☆ 4.6 Article

GnRH antagonists and endometrial receptivity in oocyte recipients: a prospective randomized trial

REPRODUCTIVE BIOMEDICINE ONLINE (2009)

Journal

REPRODUCTIVE BIOMEDICINE ONLINE

Volume 18, Issue 2, Pages 276-281

Publisher

ELSEVIER SCI LTD

DOI: 10.1016/S1472-6483(10)60266-0

Keywords

endometrium; implantation rate; IVF; oocyte donation; pregnancy rate

Categories

Obstetrics & Gynecology Reproductive Biology

Ask authors/readers for more resources

Protocol

Community support

Reagent

Community support

Abstract

The effect that gonadotrophin-releasing hormone (GnRH) antagonists exert on endometrial receptivity has not yet been elucidated. GnRH antagonists might directly affect oocytes, the embryo and/or the endometrium. The aim of this study was to investigate the direct effect of GnRH antagonists on the endometrium in oocyte donation cycles. In an oocyte donation programme, oocytes from each donor (n = 49), stimulated with gonadotrophins and a GnRH antagonist, were equally shared between two different matched recipients. Recipients were randomly allocated to either receive a GnRH antagonist concomitant to donor during their endometrial priming with oestradiol (group 1, n = 49) or to solely continue with their endometrial preparation (group 11, n = 49). Pregnancy rate was 55.1% in group I and 59.1% in group II. Implantation rate was 26.1% in group I and 24.4% in group II. Endometrial thickness was also similar between the two groups on the day of human chorionic gonadotrophin injection to the donor. In conclusion, GnRH antagonist administration during the proliferative phase at a dose of 0.25 mg per day does not appear to adversely affect endometrial receptivity in oocyte recipients.

Authors

I am an author on this paper

Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6

Not enough ratings

Secondary Ratings

Novelty

-

Significance

-

Scientific rigor

-

Rate this paper

Recommended

Article Endocrinology & Metabolism

Is It Possible to Expand Oocyte Donors by Decreasing Number of Oocytes for Own Use? Insights From a Large Single-Center Study

Zhiqin Bu, Jiaxin Zhang, Yile Zhang, Yingpu Sun

Summary: The study found that oocyte donation does not compromise CLBR and can reduce embryo wastage. Additionally, in patients with 10 retrieved oocytes, CLBR remained good at 73%. Therefore, it is possible to expand oocyte donors by decreasing the number of oocytes kept for own use from 15 to 10 after adequate communication with patients.

FRONTIERS IN ENDOCRINOLOGY (2021)

Add to Collection

Review Obstetrics & Gynecology

The effect of hyaluronic acid in embryo transfer media in donor oocyte cycles and autologous oocyte cycles: a systematic review and meta-analysis

Devorah Heymann, Liat Vidal, Zeev Shoham, Elena Kostova, Marian Showell, Yuval Or

Summary: The study aimed to investigate the effects of hyaluronic acid (HA) on pregnancy outcomes in autologous and oocyte donation IVF cycles. The study found that the addition of HA to embryo transfer medium improves live birth rate, clinical pregnancy rate, and multiple pregnancy rate in autologous oocyte cycles. However, it showed little effect in donor oocyte cycles.

HUMAN REPRODUCTION (2022)

Add to Collection

Article Obstetrics & Gynecology

Low-dose clomiphene citrate does not reduce implantation and live birth rates in otherwise unstimulated modified natural cycle IVF-retrospective cohort study

Flavia Gradel, Michael von Wolff, Alexandra Sabrina Kohl Schwartz, Vera Ruth Mitter

Summary: This study aimed to investigate whether the antiestrogen effect of clomiphene citrate on the endometrium reduces implantation and subsequently decreases pregnancy and live birth rates per transferred embryo. The results showed that low-dose clomiphene citrate does not negatively affect embryo implantation or pregnancy rates, and can be safely used in infertility treatment.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2023)

Add to Collection

Review Biochemistry & Molecular Biology

MicroRNAs in the Regulation of Endometrial Receptivity for Embryo Implantation

Manizha Shekibi, Sophea Heng, Guiying Nie

Summary: The development of endometrial receptivity is crucial for successful embryo implantation and pregnancy initiation. Recent studies have focused on the role of microRNAs (miRNAs) in the regulation of endometrial receptivity. This review provides an up-to-date knowledge of the miRNAs identified in humans and mice that may play a functional role in the establishment of receptivity. The findings suggest that miRNAs could be potential biomarkers and therapeutic targets for improving endometrial receptivity in human fertility treatment.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Add to Collection

