Article
Immunology
Lina Chen, Lele Wang, Yihong Luo, Qian Huang, Kaiyuan Ji, Junjie Bao, Huishu Liu
Summary: This study utilized RNA sequencing and mass spectrometry to uncover that inflammation and hypoxia play a role in differentially expressed proteins and mRNA in the myometrium during labor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mary C. Peavey, San-Pin Wu, Rong Li, Jian Liu, Olivia M. Emery, Tianyuan Wang, Lecong Zhou, Margeaux Wetendorf, Chandra Yallampalli, William E. Gibbons, John P. Lydon, Francesco J. DeMayo
Summary: The study revealed that overexpression of progesterone receptor PGR-B leads to relaxation of uterine muscles, prolonged gestational length, and increased incidence of labor dystocia, while overexpression of PGR-A increases uterine muscle contraction without affecting gestational length.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Anesthesiology
Asha Tyagi, Aparna Mohan, Yuvraj Singh, Ankit Luthra, Devansh Garg, Rajeev Kumar Malhotra
Summary: Patients with preeclampsia require a higher dose of oxytocin to achieve satisfactory uterine contraction during cesarean delivery, especially in those receiving preoperative magnesium therapy, compared to normotensive patients.
ANESTHESIA AND ANALGESIA
(2022)
Article
Pharmacology & Pharmacy
Chaolu Chen, Shuaiying Zhu, Long Bai, Meihua Sui, Danqing Chen
Summary: This study analyzed the myometrial transcriptome during parturition and found that the onset of labor was associated with an inflammatory response. Hub genes, including FPR1, were identified as being associated with the onset of labor, with FPR1 playing a novel role as a modulator of myometrial contraction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Nanase Takahashi, Toshiaki Okuno, Hiroki Fujii, Shintaro Makino, Masaya Takahashi, Mai Ohba, Kazuko Saeki, Atsuo Itakura, Satoru Takeda, Takehiko Yokomizo
Summary: The study revealed that the production of PGE(2) in fetal-membrane is influenced by COXs, cPGES, and SLCO2A1, which play roles in the accumulation of PGE(2) in amniotic fluid.
Review
Endocrinology & Metabolism
Melissa L. Kozakiewicz, Chad A. Grotegut, Allyn C. Howlett
Summary: The endocannabinoid system plays a crucial role in early pregnancy success, embryo development, and parturition, influencing uterine activation and maternal-fetal interaction, regulating pregnancy maintenance and timing of labor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Genetics & Heredity
Lina Chen, Yihong Luo, Yunshan Chen, Lele Wang, Xiaodi Wang, Guozheng Zhang, Kaiyuan Ji, Huishu Liu
Summary: This study investigates the role of competing endogenous RNA (ceRNA) network in labor, by performing transcriptome sequencing and analysis. The study identifies a large number of RNAs correlated with labor duration, which are involved in protein metabolism, transport, and cytoskeleton functions. In addition, the analysis of postpartum bleeding reveals the key role of inflammatory response, angiogenesis, and hemostasis.
FRONTIERS IN GENETICS
(2022)
Article
Biology
Li Chen, Zhenzhen Song, Xiaowan Cao, Mingsong Fan, Yan Zhou, Guoying Zhang
Summary: The study suggests that IL-33 may be involved in the initiation of labor in human uterine smooth muscle cells by inducing endoplasmic reticulum stress through calcium influx.
Article
Obstetrics & Gynecology
Yinuo Li, Ross P. McNally, Yue Feng, J. Julie Kim, Jian-Jun Wei
Summary: This study reveals significant differences in Mediator Complex Subunit 12 mutations, transcriptomics, and protein expression between Black and White women in uterine myometrium and leiomyomas.
HUMAN REPRODUCTION
(2023)
Article
Multidisciplinary Sciences
Yosuke Sugita, Yoshimitsu Kuwabara, Akira Katayama, Shigeru Matsuda, Ichiro Manabe, Shunji Suzuki, Yumiko Oishi
Summary: Preterm birth (PTB) is a leading cause of neonatal mortality and reducing the PTB rate is crucial. Cervical insufficiency (CI), a major cause of PTB, is characterized by premature cervical ripening and recurrent pregnancy loss. This study explored the molecular mechanism of CI and found that downregulation of progesterone signaling at the receptor level is responsible for abnormal cervical ripening in CI, providing new insights into the understanding of PTB.
SCIENTIFIC REPORTS
(2023)
Article
Biology
Yali Shan, Shiping Shen, Jing Long, Zhengshan Tang, Cichun Wu, Xin Ni
Summary: The study reveals that there is an increase in inflammatory response, particularly from macrophages, during term and preterm labor. This inflammation plays a critical role in the initiation of parturition.
Review
Biochemistry & Molecular Biology
Iain L. O. Buxton, Hazik Asif, Scott D. D. Barnett
Summary: Preterm labor leading to preterm birth is currently not preventable. Beta 2 agonists and nitric oxide, which are effective in relaxing smooth muscles, have been ineffective in preventing preterm birth. However, recent studies suggest that the repurposing of approved medication, such as mirabegron, may advance the prevention of preterm birth.
Article
Biochemistry & Molecular Biology
Barbara Jana, Jaroslaw Calka, Krzysztof Witek
Summary: Severe acute endometritis in pigs reduces the relative abundance of PAC1R protein in the myometrium, and PAC1R mediates the influence of PACAP on inflamed uterus contractility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Susan Wray, Sarah Arrowsmith
Summary: This article reviews the advances in the understanding of myometrial physiology, focusing on excitation and the effects of gestation on ion channels. It discusses the role of various ion channels in myometrium, their modulation by key hormones, and their integration throughout gestation.
