Review
Chemistry, Multidisciplinary
Xiao-Xue Xu, Si-Yi Chen, Ning-Bo Yi, Xin Li, Si-Lin Chen, Zhixin Lei, Dong-Bing Cheng, Taolei Sun
Summary: Hypoxia at the tumor site is closely related to tumor progression and treatment resistance. Hypoxia-associa-tive nanomedicine has been proposed as a potential solution for tumor treatment. This review summarizes the design principles, applications, and limitations of hypoxia-associa-tive nanomedicine in recent years, as well as explores its development trends in the treatment of solid tumors.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Yue Zhao, Shanliang Song, Dongdong Wang, He Liu, Junmin Zhang, Zuhao Li, Jincheng Wang, Xiangzhong Ren, Yanli Zhao
Summary: In this study, a nanozyme reinforced hydrogel was developed to improve the effects of stem cell transplantation in a disease state microenvironment. The hydrogel demonstrated improved osteointegration and alleviated symptoms of rheumatoid arthritis, making it a promising intervention for improving prosthetic interface osseointegration.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Biomedical
Han Zhang, Chao Shi, Fuping Han, Mengqi Li, He Ma, Rui Sui, Saran Long, Wen Sun, Jianjun Du, Jiangli Fan, Haozhe Piao, Xiaojun Peng
Summary: Hypoxia is a prominent feature of solid tumors, and hypoxia-activated prodrugs (HAPs) have the potential to turn hypoxia into an advantage in precision therapy. In this study, a novel nanoparticle was designed and synthesized to inhibit gliomas by enhancing hypoxia. The results showed that the photosensitizer-enhanced activation of HAPs can effectively suppress gliomas growth.
Editorial Material
Urology & Nephrology
Gunnar Schley, Margarete Goppelt-Struebe
Summary: Labes et al. analyzed the phosphoproteome in a mouse model of chronic cyclosporine A nephrotoxicity and found significant changes in the angiogenic pathway. By coadministering the hypoxia-inducible factor prolyl hydroxylase inhibitor daprodustat, they were able to almost completely prevent these changes and preserve the microvasculature of the kidney.
KIDNEY INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Fan Wu, Yuancheng Li, Lijuan Wang, Can Peng, Youhui Zeng, Jinfeng Yang, Huijun Zhou, Jing Zheng
Summary: We proposed a mucin 1 and azoreductase dual-responsive DNA tetrahedral nanoprobe for two-step lighting imaging-guided photodynamic therapy of tumors. We hope that this highly specific, responsive and well biocompatible drug delivery system can be effectively used for cancer therapy in the hypoxia-related biomedical field.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Luca Filippi, Francesca Pascarella, Alessandro Pini, Maurizio Cammalleri, Paola Bagnoli, Riccardo Morganti, Francesca Innocenti, Nicola Castagnini, Alice Melosi, Rosa Teresa Scaramuzzo
Summary: The embryo and fetus grow in a hypoxic environment and intrauterine oxygen levels fluctuate throughout pregnancy. A retrospective study on healthy newborns with gestational age < 37 weeks showed a progressive decrease in oxygen levels starting from the 23rd week until the 33-34th week of gestation, followed by an increase in fetal oxygenation until birth. This biphasic trend indicates the role of placenta in regulating oxygen availability to promote stemness and differentiation at specific times and tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biology
Li Li, Susan Shen, Philip Bickler, Matthew P. Jacobson, Lani F. Wu, Steven J. Altschuler
Summary: The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms. This review summarizes known and potential hypoxia sensors among human O-2-dependent enzymes and highlights their possible roles in hypoxia-related adaptation and diseases.
Article
Cell Biology
Zhou Yang, Wei Su, Xiyi Wei, Shuang Qu, Dan Zhao, Jingwan Zhou, Yunjun Wang, Qing Guan, Chao Qin, Jun Xiang, Ke Zen, Bing Yao
Summary: Solid tumors have robust resistance against ferroptosis, but the underlying regulation mechanism in solid tumors is unclear. It is found that the hypoxic tumor microenvironment promotes ferroptosis resistance in a manner dependent on hypoxia-inducible factor 1a (HIF-1a), along with HIF-2a which promotes tumor ferroptosis under hypoxia. Mechanistically, HIF-1a-induced lactate contributes to pH-dependent ferroptosis resistance, parallel to the classical SLC7A11 and FSP1 systems. Additionally, HIF-1a enhances the transcription of SLC1A1, an important glutamate transporter, and promotes cystine uptake to promote ferroptosis resistance. Silencing HIF-1a sensitizes mouse solid tumors to ferroptosis inducers, supporting the role of hypoxia in ferroptosis resistance. In conclusion, this study reveals a mechanism by which hypoxia drives ferroptosis resistance and suggests the combination of hypoxia alleviation and ferroptosis induction as a promising therapeutic strategy for solid tumors.
