Article
Cell Biology
Hai-Ping Tao, Gong-Xue Jia, Xiao-Na Zhang, Yu-Jun Wang, Bin-Ye Li, Qi-En Yang
Summary: Environmental hypoxia exposure affects fertility in humans and animals, impairing spermatogenesis and early embryo development.
Article
Obstetrics & Gynecology
Giovanni Coticchio, Kenji Ezoe, Cristina Lagalla, Carlotta Zaca, Andrea Borini, Keiichi Kato
Summary: Comparing embryos reaching the blastocyst stage between Days 4-7, it was found that longer times to blastocyst formation are associated with worse clinical outcomes and disruptions in developmental patterns. These differences emerge as early as the fertilization stage.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Sara Stigliani, Claudia Massarotti, Francesca Bovis, Ida Casciano, Fausta Sozzi, Valentino Remorgida, Angelo Cagnacci, Paola Anserini, Paola Scaruffi
Summary: The study evaluated whether the consensus pronuclear score could improve prediction of embryo implantation potential. Results showed that embryos with PN score 1 had higher implantation success compared to score 2-3 embryos. The pronuclear score remained predictive of implantation in top quality embryos. Therefore, the consensus pronuclear score may be routinely included among criteria for embryo evaluation to increase patients' chance of becoming pregnant.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Obstetrics & Gynecology
Haowen Zou, James M. Kemper, Elizabeth R. Hammond, Fengqin Xu, Gensheng Liu, Lintao Xue, Xiaohong Bai, Hongqing Liao, Songguo Xue, Shuqin Zhao, Lan Xia, Jean Scott, Vincent Chapple, Masoud Afnan, Dean E. Morbeck, Ben W. J. Mol, Yanhe Liu, Rui Wang
Summary: The transfer of single low-grade blastocysts resulted in a reduced live birth rate compared to single good-grade blastocysts, but did not lead to more adverse perinatal outcomes.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Richard Musson, Lukasz Gasior, Simona Bisogno, Grazyna Ewa Ptak
Summary: This review discusses the sources of DNA damage in gametes and preimplantation embryos, with a focus on current knowledge, limits in DNA damage detection, and screening strategies. It also explores obstacles and future perspectives in the clinical diagnosis and treatment of DNA damaged embryos.
HUMAN REPRODUCTION UPDATE
(2022)
Article
Obstetrics & Gynecology
Enver Kerem Dirican, Safak Olgan, Mehmet Sakinci, Mete Caglar
Summary: Blastocyst transfers showed higher clinical pregnancy rates in patients with more zygotes compared to cleavage-stage transfers, while there was no significant difference in clinical pregnancy rates between the two transfer methods for patients with fewer zygotes.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2022)
Article
Obstetrics & Gynecology
Marija Kljajic, Nabil Sayme, Thomas Krebs, Gudrun Wagenpfeil, Simona Baus, Erich-Franz Solomayer, Mariz Kasoha
Summary: The main aim of this study was to identify noninvasive biomarkers of blastocyst quality in countries with restrictive reproductive medicine laws. Morphokinetic parameters, such as zygote diameter and total cytoplasmic volume, pronuclear disappearance rate, and the spatial arrangement of blastomere, were found to be associated with blastocyst quality.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2023)
Article
Obstetrics & Gynecology
Marija Kljajic, Nabil Sayme, Thomas Krebs, Gudrun Wagenpfeil, Simona Baus, Erich-Franz Solomayer, Mariz Kasoha
Summary: This study identified morphokinetic parameters that could serve as noninvasive biomarkers of blastocyst quality in countries with restrictive reproductive medicine laws. The findings showed correlations between zygote diameter, total cytoplasmic volume, pronuclear disappearance speed, late-stage parameters, and blastomere spatial arrangement with blastocyst quality. Tetrahedral embryos were more likely to form good-quality blastocysts. The results may help enhance embryo selection methods, especially in countries with strict regulations.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2023)
Article
Pediatrics
Chen Wang, Anna L. Johansson, Kenny A. Rodriguez-Wallberg, Catarina Almqvist, Sonia Hernandez-Diaz, A. Sara Oberg
Summary: The study found that children conceived with assisted reproductive techniques (ART) had a lower risk of ADHD and performed better in school compared to other children. Differences in parental characteristics explained and even reversed associations, with no disadvantage seen when comparing children of couples with known infertility.
