Article
Chemistry, Multidisciplinary
Bon Il Koo, Inhye Kim, Moon Young Yang, Sung Duk Jo, Kunmo Koo, Seo Yeon Shin, Kyung Mok Park, Jong Min Yuk, Eunji Lee, Yoon Sung Nam
Summary: Researchers have developed a method to efficiently incorporate proteins into multilamellar protein-lipid hybrid vesicles using protein-induced reorganization of 'pre-formed' unilamellar lipid vesicles, without the need for chemical modification. This approach improves the structural, chemical, and biological stability of the loaded proteins without the use of specialized instruments, high energy, coupling agents, or organic solvents, providing a promising strategy for protein encapsulation.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Kimika Ono, Hiroyuki Hashimoto, Tokitaka Katayama, Natsumi Ueda, Koji Nagahama
Summary: A novel focal EPT approach utilizing nanocomposite hydrogels can effectively alleviate the potential side effects of systemic delivery systems, providing long-lasting antitumor activity.
Article
Materials Science, Multidisciplinary
Zhijie Wen, Hudie Fu, Xuexin Ye, Xuedan Yang, Shengpeng Zhu, Jie Hu, Li Kang, Xiaojun Li, Xinzhou Yang, Yan Hu
Summary: In this study, a novel hybrid lipid-polymer nanocomposite was designed to improve drug delivery for liver cancer. The system combines the beneficial features of both polymer-based and lipid-based delivery systems and accurately delivers drugs to tumor cells. The study improves the antitumor activity of curcumin and provides a new formulation for the clinical application of antitumor drugs.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Cell Biology
Xin Zhou, Yunqiu Miao, Ying Wang, Shufang He, Linmiao Guo, Junsong Mao, Mingshu Chen, Yuting Yang, Xinxin Zhang, Yong Gan
Summary: This study successfully isolated TDEV membranes from hepatocellular carcinoma cells and fabricated innovative TDEV membrane hybrid lipid nanovesicles (LEVs) for precise delivery to tumors and efficient siRNA transfection. The LEVs, equipped with 'homing' targeting ability, showed improved siRNA delivery efficiency compared to liposomes. In animal experiments, siRNA loaded LEVs demonstrated enhanced antitumor efficacy in hepatocellular carcinoma tumors.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Nanoscience & Nanotechnology
Lalithasri Ramasubramanian, Harsha Jyothi, Leora Goldbloom-Helzner, Brandon M. Light, Priyadarsini Kumar, Randy P. Carney, Diana L. Farmer, Aijun Wang
Summary: This study validates lipid rafts as a functional biomaterial for synthesizing biomimetic nanovesicles and shows their potential in promoting neurogenesis and angiogenesis.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Pharmacology & Pharmacy
Diego A. Rodriguez, Pieter Vader
Summary: The continuous development of nanomedicine has led to the creation of novel vehicles for effective drug delivery. Synthetic drug delivery systems have limitations, prompting researchers to explore alternative strategies such as EV-based hybrid systems. These hybrid systems offer advantages such as enhanced cellular uptake and drug delivery, immune evasion, ability to cross biological barriers, and tissue targeting.
