Article
Critical Care Medicine
Steven L. Shein, Aline B. Maddux, Margaret J. Klein, Anoopindar Bhalla, George Briassoulis, Mary K. Dahmer, Guillaume Emeriaud, Heidi R. Flori, Rainer Gedeit, Stavroula Ilia, Martin C. J. Kneyber, Natalie Napolitano, Shinichiro Ohshimo, Marti Pons-Odena, Sarah Rubin, Benjamin R. White, Nadir Yehya, Robinder Khemani, Lincoln Smith
Summary: This study aimed to characterize the frequency and outcomes of children meeting at risk for pediatric acute respiratory distress syndrome criteria. The results showed that the criteria identified high-risk critically ill children and were associated with increased mortality and longer treatment durations.
CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Elias Baedorf Kassis, Henry K. Su, Alexander R. Graham, Victor Novack, Stephen H. Loring, Daniel S. Talmor
Summary: Reverse triggering is an underexplored form of dyssynchrony with important clinical implications in patients with acute respiratory distress syndrome. Different phenotypes of reverse triggering have varying effects on lung inflation and transpulmonary pressure, emphasizing the importance of understanding these events for clinical management.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Pediatrics
Jennifer A. Blumenthal, Melody G. Duvall
Summary: There is a lack of research on the best practices in managing pediatric severe COVID-19 with respiratory failure, highlighting the urgent need for more studies as the pandemic continues to impact children and as vaccination efforts progress. Management of acute respiratory failure in children with COVID-19 requires individualized approach based on lung conditions.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Critical Care Medicine
Michael Hultstrom, Ola Hellkvist, Lucian Covaciu, Filip Freden, Robert Frithiof, Miklos Lipcsey, Gaetano Perchiazzi, Mariangela Pellegrini
Summary: This study found that switching from HFNC to other respiratory support methods caused significant changes in PaO2/FIO2 ratio, while switching between NIV and MV did not consistently affect the ratio. This suggests caution should be used in assessing ARDS severity under different respiratory support methods, particularly with HFNC.
Article
Critical Care Medicine
Yoann Zerbib, Alexis Lambour, Julien Maizel, Loay Kontar, Bertrand De Cagny, Thierry Soupison, Thomas Bradier, Michel Slama, Clement Brault
Summary: The study found that high recruitability patients showed a significant increase in respiratory system compliance after lung recruitment maneuvers, while low recruitability patients experienced a decrease in pulse pressure, potentially indicating a drop in cardiac output.
Review
Pharmacology & Pharmacy
Kaitlin M. Landolf, Steven M. Lemieux, Christina Rose, Jackie P. Johnston, Christopher D. Adams, Jerry Altshuler, Karen Berger, Deepali Dixit, Muhammad K. Effendi, Mojdeh S. Heavner, Diana Lemieux, Audrey J. Littlefield, Andrea M. Nei, Kent A. Owusu, Marisa Rinehart, Blake Robbins, Ginger E. Rouse, Melissa L. Thompson Bastin
Summary: Studies suggest that the use of corticosteroids can improve mortality and mechanical ventilation-free days in patients with both COVID-19 and non-COVID-19 ARDS. However, there is still controversy surrounding the optimal corticosteroid agent, dose, and duration utilized in these trials.
Review
Medicine, General & Internal
Alicia N. Rizzo, Neil R. Aggarwal, B. Taylor Thompson, Eric P. Schmidt
Summary: Acute respiratory distress syndrome (ARDS) is a common and life-threatening cause of respiratory failure, and there are no effective pharmacologic therapies to treat this disease. The shift in focus towards understanding the mechanisms underlying the heterogeneity of ARDS aims to move towards personalized medicine and identify patients who will benefit the most from targeted treatments. This review discusses the historical perspective, clinical trials, challenges, and potential strategies for future research in ARDS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Critical Care Medicine
Matthieu Schmidt, Christoph Fisser, Gennaro Martucci, Darryl Abrams, Thomas Frapard, Konstantin Popugaev, Antonio Arcadipane, Bianca Bromberger, Giovanni Lino, Alexis Serra, Sacha Rozencwajg, Matthias Lubnow, Sergey Petrikov, Thomas Mueller, Alain Combes, Tai Pham, Daniel Brodie
Summary: This study aimed to evaluate the complications, sedative and analgesic use, and level of consciousness in patients undergoing tracheostomy during or after ECMO treatment. The results showed a higher risk of local bleeding in patients who underwent tracheostomy during ECMO, while patients who underwent tracheostomy after ECMO decannulation had a more rapid decrease in sedative consumption and a significant improvement in consciousness levels.
