Article
Medicine, General & Internal
Amr Moubasher, Tarek Abdel-Raheem, Hossam Ahmed, Ahmed Salem, Alpesh Doshi, Amr Abdel Raheem
Summary: This study compared the outcomes of intracytoplasmic morphologically selected sperm injection (IMSI) and intracytoplasmic sperm injection (ICSI) in vitro fertilization (IVF) procedures, and found that ICSI had statistically better results in terms of chemical pregnancy, clinical pregnancy, live birth, and fertilization rates compared to IMSI. Although there were no significant differences in miscarriage rates, ICSI showed significant advantages in certain subgroups regarding chemical and clinical pregnancy rates.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Review
Medicine, General & Internal
Sandrine Chamayou, Filippo Giacone, Rossella Cannarella, Antonino Guglielmino
Summary: The intracytoplasmic sperm injection (ICSI) technique was invented to address severe male infertility caused by altered sperm parameters. It is now widely used worldwide for couple infertility treatment. ICSI can be performed using any available spermatozoon, regardless of motility, morphology, or quantity. Published data shows that ICSI accelerates zygote kinetics and leads to higher fertilization rates and more blastocysts for clinical use compared to conventional IVF. Various sperm and spermatozoa characteristics, such as parameters, morphology, vitality, DNA content, RNA content, epigenetics, and recovery site, have different impacts on fertilization, blastocyst rates, and embryo kinetics. While ICSI is the most common solution for couple infertility, understanding the causes of male infertility is crucial for producing competent spermatozoa that contribute to normal embryonic development and healthy offspring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Krzysztof Lukaszuk, Grzegorz Jakiel, Izabela Woclawek Potocka, Jolanta Kiewisz, Jolanta Olszewska, Wlodzimierz Sieg, Amira Podolak, Ewa Pastuszek, Artur Wdowiak
Summary: ICSI is a commonly used treatment for oocyte fertilization, and the quality of sperm selection depends on accurate visualization of morphology. We emphasize the importance of optical system's resolution in observing sperm and provide specific microscope system setup recommendations. Furthermore, a lack of standardization in microscopy techniques for both ICSI and IMSI may contribute to mixed research results.
Article
Veterinary Sciences
Effrosyni Fatira, Milos Havelka, Taiju Saito, Jose Landeira, Marek Rodina, David Gela, Martin Psenicka
Summary: In this study, the researchers applied intracytoplasmic sperm injection (ICSI) technology to endangered sturgeons and found that it successfully produced embryos and larvae. Furthermore, molecular analysis showed genome integration of both egg and sperm donor species, demonstrating the potential of ICSI for assisted reproduction in sturgeons.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Genetics & Heredity
Veena Unnikrishnan, John Kastelic, Jacob Thundathil
Summary: In cattle, the efficiency of ICSI is hindered by failed oocyte activation post sperm injection. Research focusing on proteins like Na/K-ATPase and PLC zeta is key to improving the success rate. Enhancing the efficiency of bovine ICSI has significant implications for the cattle breeding industry.
Review
Obstetrics & Gynecology
Felipe Dieamant, Claudia G. Petersen, Laura D. Vagnini, Adriana Renzi, Bruna Petersen, Fabiana Massaro, Camila Zamara, Andreia Nicoletti, Juliana Ricci, Antonio H. Oliani, Joao Batista A. Oliveira, Jose G. Franco Jr
Summary: Through a systematic review and meta-analysis, it was found that IMSI reduced the incidence of structural defects compared to ICSI, but did not have an impact on the occurrence of chromosomal abnormalities.
