Article
Agricultural Engineering
Haiyu Wang, Zhe Gu, Junzeng Xu, Shuai Li, Zhiming Qi, Yawei Li, Jiaoyan Zhou
Summary: China currently relies on manual labour for fertilising paddy fields, which hinders the improvement of fertilisation uniformity and efficiency. This study developed an automatic fertilisation system that accurately controls the flowrate of fertiliser based on the irrigation flowrate, resulting in improved uniformity and precision of fertilisation. The system reduces labour costs, enhances management efficiency, decreases potential pollution, and contributes to the development of precision agriculture.
BIOSYSTEMS ENGINEERING
(2022)
Article
Multidisciplinary Sciences
Jiajia Wan, Qifu Liang, Ruonan Zhang, Yu Cheng, Xin Wang, Hui Wang, Jieting Zhang, Dongsheng Jia, Yu Du, Wenhui Zheng, Dingzhong Tang, Taiyun Wei, Qian Chen
Summary: The authors identified the sperm-specific serpin protein HongrES1 as a mediator of paternal transmission of rice gall dwarf virus and a previously undescribed symbiotic virus in leafhoppers. They found that HongrES1 facilitates the direct binding of virions to leafhopper sperm surfaces and subsequent paternal transmission via interaction with viral capsid proteins. These findings provide important insights into the cooperative hijacking of insect sperm-specific proteins by different viruses for paternal transmission.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Christelle Damon-Soubeyrand, Antonino Bongiovanni, Areski Chorfa, Chantal Goubely, Nelly Pirot, Luc Pardanaud, Laurence Piboin-Fragner, Caroline Vachias, Stephanie Bravard, Rachel Guiton, Jean-Leon Thomas, Fabrice Saez, Ayhan Kocer, Meryem Tardivel, Joel R. Drevet, Joelle Henry-Berger
Summary: The epididymis plays a crucial role in male fertility and has both secretory and immune functions. However, the organization of blood and lymphatic networks in the epididymis is still largely unknown.
Article
Pharmacology & Pharmacy
Francisco Mateus Gonsalves Trajano, Luana Talinne da Costa Gomes, Pedro Brutch Dantas, Maele Oliveira de Sena, Jonas Ivan Nobre Oliveira, Sabatino Ventura, Elaine Cristina Gavioli, Edilson Dantas da Silva Jr
Summary: This study found that histamine can induce phasic contractions of the rat distal cauda epididymis duct via H2 receptors and autonomic neurotransmitters. It may also have modulatory actions on contractions induced by adrenergic receptor agonists. Further research is needed to determine the localization of histamine receptors in the epididymal duct and the effects of manipulating the histaminergic system on epididymal function and male fertility.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Agricultural Engineering
Xinyu Hu, Xin Chen
Summary: The study investigates the impact of fertilizer dissolution on optimal fertilization, proposing a method considering dissolution. It is found that fertilizer dissolution increases optimal fertilization time and leads to reduced inlet flux compared to the case without dissolution. Implications of environmental impact assessment and benefits of optimal fertilization over traditional methods are also discussed.
BIOSYSTEMS ENGINEERING
(2021)
Article
Multidisciplinary Sciences
Ming Wang, Yalong Yang, Dilay Cansever, Yiming Wang, Crystal Kantores, Sebastien Messiaen, Delphine Moison, Gabriel Livera, Svetoslav Chakarov, Tobias Weinberger, Christopher Stremmel, Monika Fijak, Britta Klein, Christiane Pleuger, Zhexiong Lian, Wentao Ma, Qingzhi Liu, Kathrin Klee, Kristian Handler, Thomas Ulas, Andreas Schlitzer, Joachim L. Schultze, Burkhard Becher, Melanie Greter, Zhaoyuan Liu, Florent Ginhoux, Slava Epelman, Christian Schulz, Andreas Meinhardt, Sudhanshu Bhushan
Summary: Macrophages in the testis and epididymis originate from different stages of cell development and can self-maintain independently of bone marrow hematopoietic cells in a steady state. However, during radiation-induced macrophage ablation or infection, bone marrow-derived cells are recruited to the testis and epididymis, leading to an inflammatory response.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Agronomy
Aleksandra Radawiec, Wieslaw Szulc, Beata Rutkowska
Summary: This study analyzed the effects of soil and foliar fertilization with sodium selenate (VI) on selenium content in spring wheat grain. The results showed that a combination of soil and foliar fertilization significantly increased selenium content in the grain. The best timing for foliar fertilization treatment was found to be in the stem elongation phase.
