Article
Obstetrics & Gynecology
Georgina M. Chambers, Silke Dyer, Fernando Zegers-Hochschild, Jacques de Mouzon, Osamu Ishihara, Manish Banker, Ragaa Mansour, Markus S. Kupka, G. David Adamson
Summary: In 2014, 1.93 million ART cycles were performed in 76 countries, with trends showing increased success rates, frozen embryo transfer cycles, single embryo transfer, and preimplantation genetic testing. Utilization rates and effectiveness of ART continue to improve globally.
HUMAN REPRODUCTION
(2021)
Article
Reproductive Biology
Ayumi Hasegawa, Keiji Mochida, Shogo Matoba, Kimiko Inoue, Daiki Hama, Masayo Kadota, Noriko Hiraiwa, Atsushi Yoshiki, Atsuo Ogura
Summary: This study developed assisted reproductive technologies for wild-derived Mus spretus mice, enabling efficient production of embryos and successful interspecies embryo transfer into laboratory mice, demonstrating the potential for safe preservation and utilization of strains in research settings.
BIOLOGY OF REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Manish Banker, Silke Dyer, Georgina M. Chambers, Osamu Ishihara, Markus Kupka, Jacques de Mouzon, Fernando Zegers-Hochschild, G. David Adamson
Summary: The report provides data on the utilization, effectiveness, and safety of assisted reproductive technology (ART) globally in 2013, showing an increase in ART cycles and changes in trends such as a rise in the proportion of older women undergoing non-donor ART. Further efforts are needed to improve the quality and consistency of reporting ART data by registries.
FERTILITY AND STERILITY
(2021)
Article
Cardiac & Cardiovascular Systems
Maria C. Magnus, Abigail Fraser, Siri E. Haberg, Kristiina Rono, Liv Bente Romundstad, Christina Bergh, Anne Laerke Spangmose, Anja Pinborg, Mika Gissler, Ulla-Britt Wennerholm, Bjorn Olav Asvold, Deborah A. Lawlor, Signe Opdahl
Summary: This study examines the associations between different combinations of aerobic and muscle strengthening activity with mortality rates. The findings suggest that balanced levels of aerobic activity and muscle strengthening may reduce the risk of mortality.
Article
Cardiac & Cardiovascular Systems
Maria C. Magnus, Abigail Fraser, Siri E. Haberg, Kristiina Rono, Liv Bente Romundstad, Christina Bergh, Anne Laerke Spangmose, Anja Pinborg, Mika Gissler, Ulla-Britt Wennerholm, Bjorn Olav Asvold, Deborah A. Lawlor, Signe Opdahl
Summary: A study using nationwide data from Denmark, Finland, Norway, and Sweden found that women who gave birth after assisted reproductive technologies (ART) did not have an increased risk of cardiovascular disease (CVD) compared to those who conceived without ART during a median follow-up of 11 years. Longer-term studies are needed to further investigate the association between ART and higher risk of CVD.
Article
Obstetrics & Gynecology
Seiko Matsuo, Takafumi Ushida, Sho Tano, Kenji Imai, Shigeru Yoshida, Mamoru Yamashita, Hiroaki Kajiyama, Tomomi Kotani
Summary: This study found that assisted reproductive technology (ART), especially frozen embryo transfer, hormone replacement cycle frozen embryo transfer, or blastocyst-stage embryo transfer, was associated with an increased risk of head circumference ≥ 90th percentile compared to non-ART fertility treatment or natural conception. This increased risk was observed only in male neonates.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Obstetrics & Gynecology
Shu Qin Wei, Marianne Bilodeau-Bertrand, Ernest Lo, Nathalie Auger
Summary: The publicly funded ART program in Quebec was found to be associated with reduced risks of preeclampsia, cesarean delivery, preterm birth, low birth weight, and other adverse outcomes. This study suggests that publicly funded ART programs encouraging single embryo transfer may have substantial benefits for a range of maternal and infant outcomes.
