Review
Biochemistry & Molecular Biology
Maria Bogdan, Andreea-Daniela Meca, Adina Turcu-Stiolica, Carmen Nicoleta Oancea, Roxana Kostici, Marin Valeriu Surlin, Cristina Florescu
Summary: Cancer is a leading cause of death worldwide, but can be cured if detected early and treated effectively. Chronic inflammation and angiogenesis promote tumor development through metabolic dysregulation, while appropriate immune response limits tumor growth. Pentraxin-3 (PTX-3), a member of the long pentraxin subfamily, plays a crucial role in regulating inflammation, immune response, angiogenesis, and tissue remodeling. PTX-3 has both pro- and anti-tumor functions, making it a potential biomarker for cancer diagnosis, prognosis, and treatment monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Damiano Chiari, Barbara Pirali, Vittoria Perano, Roberto Leone, Alberto Mantovani, Barbara Bottazzi
Summary: This article investigates the role of long pentraxin 3 (PTX3) in immune dysregulation, tissue remodeling, and oncogenesis, and finds that PTX3 may be a common factor underlying nodular thyroid disease, thyroid cancer, and autoimmune thyroid disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Kaluzna, Agnieszka Jura-Poltorak, Alicja Derkacz, Krystyna Olczyk, Katarzyna Komosinska-Vassev
Summary: This case-control study aimed to identify novel biomarkers for Crohn's disease (CD) and found significant differences in serum concentrations of proguanylin (pro-GN), pentraxin 3 (PTX3), and S100A12 between CD patients and healthy individuals. The serum profile of PTX3 was also correlated with disease activity and treatment response. These findings suggest that measuring pro-GN, PTX3, and S100A12 could be beneficial for the diagnosis and monitoring of CD.
Article
Biochemistry & Molecular Biology
Cheng Qiu, Jingwei Liu, Jinghang Li, Derun Di, Manyu Li, Tianyi Liu, Xinyu Wang, Yunpeng Zhao, Lianlei Wang, Xinyu Liu
Summary: The study found that Pentraxin 3 (PTX3) plays an important role in osteoarthritis, and Ptx3 knockout can alleviate cartilage degeneration and reduce systemic inflammation. This research is of great significance for understanding the mechanism of osteoarthritis and finding new treatment strategies.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Pharmacology & Pharmacy
Yinghui Wang, Lu Gao
Summary: Chronic kidney disease and cardiac insufficiency often co-exist, especially in uremic patients on hemodialysis. Impaired renal function is often indicative of poor prognosis in patients with cardiac insufficiency. Inflammation plays a significant role in the development of cardiovascular complications in patients with chronic kidney disease and is indicative of prognosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Immunology
Lina Wirestam, Sofia Pihl, Muna Saleh, Jonas Wettero, Christopher Sjowall
Summary: This study aimed to determine pregnancy-specific reference intervals for CRP and PTX3, finding that these two markers are correlated during pregnancy and both increase in the third trimester. Elevations of CRP and PTX3 during the later phase of pregnancy may occur in the absence of infection, highlighting the importance of considering pregnancy-specific reference values.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Clinical Neurology
Yuta Kojima, Akiyuki Uzawa, Yukiko Ozawa, Manato Yasuda, Yosuke Onishi, Hiroyuki Akamine, Naoki Kawaguchi, Keiichi Himuro, Yu-ichi Noto, Toshiki Mizuno, Satoshi Kuwabara
Summary: This study investigated whether circulating PTX3 is a useful biomarker for assessing disease activity in myasthenia gravis (MG). Although there was no significant difference in serum PTX3 levels between MG patients and controls, PTX3 moderately correlated with disease severity scores, suggesting its potential involvement in the pathogenesis of MG.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Immunology
Uri Rozovski, Ivo Veletic, David M. Harris, Ping Li, Zhiming Liu, Preetesh Jain, Taghi Manshouri, Alessandra Ferrajoli, Jan A. Burger, Prithviraj Bose, Phillip A. Thompson, Nitin Jain, William G. Wierda, Srdan Verstovsek, Michael J. Keating, Zeev Estrov
