Article
Biochemistry & Molecular Biology
Hiroto S. Fukushima, Hiroyuki Takeda, Ryohei Nakamura
Summary: Epigenetic modifications undergo erasure and reestablishment after fertilization, with some histone modifications escaping reprogramming. In nonmammalian vertebrates, most histone modifications are thought to be intensively erased and reestablished. However, the histone modifications that escape reprogramming in nonmammalian vertebrates and their potential functional roles remain unknown.
Review
Genetics & Heredity
Yamei Li, Qiang Sun
Summary: This review summarizes the epigenetic barriers in somatic cell nuclear transfer (SCNT) embryos and discusses strategies to correct these defects and prevent abnormalities in cloned animals.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Richa Pant, Priyanka Firmal, Vibhuti Kumar Shah, Aftab Alam, Samit Chattopadhyay
Summary: Obesity is a major public health concern characterized by an increase in adipose tissue mass, which can lead to impaired metabolic health and even influence cancer progression. Dysfunction in adipocyte function is influenced by genetics and environmental factors, affecting gene expression and onset of obesity. Understanding the complexities of adipogenesis is crucial for recognizing disease conditions and identifying therapeutic interventions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Elisabetta Di Fede, Paolo Grazioli, Antonella Lettieri, Chiara Parodi, Silvia Castiglioni, Esi Taci, Elisa Adele Colombo, Silvia Ancona, Alberto Priori, Cristina Gervasini, Valentina Massa
Summary: Chromatinopathies are genetic disorders caused by mutations in genes involved in chromatin state balance. There are 82 human conditions described so far, sharing molecular features and clinical signs. Combining clinical and basic research is essential for understanding the molecular cascade and exploring therapeutic strategies. Animal models are invaluable tools for studying chromatinopathies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jing Yang, Jin Xu, Wei Wang, Bo Zhang, Xianjun Yu, Si Shi
Summary: Researchers have focused on the epigenetic control of DNA-templated processes for many years. Epigenetic modifications like histone modification, DNA methylation, chromatin remodeling, RNA modification, and noncoding RNAs play a crucial role in the development of cancers. Dysregulation of the epigenome leads to abnormal transcriptional programs, and targeting the dysregulated epigenetic modifications might be an effective strategy for cancer treatment. Additionally, epigenetics influences tumor immunogenicity and immune cells involved in antitumor responses, suggesting the potential of combining epigenetic therapy and cancer immunotherapy for better cancer treatment.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Genetics & Heredity
Monica Strawn, Susanta K. Behura
Summary: This study assesses DNA methylation changes in the pig fetal brain and identifies specific methylation changes that occur during rapid growth. These differential methylations are overrepresented in specific genomic features and show mutual informativeness. Sex-bias methylations of known single nucleotide polymorphic sites are also identified.
Article
Biology
Subba Reddy Palli
Summary: Modifications to DNA and core histones play crucial roles in chromatin organization and gene expression, affecting various biological processes. Studies have identified genes encoding enzymes that modify core histones in multiple insect genomes, with some enzymes contributing to post-embryonic development. Research on epigenetic modifiers could help identify inhibitors that may be used to control pests and disease vectors.
CURRENT OPINION IN INSECT SCIENCE
(2021)
Review
Plant Sciences
Elizabeth A. Hemenway, Mary Gehring
Summary: The establishment, maintenance, and removal of epigenetic modifications in plants provide an additional layer of regulation beyond genetic factors, allowing for control of developmental processes and adaptation to the environment. Epigenetic inheritance, which can refer to information not encoded in the DNA sequence inherited between generations or epigenetic modifications reset between generations, is of great interest in understanding the functions and mechanisms in plants. This article discusses examples of epigenetic dynamics and maintenance during growth and development stages and their functional consequences, as well as the dynamic nature of epigenetic states in response to stress and their impact on transposable element regulation. The emerging area of research focuses on understanding how epigenetic resetting occurs during normal development and in response to stress.
