Editorial Material
Obstetrics & Gynecology
Dominique de Ziegler, Rene F. Frydman
Summary: Recurrent pregnancy loss (RPL) is defined as two to three spontaneous pregnancy terminations before 12 weeks of gestation, potentially caused by factors like gamete quality, uterine issues, endometrial receptivity alterations, immunologic factors, and thrombophilia.
FERTILITY AND STERILITY
(2021)
Article
Obstetrics & Gynecology
Haley G. Genovese, Dana B. Mcqueen
Summary: This manuscript reports on the prevalence of early pregnancy loss and discusses the impact of improved pregnancy diagnosis, as well as the influence of increased age and body mass index at first birth.
FERTILITY AND STERILITY
(2023)
Review
Medicine, General & Internal
Akbayan Turesheva, Gulzhanat Aimagambetova, Talshyn Ukybassova, Aizada Marat, Perizat Kanabekova, Lyazzat Kaldygulova, Ainur Amanzholkyzy, Svetlana Ryzhkova, Anastassiya Nogay, Zaituna Khamidullina, Aktoty Ilmaliyeva, Wassim Y. Almawi, Kuralay Atageldiyeva
Summary: Recurrent pregnancy loss is a complex health challenge with no universally accepted definition. The true incidence is difficult to estimate due to inconsistency in definitions and criteria applied by international guidelines. The exact etiology remains questionable and up to 75% of cases are unexplained. This review aimed to summarize accumulated knowledge on etiology, risk factors, diagnostic options, and management approach to recurrent pregnancy loss.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Pedro Melo, Rima Dhillon-Smith, Md Asiful Islam, Adam Devall, Arri Coomarasamy
Summary: Approximately 80% of miscarriages occur within the first 12 weeks of gestation, with more than half resulting from genetic defects. Recent use of big data has led to the discovery of specific gene mutations that may be implicated in sporadic and recurrent miscarriages.
FERTILITY AND STERILITY
(2023)
Article
Allergy
Casper Tidemandsen, Pia Egerup, Charlotte Suppli Ulrik, Vibeke Backer, David Westergaard, Anders Pretzmann Mikkelsen, Ojvind Lidegaard, Henriette Svarre Nielsen
Summary: This study found a significant positive association between asthma and the number of pregnancy loss (PL) and recurrent pregnancy loss (RPL). Early-onset asthma and uncontrolled asthma were more strongly associated with PL than adult-onset and late-onset asthma and controlled asthma.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Genetics & Heredity
Deeba S. Jairajpuri, Zainab H. Malalla, Naeema Mahmood, Farah Khan, Wassim Y. Almawi
Summary: Recurrent pregnancy loss (RPL) affects 2-3% of pregnancies, lacking effective therapy and reliable biomarkers. This study identified 10 differentially expressed microRNAs in RPL, including 5 novel microRNAs associated with RPL for the first time. The findings provide insight into the role of circulating microRNAs in RPL pathogenesis and their potential as noninvasive diagnostic and prognostic biomarkers.
Article
Obstetrics & Gynecology
Jade E. Bilardi, Meredith Temple-Smith
Summary: Miscarriage and recurrent miscarriage have profound and prolonged psychological impacts, yet support for miscarriage remains inadequate. Acknowledgment and validation of grief, provision of information, and addressing the discrepancy between bereavement care offered and desired are important steps to ameliorate the impact. Collecting national miscarriage data and establishing national research funding priorities would allow for a better understanding of the socioeconomic cost and burden of miscarriage and enable targeted research for public health benefit.
FERTILITY AND STERILITY
(2023)
Article
Obstetrics & Gynecology
Mohamed A. Bedaiwy, Bahi Fayek, Emily C. Yang, Mahmoud S. Iews, Mohamed Elgendi, Amr O. Abdelkareem, Ahmed H. Abdellah, Yang Doris Liu, Adrian Jones, Ulrike Mayer, Faten F. Abdel Hafez
Summary: This study examined the impact of non-visualized pregnancy loss (NVPL) on future reproductive outcomes in patients with recurrent pregnancy loss (RPL). The results showed that the number of previous NVPLs is a significant predictor of subsequent live birth.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Paul Pirtea, Ettore Cicinelli, Rosalba De Nola, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Chronic inflammatory processes affecting the endometrium can impact endometrial receptivity, leading to early pregnancy losses and recurrent pregnancy losses. Conditions like endometriosis may increase the risk of miscarriages, but assisted reproductive technology can mitigate these risks.
FERTILITY AND STERILITY
(2021)
Article
Medicine, General & Internal
Hye In Kim, Eun A. Choi, Eun Chan Paik, Soohyeon Park, Yu Im Hwang, Jae Hoon Lee, Seok Kyo Seo, SiHyun Cho, Young Sik Choi, Byung Seok Lee, Jimyeong Park, Sanghoo Lee, Kyoung-Ryul Lee, Bo Hyon Yun
Summary: This study found a significant association between the risk of RPL and the miR-449b/TNF-alpha combination, suggesting that genetic analysis of specific combined genotypes can be an important screening method for RPL in Korean women.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Review
Obstetrics & Gynecology
Marita Hennessy, Rebecca Dennehy, Sarah Meaney, Laura Linehan, Declan Devane, Rachel Rice, Keelin O'Donoghue
Summary: A systematic review was conducted to identify clinical practice guidelines for recurrent miscarriage within high-income countries published since 2000. Most guidelines scored poorly in terms of applicability and editorial independence, with varying levels of consensus and some conflicting recommendations between guidelines.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Obstetrics & Gynecology
Pirkko Peuranpaea, Tiina Holster, Schahzad Saqib, Ilkka Kalliala, Aila Tiitinen, Anne Salonen, Hanna Hautamaki
Summary: This study found that dysbiosis of the endometrial and vaginal microbiota is associated with recurrent pregnancy loss and may represent a novel risk factor for pregnancy loss. Specifically, there was a decrease in relative abundance of Lactobacillus crispatus in endometrial samples and an increase in Gardnerella vaginalis abundance in the RPL group.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Marie Carbonnel, Paul Pirtea, Dominique de Ziegler, Jean Marc Ayoubi
Summary: Both congenital and acquired uterine anomalies are associated with recurrent pregnancy loss. Initial evaluation of uterine anatomy is crucial for women with RPL. Surgical management of certain uterine anomalies, such as uterine septa, endometrial polyps, intrauterine adhesions, and submucosal myomas, may improve subsequent pregnancy outcomes in specific circumstances.
FERTILITY AND STERILITY
(2021)
Article
Cardiac & Cardiovascular Systems
Laura Kasak, Kristiina Rull, Tao Yang, Dan M. Roden, Maris Laan
Summary: This study investigated a nonconsanguineous Estonian family and identified a potential rare genetic variant in the mother as a potential novel cause behind recurrent fetal loss.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Obstetrics & Gynecology
A. Youssef, M. L. P. van der Hoorn, M. Dongen, J. Visser, K. Bloemenkamp, J. van Lith, N. van Geloven, E. E. L. O. Lashley
Summary: This study externally validated the Brigham prognostic model in couples with unexplained recurrent pregnancy loss, showing that the model overestimates the chances of successful pregnancy, predicts too extremely, and lacks discrimination, indicating a need for revision for more accurate prediction.
HUMAN REPRODUCTION
(2022)