Article
Chemistry, Medicinal
Jiayin Zhang, Chi-Kong Chan, Nikola M. Pavlovic, Wan Chan
Summary: This study investigated the effect of different nutrients, food additives, or health supplements on DNA adduct formation by aristolochic acid I (AA-I). It was found that cells cultured in media enriched with fatty acids, acetic acid, and amino acids produced ALI- dA adducts at significantly higher frequencies. On the other hand, the addition of sodium bicarbonate, GSH, and NAC reduced ALI-dA adduct formation rates. These findings provide insights into the impact of dietary habits on cancer and BEN development.
CHEMICAL RESEARCH IN TOXICOLOGY
(2023)
Article
Engineering, Environmental
Wanlin Guo, Jiayin Zhang, Zhihan Sun, William H. Orem, Calin A. Tatu, Niko S. Radulovic, Dragan Milovanovic, Nikola M. Pavlovic, Wan Chan
Summary: The study found significantly higher concentrations of PAHs and phthalate esters in maize and wheat samples from endemic villages in the Balkans. It warns of the potential risks of prolonged coexposure to these environmental contaminants through dietary intake, which may lead to greater toxicity and accelerated development of Balkan endemic nephropathy (BEN).
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Genetics & Heredity
Damir Dittrich, Marija Maskalan, Zeljko Kastelan, Hrvoje Palenkic, Zorana Grubic
Summary: This study found a positive association between the presence of HLA-B*35:02 and DRB1*04:02 alleles and BEN, while HLA-A*01:01, B*27:05, and B*57:01 alleles may have a protective effect. Additionally, certain HLA haplotypes were associated with BEN susceptibility among Croatians, indicating genetic susceptibility to the disease and the need for further studies to understand its pathogenesis.
Article
Biochemistry & Molecular Biology
Frantisek Barta, Alena Dedikova, Michaela Bebova, Sarka Duskova, Jaroslav Mraz, Heinz H. Schmeiser, Volker M. Arlt, Petr Hodek, Marie Stiborova
Summary: The exposure to AAI/AAII mixture may enhance AA-DNA adduct formation in rat livers and kidneys, partially due to inhibition of AAI detoxification and induction of NQO1. Additionally, AAII may act as an inhibitor of AAI detoxification, leading to increased AAI residues in liver and kidney tissues and enhanced AAI DNA adduct formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Liping Ma, Zhuowei Shen, Haihong Hu, Hui Zhou, Lushan Yu, Huidi Jiang, Su Zeng
Summary: The study demonstrated that co-administration with rhein significantly increased the plasma exposure of AAI and AAIa while decreasing their renal accumulation in rats. RP extract reduced the renal accumulation of AAI and AAIa, but had no significant effect on their plasma exposure levels in rats.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Hongjian Ji, Jingyin Hu, Guozhe Zhang, Jianxiang Song, Xiaohua Zhou, Dean Guo
Summary: This study conducted a scientometric analysis of global research literature on Aristolochic acid nephropathy (AAN), indicating the significant research topic in nephrology with a focus on the mechanisms of AA-induced nephropathy.
Article
Physiology
Aleix Navarro Garrido, Young Chul Kim, Yuji Oe, Haiyan Zhang, Maria Crespo-Masip, Helen A. Goodluck, Sadhana Kanoo, Paul W. Sanders, Stefan Broer, Volker Vallon
Summary: B0AT1 plays an important role in the retention of renal glucose and albumin, but may have adverse effects on kidney response following aristolochic acid-induced kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Biology
Chu-Kuang Chou, Yu-Shen Huang, Pei-Yu Lin, Kazuhiro Imai, Shih-Ming Chen, Jen-Ai Lee
Summary: This study revealed that Panax ginseng extract and ginsenoside saponin can significantly reduce renal injuries induced by aristolochic acid, with Rg(1) showing the best renoprotective effect among all GS-treated groups. The mechanism and renoprotective effects of Rg(1) were found to be associated with the expression of mitochondrial proteins, particularly ACO2, Usmg5, and COX5a.
Article
Oncology
Fan Lin, Yunqi Liu, Lili Tang, Xiaohui Xu, Xueli Zhang, Yifan Song, Bicheng Chen, Yeping Ren, Xiangdong Yang
Summary: The study demonstrated that rapamycin protects against aristolochic acid-induced nephropathy by activating the mTOR-autophagy axis. This finding provides evidence for rapamycin as a promising pharmacological target for the treatment of aristolochic acid nephropathy.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Medicine, General & Internal
Thomas Baudoux, Ines Jadot, Anne-Emilie Decleves, Marie-Helene Antoine, Jean-Marie Colet, Olivia Botton, Eric De Prez, Agnieszka Pozdzik, Cecile Husson, Nathalie Caron, Joelle L. Nortier
Summary: This review discusses the pathogenesis of aristolochic acid nephropathy (AAN) and its mechanisms of kidney damage. By reproducing human AAN in rodent models, the researchers have discovered the process of transition from acute kidney injury (AKI) to chronic kidney disease (CKD) and identified key factors involved in this transition. These findings are important for a better understanding of the complex AKI-to-CKD transition.