ANNUAL REVIEW OF PLANT BIOLOGY
(2023)
Article
Multidisciplinary Sciences
J. Brucker Nourse, Shannon N. Russell, Nathan A. Moniz, Kylie Peter, Lena M. Seyfarth, Madison Scott, Han-A Park, Kim A. Caldwell, Guy A. Caldwell
Summary: This study investigates the TNK2 gene variants in Parkinson's disease (PD) patients and their potential impact on dopaminergic neurodegeneration. The findings suggest that TNK2 dysfunction may contribute to PD, possibly through sustained or aberrant activity. The study also highlights the importance of TNK2 and its ortholog SID-3 in coordinating dopaminergic and epigenetic signaling. Experimental results using Caenorhabditis elegans and rat primary neurons demonstrate the neuroprotective effects of TNK2 inhibition and NEDD4 activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Biochemistry & Molecular Biology
Ajay Ashok, Sarita Pooranawattanakul, Wai Lydia Tai, Kin-Sang Cho, Tor P. Utheim, Dean M. Cestari, Dong Feng Chen
Summary: This review article focuses on the influence of epigenetic factors on optic nerve development and homeostasis, as well as the associated molecular apparatus. Understanding the epigenetic regulation in the optic nerve can lead to the discovery of novel molecular pathways and contribute to the design of effective therapeutics for optic nerve protection, repair, and regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Nikolas James Tsiouplis, David Wesley Bailey, Lilly Felicia Chiou, Fiona Jane Wissink, Ageliki Tsagaratou
Summary: TET proteins oxidize 5-methylcytosine to facilitate DNA demethylation and serve as novel epigenetic marks. Loss of TET function is strongly associated with cancer, especially in hematological malignancies. TET proteins govern cell fate decisions by activating cell-specific gene expression programs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Masamitsu Yamaguchi, Kentaro Omori, Satoshi Asada, Hideki Yoshida
Summary: ALS and CMT are common neurodegenerative disorders with significant phenotypic heterogeneity, potentially due to modifiers that influence disease characteristics. Epigenetic regulation of biological functions through gene expression may be an important mechanism in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dermatology
Ramile Dilshat, Hong Nhung Vu, Eirikur Steingrimsson
Summary: Melanocytes originate in the neural crest, migrate and proliferate before differentiating into pigment-producing cells, determining color and protecting against UV radiation; their lineage is regulated by transcription factors and signaling pathways, with epigenetic modifiers and replacement histones playing key roles in this process.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Dermatology
Liat Oss-Ronen, Idan Cohen
Summary: Merkel cell formation is regulated by Polycomb group proteins, major signaling pathways involved in skin development, and specific transcription factors.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tae Hoon Kim, Nayoung Bae, Taeho Kim, Albert L. Hsu, Mark Hunter, Jung-Ho Shin, Jae-Wook Jeong
Summary: Endometriosis is positively associated with obesity, but negatively associated with low BMI. High-fat diet-induced obesity can increase the development of endometriosis, while obesity with leptin deficiency and leptin receptor deficiency can suppress the development of endometriosis. These findings suggest that leptin and its receptor play a critical role in the development of endometriosis.
Review
Biochemistry & Molecular Biology
Dinko Mitrecic, Valentina Hribljan, Denis Jagecic, Jasmina Isakovic, Federica Lamberto, Alex Horanszky, Melinda Zana, Gabor Foldes, Barbara Zavan, Augustas Pivoriunas, Salvador Martinez, Letizia Mazzini, Lidija Radenovic, Jelena Milasin, Juan Carlos Chachques, Leonora Buzanska, Min Suk Song, Andras Dinnyes
Summary: The success of in vitro cell cultivation has opened up new opportunities for medical research, particularly in the development of tissue-specific cultures and the transplantation of standardized cells for tissue regeneration. However, regenerative neurology and cardiology face different obstacles due to the unique needs of different cell types. In this review, European experts in neurology and cardiology discuss the hurdles and potential strategies for accelerating the development of these fields.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Elisabeth Kemter, Antonio Citro, Lelia Wolf-van Buerck, Yi Qiu, Anika Boettcher, Martina Policardi, Silvia Pellegrini, Libera Valla, Marianna Alunni-Fabbroni, Julianna Kobolak, Barbara Kessler, Mayuko Kurome, Valeri Zakhartchenko, Andras Dinnyes, Clemens C. Cyran, Heiko Lickert, Lorenzo Piemonti, Jochen Seissler, Eckhard Wolf
Summary: This study successfully generated reporter pigs expressing iRFP, confirming their good functional characteristics for islet transplantation and long-term monitoring using optical imaging techniques, which were validated in different models.
