Article
Obstetrics & Gynecology
Michael S. Awadalla, Nicole L. Vestal, Lynda K. McGinnis, Ali Ahmady, Richard J. Paulson
Summary: The study found that for women of all ages, the sustained implantation rates for day 5 good quality blastocysts were higher than for day 5 fair, day 5 poor, and day 6 blastocysts. There were also higher sustained implantation rates for younger patients compared to older patients when controlling for morphology and day of biopsy, showing that age plays a significant role in the success of implantation.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
He Li, Xiaoxi Sun, Junyi Yang, Lu Li, Wenbi Zhang, Xiang Lu, Junling Chen, Hua Chen, Min Yu, Wei Fu, Xiandong Peng, Jiazhou Chen, Ernest Hung Yu Ng
Summary: The study compared immediate and delayed frozen embryo transfers following a stimulated IVF cycle and found that immediate FET resulted in significantly higher ongoing pregnancy and live birth rates. This suggests that immediate FET may be more effective after a stimulated IVF cycle.
HUMAN REPRODUCTION
(2021)
Article
Genetics & Heredity
He Li, Wenbi Zhang, Xiaoxi Sun
Summary: This study aims to investigate the predictive ability of serum kisspeptin for first-trimester miscarriage and compare it with serum HCG. The results suggest that serum kisspeptin levels on days 21 and 28 after FET are associated with early miscarriage but have poor predictive value.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2023)
Review
Endocrinology & Metabolism
Ruxin Wang, Haixia Huang, Yong Tan, Guicheng Xia
Summary: This study aimed to explore the efficacy of atosiban on pregnancy outcomes in patients with repeated embryo implantation failure who underwent in vitro fertilization-embryo transfer (IVF-ET). A systematic search of English and Chinese databases found that atosiban was associated with a higher clinical pregnancy rate in patients with repeated implantation failure. However, more thorough and larger prospective randomized controlled studies are needed to confirm this conclusion.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Rong Luo, Jiahui Wang, Yu Yang, Cen Xu, Minyan Yang, Dandan Zhu, Jia Wang, Ping Zhang, Hongshan Ge
Summary: This study aimed to assess the impact of vitamin D levels on embryo quality and pregnancy outcomes in patients with normal ovarian reserve undergoing the first IVF/ICSI cycle. The findings suggest that serum vitamin D level is not associated with embryo quality and pregnancy outcomes for these patients. Further studies are needed to elucidate the relationships between vitamin D levels and IVF outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Shiming Wang, Lin Qi, Yaping Liu, Hao Shi, Xiaoli Chen, Ningning Wang, Yingchun Su
Summary: This retrospective study investigated the impact of endometrial thickness on ectopic pregnancy rate and clinical pregnancy rate in fresh embryo transfer patients with early follicular phase long-acting regimen. The results showed that endometrial thickness was positively correlated with clinical pregnancy rate and negatively correlated with ectopic pregnancy rate. When the endometrial thickness was greater than or equal to 11mm, it could achieve lower ectopic pregnancy rate and higher clinical pregnancy rate simultaneously.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
G. Griesinger, C. Blockeel, P. Pierzynski, H. Tournaye, H. Visnova, A. Humberstone, P. Terrill, O. Pohl, E. Garner, J. Donnez, E. Loumaye
Summary: The study found that a single oral dose of nolasiban 900 mg significantly increased pregnancy rates in women undergoing IVF, supporting the hypothesis that oxytocin receptor antagonism at the time of embryo transfer may have a positive impact.
