Article
Obstetrics & Gynecology
Birgit Alsbjerg, Ulrik S. Kesmodel, Helle Elbaek, Rita Laursen, Steen B. Laursen, Dorthe Andreasen, Betina B. Povlsen, Peter Humaidan
Summary: The study did not find a significant reduction in total pregnancy loss or biochemical pregnancy loss with GnRHa supplementation in HRT-FET cycles. However, participants who had a live birth had higher progesterone concentrations. Additionally, there was a trend for higher live birth rates correlated with the highest estradiol concentrations.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Lan N. Vuong, Toan D. Pham, Khanh T. Q. Le, Trung T. Ly, Ho L. Le, Diem T. N. Nguyen, Vu N. A. Ho, Vinh Q. Dang, Tuan H. Phung, Robert J. Norman, Ben W. Mol, Tuong M. Ho
Summary: Adding oral dydrogesterone to vaginal progesterone as luteal phase support in frozen embryo transfer cycles may improve pregnancy outcomes, with higher live birth rates and lower miscarriage rates. Prospective cohort studies with limited bias could provide valuable information for clinical practice as an alternative to randomized controlled trials.
HUMAN REPRODUCTION
(2021)
Review
Obstetrics & Gynecology
Yanbiao Jiang, Liyan Wang, Haofei Shen, Bin Wang, Jingyuan Wu, Kaiyan Hu, Yiqing Wang, Bin Ma, Xuehong Zhang
Summary: The study investigated the effect of progesterone supplementation on the reproductive outcomes of patients undergoing NC-FET cycles. The results showed that progesterone supplementation was associated with increased live birth rate and clinical pregnancy rate, especially in traditional NC-FET cycles.
FERTILITY AND STERILITY
(2023)
Article
Reproductive Biology
Daniel Veraguas-Davila, Maria Francisca Cordero, Soledad Saez, Darling Saez-Ruiz, Alejandro Gonzalez, Fernando Saravia, Fidel Ovidio Castro, Lleretny Rodriguez-Alvarez
Summary: The study evaluated the effects of zona pellucida removal on the in vitro and in vivo development of domestic cat embryos. Results showed that removal of the zona pellucida negatively impacted gene expression and prevented successful implantation of the embryos.
Article
Endocrinology & Metabolism
Jiaqi Tang, Linglu Qi, Yun He, Na Li, Ze Zhang, Xiuwen Zhou, Hongyu Su, Qiutong Zheng, Yumeng Zhang, Jianying Tao, Zhice Xu
Summary: This study investigated the effect of frozen embryo transfer (ET) on histamine-induced vascular contraction in the human umbilical vein (HUV) and its underlying mechanisms. The results showed that frozen ET increased histamine concentration in umbilical plasma and enhanced histamine-mediated vasoconstriction in HUV. The increased sensitivity to histamine in HUV following frozen ET cycles was associated with the upregulation of PKC beta protein expression and function. These findings provide important insights into the influence of frozen ET on fetal vessel development and potential long-term effects.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Zhanhui Ou, Jing Du, Nengqing Liu, Jieliang Li, Xiufeng Lin
Summary: This study aimed to investigate the impact of a reduced dose of follicle-stimulating hormone (FSH) before human chorionic gonadotropin (hCG) trigger on in vitro fertilization (IVF) outcomes. Compared to the group that did not receive a reduced dose of FSH, the group with reduced dose experienced lower estrogen (E2) and progesterone (P) levels on the day of hCG trigger and had a higher fresh embryo-transfer cycle rate. However, the reduced dose of FSH did not significantly affect the number of retrieved oocytes, total number of mature oocytes, fertilization rate, cleavage rate, quality rate on Day 3, implantation rate, pregnancy rate per cycle, and early pregnancy loss rate.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
K. Wanggren, M. Dahlgren Granbom, S. I. Iliadis, J. Gudmundsson, A. Stavreus-Evers
Summary: The supplementation with vaginal tablets of progesterone after frozen-thawed embryo transfer in natural cycles significantly improves the number of live births.