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA
(2021)
Review
Multidisciplinary Sciences
Andrea Busnelli, Edgardo Somigliana, Federico Cirillo, Annamaria Baggiani, Paolo Emanuele Levi-Setti
Summary: This systematic review and meta-analysis assessed the effect of different therapeutic options for repeated embryo implantation failure (RIF) on subsequent IVF cycle outcomes. Intrauterine PBMC infusion and subcutaneous G-CSF administration were found to be the most promising therapeutic options for RIF. Further well-conducted randomized controlled trials are needed before their introduction into clinical practice.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Ioannis Rigos, Vasileios Athanasiou, Nikolaos Vlahos, Nikolaos Papantoniou, Dimitrios Profer, Charalampos Siristatidis
Summary: The study found that in IVF treatment, performing hysteroscopic endometrial injury in patients with recurrent implantation failure, in conjunction with the freeze-all technique, did not significantly improve pregnancy rates, including live birth.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Li Zhang, Jia-ming Mao, Ming Li, Ying Lian, Sheng-li Lin, Li-xue Chen, Li-ying Yan, Jie Qiao, Ping Liu
Summary: The presence of AZFc microdeletions resulted in poorer outcomes in intracytoplasmic sperm injection (ICSI), with lower pregnancy and live birth rates compared to control groups. Patients with these deletions should be aware of their reduced chances of biological fatherhood.
FERTILITY AND STERILITY
(2021)
Article
Andrology
Hong-Liang Zhang, Lian-Ming Zhao, Jia-Ming Mao, De-Feng Liu, Wen-Hao Tang, Hao-Cheng Lin, Li Zhang, Ying Lian, Kai Hong, Hui Jiang
Summary: This study aimed to compare the SRRs and clinical outcomes of patients with different causes of azoospermia who underwent micro-TESE-ICSI. Patients with orchitis had the highest and most successful SRR, along with higher rates of clinical pregnancy, implantation, and live birth. On the other hand, patients with AZFc microdeletion had a higher SRR but worse clinical outcomes.
ASIAN JOURNAL OF ANDROLOGY
(2021)
Article
Obstetrics & Gynecology
Ahmad Aboukhshaba, Nahid Punjani, Sofia Doukakis, Nikica Zaninovic, Gianpiero Palermo, Peter N. Schlegel
Summary: The study aimed to evaluate the impact of sperm characteristics on intracytoplasmic sperm injection (ICSI) outcomes in men with nonobstructive azoospermia (NOA) following microdissection testicular sperm extraction (mTESE). The results showed that specific sperm defects did not completely preclude the chance of clinical pregnancy. This study is the first comprehensive evaluation of the importance of these characteristics in ICSI outcomes.
FERTILITY AND STERILITY
(2022)
Article
Endocrinology & Metabolism
Ning Huang, Lixue Chen, Ying Lian, Haining Wang, Rong Li, Jie Qiao, Hongbin Chi
Summary: The presence of thyroid autoimmunity in patients with infertility did not impair embryo quality or affect pregnancy outcomes, including clinical pregnancy, miscarriage, preterm delivery, and live birth. However, it decreased the number of oocytes retrieved and birth weight in twin pregnancy. Subgroup analysis showed no association between the types or titers of thyroid antibodies and adverse IVF/ICSI outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Lauren Lacey, Sibte Hassan, Sebastian Franik, Mourad W. Seif, M. Ahsan Akhtar
Summary: The effects of assisted hatching (AH) on live birth rates are uncertain and may increase the risk of multiple pregnancies. Although AH may offer a slightly increased chance of achieving a clinical pregnancy, the quality of data is low, and it is uncertain whether it influences miscarriage rates.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Andrology
Hong-Liang Zhang, Jia-Ming Mao, De-Feng Liu, Lian-Ming Zhao, Wen-Hao Tang, Kai Hong, Li Zhang, Ying Lian, Hao-Cheng Lin, Hui Jiang
Summary: This study evaluated the clinical outcomes of microdissection testicular sperm extraction-intracytoplasmic sperm injection (micro-TESE-ICSI) treatment using fresh or cryopreserved sperm in patients with nonobstructive azoospermia (NOA). Results showed that fresh testicular sperm yielded higher rates of clinical pregnancy and live birth compared to cryopreserved sperm, suggesting that fresh testicular sperm may produce better ICSI outcomes in NOA patients.