Article
Green & Sustainable Science & Technology
Maciej Kubon, Magdalena Tyminska, Zbigniew Skibko, Andrzej Borusiewicz, Jacek Filipkowski, Sylwester Tabor, Stanislaw Derehajlo
Summary: Using natural fertilisers in agriculture improves quantity and quality yields, but it cannot be guaranteed that better yields of field crops will be achieved by using digestates as manure. Farmers need knowledge and accuracy in dosing when enriching the soil with organic substances to comply with permissible concentrations of macronutrients.
Article
Cell Biology
Giuliana C. Coatti, Alekh Paranjapye, Ann Harris
Summary: Primary human epididymis epithelial (HEE) cells are valuable reagents for functional studies on the human epididymis. Previous research has found that a cocktail of small molecules can extend the replicative potential and maintain the differentiation status of HEE cells. This study is important for understanding the molecular, cellular, and functional aspects of the epididymis.
CELL AND TISSUE RESEARCH
(2023)
Article
Reproductive Biology
F. Hassan, W. Holtz
Summary: Through a study involving radioactively labeled thymidine infusion in 48 sexually rested young adult boars, it was discovered that labeled sperm first appeared in the proximal caput after 28 days, then reached the distal caput after 2 days, with the majority found in the corpus after another 2 days. Progress was halted at the transition of corpus and cauda on Day 11, but resumed on Day 12 and by Day 13 sperm had exited the epididymis via the ductus deferens.
Article
Reproductive Biology
Saulo Menegatti Zoca, Emmalee J. Northrop-Albrecht, Julie A. Walker, Robert A. Cushman, George A. Perry
Summary: Sperm stored in the epididymis have a longer lifespan, but their motility increases and lifespan decreases upon ejaculation. This study aimed to identify protein differences between epididymis and ejaculated samples that are associated with longevity. The analysis revealed that energy metabolism in the epididymis is more glycolytic and epididymal sperm have more antioxidants, which may contribute to maintaining sperm in a quiescent state.
Article
Medicine, General & Internal
Qiaofeng Wang, Qi Wan, Xiaoqing Bu, Qian Feng, Tian Li, Xingyu Lv, Xiangqian Meng, Mingxing Chen, Yue Qian, Yin Yang, Lihong Geng, Zhaohui Zhong, Xiaojun Tang, Yubin Ding
Summary: This study established visual prediction models for low fertilisation rate (LFR) and total fertilisation failure (TFF) in conventional IVF cycles. Logistic regressions identified the independent predictors for LFR and TFF, which were then incorporated into the nomogram models. The models showed good predictive ability and calibration in both the training and validation sets.
Article
Endocrinology & Metabolism
Xunwei Wu, Xiaomei He, Qian Liu, Honggang Li
Summary: The obstructive epididymal environment affects sperm quality and embryonic development, as well as the abundance of the developmental miR-17-92 cluster and the Sfmbt2 miRNA cluster in sperm, but these miRNA clusters are not the cause of abnormal embryonic development. This suggests that the epididymis plays an important role in early embryonic development and may have a potential role in sperm epigenome.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2022)
Article
Urology & Nephrology
Anthony D'Oro, Ilina Rosoklija, Elizabeth B. Yerkes, Bruce W. Lindgren, Karen Rychlik, Earl Y. Cheng
Summary: Patients with proximal hypospadias have an increased risk of acquired cryptorchidism, and operative notes reveal a high rate of epididymal nonfusion with ascended testes. Close monitoring of testis position is necessary for these patients.
