Review
Cell Biology
Cara C. Hardy, Ron Korstanje
Summary: Age-associated alterations in bladder control have a significant impact on millions of older adults, bringing economic and quality of life burdens to their families. Understanding the effects of aging on the brain-bladder axis and identifying genetic targets related to functional outcomes are crucial for improving therapeutic options for older adults. Changes in both the central nervous system and the bladder itself contribute to age-related alterations in bladder control.
Article
Plant Sciences
Marcelo Augusto Altieri, Luis Manuel Sarmiento-Machado, Guilherme Ribeiro Romualdo, Nelci Antunes de Moura, Luis Fernando Barbisan
Summary: The study found that dietary capsaicin can reduce the development of urothelial lesions in rats, demonstrating a protective effect.
PLANT FOODS FOR HUMAN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Bengt Uvelius, Karl-Erik Andersson
Summary: This study in rats aimed to identify the mechanisms that persist after the removal of obstruction in the lower urinary tract symptoms (LUTSs) due to prostatic enlargement. The results showed significant differences in mRNA expressions and ultrastructure between control, obstructed, and de-obstructed bladders, suggesting distinct properties in gene expressions, morphologies, and functional properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Veterinary Sciences
Xinyu Wang, Yue Wu, Lin Liu, Hui Bai, Zhiheng Zhang, Mingchao Zhao, Tianwen Ma, Xiaopeng Song, Lina Jia, Liangyu Lv, Yue Yu, Xinyu Xu, Hong Chen, Li Gao
Summary: This study provides new evidence that the anesthetic and analgesic effects of Xyl are related to the inhibition of the NO-cGMP signaling pathway.
JOURNAL OF VETERINARY SCIENCE
(2022)
Article
Neurosciences
Iris Speigel, Kishan Patel, Vanessa Osman, Huge C. Hemmings Jr
Summary: Volatile anesthetics alter presynaptic function through effects on Ca2+ influx and neurotransmitter release, and this is mediated by the NO/cGMP signaling pathway. These findings provide new insights into the mechanisms of volatile anesthetics.
Article
Chemistry, Analytical
Heena Tyagi, Emma Daulton, Ayman S. Bannaga, Ramesh P. Arasaradnam, James A. Covington
Summary: Bladder cancer and prostate cancer are commonly diagnosed with invasive techniques, but a non-invasive diagnostic approach using volatile organic compounds (VOCs) shows promise. Analysis of urinary VOC profiles using GC-IMS and GC-TOF-MS can effectively distinguish between BCa and PCa, offering potential for cancer diagnosis.
Article
Multidisciplinary Sciences
Arkadiusz Jundzill, Henryk Witmanowski, Ewa Zary-Sikorska, Jan Adamowicz, Magdalena Bodnar, Andrzej Marszalek, Tomasz Kloskowski, Kaja Mecinska-Jundzill, Maciej Gagat, Natalia Siedlecka, Tomasz Drewa, Marta Pokrywczynska
Summary: This study developed a new procedure for urinary bladder transplantation on a rat model, achieving a high success rate and observing no complications two weeks post-surgery. The research aimed to acquire necessary knowledge about urinary bladder transplantation and proposed a technique that offers a new approach to existing orthotopic models.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Jan Hrbacek, Vojtech Tlaskal, Pavel Cermak, Vitezslav Hanacek, Roman Zachoval
Summary: This study found associations between the human urinary microbiota and certain clinical conditions, including factors like age, diabetes mellitus, dyslipidemia, smoking, and chronic kidney disease, suggesting that UM may play a role in the development of diseases.
Article
Cell Biology
Laura E. Pascal, Taro Igarashi, Shinsuke Mizoguchi, Wei Chen, Lora H. Rigatti, Caroline G. Madigan, Rajiv Dhir, Wade Bushman, Donald B. DeFranco, Naoki Yoshimura, Zhou Wang
Summary: The decrease in E-cadherin is associated with increased inflammation and bladder overactivity in aging prostate, promoting the development and progression of BPH/LUTS.
Article
Genetics & Heredity
Wenzhi Du, Tianyi Wang, Wenxiu Zhang, Yu Xiao, Xinghuan Wang
Summary: By performing a two-sample Mendelian randomization analysis, this study found a possible association between genetically predicted benign prostate hyperplasia (BPH) and bladder cancer (BLCA). BPH was found to play a key role in the development of BLCA, while there was no significant evidence for the causality of BLCA on BPH. Further studies are needed to uncover the underlying mechanisms.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Emad A. Hindi, Craig J. Williams, Leo A. H. Zeef, Filipa M. Lopes, Katie Newman, Martha M. M. Davey, Nigel W. Hodson, Emma N. Hilton, Jennifer L. Huang, Karen L. Price, Neil A. Roberts, David A. Long, Adrian S. Woolf, Natalie J. Gardiner
Summary: The study found wide-ranging gene expression changes in the bladders of diabetic rats, including genes regulating extracellular matrix and neural molecules. The reduced birefringent collagen and significant decrease in tissue stiffness in diabetic rat bladders may contribute to voiding dysfunction in diabetic individuals.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Jiliang Wen, Zhenghao Chen, Si Wang, Mengmeng Zhao, Shaoyong Wang, Shengtian Zhao, Xiulin Zhang
Summary: As animals age, the electrical properties of bladder afferents undergo differential changes, with a decrease in excitability potentially contributing to reductions in bladder sensory function.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sanjit O. Tewari, Zeyad A. Metwalli, Guofan Xu
Summary: This article presents a potential pitfall in restaging PSMA PyL PET/CT, where a large non-PSMA-avid cystic structure in the mid pelvis was mistaken for the urinary bladder, leading to a misdiagnosis of a displaced and crescentic bladder as recurrence. Biopsy and retrospective review of images subsequently confirmed the presence of physiologic excreted activity in the displaced bladder.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Sujin Lee, Ja Yoon Ku, Byeong Jin Kang, Kyung Hwan Kim, Hong Koo Ha, Suhkmann Kim
Summary: This study investigated the urinary metabolic differences in male patients with prostate cancer, bladder cancer, and renal cell carcinoma to find distinct metabolites and potential biomarkers among the three cancers. The results showed significant differences in metabolite levels, particularly 4-hydroxybenzoate, N-methylhydantoin, creatinine, glutamine, and acetate. Receiver operating characteristic analysis demonstrated good discriminatory accuracy between the different types of cancers. This preliminary study highlights the potential of metabolomics in the exploration of human urine for cancer detection.
Article
Pharmacology & Pharmacy
Betul Rabia Erdogan, Zeynep Elif Yesilyurt, Ebru Arioglu-Inan, Martin Christian Michel
Summary: The study showed that fenoterol is a suitable tool to evaluate beta(2)-AR-mediated relaxation responses in the rat urinary bladder and other smooth muscle preparations containing multiple subtypes of beta-AR.