Article
Critical Care Medicine
Roberta De Santis Santiago, Maddalena Teggia Droghi, Jacopo Fumagalli, Francesco Marrazzo, Gaetano Florio, Luigi G. Grassi, Susimeire Gomes, Caio C. A. Morais, Ozires P. S. Ramos, Maurizio Bottiroli, Riccardo Pinciroli, David A. Imber, Aranya Bagchi, Kenneth Shelton, Abraham Sonny, Edward A. Bittner, Marcelo B. P. Amato, Robert M. Kacmarek, Lorenzo Berra
Summary: The study found that obese patients with ARDS require higher airway pressure to improve lung function during mechanical ventilation, but it does not lead to lung overdistension, and they can tolerate lung recruitment maneuvers with high airway pressure. In addition, LRM and PEEP can reduce pulmonary vascular resistance and normalize ventilation-perfusion ratio.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Medicine, General & Internal
Qing Qing, Ping Zha, Li-Ying Dai, Yang Wang
Summary: This study investigated the clinical efficacy of different ventilation strategies combined with pulmonary surfactant (PS) therapy in the treatment of neonatal respiratory distress syndrome (NRDS). The findings showed that the integration of high-frequency oscillatory ventilation (HFOV) with PS effectively expedited the treatment duration, decreased the occurrence of complications, and secured therapeutic efficacy in managing NRDS.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Critical Care Medicine
Francois Beloncle, Antoine Studer, Valerie Seegers, Jean-Christophe Richard, Christophe Desprez, Nicolas Fage, Hamid Merdji, Bertrand Pavlovsky, Julie Helms, Sibylle Cunat, Satar Mortaza, Julien Demiselle, Laurent Brochard, Alain Mercat, Ferhat Meziani
Summary: Differences in physiology were found between COVID-19 and non-COVID-19 patients with ARDS, with higher C-RS in COVID-19 patients initially. The relationship between C-RS and oxygenation was only seen in non-COVID-19 patients on day 1. Both COVID-19 and non-COVID-19 patients showed similar C-RS and VR at day 7.
Article
Critical Care Medicine
Sachin Sud, Jan O. Friedrich, Neill K. J. Adhikari, Eddy Fan, Niall D. Ferguson, Gordon Guyatt, Maureen O. Meade
Summary: The study suggests that combining low tidal volume with prone ventilation is associated with the greatest reduction in mortality for critically ill adults with moderate-to-severe ARDS.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Gerard Moreno, Raquel Carbonell, Ignacio Martin-Loeches, Jordi Sole-Violan, Eudald Correig Fraga, Josep Gomez, Manuel Ruiz-Botella, Sandra Trefler, Maria Bodi, Josefa Murcia Paya, Emili Diaz, Pablo Vidal-Cortes, Elisabeth Papiol, Antonio Albaya Moreno, Susana Sancho Chinesta, Lorenzo Socias Crespi, Maria Del Carmen Lorente, Ana Loza Vazquez, Rebeca Vara Arlanzon, Maria Teresa Recio, Juan Carlos Ballesteros, Ricard Ferrer, Elisabeth Fernandez Rey, Marcos Restrepo, Angel Estella, Antonio Margarit Ribas, Neus Guasch, Luis F. Reyes, Judith Marin-Corral, Alejandro Rodriguez
Summary: The effectiveness of corticosteroid treatment in ICU mortality among mechanically ventilated COVID-19-associated ARDS patients is inconclusive, with a potential short-term survival benefit observed in certain subgroups. Further research is needed to identify treatment-responsive subgroups among mechanically ventilated COVID-19-associated ARDS patients.
ANNALS OF INTENSIVE CARE
(2021)
Article
Critical Care Medicine
Martina Hermann, Daniel Laxar, Christoph Krall, Christina Hafner, Oliver Herzog, Oliver Kimberger, Sebastian Koenig, Felix Kraft, Mathias Maleczek, Klaus Markstaller, Oliver Robak, Bernhard Roessler, Eva Schaden, Peter Schellongowski, Mathias Schneeweiss-Gleixner, Thomas Staudinger, Roman Ullrich, Marion Wiegele, Harald Willschke, Christian Zauner, Alexander Hermann
Summary: This study aimed to investigate the influence of duration of invasive mechanical ventilation (IMV) prior to extracorporeal membrane oxygenation (ECMO) on ICU mortality in coronavirus disease 2019 (COVID-19) related acute respiratory distress syndrome (ARDS) patients. The results showed that the duration of IMV prior to ECMO cannulation did not affect survival. Therefore, the suitability of ECMO treatment should be assessed for COVID-19 related ARDS patients.
ANNALS OF INTENSIVE CARE
(2022)
Article
Medicine, General & Internal
Davide Chiumello, Andrea Meli, Tommaso Pozzi, Manuela Lucenteforte, Paolo Simili, Elda Sterchele, Silvia Coppola
Summary: This study assessed the effects of four different inspiratory flow waveforms in ARDS patients, finding that they did not provide relevant changes in oxygenation and respiratory mechanics.
JOURNAL OF CLINICAL MEDICINE
(2021)