Journal
REPRODUCTIVE BIOMEDICINE ONLINE
Volume 24, Issue 2, Pages 197-205Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rbmo.2011.10.010
Keywords
apoE-containing high-density lipoprotein; inflammation; oxidative stress; PAF acetylhydrolase; polycystic ovary syndrome
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Funding
- Chinese National Natural Science Foundation [81070463]
- National Basic Research Program of China (973 program) [2007CB948101]
- Sichuan Province Science and Research Foundation of China [2008SZ0029]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0935]
- West China Second Hospital of Sichuan University
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PAF and PAF-like oxidized phospholipids hydrolysed by platelet-activating factor (PAF) acetylhydrolase (AH) are potent lipid mediators involved in inflammation and atherosclerosis. Apolipoprotein (apo) E-containing high-density lipoprotein (HDL) has antioxidant, anti-inflammatory and anti-atherogenic properties. The study investigated apoE-containing HDL-associated PAF-AH (HDL-PAF-AH) and total (apoE-containing + apoE-poor) HDL-PAF-AH activities as well as malondialdehyde (MDA) concentration in 291 patients with polycystic ovary syndrome (PCOS) using the Rotterdam consensus criteria and 281 control women. Compared with the control women, patients with hyperandrogenism + oligo/anovulation + polycystic ovaries (PCO) or hyperandrogenism + PCO had lower total, apoE-containing and apoE-poor HDL-PAF-AH activities, while those with oligo/anovulation + PCO showed decreased total and apoE-poor HDL-PAF-AH activities. Other factors including insulin resistance and obesity in PCOS had the adverse effects associated with the HDL-PAF-AH activities. Serum MDA concentration was associated with PCOS, hyperandrogenism, insulin resistance and hypertriglyceridaemia in patients with PCOS. Decreased total and apoE-containing HDL-PAF-AH activities and increased serum MDA concentration may contribute to the pathogenesis of PCOS and potentially link to related complications responsible for oxidative stress and inflammation such as an increased risk for type 2 diabetes mellitus and/or future cardiovascular diseases in PCOS patients. (C) 2011, Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
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