Review
Environmental Sciences
Chiara Talia, Lisa Connolly, Paul A. Fowler
Summary: This review discusses the effects of endocrine disruptors on the IGF system, focusing on different categories of EDs and their potential molecular mechanisms. While there is a lack of studies linking ED exposure to changes in IGF levels for some ED classes, this remains an area of concern that requires further research to improve reproducibility and determine the degree of risk EDs pose to the IGF system.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Cell & Tissue Engineering
Haijian Sun, Shuang Wang, Zheng Yang, Lijie Tian, Xiaoxia Li, Jie Zhou, Baoli Wang
Summary: In this study, the researchers found that CHRDL1 acts as an antagonist of BMPs by binding to them and blocking their interaction with BMP receptors. They revealed that CHRDL1 suppresses osteoblast differentiation while promoting adipocyte differentiation. Mechanistic exploration showed that CHRDL1 stabilizes IGFBP3 and differentially modulates AKT/mTORC1 signaling, thereby regulating the differentiation of osteoblasts and adipocytes.
Article
Biochemistry & Molecular Biology
Whitney L. Stuard, Rossella Titone, Danielle M. Robertson
Summary: This study reveals a novel role for IGFBP-3 in regulating mitochondrial homeostasis through the regulation of mitophagy receptors in corneal epithelial cells. Additionally, IGFBP-3 affects mitochondrial morphology and respiration.
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Cell Biology
Charmaine J. Green, Miriam Span, Monique H. Rayhanna, Marisa Perera, Margot L. Day
Summary: The viability of embryos cultured in vitro is poor compared to those that develop in vivo. This study investigated the role of autocrine and exogenous IGFBP3 in mouse preimplantation embryos. Addition of exogenous IGFBP3 to embryo culture media increased the rate of development, and the effect was mediated by IGF1 and EGF receptors. Acute exposure to IGFBP3 activated the PI3-kinase/Akt pathway to promote cell proliferation and survival. Therefore, addition of IGFBP3 to IVF culture media should be considered.
Article
Medicine, General & Internal
Yun Luo, Chao-Qun Hong, Bin-Liang Huang, Tian-Yan Ding, Ling-Yu Chu, Biao Zhang, Qi-Qi Qu, Xin-Hao Li, Can-Tong Liu, Yu-Hui Peng, Hai-Peng Guo, Yi-Wei Xu
Summary: This study found that serum IGFBP3 could be a potential biomarker for the diagnosis and prognosis of oesophageal squamous cell carcinoma (ESCC). The combination of serum IGFBP3 with other factors improved the predictive ability of ESCC prognosis.
ANNALS OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Christina Stern, Sarah Schwarz, Gerit Moser, Silvija Cvitic, Evelyn Jantscher-Krenn, Martin Gauster, Ursula Hiden
Summary: During pregnancy, the placenta plays a crucial role in regulating maternal physiology by secreting a variety of hormones and proteins. Maternal insulin resistance increases to supply glucose for the developing fetus, with a compensation in beta-cell mass and function. Sex differences may influence placenta-derived hormones and proteins, impacting the regulation of maternal glucose metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Kelsey R. Pool, Faustine Chazal, Jeremy T. Smith, Dominique Blache
Summary: Phytoestrogens have an impact on reproductive health and can influence reproductive capacity in various species. Our understanding of the mechanisms linking phytoestrogens and compromised reproduction in sheep is limited.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Food Science & Technology
Erica Selin, Geeta Mandava, Maria Karlsson, Johan Lundqvist
Summary: This study evaluated the feasibility of using in vitro methods as a screening tool for monitoring chemical hazards in milk. Thirty-two milk samples were tested, and the results showed that estrogen and androgen receptor inhibition, as well as aryl hydrocarbon receptor activity, were the most responsive endpoints. There were no major differences between organic and conventional milk samples in these endpoints.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Obstetrics & Gynecology
Chendi Zhu, Wei Luo, Zhuqing Li, Xiruo Zhang, Jingmei Hu, Shidou Zhao, Xue Jiao, Yingying Qin
Summary: The study revealed a continuous decline in serum INSL3 levels with progression of ovarian insufficiency, showing strong associations with FSH and other markers, serving as a good predictor for bPOI and POI. There was no significant difference in INSL3 levels in follicular fluid between bPOI patients and control women.
FERTILITY AND STERILITY
(2021)
Article
Physiology
Lauren A. Vaccaro, Tom E. Porter, Laura E. Ellestad
Summary: The somatotropic axis and insulin-like growth factor (IGF) signaling play important roles in the growth and metabolism of commercial meat-type chickens. This study investigates the effect of genetic selection on the somatotropic axis activity in broiler lines. Differential expression of IGF and IGF-binding proteins (IGFBPs) in different tissues and developmental stages suggests a tissue-specific and stage-specific regulation of local IGF signaling. These findings contribute to our understanding of the mechanisms underlying the rapid growth and muscle accretion in modern broiler chickens.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Environmental Sciences
Tao Huang, Yuanhui Zhao, Jia He, Hongguang Cheng, Christopher J. Martyniuk
Summary: Azole fungicides have been shown to disrupt the endocrine system in fish, particularly affecting the HPG, HPT, and HPA axis. Some azoles have well-documented endocrine disruptor effects, while others lack data, revealing a knowledge gap in understanding azole toxicity. Further studies are needed to focus on non-steroid endocrine pathways, mechanisms of neuroendocrine disruption, and transgenerational effects of azoles on fish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Yong-Shiou Lin, Wen-Ling Cheng, Jui-Chih Chang, Ta-Tsung Lin, Yi-Chun Chao, Chin-San Liu
Summary: This study investigated the therapeutic potential of IGF-1 in treating SCA3 and found that IGF-1 can improve locomotor function, minimize degeneration of the cerebellar cortex, and alleviate the symptoms of SCA3 through inhibition of mitochondrial fission and enhancement of autophagy.