FRONTIERS IN MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Gordana Kocic, Mihajlo Gajic, Katarina Tomovic, Jovan Hadzi-Djokic, Marko Anderluh, Andrija Smelcerovic
Summary: Aristolochic acid nephropathy is a progressive disease leading to end-stage renal disease and malignancies. New insights are provided on the energy crisis induced by aristolochic acid and the potential links with known mechanisms.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qian Zhang, Piao Luo, Jiayun Chen, Chuanbin Yang, Fei Xia, Junzhe Zhang, Huan Tang, Dandan Liu, Liwei Gu, Qiaoli Shi, Xueling He, Tong Yang, Jigang Wang
Summary: This study reveals the targeting molecular mechanisms of AA-induced nephrotoxicity. Key enzymes involved in metabolic processes and mitochondrial respiration were found to be directly bound by AA, disrupting metabolic biosynthesis processes and impairing mitochondrial functions. This ultimately leads to renal cell apoptosis and the development of aristolochic acid nephropathy.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Zana Radic Savic, Vesna Coric, Stojko Vidovic, Vanja Vidovic, Jelena Becarevic, Irina Milovac, Zorica Reljic, Bosa Mirjanic-Azaric, Ranko Skrbic, Radoslav Gajanin, Marija Matic, Tatjana Simic
Summary: By analyzing the genotypes of 209 BEN patients and 140 controls, it was found that female patients carrying both variant GPX3 rs8177412 and MDR1 rs1045642 genotypes in combination showed a significant risk towards BEN. Furthermore, a significant association was determined between GPX3rs8174412 polymorphism and the risk for urothelial carcinoma. There was no individual or combined impact on BEN development and BEN-associated tumors among all examined polymorphisms. Therefore, BEN patients carrying variant GPX3 genotype should be more frequently monitored for possible upper tract urothelial carcinoma development.
MEDICINA-LITHUANIA
(2023)
Article
Immunology
Xiaoyan Wang, Ping Jia, Ting Ren, Zhouping Zou, Sujuan Xu, Yunlu Zhang, Yiqin Shi, Siyu Bao, Yingxiang Li, Yi Fang, Xiaoqiang Ding
Summary: This study reveals the involvement of miR-382 in macrophage activation during AA-induced kidney fibrosis. Knockout of miR-382 inhibits M2-like macrophage activation and kidney interstitial fibrosis, while overexpression of miR-382 promotes kidney injury. The findings highlight the important role of miR-382 in regulating kidney fibrosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kentaro Yamada, Tomoaki Takata, Takuji Iyama, Shintaro Hamada, Yukari Mae, Takaaki Sugihara, Hajime Isomoto
Summary: This study investigated the feasibility of urinary fluorescence imaging using enzyme-activatable probes for differentiating diabetic kidney disease and other glomerular diseases. The results showed that urinary fluorescence was significantly stronger in patients with diabetic kidney disease compared to those with glomerulonephritis/nephrosclerosis after DPP-HMRG, and stronger in patients with nephrosclerosis than in patients with glomerulonephritis after GGT-HMRG. Subgroup analyses of patients with diabetes showed consistent results. This suggests that urinary fluorescence imaging using enzyme-activatable probes could be a noninvasive assessment technique for kidney diseases in patients with diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
Sladjana Ugrenovic, Ivan Jovanovic, Ljiljana Vasovic, Braca Kundalic, Rade Cukuranovic, Vladisav Stefanovic
ANATOMICAL SCIENCE INTERNATIONAL
(2016)
Article
Anatomy & Morphology
Slobodan Vlajkovic, Ljiljana Vasovic, Milena Trandafilovic, Ivan Jovanovic, Sladana Ugrenovic, Gordana Dordevic
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2015)
Article
Cardiac & Cardiovascular Systems
Ruzica Jankovic-Tomasevic, Sinisa U. Pavlovic, Tatjana Jevtovic-Stoimenov, Svetlana Apostolovic, Dragana Stanojevic, Ivan Jovanovic, Goran Koracevic, Danijela Djordjevic-Radojkovic, Miodrag Damjanovic, Sonja Salinger-Martinovic, Milan Pavlovic
Article
Medicine, Research & Experimental
Milica Veljkovic, Dragana R. Pavlovic, Nenad Stojiljkovic, Sonja Ilic, Aleksandar Petrovic, Ivan Jovanovic, Mirjana Radenkovic
Article
Chemistry, Medicinal
Milica Veljkovic, Dragana R. Pavlovic, Nenad Stojiljkovic, Sonja Ilic, Ivan Jovanovic, Natasa Poklar Ulrih, Violeta Rakic, Ljubinka Velickovic, Dusan Sokolovic
PHYTOTHERAPY RESEARCH
(2017)
Article
Anatomy & Morphology
Sladjana Petrovic, Ivan Jovanovic, Sladjana Ugrenovic, Zoran Radovanovic, Zoran Pesic, Ivica Vuckovic, Nikola Stojkovic, Filip Petrovic
SURGICAL AND RADIOLOGIC ANATOMY
(2017)
Article
Anatomy & Morphology
Sladjana Petrovic, Ivan Jovanovic, Sladjana Ugrenovic, Zoran Radovanovic, Zoran Pesic, Ivica Vuckovic, Nikola Stojkovic, Filip Petrovic
SURGICAL AND RADIOLOGIC ANATOMY
(2017)
Article
Anatomy & Morphology
Jovana Cukuranovic Kokoris, Ivan Jovanovic, Vukica Pantovic, Miljan Krstic, Milica Stanojkovic, Verica Milosevic, Sladana Ugrenovic, Vesna Stojanovic