Article
Obstetrics & Gynecology
Luca Gianaroli, Amerigo Vitagliano, Anna P. Ferraretti, Silvia Azzena, Gaia Terzuoli, Davide Perruzza, Guido Ambrosini, Carla Tabanelli, M. Cristina Magli
Summary: This study investigated the effectiveness and safety of a mild ovarian stimulation program called IVF Lite in good prognosis patients. The results showed that the program was effective and safe for patients with a good response to clomiphene citrate stimulation, and two-thirds of the patients achieved a live birth at the completion of the program.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Chase Medwin, Genia Rozen, Franca Agresta, Nassar Nassar, Alex Polyakov
Summary: This study aims to formulate a clinically relevant OHSS classification for inpatient settings, estimate the prevalence of OHSS requiring hospital admission, and determine the preventability of OHSS with clinical strategies. The results showed a low prevalence of OHSS requiring hospital admission, and established risk factors may not accurately predict clinically relevant OHSS risk. Further monitoring, clinician, and patient education are needed to minimize the risk of significant OHSS.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2023)
Article
Obstetrics & Gynecology
Emanuele Garzia, Valentina Galiano, Jennifer Riparini, Patrizia Sulpizio
Summary: This case study describes a rare complication of unilateral massive hydrothorax after controlled ovarian stimulation for IVF in a patient lacking typical features and risk factors of OHSS. Treatment involved pleural drainage, hydration, albumin perfusion, and management of the intercurrent pregnancy, leading to improvement in clinical and hematological parameters. A high index of suspicion is necessary for prompt diagnosis and treatment in such cases.
REPRODUCTIVE SCIENCES
(2021)
Article
Obstetrics & Gynecology
Ginevra Mills, Michael H. Dahan
Summary: In the study, the use of GnRH antagonists in GnRH agonist cycles was found to reduce the risk of developing moderate and severe OHSS by promoting luteolysis and downregulating VEGF production and receptor response, thereby decreasing vascular permeability.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Endocrinology & Metabolism
Xiaofang Du, Wen Zhang, Xingling Wang, Xiaona Yu, Zhen Li, Yichun Guan
Summary: The patient with recurrent pituitary adenoma secreting FSH suffered from ovarian hyperstimulation syndrome (sOHSS) and was successfully treated with in vitro fertilization and embryo transfer (IVF-ET) after various treatments. IVF-ET was found to be effective for the treatment of recurrent pituitary adenoma, offering a therapeutic option for such cases.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Federica Di Guardo, Chiara Lello, Giosue Giordano Incognito, Maria Teresa Bruno, Marco Palumbo
Summary: Ovarian Hyperstimulation Syndrome (OHSS) is a serious complication in ovarian stimulation treatment, characterized by ovarian enlargement and various symptoms. Letrozole has shown potential as an effective preventive option for OHSS, although it is not yet officially recommended in guidelines. This study discusses the scientific approaches of using Letrozole to prevent OHSS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Rachel S. Mandelbaum, Liat Bainvoll, Caroline J. Violette, Meghan B. Smith, Shinya Matsuzaki, Maximilian Klar, Jacqueline R. Ho, Kristin A. Bendikson, Richard J. Paulson, Koji Matsuo
Summary: Obesity is associated with decreased rates of complications related to ovarian hyperstimulation syndrome in hospitalized patients.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Liat Bainvoll, S. Rachel Mandelbaum, J. Caroline Violette, Shinya Matsuzaki, R. Jacqueline Ho, D. Jason Wright, J. Richard Paulson, Koji Matsuo
Summary: Research suggests that higher hospital treatment volume for ovarian hyperstimulation syndrome (OHSS) may be associated with improved outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Review
Endocrinology & Metabolism
Bhavna Sharma, Kanyada Koysombat, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara
Summary: Infertility is a global health issue causing psychological distress. In vitro fertilisation (IVF) involves stimulating ovaries with hormones to retrieve multiple eggs. Excessive stimulation can lead to complications like OHSS and multiple pregnancies. The choice of trigger for egg maturation can affect IVF efficacy and safety. Kisspeptin, a regulator of the HPG axis, is being explored as a potential trigger for egg maturation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Nafeesathu Misiriyyah, Khansa Qurban, Aasiya Beevi, Litty Paulose, Haroutyoun Margossian
Summary: Adnexal torsion is a well-recognized complication of assisted reproductive techniques such as in vitro fertilization (IVF). We present a case of a 35-year-old primigravida who had previously undergone ovulation induction and was diagnosed with ovarian hyperstimulation syndrome (OHSS). Despite initial conservative management for recurrent OHSS, laparoscopic surgery was later performed due to worsening symptoms. The patient recovered without complications.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Article
Obstetrics & Gynecology
Hadas Ganer Herman, Yossi Mizrachi, Eran Horowitz, Ariel Weissman, Ben Sabban, Ohad Gluck, Arieh Raziel, Michal Kovo