JOURNAL OF UROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Musa Adamu Ibrahim, Syaizwan Zahmir Zulkifli, Mohammad Noor Amal Azmai, Ferdaus Mohamat-Yusuff, Ahmad Ismail
Summary: The study showed that 3,4-DCA has reproductive toxicity on Javanese medaka, leading to low fecundity in female fish and alterations in gonadal tissues and gametes development. This finding emphasizes the importance of native species in monitoring the toxicity effects of chemicals in aquatic environments.
Article
Immunology
Kelly M. Cautivo, Peri R. Matatia, Carlos O. Lizama, Nicholas M. Mroz, Madelene W. Dahlgren, Xiaofei Yu, Julia Sbierski-Kind, Marcela T. Taruselli, Jeremy F. Brooks, Adam Wade-Vallance, Sofia E. Caryotakis, Anthony A. Chang, Hong-Erh Liang, Julie Zikherman, Richard M. Locksley, Ari B. Molofsky
Summary: Allergic immunity is regulated by ILC2s and Th2 cells at various barriers, and their dynamic repositioning during immune perturbations is observed. Allergic inflammation drives the invasion of lung and liver non-adventitial parenchyma by ILC2s and Th2 cells. Concurrent type 1 and type 2 mixed inflammation can block the parenchymal trafficking of ILC2s and subsequent cell survival by IFNg from type 1 lymphocytes. The confinement of ILC2s and Th2 cells to adventitia limits mortality by type 1 pathogen Listeria monocytogenes.
Article
Cell Biology
Maria de los Angeles Juricic Urzua, Javiera Gallardo Rojas, Andres Couve Correa, Mauricio Cerda, Steffen Hartel Grundler, Carolina Gonzalez-Silva
Summary: This study characterized the distribution and dynamics of neuronal ERGIC structures. Long-distance ERGIC transport in dendrites occurs via an intermittent mechanism, with both stationary and mobile structures. Interestingly, this movement depends not only on the integrity of the microtubule cytoskeleton, but also on the actin cytoskeleton.
Article
Immunology
Romina Ulloa, Oreste Corrales, Fernanda Cabrera-Reyes, Jorge Jara-Wilde, Juan Jose Saez, Christopher Rivas, Jonathan Lagos, Steffen Haertel, Clara Quiroga, Maria-Isabel Yuseff, Jheimmy Diaz-Munoz
Summary: This study reveals that changes in nuclear morphology and positioning are critical for the formation of immune synapse and efficient antigen extraction in B cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Tanvi Sinha, Kelly Lammerts van Bueren, Diane E. Dickel, Ivana Zlatanova, Reuben Thomas, Carlos O. Lizama, Shan-Mei Xu, Ann C. Zovein, Kohta Ikegami, Ivan P. Moskowitz, Katherine S. Pollard, Len A. Pennacchio, Brian L. Black
Summary: This study investigates the initiation of gene-regulatory networks (GRNs) for endothelial and erythropoietic development by analyzing a hypomorphic Etv2 mutant. The researchers find that Etv2 has different threshold requirements for initiating the downstream GRNs for each lineage, directly regulating the endothelial GRN and indirectly activating Tal1 for erythropoietic development.
Article
Cell Biology
Tamara Marin, Andres E. Dulcey, Fabian Campos, Catalina de la Fuente, Mariana Acuna, Juan Castro, Claudio Pinto, Maria Jose Yanez, Cristian Cortez, David W. McGrath, Pablo J. Saez, Kirill Gorshkov, Wei Zheng, Noel Southall, Maria Carmo-Fonseca, Juan Marugan, Alejandra R. Alvarez, Silvana Zanlungo
Summary: Niemann-Pick type A (NPA) disease is a fatal lysosomal neurodegenerative disorder. Recent studies have shown that c-Abl tyrosine kinase activity plays a role in neuronal damage and death in NPA disease. There is potential for the use of c-Abl inhibitors in the clinical treatment of NPA patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Neurosciences
Nohela B. Arevalo, Cristian M. Lamaizon, Viviana A. Cavieres, Patricia V. Burgos, Alejandra R. alvarez, Maria J. Yanez, Silvana Zanlungo
Summary: Gaucher disease (GD) is a genetic disorder caused by mutations in the GBA1 gene, leading to GluCer accumulation in lysosomes. Previous studies have focused on lysosomal dysfunction, but recent evidence suggests alterations in other organelles such as the endoplasmic reticulum (ER) and mitochondria. This review collects evidence of organelle dysfunction beyond lysosomes in neuronopathic Gaucher disease (nGD).