Article
Multidisciplinary Sciences
Krishna K. Yadav, Yogesh Nimonkar, Stefan J. Green, Sahabram Dewala, Manikprabhu N. Dhanorkar, Rohit Sharma, Vinay R. Rale, Om Prakash
Summary: This study reveals that Scedosporium apiospermum strains show increased growth potential and drug susceptibility under anaerobic conditions. Antifungal azoles are effective against the isolates under both aerobic and anaerobic conditions, while echinocandins and polyenes show resistance under aerobic conditions but sensitivity under anaerobic conditions.
Article
Multidisciplinary Sciences
BeumJin Park, Seok-Jae Heo, Yong Joon Lee, Mi-Kyoung Seo, Jiyun Hong, Eui-Cheol Shin, Inkyung Jung, Sangwoo Kim
Summary: CD8(+) T cells can recognize and kill early tumor cells, with the efficiency influenced by the coverage of HLA-I tumor antigens. Tumors with HLA-I homozygosity show earlier onset. The association may depend on the tumor type and driver mutation specificity. Testing on an independent dataset confirmed the acceleration of tumor onset in a specific type of tumor with HLA-I heterozygosity.
Article
Biochemistry & Molecular Biology
Yukai Jing, Li Luo, Ying Chen, Lisa S. Westerberg, Peng Zhou, Zhiping Xu, Andres A. Herrada, Chan-Sik Park, Masato Kubo, Heng Mei, Yu Hu, Pamela Pui-Wah Lee, Bing Zheng, Zhiwei Sui, Wei Xiao, Quan Gong, Zhongxin Lu, Chaohong Liu
Summary: SARS-CoV-2 infection causes changes in the immune phenotype of B cells in recovered COVID-19 patients, with reduced CD19 expression and disrupted immune regulation, providing a new target for treating COVID-19.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Mingfu Tian, Weiyong Liu, Xiang Li, Peiyi Zhao, Muhammad Adnan Shereen, Chengliang Zhu, Shanyu Huang, Siyu Liu, Xiao Yu, Miaomiao Yue, Pan Pan, Wenbiao Wang, Yongkui Li, Xulin Chen, Kailang Wu, Zhen Luo, Qiwei Zhang, Jianguo Wu
Summary: The cytokine storm induced by SARS-CoV-2 is a major pathological feature of COVID-19, with HIF-1α and pro-inflammatory cytokines playing key roles in infection and inflammatory responses. The production of HIF-1α, inflammatory responses, and high mortalities in elderly patients indicate its crucial role in exacerbating COVID-19.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Medicine, General & Internal
An-Kwok Ian Wong, Marie Charpignon, Han Kim, Christopher Josef, Anne A. H. de Hond, Jhalique Jane Fojas, Azade Tabaie, Xiaoli Liu, Eduardo Mireles-Cabodevila, Leandro Carvalho, Rishikesan Kamaleswaran, R. W. M. A. Madushani, Lasith Adhikari, Andre L. Holder, Ewout W. Steyerberg, Timothy G. Buchman, Mary E. Lough, Leo Anthony Celi
Summary: This study examined racial and ethnic differences in oxygen saturation levels between Spo(2) and Sao(2) measurements, and found that patients with hidden hypoxemia had higher organ dysfunction scores and higher in-hospital mortality rates after arterial blood gas testing.
Article
Biochemical Research Methods
Charlotte Bouquerel, William Cesar, Lara Barthod, Sarah Arrak, Aude Battistella, Giacomo Gropplero, Fatima Mechta-Grigoriou, Gerard Zalcman, Maria Carla Parrini, Marine Verhulsel, Stephanie Descroix
Summary: In vitro cell cultures are often performed in unphysiological hyperoxia. A new system called Oxalis is introduced here, which allows precise control of the dissolved oxygen level in the cell culture medium. Oxalis regulates both the gas composition and the inlet reservoir pressure, offering unprecedented features for accurate investigations on physiological and pathological processes.
