Article
Nutrition & Dietetics
Ioana Adriana Muntean, Ioana Corina Bocsan, Lena Katharina Wiest, Irena Pintea, Carmen Teodora Dobrican, Emanuela Duca, Corina Ureche, Anca Dana Buzoianu, Diana Deleanu
Summary: This study analyzed clinical and biological factors that might predict tolerance in patients with IgE-mediated cow milk allergy. The results suggest that basal levels of sIgE to milk and casein may help identify patients who could become tolerant to milk.
Review
Immunology
Mengmeng Jin, Jianxiong Ji, Xi Chen, Ying Zhou, Dimin Wang, Aixia Liu
Summary: A dysregulated immune microenvironment at the maternal-fetal interface in early pregnancy can lead to pregnancy complications. The role of epigenetic modifications, specifically DNA methylation and TET enzymes, in regulating the immune microenvironment during decidualization and embryo implantation is explored. Further research is needed to understand the functional role of TET enzymes and potential therapeutic strategies for pregnancy-related diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Marijke M. Faas, Yuanrui Liu, Lieske Wekema, Gisela A. Weiss, Carolien A. van Loo-Bouwman, Luis Silva Lagos
Summary: This study found that inducing gut dysbiosis during pregnancy by antibiotic treatment alters the maternal immune response, which may affect fetal and placental weight.
Article
Multidisciplinary Sciences
Nuriban Valero-Pacheco, Eric K. Tang, Noura Massri, Rachel Loia, Anat Chemerinski, Tracy Wu, Salma Begum, Darine W. El-Naccache, William C. Gause, Ripla Arora, Nataki C. Douglas, Aimee M. Beaulieu
Summary: Recent studies have found a correlation between dysregulated expression of IL-33 and poor pregnancy outcomes in women. In this study with mice, we found that IL-33 signaling is crucial for uterine tissue remodeling and immune cell function during early pregnancy. IL-33 deficiency led to delayed embryogenesis, increased resorptions, and impaired fetal and placental growth. The research highlights the importance of interaction between IL-33-producing non-immune cells and ST2(+) immune cells at the maternal-fetal interface in supporting pregnancy progression in mice.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Pharmacology & Pharmacy
Xue Xu, Mei-Ying Liang, Yi-Lin Wang, Jian-Liu Wang, Xiao-Hui Zhang
Summary: This study found that oral low-dose prednisone therapy for pregnant patients with severe ITP had similar efficacy to high-dose treatment. LD treatment significantly reduced the incidence of hypertension and had no significant impact on neonatal outcomes.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Reproductive Biology
Seid Mohammed, Mohanned Naif Alhussien, Ajay Kumar Dang
Summary: The study evaluated the expression changes of relevant genes in blood neutrophils during pregnancy in dairy cows and found that neutrophils play a critical role in embryo implantation and pregnancy maintenance. The results contribute to uncovering the mechanism of neutrophil-associated immunological infertility in bovines.
Article
Immunology
Kirsten Maertens, Marjolein R. P. Orije, Sereina A. Herzog, Ludo M. Mahieu, Niel Hens, Pierre Van Damme, Elke Leuridan
Summary: Maternal Tdap vaccination can improve the immune response in preterm infants, and preterm birth does not affect the primary immune response but is associated with a lower booster immune response.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Immunology
Ling Yang, Yao Meng, Yuxiang Shi, Hongxu Fang, Leying Zhang
Summary: This review focuses on the anatomical and immunological adaptations of the maternal liver during pregnancy, as well as the associated diseases. It also presents the factors that regulate hepatic immunology during pregnancy. These findings are important for the prevention of embryo loss, abortion, and pregnancy-associated liver diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gastroenterology & Hepatology
Ralley E. Prentice, Emily K. Wright, Emma Flanagan, Rod W. Hunt, Gregory T. Moore, Claudia A. Nold-Petry, Sally J. Bell, Marcel F. Nold, Rimma Goldberg
Summary: Autoimmune and inflammatory disorders in women of childbearing age may affect the development of the neonatal immune system, potentially increasing the risk of disease. Maternal inflammation, IBD-associated intestinal dysbiosis, and the use of immunomodulatory drugs may all have an impact on infant immune system development.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Olivier Manches, Khemary Um, Anne Boudier, Yasmina Maddouri, Sarah Lyon-Caen, Sam Bayat, Remy Slama, Claire Philippat, Valerie Siroux, Laurence Chaperot