HUMAN REPRODUCTION
(2021)
Review
Obstetrics & Gynecology
Hui Ju Chih, Flavia T. S. Elias, Laura Gaudet, Maria P. Velez
Summary: This study found through systematic review and meta-analysis that pregnancies conceived through assisted reproductive technology (ART) are more likely to develop hypertensive disorders of pregnancy (HDP) and preeclampsia compared to pregnancies from spontaneous conception (SC), especially in cases of frozen embryo transfer and oocyte donation.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Ben W. Mol, Bo Jacobsson, William A. Grobman, Kelle Moley
Summary: FIGO supports the use of assisted reproductive technologies for achieving pregnancy but stresses the importance of considering the increased risk of preterm birth. Single embryo transfer is recommended to reduce the risk of preterm birth in IVF cycles.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Obstetrics & Gynecology
Anja Pinborg, Ulla-Britt Wennerholm, Christina Bergh
Summary: More than 10 million children worldwide, accounting for 7.9% of children born in Europe and 5.1% of children born in the US in 2018, have been born after ART. Short-term outcomes show higher rates of preterm birth and low birth weight in children born after fresh embryo transfer, while higher rates of large for gestational age and high birth weight are found in children born after frozen embryo transfer. Long-term health outcomes in children born after ART suggest an increased risk of altered blood pressure and cardiovascular function. This review summarizes these long-term health outcomes and explores the factors associated with the increased health risks. The future of ART treatment strategies and the safety of the mother and child are also discussed. (Fertil Sterile 2023;120:449-56. & COPY; 2023 by American Society for Reproductive Medicine.)
FERTILITY AND STERILITY
(2023)
Article
Multidisciplinary Sciences
Fang Fang, Zili Li, Jiangyu Yu, Yuting Long, Qian Zhao, Xiaofang Ding, Li Wu, Shumin Shao, Ling Zhang, Wenpei Xiang
Summary: The study suggests that miRNAs secreted by human embryos in culture media could serve as potential biomarkers for non-invasive embryo selection in assisted reproductive technology. Embryos with successful pregnancy release different miRNA profiles compared to those with failed pregnancy, indicating their predictive potential in reproductive outcomes. Selected miRNAs like hsa-miR-26b-5p and hsa-miR-21-5p show promising results as potential biomarkers for reproductive outcomes.
JOURNAL OF ADVANCED RESEARCH
(2021)
Review
Obstetrics & Gynecology
Diane De Neubourg, Eline A. F. Dancet, Anja Pinborg
Summary: This review examines the difference between single-embryo transfer (SET) and double-embryo transfer (DET) in assisted reproductive technology. It suggests that SET is safer, equally effective, and more cost-efficient, and should be the standard offered to all patients. The review emphasizes patient-centered care, informed decision-making, and individual values.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Review
Peripheral Vascular Disease
Molly S. Kornfield, Susan B. Gurley, Lisa A. Vrooman
Summary: This review assesses the association between assisted reproductive technology (ART) and preeclampsia, based on recent available data. Retrospective clinical studies predominantly support the link between ART and preeclampsia. Both clinical and pre-clinical studies suggest that specific ART procedures, such as in vitro embryo handling and development, hormone stimulation, transfer cycle types, and use of donor oocytes/embryos, may contribute to the increased risk. Potential mechanisms include epigenetic aberrations, absence of factors secreted by the corpus luteum, and immunologic responses to allogenic gametes.
CURRENT HYPERTENSION REPORTS
(2023)
Review
Agriculture, Dairy & Animal Science
Luciana Diniz Rola, Marcos Eli Buzanskas, Luciana Magalhaes Melo, Maiana Silva Chaves, Vicente Jose Figueiredo Freitas, Jose Mauricio Barbanti Duarte
Summary: Deer species in the Neotropical region are experiencing population declines and decreased genetic diversity due to rapid habitat loss and human activities. Assisted reproductive technology (ART) shows promise in advancing wildlife conservation efforts and maintaining genetic diversity in deer. Techniques such as in vitro embryo production (IVP) and proteomics are being utilized to better understand and address reproductive challenges facing Neotropical deer.
Article
Obstetrics & Gynecology
Nicholas Saleem Raja, Colin B. Russell, Molly B. Moravek
Summary: This study discusses fertility concerns specific to LGBTQ+ and single-parent-to-be populations and reviews special considerations for evaluating and treating these patients in reproductive medicine. It emphasizes the need for equitable treatment regardless of sexual orientation or partner status and the importance of healthcare providers being comfortable and confident in addressing the needs of these populations.
FERTILITY AND STERILITY
(2022)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)