Article
Obstetrics & Gynecology
Wenhao Shi, Lei Jin, Jiayin Liu, Cuilian Zhang, Yang Mi, Juanzi Shi, Hui Wang, Xiaoyan Liang
Summary: The study found that blastocysts with loosely arranged inner cell mass cells combined with tightly packed trophectoderm cells were associated with a higher risk of monozygotic twinning.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keng Po Lai, Cherry Chi Tim Leung, Delbert Almerick T. Boncan, Nathan Tam, Xiao Lin, Simon Yuan Wang, Ting Fung Chan, Rudolf Shiu Sun Wu, Richard Yuen Chong Kong
Summary: Hypoxia can cause dysregulation of miRNA in the ovaries, leading to reproductive impairments in fish. Integrated miRNA-mRNA analysis reveals several dysregulated miRNA that are involved in biological processes related to reproduction. Furthermore, the study identifies specific miRNA-mRNA pairs that play a potential epigenetic role in hypoxia-induced reproductive impairments.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Review
Obstetrics & Gynecology
Alessio Paffoni, Marco Reschini, Stefania A. Noli, Paola Vigano, Fabio Parazzini, Edgardo Somigliana
Summary: Maternal nutrition, especially the importance of folate in reproductive success, is well recognized. However, data on folate levels in women undergoing infertility treatments are scarce. Studies have shown varied results on the association between folate status and success rates in assisted reproductive techniques.
REPRODUCTIVE SCIENCES
(2022)
Article
Plant Sciences
Haruka Shinkawa, Masataka Kajikawa, Tomoyuki Furuya, Ryuichi Nishihama, Hirokazu Tsukaya, Takayuki Kohchi, Hideya Fukuzawa
Summary: This study discovered the important role of DYRKs protein kinases, specifically the MpYAK1 subfamily, in regulating plant growth and development in the liverwort Marchantia polymorpha. MpYAK1 was found to be involved in maintaining plant responses to light conditions and nutrient signaling.
PLANT AND CELL PHYSIOLOGY
(2022)
Review
Genetics & Heredity
Antonio Capalbo, Maurizio Poli, Chaim Jalas, Eric J. Forman, Nathan R. Treff
Summary: The use of aneuploidy testing in IVF cycles is increasing, with almost half of cycles in the US undergoing PGT-A. Evidence shows that embryos diagnosed with uniform whole-chromosome aneuploidy rarely result in live births, while embryos with low-level mosaicism for whole chromosomes have reproductive capabilities similar to euploid embryos. Differentiating between uniform and mosaic aneuploidy is crucial in clinical and research settings for proper management of aneuploid embryos.
AMERICAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Obstetrics & Gynecology
Jonah Bardos, Jaclyn Kwal, Wayne Caswell, Samad Jahandideh, Melissa Stratton, Michael Tucker, Alan DeCherney, Kate Devine, Micah Hill, Jeanne E. O'Brien
Summary: The objective of this study was to evaluate the potential variation in euploid blastocyst and live birth rates among 4 reproductive genetics laboratories in the United States. The results showed that Laboratory A had significantly higher euploid blastocyst and live birth rates compared to Laboratories B, C, and D. This comparison provides important insights into the role of the PGT-A process in outcomes and further research is needed to understand the differences in laboratory techniques and bioinformatic algorithms.
FERTILITY AND STERILITY
(2023)
Article
Oncology
Selcen Celik, Yan Li, Chris O'Neill
EXPERIMENTAL CELL RESEARCH
(2015)
Review
Developmental Biology
J. Salvaing, Y. Li, N. Beaujean, C. O'Neill
REPRODUCTION FERTILITY AND DEVELOPMENT
(2015)
Review
Developmental Biology
Michael J. Bertoldo, Yann Locatelli, Christopher O'Neill, Pascal Mermillod
REPRODUCTION FERTILITY AND DEVELOPMENT
(2015)
Article
Oncology
L. Ganeshan, X. L. Jin, C. O'Neill
EXPERIMENTAL CELL RESEARCH
(2017)
Editorial Material
Andrology
Chris O'Neill
ASIAN JOURNAL OF ANDROLOGY
(2013)
Article
Multidisciplinary Sciences
Selcen Celik, Yan Li, Chris O'Neill
Article
Multidisciplinary Sciences
Yongxia Zhou, Fang Yu, Timothy Duong
Article
Multidisciplinary Sciences
Yuan Zhou, Ikuo Hayashi, Jacky Wong, Katherine Tugusheva, John J. Renger, Celina Zerbinatti
Article
Developmental Biology
X. L. Jin, C. O'Neill
Article
Developmental Biology
Jane C. Fenelon, Geoff Shaw, Chris O'Neill, Stephen Frankenberg, Marilyn B. Renfree
Review
Reproductive Biology
C. O'Neill, Y. Li, X. L. Jin
Article
Developmental Biology
C. Rollo, Y. Li, X. L. Jin, C. O'Neill
Article
Developmental Biology
Y. Li, Michelle K. Y. Seah, C. O'Neill
Article
Biology
C. O'Neill, Y. Li, X. L. Jin
CELL SIGNALING DURING MAMMALIAN EARLY EMBRYO DEVELOPMENT
(2015)