Summary: The study explores the relationship between maternal and neonatal immune function, specifically focusing on cytokine secretion. It found that pregnant women and neonates have distinct cytokine secretion profiles. Several factors, including pre-conception BMI and smoking, were associated with cytokine levels in both mothers and children. This research provides insights into fetal immune development and the factors influencing maternal-child immune interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ayleen Fernandez-Fierro, Samanta C. Funes, Mariana Rios, Camila Covian, Jorge Gonzalez, Alexis M. Kalergis
Summary: The heme oxygenase (HO) system involves three isoforms, with HO-1 being the most studied and overexpression of this enzyme promoting anti-inflammatory products. However, overexpression of HO leading to neonatal jaundice has prompted the development of inhibitors. Various types of inhibitors have been identified, including competitive and non-competitive ones, with potential medical implications in metabolic diseases and immune-mediated diseases such as cancer and Alzheimer's disease. Selective inhibition of HO isoforms may contribute to the treatment of these ailments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Brian T. Kalish, Eunha Kim, Benjamin Finander, Erin E. Duffy, Hyunju Kim, Casey K. Gilman, Yeong Shin Yim, Lilin Tong, Randal J. Kaufman, Eric C. Griffith, Gloria B. Choi, Michael E. Greenberg, Jun R. Huh
Summary: The study found that maternal immune activation in mice induces changes in the mRNA translation machinery in the fetal brain and activates the integrated stress response in male fetuses, which mediates neurobehavioral abnormalities.
NATURE NEUROSCIENCE
(2021)
Article
Reproductive Biology
Colby A. Redifer, Natalie B. Duncan, Allison M. Meyer
Summary: The study found that maternal age and body condition score affected placental size, while calf size at birth was positively correlated with placental weight. However, it is still unknown which factors control and signal the growth of each other.
Article
Biochemistry & Molecular Biology
Julia Rimboeck, Michael Gruber, Marco Weigl, Pia Huber, Dirk Lunz, Walter Petermichl
Summary: HELLP syndrome is a severe complication during pregnancy, which is associated with individual risk factors such as obesity. This study found differences in PMN activity and function in obese pregnant women, which may be related to chronic inflammation status and immune triggers. These findings provide a new perspective on the pathogenesis of PE and HELLP syndrome.
Article
Cell Biology
Amber R. Moore, Nora Vivanco Gonzalez, Katherine A. Plummer, Olivia R. Mitchel, Harleen Kaur, Moises Rivera, Brian Collica, Mako Goldston, Ferda Filiz, Michael Angelo, Theo D. Palmer, Sean C. Bendall
Summary: The immune system and placenta have a dynamic relationship during gestation, playing an important role in fetal growth and development. By immunophenotyping the maternal-fetal interface, distinct immune profiles can be identified, and the significant role of the innate immune system in placental development is revealed.
Article
Biochemistry & Molecular Biology
Alessandra Bridi, Gabriella M. Andrade, Maite del Collado, Juliano R. Sangalli, Ana C. F. C. M. de Avila, Igor G. Motta, Julio C. B. da Silva, Guilherme Pugliesi, Luciano A. Silva, Flavio V. Meirelles, Juliano C. da Silveira, Felipe Perecin
Summary: In vivo- and in vitro-produced bovine embryos have distinct metabolic profiles and gene transcription patterns, with differences in their ability to establish and maintain early pregnancies. The miRNA profiles of hatched bovine blastocysts and the sEVs secreted by them vary between in vivo and in vitro groups. These miRNAs expressed in embryos and sEVs can regulate early embryonic development and endometrial pathways, influencing embryo-maternal communication and pregnancy establishment during early pregnancy.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2021)
Article
Reproductive Biology
Juliano Coelho da Silveira, Gabriella Mamede Andrade, Rosineide Costa Simas, Helio Alves Martins-Junior, Marcos Nogueira Eberlin, Lawrence Charles Smith, Felipe Perecin, Flavio Vieira Meirelles
Summary: Cell communication within the ovarian follicle is crucial for the oocyte to achieve developmental competence, with follicular fluid facilitating intercellular communication. Recent studies have described the presence of extracellular vesicles containing mRNAs, miRNAs, proteins, and lipids in mammalian follicular fluid, suggesting a potential role in signaling and pathway modulation. The lipid profiles of EVs in follicular fluid may serve as biomarkers associated with the oocyte's developmental capability to reach the blastocyst stage.