Article
Food Science & Technology
J. S. McLeod, A. H. J. Paterson, J. E. Bronlund, J. R. Jones
INTERNATIONAL DAIRY JOURNAL
(2016)
Article
Food Science & Technology
Shailesh G. Agrawal, Anthony (Tony) Paterson, Jim R. Jones, Jeremy S. Mcleod, John Bronlund, Harshit Bajpai
INTERNATIONAL DAIRY JOURNAL
(2017)
Article
Food Science & Technology
Eli M. Gray-Stuart, Jim R. Jones, John E. Bronlund
JOURNAL OF TEXTURE STUDIES
(2017)
Article
Food Science & Technology
G. C. F. Ng, E. M. Gray-Stuart, M. P. Morgenstern, J. R. Jones, N. P. Grigg, J. E. Bronlund
JOURNAL OF TEXTURE STUDIES
(2017)
Article
Engineering, Manufacturing
Gonzalo A. Martinez-Hermosilla, Celia Kueh, Karl Dahm, John E. Bronlund
PACKAGING TECHNOLOGY AND SCIENCE
(2018)
Article
Engineering, Manufacturing
Celia S. L. Kueh, Karl Dahm, Grant Emms, Kelly Wade, John E. Bronlund
PACKAGING TECHNOLOGY AND SCIENCE
(2019)
Article
Engineering, Manufacturing
Mohamad Aiman Jamsari, Celia Kueh, Eli Gray-Stuart, Gonzalo A. Martinez-Hermosilla, Karl Dahm, John E. Bronlund
PACKAGING TECHNOLOGY AND SCIENCE
(2019)
Article
Engineering, Manufacturing
Mohamad Aiman Jamsari, Celia Kueh, Eli M. Gray-Stuart, Karl Dahm, John E. Bronlund
PACKAGING TECHNOLOGY AND SCIENCE
(2019)
Article
Engineering, Manufacturing
Mohamad Aiman Jamsari, Celia Kueh, Eli M. Gray-Stuart, Karl Dahm, John E. Bronlund
PACKAGING TECHNOLOGY AND SCIENCE
(2020)
Article
Biotechnology & Applied Microbiology
Paul Chambonniere, John Bronlund, Benoit Guieysse
Summary: High-rate algae ponds can effectively combine wastewater treatment with biomass production for biofuel. However, the presence of algae in HRAPs can negatively impact pathogen removal. Factors such as high pH, dissolved oxygen levels, and mixing can enhance sunlight-mediated pathogen removal. Predation may also play a role, but further research is needed to understand its quantitative impact.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Review
Food Science & Technology
Joanna Nadia, John Bronlund, Rajinder Paul Singh, Harjinder Singh, Gail M. Bornhorst
Summary: This review discusses the physical breakdown of starch-based foods in the mouth and stomach, the quantification of these breakdown processes, and their links to physiological outcomes, such as gastric emptying and glycemic response. It emphasizes that the physical breakdown prior to small intestinal digestion, especially during gastric digestion, should not be neglected in understanding the digestion of solid starch-based foods.
COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY
(2021)
Article
Engineering, Chemical
Muhammad Syahmeer How, Jim R. Jones, Marco P. Morgenstern, Eli Gray-Stuart, John E. Bronlund
Summary: Chewing food prepares it for safe swallowing by reducing particle size, exposing new surface, and blending it with saliva to benefit both digestion and the sensory experience of consumers. Feed technologists play a role in enhancing the outcomes of a multitude of rate processes, including particle size reduction through subsequent selection and breakage in each chewing cycle.
JOURNAL OF FOOD ENGINEERING
(2022)
Article
Engineering, Manufacturing
Eli M. Gray-Stuart, Kelly Wade, Gabe P. Redding, Kate Parker, John E. Bronlund
Summary: The effect of load and relative humidity on box creep in cool storage conditions was studied. Results showed that filled boxes had reduced performance, while boxes with only two exposed panels performed better.
PACKAGING TECHNOLOGY AND SCIENCE
(2022)
Article
Chemistry, Applied
Sebastian Linnenkugel, Anthony H. J. Paterson, Lee M. Huffman, John E. Bronlund
Summary: The right storage conditions for food powders containing amorphous carbohydrates are crucial to avoid structural changes. This study combines sorption isotherm and glass transition temperature (Tg) data to predict the stability of food powders. The results demonstrate the effectiveness of the method in predicting the relation between Tg and water activity for carbohydrate mixtures.
FOOD HYDROCOLLOIDS
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Ramin Odisho, Weiliang Xu, John Bronlund, Marie-Agnes Peyron
2017 IEEE 26TH INTERNATIONAL SYMPOSIUM ON INDUSTRIAL ELECTRONICS (ISIE)
(2017)