Journal
REPRODUCTIVE SCIENCES
Volume 15, Issue 2, Pages 156-165Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1933719107310308
Keywords
matrix metalloproteinase; MMP-7; premature rupture of membranes
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Amnion, chorion, and decidua were separated from fetal membranes at term from women with no labor (Cesarean delivery [CS], n = 10), labor (normal delivery, n = 10), and labor during premature rupture Of membranes (PROM, n = 8)for evaluation of matrix metalloproteinase (MMP)-7. The expression of pro-MMP-7 was immunohistochemically demonstrated in amnion, chorion, and decidua. Interestingly, however, Western blotting revealed that pro-MMP-7 and MMP-7 expression was the lowest in amnion from PROM, whereas it was the highest in chorion, and decidua from PROM. Importantly, the enzymatic activity of MMP-7 determined with an MMP-7-specific substrate was higher in amnion from PROM than that from CS. Moreover, the tissue inhibitor of metalloproteinase (TIMP)-1 level was lower in amnion from PROM than that from CS. Thus, MMP-7 is expressed in fetal membranes (amnion, chorion, and decidua), and its activity is increased in amnion of PROM at term, accompanied with the reduced level of TIMP-1, which may suggest the possible involvement of MMP-7 in PROM.
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