Article
Obstetrics & Gynecology
Sara Batha, Goli Ardestani, Olcay Ocali, Pam Jarmuz, Denis A. Vaughan, C. Brent Barrett, Denny Sakkas
Summary: The use of r-ICSI can eliminate concerns about total fertilization failure (TFF) after conventional IVF (C-IVF) and achieve high live birth rates after frozen blastocyst transfer.
HUMAN REPRODUCTION
(2023)
Article
Obstetrics & Gynecology
Martin Stimpfel, Nina Jancar, Eda Vrtacnik-Bokal
Summary: Collecting semen samples at home has a positive effect on sperm quality, but no significant differences in cycle outcomes are observed when these samples are used in IVF/ICSI cycles.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Biochemistry & Molecular Biology
Olga Tepla, Zinovij Topurko, Simona Jirsova, Martina Moosova, Eva Fajmonova, Radek Cabela, Katerina Komrskova, Irena Kratochvilova, Jaromir Masata
Summary: The aim of this study was to evaluate the efficiency of using meiotic spindle (MS) visibility and relative position to the polar body (PB) as indicators of oocyte maturation in order to optimize intracytoplasmic sperm injection (ICSI) timing. The visualization of MS influenced the pregnancy rate (PR) for patients over 35 years, but did not affect PR for patients under 35 years. Visualization of MS appears to be a useful parameter for assessment of oocyte maturity and ICSI timing for patients older than 35.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Maoxing Tang, Annekatrien Boel, Noemi Castelluccio, Arantxa Cardona Barberan, Antonia Christodoulaki, Bieke Bekaert, Mina Popovic, Frauke Vanden Meerschaut, Petra De Sutter, Bjorn Menten, Sofie Symoens, Arnaud V. Vanlander, Dominic Stoop, Paul J. Coucke, Bjorn Heindryckx
Summary: This study aims to explore the application of human nuclear transfer (NT) in treating mitochondrial disease transmission and failed fertilization. The experiments confirmed the effectiveness of NT in reducing mitochondrial transmission and demonstrated for the first time that NT can enable successful fertilization in cases of failed fertilization.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Obstetrics & Gynecology
Qunying Fang, Xiaohua Jiang, Shun Bai, Bo Xu, Lu Zong, Meijie Qi, Yangyang Wan, Ren-Tao Jin, Xian-Hong Tong, Li-Min Wu
Summary: This retrospective study analyzed the clinical outcomes and safety implications of early cumulus cell removal combined with early rescue ICSI in preventing fertilization failure. The results showed that early cumulus cell removal did not have a significant impact on fertilization, pregnancy, neonates, or birth defects. Compared to conventional ICSI, early rescue ICSI had similar rates of fertilization and pregnancy, but a higher polyploidy rate and lower high-quality embryo rate.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Genetics & Heredity
Takashi Shibahara, Yuu Fukasaku, Naoko Hayashi, Nozomi Miyazaki, Hiroaki Kawato, Hiroyuki Minoura
Summary: The study suggests that early ROA after ICSI is effective in rescuing unfertilized oocytes, with a higher normal fertilization rate compared to non-ROA oocytes. However, the blastocyst development rate is lower, while the implantation rate is similar to spontaneously activated oocytes.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Multidisciplinary Sciences
Hongbin Jin, Yang Han, Huasong Wang, J. Xiao He Li, Weimin Shen, Lin Zhang, Luxi Chen, Shunji Jia, Ping Yuan, Hui Chen, Anming Meng
Summary: The second polar body marks the asymmetry of the mouse zygote and plays an important role in regulating pre-implantation fate determination as well as post-implantation embryonic development.
NATIONAL SCIENCE REVIEW
(2022)
Article
Obstetrics & Gynecology
Eliza C. C. Curnow, Bianca Vannucci, Charles H. H. Muller, Christopher N. N. Herndon
Summary: We report a rare case of successful live birth after assisted oocyte activation of failed fertilized oocytes. A woman with multi-factor infertility underwent in vitro fertilization (IVF) using intracytoplasmic sperm injection (ICSI) of frozen/thawed testicular sperm aspiration (TESA) sample. The oocytes showed failed fertilization, but the cycle was rescued using an assisted oocyte activation (AOA) protocol. One genetically normal embryo resulting from the AOA was transferred and led to a normal pregnancy and live birth.