HUMAN REPRODUCTION
(2021)
Article
Medicine, General & Internal
Yun Sun, Linlin Cui, Yao Lu, Jichun Tan, Xi Dong, Tianxiang Ni, Junhao Yan, Yichun Guan, Guimin Hao, Jia-Yin Liu, Bo Zhang, Daimin Wei, Yan Hong, Yaqiong He, Jia Qi, Bing Xu, Juanjuan Lu, Qian Zhang, Shanshan Zhao, Xiaowei Ji, Xiaofang Du, Jie Zhang, Jinyong Liu, Jing Wang, Yingqin Huang, Dongmei Huang, Yanzhi Du, Hugo Vankelecom, Heping Zhang, Zi-jiang Chen
Summary: Prednisone treatment does not improve live birth rate in patients with recurrent implantation failure compared to placebo. The use of prednisone may increase the risk of preterm delivery and biochemical pregnancy loss. These findings challenge the value of prednisone use in clinical practice for the treatment of recurrent implantation failure.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Obstetrics & Gynecology
Simona Anzhel, Sirpa Makinen, Helena Tinkanen, Tiina Mikkila, Anni Haltia, Antti Perheentupa, Candido Tomas, Hannu Martikainen, Aila Tiitinen, Juha S. Tapanainen, Zdravka Veleva
Summary: The quality of embryos transferred and the presence of tubal factor infertility affect the risk of ectopic pregnancy after IVF/ICSI. Transfer of top-quality embryos is associated with a lower rate of ectopic pregnancy. To reduce the risk of ectopic pregnancy, the number of embryos transferred should be minimized.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2022)
Article
Endocrinology & Metabolism
Jihui Ai, Lei Jin, Yu Zheng, Peiwen Yang, Bo Huang, Xiyuan Dong
Summary: The blastocyst expansion stage, ICM grade, and TE grade are all associated with pregnancy outcomes. ICM grade is the strongest predictor of live birth. A blastocyst with stage 4-5, ICM grade A, and TE grade A/B should be given priority for single embryo transfer.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Obstetrics & Gynecology
Arianna D'Angelo, Costas Panayotidis, Alessandra Alteri, Saria Mcheik, Zdravka Veleva
Summary: This document provides an overview of technical aspects of ultrasound-guided embryo transfer (US-GET) after considering published data and includes preparation, procedure, post-procedure care, complications, quality assurance, and practitioner performance. Recommendations are provided based on the literature search and experts' opinions.
HUMAN REPRODUCTION OPEN
(2022)
Article
Genetics & Heredity
Ranit Hizkiyahu, Eva Suarthana, Einav Kadour Peero, Ido Feferkorn, William Buckett
Summary: This study compared the effects of fixed estrogen dose and increasing estrogen doses during hormone therapy frozen embryo transfer (HT-FET) cycles. The results showed that despite using higher doses of estrogen and longer treatment duration, the increased-dose group had thinner endometrium. However, the pregnancy rates were similar between the two groups.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Obstetrics & Gynecology
M. L. Boutet, G. Casals, B. Valenzuela-Alcaraz, L. Garcia-Otero, F. Crovetto, M. S. Civico, A. Borras, D. Manau, E. Gratacos, F. Crispi
Summary: The study found that embryos transfer impacts fetal cardiac remodeling and suboptimal function, with more pronounced changes after fresh embryo transfer compared to frozen embryo transfer. Fetuses conceived by assisted reproductive technologies showed larger atria, more globular ventricles, and thicker myocardial walls, as well as signs of suboptimal systolic and diastolic function as compared to spontaneously conceived pregnancies.
HUMAN REPRODUCTION
(2021)
Article
Endocrinology & Metabolism
Lin Song, Zhiqin Bu, Yingpu Sun
Summary: This study aimed to investigate the relationship between endometrial thickness and early pregnancy complications in frozen thawed embryo transfer cycles. The results showed that thin endometrium was associated with an increased risk of ectopic pregnancy and early spontaneous miscarriage. Therefore, endometrial thickness can serve as an independent predictor for early pregnancy complications.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kai-Lun Hu, Shan Li, Sarah Hunt, Rui Yang, Huiyu Xu, Rong Li
Summary: A retrospective cohort study revealed that a baseline AMH concentration of >= 7 ng/ml is associated with an increased risk of ectopic pregnancy in fresh embryo transfer cycles.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)