Review
Biochemical Research Methods
Gustavo de Sa Schiavo Matias, Rodrigo da Silva Nunes Barreto, Ana Claudia Oliveira Carreira, Milton Yutaka Nishiyama, Paula Fratini, Christina Ramires Ferreira, Maria Angelica Miglino
Summary: The placenta's ability for growth and remodeling is closely related to its extracellular matrix (ECM) components. A study on the proteome profile of decellularized canine placenta revealed proteins related to skeleton structuration, cell adhesion, vasculogenesis, and other functions. These findings support the importance of maintaining essential protein groups for ECM structuring and physiology in tissue engineering applications.
JOURNAL OF PROTEOMICS
(2022)
Article
Reproductive Biology
Rodrigo da Silva Nunes Barreto, Gustavo de Sa Schiavo Matias, Milton Yutaka Nishiyama-, Ana Claudia Oliveira Carreira, Maria Angelica Miglino
Summary: This study aimed to investigate protein pathways associated with placental development in bovine cloned pregnancies. Proteomic analysis revealed proteins related to extracellular matrix (ECM) and cellular junction ontologies, and identified some proteins that were upregulated in the cloned condition. The pathways enriched with the most proteins included focal adhesion, ECM-receptor interaction, and the PI3K-Akt signaling pathway. The findings suggest that the abnormal expression of these proteins and pathways in cloned pregnancies may contribute to the disruption of placental development and the increased pregnancy loss rates.
Article
Cell & Tissue Engineering
Kaiana Recchia, Lucas Simoes Machado, Ramon Cesar Botigelli, Naira Caroline Godoy Pieri, Gabriela Barbosa, Raquel Vasconcelos Guimaraes de Castro, Mariana Groke Marques, Lais Vicari de Figueiredo Pessoa, Paulo Fantinato Neto, Flavio Vieira Meirelles, Aline Fernanda de Souza, Simone Maria Massami Kitamura Martins, Fabiana Fernandes Bressan
Summary: This study successfully isolated urine-derived cells (UDCs) in a swine model and reprogrammed them into a pluripotent-like state, which has significant implications for numerous applications in both human and veterinary regenerative medicine.
WORLD JOURNAL OF STEM CELLS
(2022)
Article
Biochemistry & Molecular Biology
Juliano R. Sangalli, Ricardo Perecin Nociti, Maite del Collado, Rafael Vilar Sampaio, Juliano C. da Silveira, Felipe Perecin, Lawrence Charles Smith, Pablo J. Ross, Flavio Meirelles
Summary: Short-chain fatty acids serve as metabolic regulators of gene expression through histone posttranslational modifications. The ketone body beta-hydroxybutyrate (BHB) causes a novel epigenetic modification, histone lysine beta-hydroxybutyrylation (Kbhb), which is associated with genes upregulated in starvation-responsive metabolic pathways. Kbhb is present in bovine tissues and is responsive to BHB in vitro.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2022)
Article
Biotechnology & Applied Microbiology
Rodrigo da Silva Nunes Barreto, Ana Claudia Oliveira Carreira, Monica Duarte da Silva, Leticia Alves Fernandes, Rafaela Rodrigues Ribeiro, Gustavo Henrique Dona Rodrigues Almeida, Bruna Tassia dos Santos Pantoja, Milton Yutaka Nishiyama Jr, Maria Angelica Miglino
Summary: Bioethical limitations lead to the use of human term placentas or murine models in studies on human placental physiology. This study proposes a novel three-dimensional model to mimic the placental microenvironment by investigating the extracellular matrix (ECM) components in term mice placenta. Proteomic analysis identified 2317 proteins, of which 118 were ECM and cell junction-related. Control and decellularized conditions showed no significant differential expression in 76 ECM and cell junction-related proteins. Enriched ontologies and pathways were related to cell adhesion, collagen, lipoprotein particles, and vasculature regulation, suggesting that the preserved ECM proteins play a crucial role in tissue stiffness and cell anchoring for placental microenvironment reconstruction.