Article Agriculture, Dairy & Animal Science

Short Communication: Maternal obesity alters ovine endometrial gene expression during peri-implantation development

Sarah R. McCoski, Rebecca R. Cockrum, Alan D. Ealy

Summary: Exposure to maternal obesity during pregnancy can have significant effects on offspring development, which may not be apparent until adulthood. This study investigated how obesity influences gene expression in the endometrium during early pregnancy using a sheep model. The results showed that obesity affects gene expression related to the immune response, adhesion, and angiogenesis in the endometrium. These findings suggest that the peri-implantation endometrium is responsive to maternal obesity and changes in gene expression during early embryogenesis may contribute to developmental programming.

JOURNAL OF ANIMAL SCIENCE (2022)

Add to Collection

Article Obstetrics & Gynecology

Do donor spermatozoa improve reproductive outcomes after oocyte donation failure? A retrospective analysis of cumulative live birth rates per donor oocyte consumed

Mauro Cozzolino, Irene Hervas, Rocio Rivera-Egea, Antonio Pellicer, Nicolas Garrido

Summary: The study found that using donor spermatozoa after the first failed oocyte donation cycle can improve IVF outcomes. The cumulative live birth rate (CLBR) curves for using autologous or donor spermatozoa can be used to determine the cumulative chances of live birth and provide guidance on when to replace spermatozoa.

REPRODUCTIVE BIOMEDICINE ONLINE (2021)

Add to Collection

Review Obstetrics & Gynecology

Pre-eclampsia in pregnancies resulting from oocyte donation, natural conception or IVF: a systematic review and meta-analysis

A. Keukens, M. van Wely, C. van der Meulen, M. H. Mochtar

Summary: The prevalence of pre-eclampsia is significantly higher in pregnancies after oocyte donation compared to natural conception and in vitro fertilization with autologous oocytes.

HUMAN REPRODUCTION (2022)

Add to Collection

Article Obstetrics & Gynecology

A critical appraisal of studies on endometrial thickness and embryo transfer outcome

Begum Mathyk, Adina Schwartz, Alan DeCherney, Baris Ata

Summary: A receptive endometrium is crucial for successful embryo implantation, and ultrasonography-measured endometrial thickness is commonly used as an indicator of endometrial receptivity in assisted reproductive technology cycles. Factors like age, oestradiol concentration, and oocyte number affect both endometrial thickness and probability of live birth. Most studies on the relationship between endometrial thickness and embryo transfer outcomes lack proper addressing of confounding factors and have limitations. Despite numerous meta-analyses and large-scale studies, controversy still exists. This article provides a critical review of studies on endometrial thickness and embryo transfer outcomes, highlighting methodological issues and suggesting improvements for future research. Currently available evidence does not support modifying management solely based on arbitrary thresholds of endometrial thickness.

REPRODUCTIVE BIOMEDICINE ONLINE (2023)

Add to Collection

Review Obstetrics & Gynecology

Determinants of Embryo Implantation: Roles of the Endometrium and Embryo in Implantation Success

Awoniyi O. Awonuga, Olivia G. Camp, Husam M. Abu-Soud, Daniel A. Rappolee, Elizabeth E. Puscheck, Michael P. Diamond

Summary: The contributions of uterine endometrium and embryo in implantation success are still debated. Various measures, such as endometrial receptivity analysis (ERA), endometrial scratch (ES), endometrial microbiome, and intrauterine or intravenous measures, are recommended to improve implantation success. However, there is insufficient evidence to determine the relative importance of endometrium and embryo in implantation success and the utility of these measures, especially with euploid embryos. Evidence suggests that embryos can implant and develop on non-endometrium epithelium. The role of embryo euploidy in implantation success is currently underappreciated.

REPRODUCTIVE SCIENCES (2023)

Add to Collection

Article Medicine, General & Internal

Elevated Sperm DNA Damage in IVF-ICSI Treatments Is Not Related to Pregnancy Complications and Adverse Neonatal Outcomes

Irene Hervas, Rocio Rivera-Egea, Alberto Pacheco, Maria Gil Julia, Ana Navarro-Gomezlechon, Laura Mossetti, Nicolas Garrido

Summary: This multicenter retrospective cohort study found that high paternal DNA fragmentation does not contribute to adverse maternal events during pregnancy or worse neonatal outcomes. However, it may be associated with a higher ratio of male livebirths.