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Clinical Neurology
Julian Henao-Restrepo, Carolina Lopez-Murillo, Pablo Valderrama-Carmona, Natalia Orozco-Santa, Johana Gomez, Johanna Gutierrez-Vargas, Renato Moraga, Jorge Toledo, Jessica Lisa Littau, Steffen Haertel, Joseph F. Arboleda-Velasquez, Diego Sepulveda-Falla, Francisco Lopera, Gloria Patricia Cardona-Gomez, Andres Villegas, Rafael Posada-Duque
Summary: This study provides insights into the role of astrocytes in the development and protection of Alzheimer's disease. The study reveals differences in astrocyte reactions in different forms of the disease and suggests the potential relevance of the gliovasculature.
Review
Cell Biology
Daniela A. Gutierrez, America Chandia-Cristi, Maria Jose Yanez, Silvana Zanlungo, Alejandra R. Alvarez
Summary: This review focuses on the role of the non-receptor tyrosine kinase c-Abl in synaptic and neuronal functions. It has been found that the activation of c-Abl can be detrimental to neurons and may promote the development of neurodegenerative diseases. However, c-Abl activity plays a pivotal role in healthy synaptic plasticity, dendritic spine remodeling, and gene expression regulation after cognitive training.
NEURAL REGENERATION RESEARCH
(2023)
Article
Cell Biology
Karina Palma, Iskra A. Signore, Margarita M. Meynard, Jazmin Ibarra, Lorena Armijo-Weingart, Marcos Cayuleo, Steffen Hartel, Miguel L. Concha
Summary: This study demonstrates that the parapineal organ, while morphologically lost during ontogeny in zebrafish, its cells are integrated into the dorsal habenular nucleus and retain their structural, neurochemical, and connective features. The findings suggest that parapineal cells form an integral part of a neural circuit associated with the left habenula and may play a role as local modulators. This study provides insights into the evolutionary developmental mechanism underlying the presence/absence of the parapineal organ in teleosts and vertebrates.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Chaoqun Wang, Ben Hyams, Nancy C. Allen, Kelly Cautivo, Kiara Monahan, Minqi Zhou, Madelene W. Dahlgren, Carlos O. Lizama, Michael Matthay, Paul Wolters, Ari B. Molofsky, Tien Peng
Summary: Abnormal tissue-immune interactions are characteristic of chronic lung diseases. In emphysema, the expansion of tissue-resident lymphocytes (TRLs) was observed. A stromal niche expressing the disease-variant gene Hhip was identified, and its deletion led to the expansion of TRLs through the hedgehog-IL-7 axis. Expanded TRLs suppressed alveolar stem cell growth through IFNg, and a subset of human alveolar stem cells sensitive to IFNg was lost in emphysema.
Article
Biochemistry & Molecular Biology
Anyelo Duran, David A. Priestman, Macarena Las Heras, Boris Rebolledo-Jaramillo, Valeria Olguin, Juan F. Calderon, Silvana Zanlungo, Jaime Gutierrez, Frances M. Platt, Andres D. Klein
Summary: Using a systems genetics approach, we identified 30 shared predicted modifier genes between hepatic lysosomal enzymes and glycosphingolipids (GSLs), clustered in three pathways and associated with other diseases. Surprisingly, these genes are regulated by ten common transcription factors and miRNA-340p. These findings suggest novel therapeutic targets for Lysosomal Storage Disorders (LSDs) and indicate the potential involvement of GSL metabolism in other pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Paola Scavone, Victoria Iribarnegaray, Maria Jose Gonzalez, Nicolas Navarro, Nicole Caneles-Huerta, Jorge Jara-Wilde, Steffen Hartel, Pablo Zunino
Summary: Flagella of Proteus mirabilis play a role in biofilm formation, although their lack does not completely prevent biofilm generation. Impairment of flagellar function can contribute to biofilm prevention.
