Review
Immunology
Giorgio Santoni, Consuelo Amantini, Matteo Santoni, Federica Maggi, Maria Beatrice Morelli, Angela Santoni
Summary: NK cells play a crucial role in immune protection against viruses and tumors by killing target cells and secreting cytokines. Mechanotransduction, mediated by actin cytoskeleton, regulates NK cell functions such as adhesion, migration, and tissue infiltration. Further research on mechanotransduction may lead to new immunotherapeutic approaches tailored for NK cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Umut Can Kucuksezer, Esin Aktas Cetin, Fehim Esen, Ilhan Tahrali, Nilgun Akdeniz, Metin Yusuf Gelmez, Gunnur Deniz
Summary: NK cells are a subset of innate lymphoid cells that play important roles in anti-tumor immune responses and immune regulation, with different subgroups showing cytotoxic functions or cytokine production. Their activation is influenced by a variety of factors, including cell surface receptors and cytokines, and their dysregulation can contribute to various immune-mediated diseases. Further research on NK cell biology and their potential therapeutic applications is necessary for better understanding and treatment of inflammatory disorders.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Mario Witkowski, Caroline Tizian, Marta Ferreira-Gomes, Daniela Niemeyer, Terry C. Jones, Frederik Heinrich, Stefan Frischbutter, Stefan Angermair, Thordis Hohnstein, Irene Mattiola, Philipp Nawrath, Sophie McEwen, Silvia Zocche, Edoardo Viviano, Gitta Anne Heinz, Marcus Maurer, Uwe Koelsch, Robert Lorenz Chua, Tom Aschman, Christian Meisel, Josefine Radke, Birgit Sawitzki, Jobst Roehmel, Kristina Allers, Verena Moos, Thomas Schneider, Leif Hanitsch, Marcus A. Mall, Christian Conrad, Helena Radbruch, Claudia U. Duerr, Joseph A. Trapani, Emanuela Marcenaro, Tilmann Kallinich, Victor M. Corman, Florian Kurth, Leif Erik Sander, Christian Drosten, Sascha Treskatsch, Pawel Durek, Andrey Kruglov, Andreas Radbruch, Mir-Farzin Mashreghi, Andreas Diefenbach
Summary: Research shows that the status of NK cells in COVID-19 patients is negatively correlated with viral load, and NK cells can control SARS-CoV-2 replication by recognizing infected target cells. In severe COVID-19 patients, NK cells exhibit defects in virus control, cytokine production, and cell-mediated cytotoxicity despite high expression of cytotoxic effector molecules.
Review
Immunology
Siqin Duan, Shuwen Liu
Summary: This review highlights the immunotherapy strategies for HIV infection that utilize the beneficial properties of natural killer (NK) cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Nurul Izza Ismail
Summary: As the placenta is semi-allogenic, it is expected that maternal immune cells would attack the invading trophoblast, but studies have shown that they cooperate with the trophoblast to disrupt the arterial wall. uNK cells, unique immune cells, play a role in pregnancy. The interaction between HLA class 1b genes and maternal uNK cells in humans is described in this review.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Daun Jung, Young Seok Baek, In Jee Lee, Ki Yeon Kim, Heejoo Jang, Sohyun Hwang, Jieun Jung, Yong-wha Moon, Kyung-Soon Park, Yong-Soo Choi, Hee Jung An
Summary: This study focused on ex vivo expansion and cryopreservation of allogeneic NK cells, which showed upregulated genes related to NK cell functions and exhibited potent cytolytic activity against cancer cell lines. The research suggests the potential use of expanded and cryopreserved NK cells as a promising immunotherapy for drug-resistant cancer patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Immunology
Bert Malengier-Devlies, Jessica Filtjens, Kourosh Ahmadzadeh, Bram Boeckx, Jessica Vandenhaute, Amber De Visscher, Eline Bernaerts, Tania Mitera, Cato Jacobs, Lore Vanderbeke, Pierre Van Mol, Yannick Van Herck, Greet Hermans, Philippe Meersseman, Alexander Wilmer, Mieke D. Gouwy, Abhishek Garg, Stephanie Humblet-Baron, Frederik De Smet, Kimberly Martinod, Els Wauters, Paul Proost, Carine Wouters, Georges Leclercq, Diether Lambrechts, Joost Wauters, Patrick Matthys