Review
Chemistry, Multidisciplinary
Antonio Jose Guillot, Miquel Martinez-Navarrete, Teresa M. Garrigues, Ana Melero
Summary: Lipid vesicles offer cost-effective improvement in skin drug absorption when the production process is optimized. Designing the ideal vesicle is a significant challenge as their properties are interrelated. Size, deformability degree, and drug loading are the key features that determine transdermal drug absorption. Interest in this technology is growing exponentially, although commercialization has been limited by preservation and scalability issues, which can be overcome with freeze-drying and modern escalation methods. This predicts wider use of these technologies in the market and clinical practice.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Engineering, Biomedical
Bryan Z. Wang, Lori J. Luo, Gordana Vunjak-Novakovic
Summary: EVs act as carriers of biological signals through RNA and protein export and delivery; they have been effectively used in preclinical studies to treat various diseases and their cargo sorting within EVs requires an understanding of cellular mechanisms; standardized bioengineering methods for therapeutic EV preparation will be needed for a well-defined clinical product.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Multidisciplinary Sciences
Lizhi Liu, Dingyi Pan, Sheng Chen, Maria-Viola Martikainen, Anna Karlund, Jing Ke, Herkko Pulkkinen, Hanna Ruhanen, Marjut Roponen, Reijo Kakela, Wujun Xu, Jie Wang, Vesa-Pekka Lehto
Summary: The mechanism underlying partial coating in cell membrane (CM) coating technology has been revealed to be the adsorption of CM fragments or vesicles, which can eventually be ruptured under external force. Partial coating is difficult to self-repair due to limited membrane fluidity. Introducing external phospholipids as a helper can increase CM fluidity and promote the final fusion of lipid patches.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Martijn J. W. Evers, Simonides van de Wakker, Ellis M. de Groot, Olivier G. de Jong, Jerney J. J. Gitz-Francois, Cor S. Seinen, Joost P. G. Sluijter, Raymond M. Schiffelers, Pieter Vader
Summary: EV-liposome hybrid nanoparticles have been investigated as a potential siRNA delivery system, demonstrating their ability to encapsulate siRNA, contain EV-surface markers, and functionally deliver siRNA to different cell types. These hybrids combine the benefits of both synthetic and biological drug delivery systems, showing altered functional behavior compared to liposomes and varying efficacy among recipient cell types.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Anna Maria Tolomeo, Gaia Zuccolotto, Ricardo Malvicini, Giada De Lazzari, Alessandro Penna, Chiara Franco, Federico Caicci, Fabio Magarotto, Santina Quarta, Michela Pozzobon, Antonio Rosato, Maurizio Muraca, Federica Collino
Summary: This study aimed to evaluate the biodistribution of MSC-EVs after different routes of administration in mice. Results showed that local administration could increase the concentration of EVs in selective organs, limiting their systemic distribution and potentially reducing extra-organ effects. Biodistribution studies can help in selecting the most appropriate way of administering MSC-EVs for treating different diseases.
Review
Chemistry, Multidisciplinary
Jiaxin Hu, Yanfei Liu, Yimin Du, Xingxing Peng, Zhenbao Liu
Summary: Organelles have been developed as drug carriers, offering advantages in drug loading efficiency and therapeutic effect enhancement. This review summarizes the biogenesis, isolation, and drug-loading methods of four types of organelles, and highlights their potential as drug-delivery systems for disease treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Akila Kesavan, U. Chandrasekhar Reddy, Jais Kurian, Kannoth M. Muraleedharan
Summary: In this study, a new derivative with a fluorescent tag was designed and synthesized as a drug delivery system for anticancer drugs. The results showed that the new lipid-based carriers had small particle size, stable formulations, and efficient distribution in the cytosol of cells. The uptake rate was high, and the nanocarriers exhibited good safety profile.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Medicine, Research & Experimental
Yuta Suzuki, Yuri Katsurada, Kenji Hyodo
Summary: This article reviews the clinical trial data of three intravenously administered LNPs, summarizing the differences and similarities in their formulations, mechanisms of action, and pharmacokinetic profiles. The study found that patisiran and mRNA-1944 exhibited similar pharmacokinetic profiles with prolonged blood circulation in humans.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biology
Christelle Damon-Soubeyrand, Antonino Bongiovanni, Areski Chorfa, Chantal Goubely, Nelly Pirot, Luc Pardanaud, Laurence Piboin-Fragner, Caroline Vachias, Stephanie Bravard, Rachel Guiton, Jean-Leon Thomas, Fabrice Saez, Ayhan Kocer, Meryem Tardivel, Joel R. Drevet, Joelle Henry-Berger
Summary: The epididymis plays a crucial role in male fertility and has both secretory and immune functions. However, the organization of blood and lymphatic networks in the epididymis is still largely unknown.
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)