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ji-Hwan Park, Sung Jin Ryu, Byung Ju Kim, Hyun-Ji Cho, Chi Hyun Park, Hyo Jei Claudia Choi, Eun-Jin Jang, Eun Jae Yang, Jeong-A Hwang, Seung-Hwa Woo, Jun Hyung Lee, Ji Hwan Park, Kyung-Mi Choi, Young-Yon Kwon, Cheol-Koo Lee, Joon Tae Park, Sung Chun Cho, Yun-Il Lee, Sung Bae Lee, Jeong A. Han, Kyung A. Cho, Min-Sik Kim, Daehee Hwang, Young-Sam Lee, Sang Chul Park
Summary: Impairment of nuclear-cytoplasmic trafficking (NCT) has been linked to cellular senescence, where signals transmission between the nucleus and cytoplasm is reduced as cells age. This disrupted communication may play a critical role in the aging process by affecting cell growth and division. Additional studies are needed to fully understand the mechanisms behind this phenomenon and its impact on cellular senescence.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Physiology
Danielle J. Glynn, Kee Heng, Darryl L. Russell, David J. Sharkey, Sarah A. Robertson, Ravinder Anand-Ivell, Richard Ivell
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Physiology
Yanzhenzi Dai, Richard Ivell, Xuan Liu, Dana Janowski, Ravinder Anand-Ivell
FRONTIERS IN PHYSIOLOGY
(2017)
Article
Medical Laboratory Technology
Jakob Albrethsen, Hanne Frederiksen, Anna-Maria Andersson, Ravinder Anand-Ivell, Loa Nordkap, Anne Kirstine Bang, Niels Jorgensen, Anders Juul
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2018)
Article
Endocrinology & Metabolism
Saila Laakso, Heli Viljakainen, Marita Lipsanen-Nyman, Ursula Turpeinen, Kaisa K. Ivaska, Ravinder Anand-Ivell, Richard Ivell, Outi Makitie
HORMONE RESEARCH IN PAEDIATRICS
(2018)
Article
Physiology
Ravinder Anand-Ivell, Arieh Cohen, Bent Norgaard-Pedersen, Bo A. G. Jonsson, Jens-Peter Bonde, David M. Hougaard, Christian H. Lindh, Gunnar Toft, Morten S. Lindhard, Richard Ivell
FRONTIERS IN PHYSIOLOGY
(2018)
Review
Obstetrics & Gynecology
Richard Ivell, Ravinder Anand-Ivell
HUMAN REPRODUCTION UPDATE
(2018)
Article
Multidisciplinary Sciences
Ravinder Anand-Ivell, Colin J. Byrne, Jonas Arnecke, Sean Fair, Pat Lonergan, David A. Kenny, Richard Ivell
Article
Endocrinology & Metabolism
Richard Ivell, Waleed Alhujaili, Tetsuya Kohsaka, Ravinder Anand-Ivell
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2020)
Article
Andrology
Daniele Santi, Richard Ivell, Ravinder Anand-Ivell, Luca De Toni, Flaminia Fanelli, Marco Mezzullo, Carla Pelusi, Uberto Pagotto, Serena Belli, Antonio R. M. Granata, Laura Roli, Vincenzo Rochira, Tommaso Trenti, Alberto Ferlin, Manuela Simoni
Article
Andrology
Ravinder Anand-Ivell, Kelton Tremellen, Hiroaki Soyama, Doyo Enki, Richard Ivell
Summary: The study found that INSL3 concentration was not related to any semen parameter, but was negatively correlated with BMI. IN both cohorts, there was a significant relationship between INSL3 and FSH, but not LH concentration. Additionally, INSL3 was not correlated with androgen receptor trinucleotide repeat polymorphisms or the T/LH ratio.
Article
Biochemistry & Molecular Biology
Damien Hunter, Kee Heng, Navdeep Mann, Ravinder Anand-Ivell, Richard Ivell
Summary: This study found that maternal exposure to xenobiotics DBP or DES may cause long-term changes in hypothalamic gene expression and reproductive behavior in offspring, particularly leading to significant impact on gene expression and sexual behavior with DES treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Richard Ivell, Ravinder Anand-Ivell
Summary: The reproductive system is a highly dynamic system whose complexity and functioning at different physiological stages require further investigation. Recent scientific advancements have shed light on the components of the reproductive system, but the specific mechanisms of interaction and function in the spatial and temporal dimensions remain unclear.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Richard Ivell, Ravinder Anand-Ivell
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2017)
Review
Pharmacology & Pharmacy
Richard Ivell, Alexander I. Agoulnik, Ravinder Anand-Ivell
BRITISH JOURNAL OF PHARMACOLOGY
(2017)