XENOTRANSPLANTATION
(2022)
Article
Environmental Sciences
Maria-Viola Martikainen, Paeivi Aakko-Saksa, Lenie van den Broek, Flemming R. Cassee, Roxana O. Carare, Sweelin Chew, Andras Dinnyes, Rosalba Giugno, Katja M. Kanninen, Tarja Malm, Ala Muala, Maiken Nedergaard, Anna Oudin, Pedro Oyola, Tobias V. Pfeiffer, Topi Ronkko, Sanna Saarikoski, Thomas Sandstrom, Roel P. F. Schins, Jan Topinka, Mo Yang, Xiaowen Zeng, Remco H. S. Westerink, Pasi I. Jalava
Summary: The adverse effects of air pollutants on the respiratory and cardiovascular systems are well-known, but recent studies have found that they also have negative effects on the neurological system and cognitive function. Ultrafine particles (UFPs) play a key role in these effects, but there is still limited understanding about the smallest fraction and semivolatile compounds. The TUBE project aims to increase knowledge about harmful UFPs and semivolatile compounds, provide information for better emission legislation, and assess the impact of air pollution on the brain and its removal.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biology
Kinga Molnar, Julianna Kobolak, Andras Dinnyes
Summary: The study established a human in vitro model of MPS II and proposed a new concept for vesicle formation, highlighting the role of Golgi and challenging the traditional concept.
Article
Biochemical Research Methods
Zhonghua Jiang, Yongmei Lu, Zhuochong Liu, Wei Wu, Xinyi Xu, Andras Dinnyes, Zhonghua Yu, Li Chen, Qun Sun
Summary: Prediction of antimicrobial resistance using whole-genome sequencing data has been improved by a novel hierarchical attentive neural network model, which accurately identifies drug resistance-related genes and variants.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Toxicology
Carolina Nunes, Pranika Singh, Zahra Mazidi, Cormac Murphy, Aurore Bourguignon, Sara Wellens, Vidya Chandrasekaran, Sreya Ghosh, Melinda Zana, David Pamies, Aurelien Thomas, Catherine Verfaillie, Maxime Culot, Andras Dinnyes, Barry Hardy, Anja Wilmes, Paul Jennings, Regina Grillari, Johannes Grillari, Marie-Gabrielle Zurich, Thomas Exner
Summary: This article proposes an in vitro multi-organ strategy to assess the toxicity of chemicals using human induced pluripotent stem cells (hiPSCs)-derived models. The strategy allows parallel evaluation of chemical toxicity on multiple tissues/organs, exclusively in human cells, eliminating interspecies bias and increasing the chance to identify toxic compounds. The authors demonstrated the strategy by generating models of brain, blood-brain barrier, kidney, liver, and vasculature and exposing them to paraquat, highlighting their differential cytotoxic sensitivity and the deregulation of key signaling pathways.