Summary: This study suggests that CLL cells can produce high levels of PTX3, and phosphorylated STAT3 can transcriptionally activate the PTX3 gene. Inhibition of PTX3 may be beneficial for CLL patients.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Heng-Cheng Tsai, Shuo-Ming Ou, Chih-Cheng Wu, Chin-Chou Huang, Jyh-Tong Hsieh, Po-Yu Tseng, Chiu-Yang Lee, Chih-Yu Yang, Der-Cherng Tarng
Summary: Plasma levels of pentraxin 3 (PTX3) are associated with the risk of arteriovenous fistula (AVF) functional patency loss and mortality in chronic hemodialysis patients.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Pablo E. Pergola, Matt Devalaraja, Steven Fishbane, Michel Chonchol, Vandana S. Mathur, Mark T. Smith, Larry Lo, Kurt Herzog, Rahul Kakkar, Michael H. Davidson
Summary: Ziltivekimab significantly improved markers of inflammation, reduced ESA requirements, and increased serum albumin in hemodialysis patients with inflammation and hyporesponsiveness to ESA therapy.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Kejun Ding, Zhewei Shi, Caizhen Qian, Xuan Yang
Summary: This meta-analysis found that higher plasma levels of pentraxin-3 (PTX-3) are associated with increased risk of mortality and major adverse cardiovascular events (MACEs) in patients with coronary artery disease (CAD). This association is consistent across different CAD subtypes, follow-up durations, and whether or not C-reactive protein (CRP) is adjusted for.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Shi-Yang Guan, Yuting Chen, Ming Shao, Hui Yang, Wei Xu, Zongwen Shuai, Hui Zhao, Dahai Zhao, Faming Pan
Summary: Circulating PTX3 levels are significantly increased in rheumatoid arthritis (RA) patients and are influenced by factors such as age, disease activity, inflammatory markers, and disease duration.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Multidisciplinary Sciences
Susana Rocha, Maria Joao Valente, Susana Coimbra, Cristina Catarino, Petronila Rocha-Pereira, Jose Gerardo Oliveira, Jose Madureira, Joao Carlos Fernandes, Maria Do Sameiro-Faria, Vasco Miranda, Luis Belo, Alice Santos-Silva, Elsa Bronze-da-Rocha
Summary: Chronic inflammation plays a crucial role in chronic kidney disease, with IL6 and PTX3 levels associated with disease progression and cardiovascular events in CKD patients. The study focused on specific polymorphisms of IL6 and PTX3 genes in ESRD patients on dialysis, revealing IL6 polymorphism linked to higher inflammatory markers and mortality risk, while PTX3 polymorphism showed an association with inflammatory response but no significant impact on mortality. This highlights the importance of genetic variants in modulating inflammatory response and patient outcomes in ESRD.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Giuseppe Lapadula, Roberto Leone, Davide Paolo Bernasconi, Andrea Biondi, Emanuela Rossi, Mariella D'Angio, Barbara Bottazzi, Laura Rachele Bettini, Ilaria Beretta, Cecilia Garlanda, Maria Grazia Valsecchi, Alberto Mantovani, Paolo Bonfanti
Summary: The study assessed the prognostic value of PTX3 in patients hospitalized with COVID-19. The results showed that high levels of PTX3 were associated with a worse outcome, and the evaluation of this marker could be useful in prognostic stratification and identification of patients who could benefit from immunomodulant therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anna Paola Capra, Lelio Crupi, Giuseppe Panto, Alberto Repici, Fabrizio Calapai, Raffaele Squeri, Alessio Ardizzone, Emanuela Esposito
Summary: According to this study, Pentraxin 3 (PTX3) may serve as a valuable biomarker for assessing the severity of COVID-19 and systemic inflammatory responses. The research found elevated levels of PTX3 and other inflammatory proteins in previously infected COVID-19-positive individuals. Gender was also found to influence the severity of the disease, with higher levels of PTX3 in males compared to females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)