Article
Genetics & Heredity
Lin Zhao, Li Han, Guozhen Hei, Ran Wei, Zhen Zhang, Xiaoxiao Zhu, Qiang Guo, Chu Chu, Xiaoxiao Fu, Ke Xu, Xia Li
Summary: Unexplained recurrent spontaneous abortion (URSA) is a common condition that significantly affects women's reproductive health. This study demonstrates that downregulated miR-374c-5p is involved in the pathogenesis of URSA by enhancing IL-6 expression, suggesting that modulation of miR-374c-5p expression may be a potential therapeutic target for URSA.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Immunology
Jianan Zhu, Guangmin Song, Xiaobo Zhou, Ting-Li Han, Xinyang Yu, Hao Chen, Toby Mansell, Boris Novakovic, Philip N. Baker, Richard D. Cannon, Richard Saffery, Chang Chen, Hua Zhang
Summary: This study investigates the regulation of decidual natural killer (dNK) cells and fetal extravillous trophoblast (EVT) cells by CD39 and CD73 in unexplained recurrent spontaneous abortion (URSA). The findings suggest that reduced numbers of CD39(+) and CD73(+) cells at the maternal-fetal interface, potentially due to downregulated TGF-beta-mTOR-HIF-1α pathway, result in impaired ATP-adenosine metabolism and increased dNK cytotoxicity, contributing to URSA occurrences.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Food Science & Technology
Astri Dewayani, Kartika Afrida Fauzia, Ricky Indra Alfaray, Langgeng Agung Waskito, Dalla Doohan, Yudith Annisa Ayu Rezkitha, Abdurachman Abdurachman, Takashi Kobayashi, Reny I'tishom, Yoshio Yamaoka, Muhammad Miftahussurur
Summary: The development of Helicobacter pylori-related diseases is closely linked to chronic inflammation, which is significantly impacted by immune responses. Key cytokines such as IL-17, IL-21, and IL-23 play crucial roles in antimicrobial activity and pathogenic immune response, maintaining Th17 cells and accommodating humoral immune cells in the gut environment.
Review
Medicine, General & Internal
Kamran Ghoreschi, Anna Balato, Charlotta Enerback, Robert Sabat
Summary: Psoriasis is a chronic inflammatory disease affecting 2-3% of the global population, characterized by sharply demarcated erythematous and scaly skin lesions. The disease results from hyperproliferation and disturbed differentiation of epidermal keratinocytes provoked by immune mediators of the IL-23 and IL-17 pathway. Therapeutics targeting IL-23, IL-17, and IL-17RA have shown excellent efficacy in treating psoriasis.
Article
Health Care Sciences & Services
Malgorzata Galecka, Katarzyna Blizniewska-Kowalska, Agata Orzechowska, Janusz Szemraj, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki
Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Meilan Liu, Dongyan Wang, Liqiong Zhu, Jianlan Yin, Xiaohui Ji, Yilei Zhong, Yuan Gao, Jianping Zhang, Yukun Liu, Rui Zhang, Hui Chen
Summary: Thyroid peroxidase antibodies are associated with the first trimester miscarriage rate in euthyroid women with unexplained recurrent spontaneous abortion.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Yingying Zhang, Xi Yan, Jianhua Tan, Jifan Tan, Chunsheng Liu, Pan Yang, Yanping Xian, Qiong Wang
Summary: Exposure to heavy metals can have toxic effects on female reproduction and embryo development. This study found that calcium and selenium exposure were negatively associated with miscarriage, while lead exposure was positively associated with miscarriage. Additionally, the correlations among exposures to different metals differed slightly between the control group and the uRM group.
