Article
Multidisciplinary Sciences
Francisco J. Sanchez-Rivera, Jeremy Ryan, Yadira M. Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M. Feldser, Michael T. Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony Letai, Tyler Jacks
Summary: The level of mitochondrial apoptotic priming is a critical determinant of cell fate upon p53 reactivation, with cells having high initial priming tending to undergo apoptosis and cells with low priming tending to survive and arrest in the cell cycle. Manipulating the priming levels through BCL-2 or BCL-XL expression or inhibition can affect the outcome of p53 restoration, highlighting mitochondrial apoptotic priming as a key factor in determining cell fate. Moreover, less primed cells can be forced into apoptotic cell fate following p53 activation using p53-independent drugs that increase apoptotic priming.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Endocrinology & Metabolism
Yue Gao, Jingjie Li, Shicheng Fan, Pan Chen, Min Huang, Huichang Bi
Summary: This study used lipidomic analysis to investigate the changes in lipid profiles in ovarian hyperstimulation syndrome (OHSS) patients and identified key lipids associated with the development of OHSS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Chemistry, Medicinal
Michael Danquah
Summary: Embelin is a naturally occurring benzoquinone with potent anticancer properties, but its low water solubility hinders its clinical application. This review provides a concise summary and in-depth analysis of the design and synthesis of Embelin derivatives with increased aqueous solubility and superior therapeutic efficacy. Additionally, the potential of drug delivery systems to enhance the anticancer capabilities of Embelin and its derivatives is discussed.
Article
Cell Biology
Kira Allmeroth, Christine S. Kim, Andrea Annibal, Andromachi Pouikli, Janis Koester, Maxime J. Derisbourg, Carlos Andres Chacon-Martinez, Christian Latza, Adam Antebi, Peter Tessarz, Sara A. Wickstroem, Martin S. Denzel
Summary: The study investigates the role of polyamines in stem cell fate decisions using HFSC organoids, revealing a translation-independent function of polyamines in cell fate regulation. N1-acetylspermidine is identified as a determinant of cell fate, promoting self-renewal and maintaining stemness. This research highlights the diverse pathways of polyamine metabolism-mediated regulation of stem cell fate decisions.
JOURNAL OF CELL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Jette Lengefeld, Chia-Wei Cheng, Pema Maretich, Marguerite Blair, Hannah Hagen, Melanie R. McReynolds, Emily Sullivan, Kyra Majors, Christina Roberts, Joon Ho Kang, Joachim D. Steiner, Teemu P. Miettinen, Scott R. Manalis, Adam Antebi, Sean J. Morrison, Jacqueline A. Lees, Laurie A. Boyer, Omer H. Yilmaz, Angelika Amon
Summary: The size of stem cells plays a crucial role in their function, with small size being important for maintaining stem cell potential. Enlargement of hematopoietic stem cells under conditions of decreased function is associated with reduced proliferation and altered metabolism. Preventing stem cell enlargement can help prevent the loss of stem cell potential in exhausting conditions.
Article
Oncology
Theresa Eifert, Chen-Jen Hsu, Alicia L. Becker, Sarah Graessle, Arik Horne, Franziska Bemmann, Qirui Zhang, Michael Heuser, Valeri Vasioukhin, Sebastian Scholl, Andreas Hochhaus, Florian Siegerist, Nicole Endlich, Lars Bullinger, Steven W. Lane, Simon Haas, Tina M. Schnoeder, Florian H. Heidel
Summary: The Scribble complex proteins play a crucial role in hematopoietic cell fate decisions and self-renewal capacity. Through genetic screening, LLGL1 has been identified as a specific dependency and putative target in AML, with its inactivation leading to loss of stemness-associated gene-expression and induction of a specific phenotype in leukemia stem cells. These findings highlight the importance of LLGL1 and its cell-type specific functions in AML.
Article
Multidisciplinary Sciences
Jugal Kishore Das, Yijie Ren, Anil Kumar, Hao-Yun Peng, Liqing Wang, Xiaofang Xiong, Robert C. Alaniz, Paul de Figueiredo, Xingcong Ren, Xiaoqi Liu, Alexey G. Ryazonov, Jin-Ming Yang, Jianxun Song
Summary: eEF-2K plays a critical role in regulating the fate and function of CD8(+) T cells. Loss of eEF-2K leads to increased proliferation but decreased survival of CD8(+) T cells, along with premature senescence and exhaustion. eEF-2K deficiency also affects the metabolic activity of CD8(+) T cells and the effectiveness of CAR-T therapy against cancer.