ASIAN JOURNAL OF ANDROLOGY
(2021)
Article
Endocrinology & Metabolism
Yalong Liu, Zining He, Ning Huang, Lin Zeng, Yang Wang, Rong Li, Hongbin Chi
Summary: This study aimed to investigate the impact of thyroid autoimmunity and total 25-hydroxyvitamin D concentration on early pregnancy outcomes in women undergoing in vitro fertilization/intracytoplasmic sperm injection. The study found that patients with thyroid autoimmunity had lower vitamin D serum concentrations and fewer good-quality embryos. Aging was also found to adversely affect clinical and ongoing pregnancy in this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Laura D. Vagnini, Adriana Renzi, Claudia G. Petersen, Felipe Dieamant, Joao Batista A. Oliveira, Maria do Carmo T. Canas, Jose G. Franco Junior, Antonio H. Oliani
Summary: This study investigated the impact of SNPs TP53 rs1625895, TP73 rs3765730, MMP9 rs17576, and MTHFR rs868014 on ovarian reserve in infertile patients. The results indicated that these genetic polymorphisms were associated with low ovarian reserve in infertile patients.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Review
Obstetrics & Gynecology
Felipe Dieamant, Claudia G. Petersen, Laura D. Vagnini, Adriana Renzi, Bruna Petersen, Fabiana Massaro, Camila Zamara, Andreia Nicoletti, Juliana Ricci, Antonio H. Oliani, Joao Batista A. Oliveira, Jose G. Franco Jr
Summary: Through a systematic review and meta-analysis, it was found that IMSI reduced the incidence of structural defects compared to ICSI, but did not have an impact on the occurrence of chromosomal abnormalities.
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA
(2021)
Article
Obstetrics & Gynecology
Laura D. Vagnini, Claudia G. Petersen, Adriana Renzi, Felipe Dieamant, Joao B. A. Oliveira, Antonio H. Oliani, Maria C. T. Canas, Raul Nakano, Carlos G. Almodin, Condesmar Marcondes, Alvaro Ceschin, Adelino Amaral, Jonathas B. Soares, Joaquim Lopes, Antonio C. Franco, Jose G. Franco Jr
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA
(2020)
Meeting Abstract
Obstetrics & Gynecology
L. Vagnini, A. Renzi, B. Petersen, C. G. Petersen, A. L. Mauri, M. C. Mattila, V. A. Comar, J. Ricci, F. Dieamant, J. B. A. Oliveira, R. L. Baruffi, J. G. Franco
HUMAN REPRODUCTION
(2018)
Meeting Abstract
Obstetrics & Gynecology
A. Renzi, L. Vagnini, B. Petersen, C. G. Petersen, A. L. Mauri, M. C. Mattila, V. A. Comar, J. Ricci, F. Dieamant, J. B. A. Oliveira, R. L. R. Baruffi, J. G. Franco
HUMAN REPRODUCTION
(2018)
Meeting Abstract
Obstetrics & Gynecology
R. L. Baruffi, C. G. Petersen, A. L. Mauri, L. Vagnini, A. Renzi, B. Petersen, M. C. Mattila, V. A. A. Comar, A. Nicoletti, F. Dieamant, J. B. A. Oliveira, J. G. Franco
HUMAN REPRODUCTION
(2018)
Meeting Abstract
Obstetrics & Gynecology
J. G. Franco, F. Dieamant, C. G. Petersen, A. L. Mauri, M. C. Mattila, V. A. Comar, L. Vagnini, A. Renzi, B. Petersen, C. Zamara, J. B. A. Oliveira, R. L. R. Baruffi
HUMAN REPRODUCTION
(2018)
Article
Andrology
J. B. A. Oliveira, C. G. Petersen, A. L. Mauri, L. D. Vagnini, A. Renzi, B. Petersen, M. Mattila, F. Dieamant, R. L. R. Baruffi, J. G. Franco