Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 29, Issue 5, Pages 595-599Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2014.07.012
Keywords
HOXA7; HOXA9; Mullerian duct abnormalities; single nucleotide polymorphisms
Categories
Funding
- National Basic Research Program of China [973 program] [2012CB944700]
- National Natural Science Foundation of China [81270662, 81370687]
- Foundation for the Author of National Excellent Doctoral Dissertation of PR China [201078]
- Independent Innovation Foundation of Shandong University (IIFSDU) [2012TS130]
Ask authors/readers for more resources
HOXA genes in groups 7-13 have been proven to play a role in determining positional identity along the genitalia axis. The aim of the present study was to explore the relationship between HOXA7 and HOXA9 mutations and Mullerian duct abnormalities (MDA). One hundred and ninety-two Chinese patients with MDA abnormalities and 192 healthy controls were recruited. All coding regions of HOXA7 and HOXA9 were amplified and sequenced directly. Rs2301721 and rs2301720 in HOXA7, rs35355140 and rs7810502 in HOXA9 were identified in patients with MDA and controls. One rare single nucleotide polymorphism rs189587233 in 3' UTR of HOXA9 gene was detected in one patient with didelphic uterus and absent in the 192 controls. This polymorphism, however, is known to exist in the normal Chinese population. Our results indicated that variants in the HOXA7 and HOXA9 genes were not common in Chinese women with Mullerian duct abnormalities. (C) 2014 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available