TOXICOLOGY IN VITRO
(2022)
Article
Multidisciplinary Sciences
Anita Feher, Andrea Schnur, Suchitra Muenthaisong, Tamas Bellak, Ferhan Ayaydin, Gyorgy Varady, Elisabeth Kemter, Eckhard Wolf, Andras Dinnyes
Summary: Stem cell therapy has the potential to replace beta-cell loss in diabetic patients, but maintaining the viability and function of the engrafted cells is a key challenge. A near-infrared fluorescent mutant version of a bacteriophytochrome, iRFP720, has been developed for in vivo imaging and stem/progenitor cell tracking. Researchers have successfully generated an iRFP720 expressing human induced pluripotent stem cell (iPSC) line using the CRISPR/Cas9 technology, which allows for real-time imaging in various biological applications.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Sixian Wu, Xiaoliang Li, Peiyu Li, Tongtong Li, Gelin Huang, Qun Sun, Andras Dinnyes, Lijun Shang, Wenming Xu
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Toxicology
Liliana Capinha, Yaran Zhang, Anna-Katharina Holzer, Anna-Katharina Uckert, Melinda Zana, Giada Carta, Cormac Murphy, Jenna Baldovini, Zahra Mazidi, Johannes Grillari, Andras Dinnyes, Bob van de Water, Marcel Leist, Jan N. M. Commandeur, Paul Jennings
Summary: This study used six human derived cell models to investigate the effects of trichloroethylene (TCE) S-conjugates. The results showed that TCE S-conjugates induced Nrf2 pathway and unfolded protein response, which may explain the nephrotoxicity and neurotoxicity of TCE. This study expands our knowledge on the tissue specificity of TCE S-conjugates and highlights the value of human cell models and transcriptomics in mechanistic studies.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Cell Biology
Paul Jennings, Giada Carta, Pranika Singh, Daniel da Costa Pereira, Anita Feher, Andras Dinnyes, Thomas E. E. Exner, Anja Wilmes
Summary: Through transcriptomic analysis, this study investigated the time-dependent changes in gene expression levels in iPSC-derived renal cells treated with different compounds, and identified the early response of key genes involved in cellular stress response pathways. The findings highlight the application of iPSC cells for predicting cellular toxicity and provide new insights into the temporal and early effects of key genes in cellular stress response pathways.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Health Care Sciences & Services
Batoul Hojeij, Sam Schoenmakers, Sten Willemsen, Lenie van Rossem, Andras Dinnyes, Melek Rousian, Regine P. M. Steegers-Theunissen
Summary: This study investigates the effectiveness of the eHealth program Smarter Pregnancy on attitudes and practices towards fruit and vegetable intake and smoking in women attempting pregnancy through assisted reproductive technology (ART) or natural conception. The results show that the program can improve vegetable intake-related attitudes and practices in women undergoing ART treatment. However, there is no significant effect on fruit intake and smoking behavior.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Review
Endocrinology & Metabolism
Batoul Hojeij, Melek Rousian, Kevin D. Sinclair, Andras Dinnyes, Regine P. M. Steegers-Theunissen, Sam Schoenmakers
Summary: Periconceptional maternal obesity is associated with adverse maternal and neonatal outcomes. Identifying biomarkers of pathways affected by maternal obesity can provide insights into pathophysiological mechanisms and identify individuals at risk of adverse clinical outcomes. This systematic review identified biomarkers in the endocrine, inflammatory, and one-carbon metabolic pathways influenced by maternal obesity.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Chemistry, Applied
Zhiwei Zhou, Dan Wang, Xinyi Xu, Jin Dai, Guangjie Lao, Senlin Zhang, Xiaofang Xu, Andras Dinnyes, Youling Xiong, Qun Sun
Summary: Evidence suggests that protein-bound polyphenols can alleviate type 2 diabetes mellitus (T2DM). This study investigated the modulation of myofibrillar protein-chlorogenic acid (MP-CGA) complexes on T2DM rats from the gut microbiota perspective. Results showed that MP-CGA improved hyperglycemia and hyperlipidemia, reduced intestinal inflammation, and reconstructed gut microbiota by promoting beneficial bacteria and suppressing opportunistic pathogens. MP-CGA also elevated the concentrations of intestinal metabolites that regulate T2DM positively. Therefore, MP-CGA can modulate the gut microbiota and related metabolites to maintain stable blood glucose in T2DM rats.
Article
Food Science & Technology
Zhiwei Zhou, Dongmei Luo, Mengxue Li, Guangjie Lao, Zhiqiang Zhou, Andras Dinnyes, Wenming Xu, Qun Sun
Summary: This study developed an in vitro human maternal-fetal multicellular model to investigate the impact of Aflatoxin B-1 (AFB(1)) on fetal neurodevelopment. The results showed that even at concentrations close to the national safety level standard of China, AFB(1) induced apoptosis and DNA damage in neural stem cells, highlighting the potential harmful effects of food mycotoxin exposure during pregnancy.
Meeting Abstract
Obstetrics & Gynecology
Batoul Hojeij, Melek Rousian, Kevin D. Sinclair, Andras Dinnyes, Regine Steegers-Theunissen, Sam Schoenmakers
REPRODUCTIVE SCIENCES
(2022)