BIOENGINEERING-BASEL
(2023)
Article
Multidisciplinary Sciences
Giuliana de Avila Ferronato, Carolina Monica dos Santos, Paola Maria da S. Rosa, Alessandra Bridi, Felipe Perecin, Flavio Vieira Meirelles, Juliano Rodrigues Sangalli, Juliano Coelho da Silveira
Summary: Despite the advances in in vitro embryo production (IVP) over the years, the use of a three-dimensional system called liquid marble (LM) did not show the expected advantages in improving bovine in vitro oocyte maturation and embryo culture. The LM system did not alter oocyte nuclear maturation, but it resulted in decreased gene expression related to oocyte maturation in cumulus cells. Furthermore, embryos cultured in the LM system exhibited changes in blastocyst rate, cell counting, and epigenetic modifications.
Article
Anatomy & Morphology
R. S. N. Barreto, H. J. C. Carvalho, G. S. S. Matias, M. G. K. C. Silva, R. R. Ribeiro, T. B. Campanelli, N. N. Rigoglio, A. C. O. Carreira, M. A. Miglino
Summary: Extracellular matrix (ECM) proteins play a crucial role in the structure and regulation of the mammary gland. Alterations in the ECM can affect the development of breast tumors. Through immunohistochemistry and decellularization, the protein profile of healthy and tumoral canine mammary ECM was studied. The study also investigated the influence of the ECM on cell attachment in both healthy and tumoral conditions.
Article
Agriculture, Dairy & Animal Science
Joedson Dantas Goncalves, Jose Bento Sterman Ferraz, Flavio Vieira Meirelles, Ricardo Perecin Nociti, Maria Emilia Franco Oliveira
Summary: Our study compared the mechanisms of cervical dilation in sheep and cows in different phases of the reproductive cycle. We found differences in gene expression between the follicular and luteal phases in both species. The PI3K/Akt pathway was identified as an important mechanism in cervical relaxation.
Article
Cell Biology
Miluska Beatriz Navarrete Zamora, Thamires Santos da Silva, Monica Duarte da Silva, Gustavo Henrique Dona Rodrigues Almeida, Leandro Norberto da Silva-Junior, Bianca de Oliveira Horvath-Pereira, Amanda Trindade Baracho Hill, Francisco Acuna, Ana Claudia Oliveira Carreira, Rodrigo da Silva Nunes Barreto, Alberto Sato Sato, Maria Angelica Miglino
Summary: This study aimed to characterize the structural carbohydrate profiles in the term alpaca placenta. The results showed a high presence of carbohydrates, particularly glucose, a-linked mannose, N-acetylglucosamine, galactose, and N-acetylgalactosamine in the alpaca placenta. These carbohydrates may participate in the labor of alpacas surviving in extreme Peruvian environments.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lucas Simoes Machado, Camila Martins Borges, Marina Amaro de Lima, Juliano Rodrigues Sangalli, Jacinthe Therrien, Lais Vicari de Figueiredo Pessoa, Paulo Fantinato Neto, Felipe Perecin, Lawrence Charles Smith, Flavio Vieira Meirelles, Fabiana Fernandes Bressan
Summary: Mechanisms of cell reprogramming by pluripotency-related transcription factors or nuclear transfer seem to be mediated by similar pathways. The study suggests that OCT4 and SOX2 may contribute to both processes and help elucidate the mechanisms responsible for pluripotency.
Article
Cardiac & Cardiovascular Systems
Tarley Santos Oliveira, Igor Smirnow, Kadija Mohamed Santee, Maria Angelica Miglino, Rodrigo da Silva Nunes Barreto
Summary: This study aims to achieve the artificial development of blood vessels through the recellularization of vascular scaffolds derived from bovine placental vessels. The results showed that the decellularization process maintained the natural structure and elastin content of the vessels, and endothelial precursor cells were attached to the lumen and external surface of the decellularized vessels. Therefore, this biomaterial holds potential for use in cardiovascular medicine.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Meeting Abstract
Cell & Tissue Engineering
S. M. Barcelos, C. L. P. Villarroel, A. Bridi, E. C. I. Bispo, P. M. Rosa, E. M. Garcez, P. F. Malard, F. S. Araujo, J. C. Silveira, R. E. Pogue, F. Perecin, J. L. Carvalho
Article
Anatomy & Morphology
Rodrigo S. N. Barreto, Lilian J. Oliveira, Gustavo S. S. Matias, Rafaela R. Ribeiro, Concepts M. M. Pimentel, David Feder, Maria Angelica Miglino
Summary: Dystrophin dysfunction leads to muscle dystrophy, causing inflammation, necrosis, and fibrosis. Ursolic acid can inhibit muscle atrophy and improve muscle morphology and strength.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2022)