Summary: This study aimed to assess the correlation between ovarian hyperstimulation syndrome (OHSS) in the early course of in vitro fertilization (IVF) pregnancies and obstetric outcomes. The results showed that OHSS pregnancies were associated with an increased risk of placental abruption, while there were no significant differences in other obstetric outcomes and newborn weight between the OHSS group and the other groups.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Obstetrics & Gynecology
Tiange Qi, Yueyue Hu, Mei Liu, Liu Tian, Zhiyu Peng, Hongyi Xu, Changjun Zhang
Summary: The objective of this study was to investigate the impact of abnormally elevated serum alanine aminotransferase (ALT) on pregnancy outcomes in patients with moderate and severe ovarian hyperstimulation syndrome (OHSS). The results showed that higher ALT levels increased the risk of obstetric and neonatal complications.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Emergency Medicine
Samantha B. Schon, Angela S. Kelley, Charley Jiang, Min Xu, Marie Menke, Erica E. Marsh
Summary: This study aimed to assess the utilization of emergency departments (ED) for ovarian hyperstimulation syndrome (OHSS) over time and examine admission rates, patient demographics, and charges.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2022)
Review
Medicine, General & Internal
H. Tang, S. M. Mourad, A. Wang, S. D. Zhai, R. J. Hart
Summary: Dopamine agonists are likely effective in reducing the risk of moderate or severe OHSS, while the effects on adverse events and pregnancy outcomes remain uncertain. Co-interventions with dopamine agonists may decrease the rates of OHSS, but the impact on pregnancy outcomes is unclear. When compared to other interventions, the effects of dopamine agonists on OHSS and pregnancy outcomes are uncertain.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Endocrinology & Metabolism
Stefano Palomba, Flavia Costanzi, Scott M. Nelson, Donatella Caserta, Peter Humaidan
Summary: This study reviewed and analyzed different interventions for preventing and reducing OHSS in IVF patients. The most effective interventions were found to be GnRH-ant co-treatment and GnRH agonist triggering, with moderate evidence. Mild ovarian stimulation and dopaminergic agonists were also effective and safe interventions.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Review
Obstetrics & Gynecology
Ariel Weissman, Gon Shoham, Zeev Shoham, Simon Fishel, Milton Leong, Yuval Yarona
FERTILITY AND STERILITY
(2017)
Article
Genetics & Heredity
Nili Raz, Amir Shalev, Eran Horowitz, Ariel Weissman, Yossi Mizrachi, Hadass Ganer Herman, Arieh Raziel
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2018)
Article
Genetics & Heredity
Yossi Mizrachi, Eran Horowitz, Jacob Farhi, David Levran, Arieh Raziel, Ariel Weissman
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2018)
Article
Obstetrics & Gynecology
Eran Gold, Yossi Mizrachi, Amir Shalev, Jacob Farhi, Eran Horowitz, Amir Ravhon, Sarit Alush, David Levran, Arie Raziel, Ariel Weissman
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2019)
Article
Genetics & Heredity
Gon Shoham, Rachel Levy-Toledano, Milton Leong, Ariel Weissman, Yuval Yaron, Zeev Shoham
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Article
Endocrinology & Metabolism
Jacob Farhi, Kfir Cohen, Yossi Mizrachi, Ariel Weissman, Arieh Raziel, Raoul Orvieto
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2019)
Article
Obstetrics & Gynecology
Eran Horowitz, Yossi Mizrachi, Jacob Farhi, Amir Shalev, Arieh Raziel, Ariel Weissman
REPRODUCTIVE BIOMEDICINE ONLINE
(2019)
Review
Obstetrics & Gynecology
Yossi Mizrachi, Eran Horowitz, Jacob Farhi, Arieh Raziel, Ariel Weissman
HUMAN REPRODUCTION UPDATE
(2020)
Article
Genetics & Heredity
Yossi Mizrachi, Ariel Weissman, Gili Buchnik Fater, Maya Torem, Eran Horowitz, Letizia Schreiber, Arieh Raziel, Jacob Bar, Michal Kovo
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Article
Endocrinology & Metabolism
Eran Horowitz, Yossi Mizrachi, Maya Finkelstein, Jacob Farhi, Amir Shalev, Eran Gold, Arieh Raziel, Ariel Weissman
Summary: The study found that luteal phase support after modified natural cycle frozen-thawed embryo transfer does not improve the live-birth rate, and may therefore not be necessary.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Letter
Obstetrics & Gynecology
Yossi Mizrachi, Ariel Weissman
HUMAN REPRODUCTION UPDATE
(2021)
Article
Obstetrics & Gynecology
Eran Horowitz, Yossi Mizrachi, Hadas Ganer, Or Tovi, Jacob Farhi, Arieh Raziel, Ariel Weissman
Summary: This study aimed to investigate the changes in hormone concentrations after natural cycle frozen-thawed embryo transfer (NC-FET) and their predictive role in live birth rate. The results showed that increased serum oestradiol and progesterone concentrations in early NC-FET pregnancies are associated with an increased likelihood of live birth.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Obstetrics & Gynecology
Eran Horowitz, Ariel Weissman
THERAPEUTIC ADVANCES IN REPRODUCTIVE HEALTH
(2020)
Article
Psychology, Multidisciplinary
Shirley Ben Shlomo, Orit Taubman-Ben-Ari, Vera Skvirsky, Yoseph Azuri, Ariel Weissman, Eran Horowitz
JOURNAL OF REPRODUCTIVE AND INFANT PSYCHOLOGY
(2019)
Article
Psychology, Clinical
Yael Benyamini, Miri Gozlan, Ariel Weissman
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2017)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)