ANNUAL REVIEW OF PHYSIOLOGY, VOL 83
(2021)
Article
Multidisciplinary Sciences
Myungshin Kim, Dain Kang, Mi Yeon Kwon, Hee Jeong Lee, Min Jeong Kim
Summary: Recent studies have revealed that certain microRNAs (miRs) play a significant role in the development of leiomyoma. The expression of miRs was found to be significantly higher in leiomyoma compared to adjacent myometrium. Furthermore, miR-181a-5p, 127-3p, 28-3p, 30b-5p, and let-7c-5p were upregulated in cellular processes associated with proliferation, matrix turnover, and angiogenesis. TGFBR2 and IGF2BP1, the target molecules of these miRs, were frequently positive in leiomyoma tissues, especially in larger leiomyomas and those causing mass effect.
Article
Microbiology
Christina Clarke, Louise O'Connor, Heather Carre-Skinner, Olaf Piepenburg, Terry J. Smith
Article
Biochemistry & Molecular Biology
Markus Muttenthaler, Asa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret O'Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood
Article
Nursing
S. R. Bagge, B. Westgate, K. Few, P. Clarke, A. Adlam, J. Walsh, M. O'Brien
JOURNAL OF CHILD HEALTH CARE
(2017)
Article
Biochemistry & Molecular Biology
Markus Muttenthaler, Asa Andersson, Irina Vetter, Rohit Menon, Marta Busnelli, Lotten Ragnarsson, Christian Bergmayr, Sarah Arrowsmith, Jennifer R. Deuis, Han Sheng Chiu, Nathan J. Palpant, Margaret O'Brien, Terry J. Smith, Susan Wray, Inga D. Neumann, Christian W. Gruber, Richard J. Lewis, Paul F. Alewood
Article
Biochemical Research Methods
Owen Higgins, Eoin Clancy, Matthew S. Forrest, Olaf Piepenburg, Martin Cormican, Teck Wee Boo, Nicola O'Sullivan, Claire McGuinness, Deirdre Cafferty, Robert Cunney, Terry J. Smith
ANALYTICAL BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Owen Higgins, Eoin Clancy, Martin Cormican, Teck Wee Boo, Robert Cunney, Terry J. Smith
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Oncology
Vahid Arabkari, Eoin Clancy, Roisin M. Dwyer, Michael J. Kerin, Olga Kalinina, Emma Holian, John Newell, Terry J. Smith
PATHOLOGY & ONCOLOGY RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Owen Higgins, Terry J. Smith
Summary: PCR is crucial for infectious disease detection, especially during the COVID-19 pandemic. Real-time multiplex detection and single-base specificity play key roles in identifying single-nucleotide polymorphisms (SNPs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Vera Manageiro, Vanessa Salgueiro, Tania Rosado, Narcisa M. Bandarra, Eugenia Ferreira, Terry Smith, Elsa Dias, Manuela Canica
Summary: This study analyzed the resistome, virulome, and mobilome of an MCR-9-producing Enterobacter strain. The results highlight the spread of antibiotic resistance in aquaculture through food, the environment, and humans, posing a serious threat to human health.
Article
Social Work
Claire Cameron, Hanan Hauari, Katie Hollingworth, Margaret O'Brien, Lydia Whitaker
Summary: This paper examines the daily lives and activities of young children in one East London borough during the Covid-19 pandemic. Through qualitative interviews with parents, it was found that some children had more time and new activities with their parents, while others, particularly those in low-income households and crowded accommodation, experienced significant reductions in their relationships, social participation, and activities.
CHILDREN & SOCIETY
(2023)
Article
Family Studies
Claire Cameron, Margaret O'Brien, Lydia Whitaker, Katie Hollingworth, Hanan Hauari
Summary: This paper presents the results of a survey conducted on parents and parents to be in an ethnically diverse and socio-economically unequal borough of East London during the COVID-19 pandemic. The study found that while material assets were often insecure and in decline, familial assets were largely sustained, and community assets were less accessible or had changed means of access. The study also highlighted the importance of income and couple relationships in mitigating the adverse impacts on mental health during the pandemic. Supporting family assets and enhancing access to community assets are crucial for addressing the challenges faced by families during such crises.
JFR-JOURNAL OF FAMILY RESEARCH
(2022)
Article
Social Issues
Merve Uzunalioglu, Marie Valentova, Margaret O'Brien, Anne-Sophie Genevois
Summary: This article explores the impact of a parental leave policy reform in Luxembourg on the take-up of parental leave by marginal part-time working parents. The study found that relaxing eligibility criteria resulted in significantly more leave take-up by mothers, while the impact on fathers was limited. Additionally, it was discovered that foreign national parents were less likely to be eligible for parental leave and had lower take-up rates.
Article
Economics
Rose Cook, Margaret O'Brien, Sara Connolly, Matthew Aldrich, Svetlana Speight
Summary: While most employee parents in the UK have the right to request flexible working arrangements, a significant minority of fathers do not perceive these arrangements to be available to them, particularly in terms of reducing working hours.
WORK EMPLOYMENT AND SOCIETY
(2021)
Article
Sociology
Pedro Romero-Balsas, Margaret O'Brien, Concepcion Castrillo Bustamante
REVISTA INTERNACIONAL DE SOCIOLOGIA
(2020)
Review
Family Studies
Georgia Philip, Margaret O'Brien
CHILD & FAMILY SOCIAL WORK
(2017)