Article
Obstetrics & Gynecology
Amanda Souza Setti, Gabriela Halpern, Daniela Paes de Almeida Ferreira Braga, Assumpto Iaconelli Jr, Edson Borges Jr
Summary: Maternal lifestyle factors, such as smoking, alcohol consumption, refined sugar, and artificial sweeteners, have a significant impact on the incidence of oocyte dimorphisms and outcomes of intracytoplasmic sperm injection (ICSI) cycles. These habits are positively associated with oocyte dimorphisms and negatively associated with ovarian stimulation response, embryo development, clinical pregnancy rates, and live birth rates. The associations are dose-dependent.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Endocrinology & Metabolism
Yaoxuan Li, Shikai Wang, Dawen Li, Yueyue Huang, Haifang Liu, Xiaohui Zhang, Jie Qin, Xianbao Mao, Zhengda Li, Liangshi Chen, Pingpin Wei, Wen Shi, Lintao Xue
Summary: The study found that short-interval second ejaculation on the day of oocyte retrieval can significantly improve sperm quality and embryo development in oligoasthenozoospermic males receiving intracytoplasmic sperm injection (ICSI) treatment, suggesting a non-invasive and effective strategy for improving ICSI outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Carlotta Scarafia, Martina Masciovecchio, Stefano Canosa, Andrea Roberto Carosso, Gianluca Gennarelli, Alberto Revelli, Chiara Benedetto
Summary: The study found that in women with ovarian endometriosis, ICSI can be performed without harming oocytes or affecting the outcome. Additionally, there is no advantage in removing endometrioma before ICSI.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Sandrine Chamayou, Carmen Ragolia, Carmelita Alecci, Giorgia Storaci, Simona Romano, Roberta Sapienza, Elena Maglia, Annalisa Liprino, Clementina Cardea, Michele Fichera, Antonino Guglielmino
Summary: In split insemination treatments, the yield of clinically usable blastocysts was consistently higher in ICSI compared to IVF, with ICSI requiring fewer MII oocytes to produce one clinically usable blastocyst and producing more blastocysts for clinical use from fewer MII oocytes across all sub-groups. The new KPI of the number of needed oocytes to produce one clinically usable embryo tests the clinical efficiency of the IVF laboratory.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Camille Robin, Audrey Uk, Christine Decanter, Helene Behal, Pierre Collinet, Chrystele Rubod, Anne-Laure Barbotin, Geoffroy Robin
Summary: The study aimed to evaluate the relationship between endometriosis and oocyte morphology after controlled ovarian stimulation for intracytoplasmic sperm injection (ICSI) on a large oocyte cohort, finding that endometriosis does not have a negative impact on oocytes' morphology in IVF-ICSI.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Martin Stimpfel, Nina Jancar, Eda Vrtacnik-Bokal
Summary: Collecting semen samples at home has a positive effect on sperm quality, but no significant differences in cycle outcomes are observed when these samples are used in IVF/ICSI cycles.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Physiology
Xue Wang, YaLing Xiao, ZhengYi Sun, JingRan Zhen, Qi Yu
Summary: The presence of smooth endoplasmic reticulum clusters (SERCs) in oocytes may negatively impact blastocyst quality and development speed, with lower rates of fertilization, good quality blastocysts, and slower blastocyst development observed in SERC (+) oocytes compared to unaffected oocytes. These findings were consistent even after controlling for various factors, suggesting a significant association between SERCs and compromised blastocyst development.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Jana Rychtarova, Alena Langerova, Helena Fulka, Pasqualino Loi, Michal Benc, Josef Fulka
Summary: The long-term storage of biological material is crucial for various fields, and a simple approach for evaluating sperm DNA damage level has been proposed to address the issue of limited frozen biological material quantities.
Article
Reproductive Biology
Angelica C. dos Santos, Daniel C. Joaquim, Ricardo P. Nociti, Carolina H. Macabelli, Rafael V. Sampaio, Aline S. Oliveira, Maico O. Pita, Robinson A. M. de Oliveira, Juliano C. da Silveira, Flavio V. Meirelles, Osnir Y. Watanabe, Yeda F. Watanabe, Marcos R. Chiaratti
Summary: Micro-vibration treatment during in vitro embryo culture improves the cryoresistance of bovine embryos, but it may also lead to epigenetic and transcriptional abnormalities.