JOURNAL OF CLINICAL MEDICINE (2023)

Add to Collection

Article Biochemistry & Molecular Biology

Endometrial gene expression profiling of recurrent implantation failure after in vitro fertilization

Irem Gulfem Albayrak, Fatemeh Azhari, Ezgi Nur Colak, Burcin Karamustafaoglu Balci, Ege Ulgen, Ugur Sezerman, Ercan Bastu, Tuba Gunel

Summary: Recurrent implantation failure (RIF) is diagnosed when good-quality embryos repeatedly fail to implant after transfer, potentially due to dysregulated gene expression. This study focused on identifying significantly dysregulated genes related to implantation between healthy fertile women and RIF patients. The study found up-regulated expression of MME and WWC1 genes, and down-regulated expression of TNC gene in RIF samples compared to controls, suggesting potential mechanisms underlying RIF.

MOLECULAR BIOLOGY REPORTS (2021)

Add to Collection

Review Obstetrics & Gynecology

Evidence-Based Pre-Pregnancy Counseling for Oocyte Donation Pregnancies: a Systematic Review and Guide for Physicians

Marie-Louise Van der Hoorn, Kim van Bentem, Eileen Lashley

Summary: This study aims to provide pre-pregnancy counseling information for healthcare workers regarding oocyte donation (OD) pregnancies. The study found that OD pregnancies have a higher risk of complications, including hypertensive disorders, cesarean section, preterm birth, postpartum hemorrhage, and low birth weight. Pre-pregnancy counseling is recommended to prevent complications in subsequent pregnancies, and women should be informed about the increased risk of complications during OD pregnancies. Other recommendations include the prophylactic use of aspirin during pregnancy and restriction to single embryo transfer.

REPRODUCTIVE SCIENCES (2022)

Add to Collection

Article Reproductive Biology

Expression pattern of microRNAs in ovine endometrium during the peri-implantation

Mehmet Kose, Mustafa Hitit, Mehmet Salih Kaya, Mesut Kirbas, Sukru Dursun, Ilyas Alak, Mehmet Osman Atli

Summary: This study aimed to elucidate the expression pattern of miRNAs in the endometrium during peri-implantation in ewes. A total of 116 ovine-specific miRNAs were detected, with 19 differentially expressed in early pregnancy. The differentially expressed miRNAs targeted a total of 315 genes, with functional enrichment in the innate immune system and signaling pathways.

THERIOGENOLOGY (2022)

Add to Collection

Article Multidisciplinary Sciences

'God helps those who help themselves' ... religion and Assisted Reproductive Technology usage amongst urban Ghanaians

Rosemond Akpene Hiadzi, Isaac Mensah Boafo, Peace Mamle Tetteh

Summary: This study explores the impact of religion on ART usage, suggesting that religion is not an inhibiting factor but rather an enabling factor for participants. It provides a framework for participants to navigate decision-making, treatment processes, and outcomes, and offers strength to endure the physical and emotional discomfort associated with ART.

PLOS ONE (2021)

Add to Collection

Article Obstetrics & Gynecology

An algorithm to personalise the diagnosis of recurrent implantation failure based on theoretical cumulative implantation rate

Genia Rozen, Peter Rogers, Wan Tinn Teh, Catharyn J. Stern, Alex Polyakov

Summary: RIF is a disorder with an imprecise definition lacking robust scientific basis, presenting significant challenges in diagnosis and treatment. The concept of 'Theoretical Cumulative Implantation Rate' is proposed to determine RIF diagnosis based on objective data. An updated and standardized definition is needed for patient counseling and research planning.

HUMAN REPRODUCTION (2021)

Add to Collection

No Data Available

Article Obstetrics & Gynecology

Gym lifestyle factors and male reproductive health: a study into young adult usage and perceptions

Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher

Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.

REPRODUCTIVE BIOMEDICINE ONLINE (2024)

Add to Collection

Article Obstetrics & Gynecology

An artificial intelligence-based approach for selecting the optimal day for triggering in antagonist protocol cycles

Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz

Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.

REPRODUCTIVE BIOMEDICINE ONLINE (2024)

Add to Collection

Article Obstetrics & Gynecology

Endometrial protein expression and phosphorylation landscape decipher aberrant insulin and mTOR signalling in patients with recurrent pregnancy loss

Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang

Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.

REPRODUCTIVE BIOMEDICINE ONLINE (2024)

Add to Collection

Article Obstetrics & Gynecology

Random-start ovarian stimulation in an oocyte donation programme: a large, single-centre, experience

Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu

Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.

REPRODUCTIVE BIOMEDICINE ONLINE (2024)

Add to Collection

© Peeref 2019-2024. All rights reserved.