Review
Biochemistry & Molecular Biology
Armita Mahdavi Gorabi, Saeed Aslani, George E. Barreto, Eliana Baez-Jurado, Nasim Kiaie, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Neuroglobin, identified in 2000 in neurons of human and mouse nervous systems, is an oxygen-binding globin that provides protective effects against hypoxic/ischemic damage by promoting oxygen availability within the mitochondria. Impaired neuroglobin functioning has been linked to the pathogenesis of multiple neurodegenerative disorders. Studies have shown the potential of neuroglobin upregulation in improving neuroprotection through modulation of mitochondrial functions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Siqi Liu, Shanshan Liu, Baiyu He, Lanlan Li, Lin Li, Jiawen Wang, Tao Cai, She Chen, Hui Jiang
Summary: The research reveals that yeast mutants deficient in certain oxidative phosphorylation complexes and mtDNA exhibit progressive reduction of mitochondrial membrane potential. These mutants activate adaptive responses, including remodeling of mitochondrial proteome and reshaping of cellular metabolism.
Article
Geriatrics & Gerontology
Sirawit Sriwichaiin, Nattayaporn Apaijai, Arintaya Phrommintikul, Thidarat Jaiwongkam, Sasiwan Kerdphoo, Wasana Pratchayasakul, Nisakron Thongmung, Usanee Mahantassanapong, Prin Vathesatogkit, Chagriya Kitiyakara, Piyamitr Sritara, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: Mitochondrial dysfunction is potentially associated with aging, although there is limited evidence regarding the relationship between mitochondrial function and aging. In this study, mitochondrial function was found to decline with age, with several parameters related to mitochondrial respiration significantly lower in older adults. However, mitochondrial ATP production and mitochondrial coupling efficiency were slightly increased in older adults. Additionally, mitochondrial mass and oxidative stress were significantly reduced in older individuals.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biology
Jingruo Zhang, Manuel A. Riquelme, Rui Hua, Francisca M. Acosta, Sumin Gu, Jean X. Jiang
Summary: This study reveals a new role of mitochondrial Cx43 and hemichannels in modulating mitochondrial function and homeostasis in bone osteocytes under oxidative stress. Through mediating K+, H+, and ATP transfer across the mitochondrial inner membrane and interacting with mitochondrial ATP synthase, mtCx43 hemichannels regulate mitochondrial ATP generation and contribute to the maintenance of mitochondrial redox levels in response to oxidative stress.
Article
Medicine, Research & Experimental
Nichakorn Worakajit, Natechanok Thipboonchoo, Soraya Chaturongakul, Promsuk Jutabha, Virawudh Soontornniyomkij, Patoomratana Tuchinda, Sunhapas Soodvilai
Summary: This study found that panduratin A can alleviate colistin-induced renal injury by attenuating mitochondrial damage and renal cell apoptosis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Alfredo Cruz-Gregorio, Ana Karina Aranda-Rivera, Omar Emiliano Aparicio-Trejo, Omar Noel Medina-Campos, Edda Sciutto, Gladis Fragoso, Jose Pedraza-Chaverri
Summary: Breast cancer is the second most common cancer in women worldwide. The mortality rate has decreased due to early diagnosis and more effective treatments, but HER2 and TNBC still have poor prognoses. The immunomodulatory peptide GK-1 is being proposed as a new alternative for immunotherapy of these aggressive tumors. GK-1 has shown promising results in reducing tumor growth and lung metastasis in experimental models.
Article
Environmental Sciences
Shiyao Sun, Zhihui Zhao, Qinxiong Rao, XiaoMin Li, Zheng Ruan, Junhua Yang
Summary: BDE-47 disrupts mitochondrial fusion/fission dynamics, leading to mitochondrial abnormalities, oxidative stresses, and dysfunction in PK15 cells. Identifying ROS-dependent pathways in mitochondrial dynamics may offer new strategies for protecting against BDE-47-induced nephrotoxicity.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Lige Gong, Wenqiao Ding, Ying Chen, Kai Yu, Changhong Guo, Baibin Zhou
Summary: The modified 10-nuclear heteroatom cluster exhibited inhibitory activity, affecting ATP production through modulation of protein expression related to metabolism. It acted as a protective agent against ROS stress by functioning as catalase and glutathione peroxidase, and showed potential as specific oxidative/antioxidant regulatory agents.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Biochemistry & Molecular Biology
Brad Ebanks, Lisa Chakrabarti
Summary: Mitochondrial ATP synthase plays a crucial role in cellular ATP production and its oxidative modifications have significant implications in neurodegenerative diseases. Understanding the importance of these modifications is essential for considering ATP synthase as a pharmacological target.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Reut Hazan (Ben-Menachem), Dvora Lintzer, Tamar Ziv, Koyeli Das, Irit Rosenhek-Goldian, Ziv Porat, Hila Ben Ami Pilo, Sharon Karniely, Ann Saada, Neta Regev-Rudzki, Ophry Pines
Summary: Vesicular transport is a means of communication between cells, and this study focuses on organelle-to-organelle communication, specifically between mitochondria. The researchers discovered that functional mitochondria in yeast can release vesicles, which are about 100 nm in size and carry selective protein cargo, including ATP synthase subunits. These vesicles also contain a functional ATP synthase complex and have the ability to fuse with naive mitochondria, potentially delivering ATP and participating in organelle-to-organelle communication.