Article
Pharmacology & Pharmacy
Chao-Chin Hsu, Isabel Hsu, Li-Hsuan Lee, Rosie Hsu, Yuan-Shuo Hsueh, Chih-Ying Lin, Hui Hua Chang
Summary: This study demonstrates that intermittent vaginal administration of gonadotropins is effective for women with poor ovarian response (POR) undergoing controlled ovarian hyperstimulation (COH), helping them obtain sufficient oocytes.
Article
Oncology
Ganggang Wang, Zhijie Zhou, Wenzhi Jin, Xin Zhang, Hao Zhang, Xiaoliang Wang
Summary: The study utilized scRNA-seq technology to analyze the characteristics of IL34(+) CAFs in HCC; further experiments showed that IL34(+) CAFs promote Tregs infiltration and suppress CD8(+) T cell toxicity; high IL34 expression is associated with increased proliferative activity in CAFs and abundance of Tregs.
NPJ PRECISION ONCOLOGY
(2023)
Review
Medical Laboratory Technology
Hamid Reza Nejabati, Leila Roshangar, Mohammad Nouri
Summary: The decrease in reproductive potential with aging is attributed to the gradual decline in quantity and quality of ovarian reserve, which increases the risk of miscarriage, pregnancy loss, low ovarian stimulation, and oocyte abnormalities. Changes in cellular composition of follicles have been shown to contribute to the reduced fertility potential of older women. Moreover, extracellular vesicles (EVs), especially non-coding RNAs like miRNAs, have been found to play a role in cellular communication and their composition has been documented to alter with age, suggesting their potential as predictors of oocyte quality.
CLINICA CHIMICA ACTA
(2023)
Article
Immunology
Yu Xiang, Hua Wang, Huimin Ding, Tianyue Xu, Xiu Liu, Zichao Huang, Honghui Wu, Hongshan Ge
Summary: The study reveals that PCOS patients with hyperandrogenemia undergoing IVF treatment have higher levels of inflammatory factors in their follicular fluid, while GCs in these patients show significant pyroptosis. Experiments on mouse and cell models demonstrate a clear association between hyperandrogenism, inflammation, and pyroptosis in PCOS, with ER stress playing a crucial role in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Jiao Wu, Chunmei Liang, Xin Wang, Yida Huang, Wanshan Liu, Ruimin Wang, Jing Cao, Xun Su, Tao Yin, Xiaolei Wang, Zhikang Zhang, Lingchao Shen, Danyang Li, Weiwei Zou, Ji Wu, Lihua Qiu, Wen Di, Yunxia Cao, Dongmei Ji, Kun Qian
Summary: Metabolic fingerprinting of follicular fluid (MFFF) using particle-assisted laser desorption/ionization mass spectrometry (PALDI-MS) is performed to encode ovarian reserve (OR) and fertility. Machine learning analysis of MFFF allows for the diagnosis of diminished OR and identification of high-quality oocytes/embryos. Metabolic biomarkers from MFFF also contribute to fertility prediction in clinics.
Article
Biochemistry & Molecular Biology
Xiaoshu Zhan, Lauren Fletcher, Serena Dingle, Enzo Baracuhy, Bingyun Wang, Lee-Anne Huber, Julang Li
Summary: Choline has a positive impact on ovarian function, increasing the number of corpus luteum and percentage of antral follicles, and the study offers insights into the mechanisms behind its positive effect on ovarian development phenotypes.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2021)
Article
Obstetrics & Gynecology
Robert B. Hood, Donghai Liang, Youran Tan, Jennifer B. Ford, Irene Souter, Jorge E. Chavarro, Dean P. Jones, Russ Hauser, Audrey J. Gaskins
Summary: This study identified the metabolic pathways and metabolites in the serum and follicular fluid that are associated with peak estradiol levels and the number of mature oocytes. The serum metabolome mainly involves fatty acid and amino acid pathways, while the follicular fluid metabolome mainly involves lipid, vitamin, and hormone pathways. These findings provide insights into the biological mechanisms underlying follicular and oocyte development.
HUMAN REPRODUCTION
(2023)
Article
Cell Biology
Ying Wang, Chenming Yan, Junxia Qi, Chunyan Liu, Juan Yu, Huabin Wang
Summary: The study found that the downregulation of miR-874-3p in epithelial ovarian cancer cells is associated with cisplatin resistance, and reversing cisplatin resistance and enhancing sensitivity to cisplatin-induced apoptosis can be achieved by targeting XIAP.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