Article
Biochemistry & Molecular Biology
Diksha Jawale, Shweta Khandibharad, Shailza Singh
Summary: IL-6, IL-17, IL-23, and IL-1 beta are important cytokines in controlling inflammation and immune response during L. major infection. The CD4+ Th17 subset plays a crucial role in lesion formation by stimulating infected macrophages and producing pro-inflammatory cytokines. The study suggests that targeting SATB1 may modulate the secretion of pro-inflammatory cytokines and abnormal immune functioning, potentially leading to the elimination of the intracellular parasite. The use of systems immunological methods helps in understanding crucial components and developing therapeutic interventions for L. major infection.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Review
Immunology
Matteo Vecellio, Vivien Xanath Hake, Connor Davidson, Maria Cristina Carena, B. Paul Wordsworth, Carlo Selmi
Summary: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with psoriasis, with genetic predisposition playing a key role in its development. The IL-23/IL-17 axis is highlighted as important in the immunopathogenesis of PsA.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Claudia Schinocca, Chiara Rizzo, Serena Fasano, Giulia Grasso, Lidia La Barbera, Francesco Ciccia, Giuliana Guggino
Summary: IL-23 is a pro-inflammatory cytokine composed of two subunits and has a key role in protective immune response, but dysregulation can exacerbate chronic immune-mediated inflammation. Activation of the IL-23/IL-17 axis contributes to the development of various inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yihe Chen, Chunyi Shao, Nai-Wen Fan, Takeshi Nakao, Afsaneh Amouzegar, Sunil K. Chauhan, Reza Dana
Summary: In a murine model of dry eye disease (DED), a linear transition from effector to memory Th17 cells was detected during the abatement phase of acute inflammation, with persistently high levels of IL-23 and diminished levels of IL-2. Additionally, in vitro culture of effector Th17 cells with IL-23 but not IL-2 led to significant generation of memory Th17 cells. The data demonstrate a new dichotomy between IL-23 and IL-2 in driving effector Th17 cells into the memory pool in autoimmune-mediated ocular surface inflammation.
MUCOSAL IMMUNOLOGY
(2021)
Article
Allergy
Hao Li, George C. Tsokos
Summary: Inflammatory rheumatic disorders involve the immune system attacking connective tissues and internal organs. Advances in understanding the cellular and molecular mechanisms have led to targeting the IL-23/IL-17 axis therapeutically, resulting in clinical benefits. The complicated interrelationship between IL-23 and IL-17 may be uncoupled in certain disease settings.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2021)
Article
Immunology
Jiayu Wang, Jinli Ding, Sainan Zhang, Xin Chen, Sisi Yan, Yan Zhang, Tailang Yin
Summary: USP2a plays a crucial role in regulating trophoblast invasion and abnormal expression of USP2a may contribute to recurrent miscarriage by affecting trophoblast invasion. Interestingly, TGF-beta secreted by M2 macrophages can induce trophoblast migration and invasion, highlighting the complex interplay of various factors in the pathogenesis of RM.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zhi Ma, Huixia Yang, Mirjana Kessler, Markus Sperandio, Sven Mahner, Udo Jeschke, Viktoria von Schoenfeldt
Summary: Carbohydrate Lewis antigens and related glycosyltransferases are dysregulated in the decidua of patients with unexplained recurrent miscarriage. The gene FUT3 is responsible for the synthesis of sLeA in the endometrium and affects endometrial receptivity. Targeting the aberrantly elevated sLeA may be a potential therapy for inappropriate implantation in unexplained recurrent miscarriage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Anissa Fries, Fanny Saidoune, Francois Kuonen, Isabelle Dupanloup, Nadine Fournier, Ana Cristina Guerra de Souza, Muzlifah Haniffa, Feiyang Ma, Johann E. Gudjonsson, Lennart Roesner, Yang Li, Thomas Werfel, Curdin Conrad, Raphael Gottardo, Robert L. Modlin, Jeremy Di Domizio, Michel Gilliet
Summary: This study establishes the role of interleukin 26 (IL-26) in the generation of IL-17A producing Th17 CD4(+) T cells, indicating its involvement in the pathogenic response of psoriasis. IL-26-producing cells infiltrate psoriatic skin and promote their own differentiation into IL17A-producing T(H)17 cells through epithelial crosstalk involving paracrine production of TGF-& beta;1.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Mehdi Mehdizadeh, Niloufar Ashtari, Xiaodan Jiao, Maryam Rahimi Balaei, Asghar Marzban, Farshid Qiyami-Hour, Jiming Kong, Saeid Ghavami, Hassan Marzban
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Seyedeh Nazanin Hajjri, Saeed Sadigh-Eteghad, Masoud Mehrpour, Fatemeh Moradi, Dariush Shanehbandi, Mehdi Mehdizadeh
JOURNAL OF MOLECULAR NEUROSCIENCE
(2020)
Article
Biochemistry & Molecular Biology
Sanaz Dehbashi, Mohammad Reza Pourmand, Mohammad Yousef Alikhani, Sara Soleimani Asl, Mohammad Reza Arabestani
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Genetics & Heredity
Farhad Monsef, Tayebe Artimani, Zohreh Alizadeh, Mahdi Ramazani, Ghasem Solgi, Mahnaz Yavangi, Sara Soleimani Asl
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Article
Endocrinology & Metabolism
Sepide Gohari Taban, Iraj Amiri, Massoud Saidijam, Sara Soleimani Asl, Mahnaz Yavangi, Elham Khanlarzadeh, Nooshin Mohammadpour, Tayebe Artimani
Summary: The study found that the expression levels of ADAMTS-4 and -5 in the cumulus cells of PCOS patients were significantly decreased, correlated with oocyte quality and progesterone receptor expression levels. This downregulation may lead to lower oocyte recovery, maturation, and fertilization rate.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2021)
Article
Andrology
Marziyeh Ajdary, Mahnaz Ashrafi, Reza Aflatoonian, Mehdi Mehdizadeh
Summary: This study found that the interaction between sperm and endometrial cells significantly upregulated the expression of multiple genes, highlighting its importance in the implantation process.