Article
Chemistry, Multidisciplinary
Namrata Singh, Somanathapura K. NaveenKumar, Motika Geethika, Govindasamy Mugesh
Summary: The study demonstrates that CeVO4 nanozyme can substitute the function of SOD1 and SOD2 in neuronal cells even when the natural enzymes are down-regulated. The nanozyme prevents mitochondrial damage by regulating superoxide levels and restores physiological levels of anti-apoptotic proteins. Additionally, it effectively prevents mitochondrial depolarization and improves cellular ATP levels under oxidative stress.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Pharmacology & Pharmacy
Ming Yang, Chongbin Liu, Na Jiang, Yan Liu, Shilu Luo, Chenrui Li, Hao Zhao, Yachun Han, Wei Chen, Li Li, Li Xiao, Lin Sun
Summary: Renal aging is a degenerative process associated with harmful accumulation. Mitochondria, the energy factories of the cell, play important roles in renal aging through abnormal mitochondrial homeostasis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Environmental Sciences
Yuting Wu, Jiwen Liu, Shuhui Liu, Wentao Fan, Chenchen Ding, Zhangshan Gao, Zhihui Tang, Yan Luo, Xizhi Shi, Lei Tan, Suquan Song
Summary: Since the outbreak of COVID-19, the increased use of disinfectants has resulted in a significant rise in the generation of disinfection byproducts such as bromoacetic acid (BAA). BAA has raised concerns due to its negative effects on the urinary system in mammals, but its nephrotoxicity and mechanism in birds remain unclear. Through a study involving chicken exposed to different doses of BAA, it was found that BAA exposure caused kidney swelling, structural disarrangement, renal dysfunction, increased apoptosis, and disrupted gene expression related to mitochondrial biogenesis, OXPHOS complex I, and Nrf2 antioxidant reactions. Moreover, BAA also affected genes related to uric acid metabolism, exacerbating kidney damage.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Andres Garcia-Sanchez, Luis Gomez-Hermosillo, Jorge Casillas-Moreno, Fermin Pacheco-Moises, Tannia Isabel Campos-Bayardo, Daniel Roman-Rojas, Alejandra Guillermina Miranda-Diaz
Summary: Obesity and hypertension are increasing health problems in developed countries. The relationship between obesity and hypertension is not fully understood, but oxidative stress and mitochondrial dysfunction may have a role. A cross-sectional study was conducted on 175 subjects with normal weight, overweight, or obesity to assess their mitochondrial function and hypertension status. The study found that obese subjects had lower ATP hydrolysis activity and increased oxidative stress compared to normal weight and overweight subjects. Subjects with hypertension also showed increased oxidative stress and inflammation markers. These findings suggest that obesity-related hypertension may involve impaired mitochondrial function and increased oxidative stress.
Article
Pharmacology & Pharmacy
Enayatollah Seydi, Marjan Rahemi, Hadi Esmaily, Abdollah Arjmand, Jalal Pourahmad
Summary: Transplanting healthy mitochondria can reduce the cytotoxicity, ROS production, MMP collapse, lysosomal damage, GSSG levels, and caspase-3 activity caused by FAV in RPTCs, while increasing ATP level, GSH content, Bcl-2 content, and GSH/GSSG ratio.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marwa Yousef, Ercan Babur, Sumeyra Delibas, Burak Tan, Aysenur Cimen, Nurcan Dursun, Cem Suer
JOURNAL OF MOLECULAR NEUROSCIENCE
(2019)
Meeting Abstract
Clinical Neurology
N. Dursun, N. Yildiz Demircan, A. Komur, C. Suer
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Clinical Neurology
B. Tan, O. Barutcu, C. Suer, N. Dursun
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Clinical Neurology
C. Suer, M. Yousef, S. Delibas, N. Dursun
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Clinical Neurology
S. Delibas, A. Cimen, C. Suer, N. Dursun
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Cem Suer, Nurbanu Yildiz, Ozlem Barutcu, Burak Tan, Nurcan Dursun
Summary: The study found that inhibiting guanylate cyclase can alter the phosphorylation state of tau protein in the dentate gyrus of the hippocampal formation, affecting induction of LTD but not LTP.
PHARMACOLOGICAL REPORTS
(2021)
Article
Neurosciences
Burak Tan, Ezgi Aslan-Gulpinar, Nurcan Dursun, Cem Suer
Summary: Blocking NMDA receptor activation can lead to synaptic depression with high-frequency stimulation and synaptic potentiation with low-frequency stimulation.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Hatice Saray, Cem Suer, Bilal Kosar, Burak Tan, Nurcan Dursun
Summary: The study showed that the Rho-kinase inhibitor fasudil can modulate tau and APP metabolism, thus regulating synaptic plasticity in the hippocampus. This suggests that inhibition of Rho-kinase could be a potential therapeutic target for cognitive disorders.
PHARMACOLOGICAL REPORTS
(2021)
Article
Neurosciences
Ercan Babur, Ozlem Canoz, Burak Tan, Cem Suer, Nurcan Dursun
Summary: Sodium selenite has a protective effect on hypothyroidism-induced impairments in rats, improving learning and memory disorders and synaptic plasticity. However, it does not affect hippocampal neurogenesis.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Meeting Abstract
Endocrinology & Metabolism
Ozlem Barutcu, Burak Tan, Nurcan Dursun, Cem Suer
NEUROENDOCRINOLOGY
(2021)
Meeting Abstract
Endocrinology & Metabolism
Hatice Saray, Nurcan Dursun, Cem Suer, Burak Tan
NEUROENDOCRINOLOGY
(2021)
Meeting Abstract
Endocrinology & Metabolism
Burak Tan, Ozlem Barutcu, Ercan Babur, Cem Suer, Nurcan Dursun
NEUROENDOCRINOLOGY
(2021)
Meeting Abstract
Physiology
Ozlem Barutcu, Nurcan Dursun, Cem Suer
Meeting Abstract
Clinical Neurology
Y. Bayar, A. Temeltas, H. Herdem, N. Dursun, C. Suer
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)
Meeting Abstract
Clinical Neurology
N. Dursun, E. Babur, B. Tan
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)