REPRODUCTIVE SCIENCES
(2023)
Article
Obstetrics & Gynecology
Chun-Mei Yu, Jing-Hua Fei-Liu, Jing-Hua Zhang, Xiu-Liang Dai, Yu-Feng Wang, Li Chen
Summary: This study aimed to verify the effectiveness of split insemination (IVF+ICSI) in patients with borderline semen for the first cycle and compare the treatment outcomes of conventional IVF and ICSI on sibling oocytes. The results showed that ICSI significantly reduced the total fertilization failure rate and had a higher fertilization rate in split oocytes compared to IVF. However, IVF had a slightly higher rate of usable blastocysts and high-quality blastocysts on day 5, as well as higher pregnancy, implantation, and live birth rates compared to ICSI, although the differences were not statistically significant. The study suggests that both IVF and ICSI can be appropriate choices for patients with borderline semen, but IVF may have better embryo development potential.
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
(2022)
Review
Endocrinology & Metabolism
Alessio Paffoni, Marco Reschini, Valerio Pisaturo, Cristina Guarneri, Simone Palini, Paola Vigano
Summary: The success rates of fresh embryo transfers after late rescue ICSI are not satisfactory, but transferring cryopreserved rescue ICSI embryos seems to offer improved results. Combining rescue ICSI with frozen embryo transfer may overcome technical and biological issues associated with fresh transfer after late rescue ICSI, possibly representing an efficient procedure for couples experiencing fertilization failure.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yilei He, Rong Li, Jingwen Yin, Zi Yang, Yuanyuan Wang, Lixue Chen, Shuo Yang, Jie Qiao
Summary: This retrospective study analyzed the levels of inflammatory factors in PCOS patients with different BMI groups and their impact on IVF/ICSI pregnancy outcomes. The results showed that PCOS patients in the high BMI group had lower oocyte and good quality embryo numbers, as well as higher levels of IL-6 and lower cumulative clinical pregnancy and live birth rates. High TNF-alpha was negatively correlated with pregnancy rates, while high IL-1 beta was positively correlated with live birth rates among PCOS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Yu Wang, Yu-Chiao Yi, Hwa-Fen Guu, Ya-Fang Chen, Hsiao-Fan Kung, Jui-Chun Chang, Li-Yu Chen, Shih-Ting Chuan, Ming-Jer Chen
Summary: Although the relationship between adenomyosis and infertility remains unclear, this study aimed to investigate its impact on IVF outcomes. The study analyzed 1720 patients from January 2016 to December 2019, finding that patients with adenomyosis had higher miscarriage rates and lower live birth rates, especially in patients aged 38 or above. GnRH agonist treatment after a more than sevenfold decrease in CA-125 level was associated with better clinical pregnancy outcomes.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Zhenxing Liu, Qingsong Xi, Lixia Zhu, Xue Yang, Lei Jin, Jiarui Wang, Tao Zhang, Xiaopei Zhou, Dazhi Zhang, Xuejie Peng, Yalin Luo, Zhou Li, Xianqin Zhang
Summary: The study identified two heterozygous missense mutations in the TUBB8 gene that resulted in oocytes with large polar bodies and fertilization failure in two patients. Bioinformatics analysis showed that these mutations are harmful.
REPRODUCTIVE SCIENCES
(2021)
Article
Medicine, General & Internal
Yangyang Wang, Yichao Tian, Liu Liu, Tin-Chiu Li, Xiaomei Tong, Haiyan Zhu, Songying Zhang
Summary: The study identified age, frozen or fresh embryo transfer, and the number of previous failed ET cycles as the most important independent factors affecting the IR, with repeated implantation failure significantly impacting the IR.
Article
Obstetrics & Gynecology
Linlin Jiang, Yifan Qian, Xiaoli Chen, Xiaohui Ji, Songbang Ou, Ruiqi Li, Dongzi Yang, Yu Li
Summary: The study found that IVF-S combined with early R-ICSI and split IVF-ICSI were effective strategies in preventing low fertilization rate. IVF-S with early R-ICSI could become the preferred approach because of its advantages-higher embryo utilization rate, fewer ICSI procedures, similar clinical pregnancy rate, and live birth rate.
REPRODUCTIVE MEDICINE AND BIOLOGY
(2022)