Summary: NK cells in COVID-19 patients display an activated phenotype and show significant differences between different stages of infection. Early-stage patients have increased expression of cytotoxic molecules, while late-stage patients show enhanced levels of cytokines. The activation of NK cells is correlated to neutrophil count and IL-15 levels, but cytotoxic killing is normal.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jose Lourenco Reis, Natacha Nurdine Rosa, Miguel Angelo-Dias, Catarina Martins, Luis Miguel Borrego, Jorge Lima
Summary: Endometriosis is a chronic inflammatory disorder characterized by the presence of endometrial cells outside the uterus. Studies indicate a correlation between the immune system, particularly NK receptors (NKR), and endometriosis, suggesting their essential role in the disease's pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Yan-Xin Niu, Zhao-Xu Xu, Li-Feng Yu, Yong-Ping Lu, Yan Wang, Ce Wu, Yi-Bo Hou, Jia-Ning Li, Shengqiang Huang, Xinyue Song, Xinyu Wang, Jiaqi Wang, Binyu Li, Yingrui Guo, Zhaojin Yu, Lin Zhao, Dong-Xu Yi, Min-Jie Wei
Summary: Fc-fusion proteins, a promising biopharmaceutical product in tumor therapy, have the potential to activate natural killer cells and kill tumor cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Lukman O. Afolabi, Jiacheng Bi, Liang Chen, Xiaochun Wan
Summary: The study demonstrated that Piperlongumine (PL), a natural alkaloid obtained from long pepper fruit, has both antitumor and immunomodulatory potential on all tested tumors, increasing tumor susceptibility to NK cell cytolysis. This suggests that PL could be explored as a complementary approach to NK cell immunotherapy for cancer treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Eva Persyn, Sigrid Wahlen, Laura Kiekens, Sylvie Taveirne, Wouter Van Loocke, Els Van Ammel, Filip Van Nieuwerburgh, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, Georges Leclercq
Summary: This study investigated the role of TXNIP in human NK cell differentiation and found that TXNIP promotes human NK cell differentiation by affecting protein synthesis and proliferation of early NK cell differentiation stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Raffaella Meazza, Loredana Ruggeri, Fabio Guolo, Paola Minetto, Paolo Canevali, Fabrizio Loiacono, Sara Ciardelli, Alessandra Bo, Silvia Luchetti, Alberto Serio, Letizia Zannoni, Christelle Retiere, Natalia Colomar-Carando, Sarah Parisi, Antonio Curti, Roberto M. M. Lemoli, Daniela Pende
Summary: NK cell-based adoptive immunotherapy in leukemia patients has shown efficacy and safety. This study compared two approaches to determine the size of alloreactive NK cells in HLA-haploidentical donors for AML patients. The phenotypic identification of NK cells and degranulation assays proved to be accurate and efficient methods for determining the size of alloreactive NK cell subset.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Erica L. Heipertz, Evan R. Zynda, Tor Espen Stav-Noraas, Andrew D. Hungler, Shayne E. Boucher, Navjot Kaur, Mohan C. Vemuri
Summary: Natural killer (NK) cells are a crucial part of the immune system, with the ability to kill virally infected and malignant cells. Current research is focused on testing the efficacy of NK cell therapy for cancer and exploring the use of CAR-NK for treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Silvia Gaggero, Kristina Witt, Mattias Carlsten, Suman Mitra
Summary: NK cells play a crucial role in tumor immune surveillance but can be rendered ineffective within the tumor microenvironment due to suppressive factors, primarily influenced by myeloid cells. While NK-myeloid cell crosstalk can promote anti-tumor responses, it can also lead to dysregulation of NK cells, affecting their function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Nora Trinks, Sebastian Reinhard, Matthias Drobny, Linda Heilig, Jurgen Loffler, Markus Sauer, Ulrich Terpitz
Summary: The study introduces an ExM method that allows super-resolved visualization of the interaction between NK cells and Aspergillus fumigatus hyphae. 4-fold expansion combined with confocal fluorescence imaging reveals details of cytoskeleton rearrangement and NK cells' lytic granules triggered by contact with an RFP-expressing A. fumigatus strain.
COMMUNICATIONS BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)