HUMAN REPRODUCTION
(2022)
Article
Endocrinology & Metabolism
Jiangman Gao, Yifeng Yuan, Jia Li, Tian Tian, Ying Lian, Ping Liu, Rong Li, Jie Qiao, Xiaoyu Long, Haiyan Wang
Summary: Sequential embryo transfer in frozen-thawed embryo transfer cycles can improve the clinical outcomes of patients with RIF, including implantation rate, clinical pregnancy rate, and multiple pregnancy rate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
B. Lawrenz, B. Ata, E. Kalafat, L. Melado, I ElKhatib, R. Del Gallego, H. Fatemi
Summary: Serum progesterone (P4) levels on the embryo transfer (ET) day are not predictive of ongoing pregnancy (OP) following a single euploid blastocyst transfer in a natural cycle (NC) when luteal phase support (LPS) is routinely given.
HUMAN REPRODUCTION
(2023)
Article
Multidisciplinary Sciences
Yi-ran Du, Ke Yang, Jie Liu
Summary: The effects of serum estrogen levels on pregnancy outcomes in hormone replacement cycles were investigated. The study found that the serum estrogen levels before frozen-thawed blastocyst transfer did not affect pregnancy outcomes, and age was found to be an independent factor affecting clinical pregnancy.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Kate Devine, Kevin S. Richter, Samad Jahandideh, Eric A. Widra, Jeffrey L. McKeeby
Summary: The study compared vaginal progesterone with intramuscular progesterone in terms of live birth rates from frozen embryo transfer (FET) and found that women receiving only vaginal progesterone had significantly lower live birth rates and higher miscarriage rates compared to those receiving intramuscular progesterone or combination treatment. Vaginal progesterone supplemented with intramuscular progesterone every third day was shown to be noninferior to daily intramuscular progesterone, offering an effective alternative regimen with fewer injections.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Reeva Makhijani, Prachi Godiwala, James Grady, Alicia Christy, Kim Thornton, Daniel Grow, Lawrence Engmann
Summary: This retrospective cohort study aimed to evaluate if racial/ethnic differences persist in pregnancy outcomes in frozen-thawed embryo transfer (FET) cycles. The results showed that Black women had a significantly lower live birth rate and implantation rate, as well as higher clinical loss rate compared to other racial/ethnic groups.
FERTILITY AND STERILITY
(2022)
Article
Medicine, General & Internal
Zhijie Hu, Danjun Li, Qiuju Chen, Weiran Chai, Qifeng Lyu, Renfei Cai, Yanping Kuang, Xuefeng Lu
Summary: In this large-sample retrospective study, the incidence of ectopic pregnancy (EP) in frozen embryo transfer (FET) cycles was found to be slightly lower than fresh embryo transfer (ET) cycles, with no significant difference. Among patients undergoing ET cycles, the long agonist protocol was associated with a significantly lower risk of EP compared to the GnRH antagonist protocol.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Baydaa Abdulrahim, Graham Scotland, Siladitya Bhattacharya, Abha Maheshwari
Summary: Couples' preferences for fresh embryo transfer versus freezing of all embryos followed by frozen embryo transfer are primarily driven by anticipated chances of live birth, miscarriage, neonatal complications, and costs. The study found that couples strongly preferred any IVF technique that offered an increase in live birth rates and reduced risk of miscarriage and neonatal complications. Older couples appeared to place less emphasis on the risk of neonatal complications than younger couples.
HUMAN REPRODUCTION
(2021)
Article
Multidisciplinary Sciences
Wen-Jing Jiang, Zhen-Gao Sun, Jing-Yan Song
Summary: Premature initiation of progesterone luteal phase support (LPS) 24 hours after hCG trigger did not affect live birth rate in modified natural cycle frozen-thawed embryo transfer. This study provides valuable insights for clinical decisions and patient choices.
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)