Article
Endocrinology & Metabolism
Bahareh Gholamigeravand, Siamak Shahidi, Iraj Amiri, Alireza Samzadeh-kermani, Roghayeh Abbasalipourkabir, Sara Soleimani Asl
Summary: This study found that selenium nanoparticles could reverse neurotoxicity induced by STZ and had neuroprotective effects on the animal model of Alzheimer's disease by increasing antioxidant capacity.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Farshid Qiyami Hour, Ronak Shabani, Behnaz Ashtrai, Alaa Moinzadeh, Mehdi Mehdizadeh
Summary: This study presents a biomimicry method that effectively labels human Wharton's jelly-derived MSCs with gold nanorods without the need for transfection agents. The labeled MSCs had an acceptable intracellular gold concentration, making them suitable for cell labeling applications.
CELL BIOCHEMISTRY AND FUNCTION
(2021)
Article
Endocrinology & Metabolism
Yasaman Razavi, Fariborz Keyhanfar, Abbas Haghparast, Ronak Shabani, Mehdi Mehdizadeh
Summary: The study found that CBD can promote neurogenesis in the hippocampal region of rats and exert neuroprotective effects by inhibiting neuronal degeneration. The CBD treatment group showed improvements in cell proliferation and neurogenesis, while the meth treatment group exhibited a significant decrease in neurogenesis markers.
METABOLIC BRAIN DISEASE
(2021)
Review
Obstetrics & Gynecology
Hamidreza Mosleh, Fatemeh Moradi, Mehdi Mehdizadeh, Marziyeh Ajdary, Alaa Moeinzadeh, Ronak Shabani
Summary: SARS-CoV-2 virus may damage male reproductive tissues and cause infertility by infecting organs with high expression of the ACE2 receptor, such as the testis. Scientists are evaluating the possible influence of COVID-19 on male infertility through the ACE2 receptor.
CLINICAL AND EXPERIMENTAL REPRODUCTIVE MEDICINE-CERM
(2021)
Article
Anatomy & Morphology
Mehrdad Ghorbanlou, Fatemeh Moradi, Mehdi Mehdizadeh
Summary: This study investigated the frequency, location, pattern, dimensions, and estimated volume of intracranial physiologic calcification (IPC) in different age groups. A significant correlation was found between calcification in the pineal gland, habenula, right lateral ventricle choroid plexus, and left lateral ventricle choroid plexus. Nodular shape of calcification was dominant among IPCs.
ANATOMY & CELL BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ali Salimi, Nejat Kheiripour, Ali Fathi Jouzdani, Hassan Ghasemi, Sara Soleimani Asl, Abolfazl Ghafouri-Khosrowshahi, Akram Ranjbar
Summary: This study evaluated the effect of nanocurcumin and curcumin on liver toxicity induced by aluminum phosphide. It was found that nanocurcumin significantly protected the liver against the toxic effects and had a more pronounced protective effect compared to curcumin.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Mohammad Ghorbani, Gholamreza Dehghan, Abdollah Allahverdi
Summary: This study investigated the effects of ibuprofen on the physical properties of the bilayer membrane model of POPC using molecular dynamics simulations. The results showed that ibuprofen significantly influenced the packing properties and intermolecular interactions of the lipid bilayer, and increased the water permeability of the bilayer.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Integrative & Complementary Medicine
Hatam Zarei, Pari Tamri, Sara Soleimani Asl, Meysam Soleimani, Shirin Moradkhani
Summary: This study investigated the anti-scarring effects of Scrophularia Striata extract (SSE) in a rabbit ear model of scarring. The results showed that SSE significantly reduced scar elevation, epidermis thickness, and collagen deposition. Additionally, SSE stimulated the expression of MMP2 and MMP9 genes.
JOURNAL OF PHARMACOPUNCTURE
(2022)
Article
Physiology
Rokhsareh Abshenas, Tayebe Artimani, Iraj Amiri, Siamak Shahidi, Sara Soleimani Asl
PHYSIOLOGY AND PHARMACOLOGY
(2020)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