Article
Endocrinology & Metabolism
Gustavo N. Cecchino, Matheus Roque, Maria Cerrillo, Rodrigo da Rosa Filho, Flavia da Silva Chiamba, Juliana Halley Hatty, Juan A. Garcia-Velasco
Summary: The study compared follicular phase stimulation (FPS) and luteal phase stimulation (LPS) in double ovarian stimulation (DuoStim), finding that LPS resulted in a higher number of retrieved oocytes and blastocysts obtained.
GYNECOLOGICAL ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Qing-Yun Yao, Xiao-Qiong Yuan, Chong Liu, Yao-Yao Du, Yang-Cheng Yao, Lin-Jing Wu, Hua-Hua Jiang, Tao-Ran Deng, Na Guo, Yan-Ling Deng, Qiang Zeng, Yu-Feng Li
Summary: Sleep characteristics such as short duration and poor quality may negatively impact the outcomes of IVF/ICSI treatment, while longer duration of nocturnal sleep could reduce the chances of successful pregnancy. The associations between sleep characteristics and IVF/ICSI outcomes are influenced by factors such as maternal age and subjective sleep quality.
HUMAN REPRODUCTION
(2022)
Article
Veterinary Sciences
Tian Zhao, Yangyang Pan, Qin Li, Tianyi Ding, Robert Niayale, Tongxiang Zhang, Jinglei Wang, Yaying Wang, Ling Zhao, Xiaohong Han, Abdul Rasheed Baloch, Yan Cui, Sijiu Yu
Summary: This study evaluated the influence of leukemia inhibitory factor (LIF) on the maturation and development ability of yak oocytes and the quality of subsequent blastocysts under in vitro culture settings. The findings revealed that adding 50 ng/mL of LIF during in vitro maturation significantly improved the maturation rate, levels of mitochondria and actin, mRNA transcription levels of anti-apoptotic and antioxidant-related genes, and reduced the generation of reactive oxygen species (ROS) and apoptosis levels in yak oocytes. Blastocysts formed from LIF-treated oocytes showed significantly larger total cell numbers and lower apoptosis rates. Overall, the addition of LIF during in vitro maturation improved the quality and competence of oocytes and subsequent blastocysts in yaks.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Obstetrics & Gynecology
Jonah Bardos, Jaclyn Kwal, Wayne Caswell, Samad Jahandideh, Melissa Stratton, Michael Tucker, Alan DeCherney, Kate Devine, Micah Hill, Jeanne E. O'Brien
Summary: The objective of this study was to evaluate the potential variation in euploid blastocyst and live birth rates among 4 reproductive genetics laboratories in the United States. The results showed that Laboratory A had significantly higher euploid blastocyst and live birth rates compared to Laboratories B, C, and D. This comparison provides important insights into the role of the PGT-A process in outcomes and further research is needed to understand the differences in laboratory techniques and bioinformatic algorithms.
FERTILITY AND STERILITY
(2023)
Article
Biochemistry & Molecular Biology
Ahmed Atef Mesalam, Marwa El-Sheikh, Myeong-Don Joo, Atif Ali Khan Khalil, Ayman Mesalam, Mi-Jeong Ahn, Il-Keun Kong
Summary: Exposing bovine oocytes to juglone at concentrations of 12.5-50.0 μM significantly impairs their development by inducing ROS accumulation, apoptosis, and mitochondrial dysfunction. This study provides insights into the adverse effects of juglone treatment on oocyte maturation and embryo development, highlighting the importance of understanding the impact of traditional medicinal components on reproductive processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Sara Stigliani, Claudia Massarotti, Francesca Bovis, Ida Casciano, Fausta Sozzi, Valentino Remorgida, Angelo Cagnacci, Paola Anserini, Paola Scaruffi
Summary: The study evaluated whether the consensus pronuclear score could improve prediction of embryo implantation potential. Results showed that embryos with PN score 1 had higher implantation success compared to score 2-3 embryos. The pronuclear score remained predictive of implantation in top quality embryos. Therefore, the consensus pronuclear score may be routinely included among criteria for embryo evaluation to increase patients' chance of becoming pregnant.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)