not seen with MAs. The increased reactivity and tone noted in NP vessels was abolished when pregnant plasma was perfused through LP arteries, suggesting these vessels adapt during pregnancy to the vasoconstricting influence of pregnant plasma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available