REVISTA ARGENTINA DE MICROBIOLOGIA
(2023)
Article
Cell Biology
Ritwik Datta, Mohammad A. Gholampour, Christopher D. Yang, Regan Volk, Sinan Lin, Michael J. Podolsky, Thomas Arnold, Florian Rieder, Balyn W. Zaro, Michael Verzi, Richard Lehner, Nada Abumrad, Carlos O. Lizama, Kamran Atabai
Summary: Enterocytes regulate postprandial lipemia by storing dietary fats in cytoplasmic lipid droplets and utilizing MFGE8 to activate hydrolases for catabolism. CES1D is identified as the key hydrolase downstream of the MFGE8-orv85 integrin pathway. The stabilization of HNF4y by MFGE8-dependent fatty acid uptake through CD36 leads to increased Ces1d transcription. This study uncovers a regulatory network that links dietary fat absorption with the expression of hydrolases responsible for catabolizing diet-derived lipid droplets.
Article
Oncology
Liz Maria de Almeida, Sandra Cortes, Marta Vilensky, Olivia Valenzuela, Laura Cortes-Sanabria, Mirian de Souza, Rafael Alonso Barbeito, Eliana Abdelhay, Nora Artagaveytia, Adrian Daneri-Navarro, Andrea S. Llera, Bettina Muller, Osvaldo L. Podhajcer, Carlos Velazquez, Elsa Alcoba, Isabel Alonso, Alicia Bravo, Natalia Camejo, Dirce Maria Carraro, Monica Castro, Sandra Cataldi, Alfonso Cayota, Mauricio Cerda, Alicia Colombo, Susanne Crocamo, Alicia Del Toro-Arreola, Raul Delgadillo-Cristerna, Lucia Delgado, Marisa Dreyer Breitenbach, Elmer Fernandez, Jorge Fernandez, Wanda Fernandez, Ramon A. Franco-Topete, Fancy Gaete, Jorge Gomez, Leivy P. Gonzalez-Ramirez, Marisol Guerrero, Susan A. Gutierrez-Rubio, Beatriz Jalfin, Alejandra Lopez-Vazquez, Dora Loria, Silvia Miguez, Andres de J. Moran-Mendoza, Gilberto Morgan-Villela, Carina Mussetti, Maria Aparecida Nagai, Antonio Oceguera-Villanueva, Rui M. Reis, Javier Retamales, Robinson Rodriguez, Cristina Rosales, Efrain Salas-Gonzalez, Laura Segovia, Juan M. Sendoya, Aida A. Silva-Garcia, Stella Vina, Livia Zagame, Beth Jones, Moyses Szklo
Summary: The molecular profile of breast cancer in Latin-American women was studied in five countries. The study described the socioeconomic characteristics, risk factors, prognostic factors, and molecular subtypes, and estimated the 60-month overall cumulative survival probabilities. Factors such as country of residence, intrinsic subtype, age, and tumor stage were found to be associated with overall survival.
FRONTIERS IN ONCOLOGY
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
V Castaneda, C. A. Figueroa, F. Horta, S. Vargas, A. Garcia, J. Jara-Wilde, S. Hartel
Summary: Over the past decade, there has been substantial growth in the use of Sperm Chromatin Dispersion tests (SCDt) to assess DNA fragmentation in human sperm, with SCDt showing clear advantages over other techniques. However, visual evaluation in SCDt remains subjective. The goal of this study was to develop an automated and objective image analysis method for evaluating DNA fragmentation in human sperm using SCDt images.
INTELLIGENT COMPUTING SYSTEMS (ISICS 2022)
(2022)