Article
Physiology
Ramon Paniagua, Elvia Garcia-Lopez, Marcela Avila-Diaz, Maria-de-Jesus Ventura, Oscar Orihuela, Maria-del-Carmen Prado-Uribe, Juan-Manuel Gallardo-Montoya, Bengt Lindholm
Summary: During peritoneal dialysis treatment with icodextrin solutions, females show higher levels of icodextrin metabolites in serum, which may lead to an increase in blood volume and blood pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Yiping Xu, Zhong Zhong, Yi Li, Zhijian Li, Yi Zhou, Zhibin Li, Haiping Mao
Summary: The study investigated the effects of baseline fasting plasma glucose (FPG) and its interaction with lipid profiles on all-cause and cardiovascular disease (CVD) cause-specific mortality in peritoneal dialysis (PD) patients. The results showed a significant interaction between baseline FPG and low-density lipoprotein cholesterol (LDL-C) on all-cause mortality, with higher FPG levels (>= 7.0 mmol/L) significantly associated with an increased risk of all-cause mortality for PD patients with LDL-C >= 3.37 mmol/L.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Xingyun Zhu, Chu Lin, Li Li, Suiyuan Hu, Xiaoling Cai, Linong Ji
Summary: SGLT2 inhibitors treatment increases plasma fasting glucagon levels in patients with diabetes, potentially leading to reduced insulin levels and elevated ketone body levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Francesca Piccapane, Mario Bonomini, Giuseppe Castellano, Andrea Gerbino, Monica Carmosino, Maria Svelto, Arduino Arduini, Giuseppe Procino
Summary: The novel formulation of dialytic solutions, replacing a substantial amount of glucose with xylitol and l-carnitine, shows better performance in terms of higher cell viability, better preservation of the integrity of the mesothelial layer, and reduced release of pro-inflammatory cytokines. This new formulation could represent a step forward towards obtaining PD solutions with high biocompatibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Rebecca Herzog, Juan Manuel Sacnun, Guadalupe Gonzalez-Mateo, Maria Bartosova, Katarzyna Bialas, Anja Wagner, Markus Unterwurzacher, Isabel J. Sobieszek, Lisa Daniel-Fischer, Krisztina Rusai, Lucia Pascual-Anton, Klaus Kaczirek, Andreas Vychytil, Claus Peter Schmitt, Manuel Lopez-Cabrera, Seth L. Alper, Christoph Aufricht, Klaus Kratochwill
Summary: Adding lithium chloride to peritoneal dialysis fluid can improve mesothelial cell survival, reduce angiogenesis and fibrosis, and provide a translatable intervention to counteract peritoneal membrane deterioration during PD therapy. This study identified a potential therapeutic strategy in repurposing LiCl as a cytoprotective PDF additive to combat PD-induced mesothelial cytotoxicity.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Joanna Stachowska-Pietka, Beata Naumnik, Ewa Suchowierska, Rafael Gomez, Jacek Waniewski, Bengt Lindholm
Summary: It was found in the study that patients on automated peritoneal dialysis with a dry day experienced lower ultrafiltration during initial exchanges, likely due to inflow of water into peritoneal tissue leading to increased hydration.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Jose Emilio Sanchez, Catalina Ulloa, Carmen Merino Bueno, Elena Astudillo, Carmen Rodriguez-Suarez
Summary: The aim of this study was to evaluate the impact of PD strategy on technique and patient survival. The results showed that the use of APD and APD/icodextrin had a positive impact on patient survival, while age and Charlson Index had a negative impact. Age and early peritoneal infection also significantly impacted technique survival.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
David A. Jaques, Andrew Davenport
Summary: The study found that factors such as fast transport type, serum sodium levels, and diabetes were positively associated with sodium to water clearance, while PD mode and the use of 2.27% glucose dialysate were negatively associated. This indicates that CAPD, fast transport, and high serum sodium levels may allow more sodium to be removed compared to water.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Hematology
Guido Filler, Aaron Haig, Neil Merritt, Ana Catalina Alvarez-Elias, Chia Wei Teoh, Timm Joachim Filler, Maria Esther Diaz-Gonzalez de Ferris
Summary: Peritoneal biopsies in pediatrics with long-term PD using physiological solutions showed significant histopathological changes, indicating that avoiding pH trauma may not completely ameliorate the effects of glucose exposure.
BLOOD PURIFICATION
(2022)
Review
Biochemistry & Molecular Biology
Mario Bonomini, Valentina Masola, Giuseppe Procino, Victor Zammit, Jose C. Divino-Filho, Arduino Arduini, Giovanni Gambaro
Summary: Peritoneal dialysis is an important but underutilized treatment for patients with end-stage kidney disease. Current glucose-based PD solutions can have deleterious effects on the peritoneal membrane, leading to fibrosis. New generation PD solutions aim to optimize biochemical processes within the peritoneal membrane to improve clinical outcomes and metabolic profiles of patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Han Shi, Yusong Ge, Hongming Wang, Yun Zhang, Weiyu Teng, Li Tian
Summary: The study revealed a positive relationship between fasting blood glucose and stroke risk, with a non-linear dose-response association. In non-diabetic populations, the association between high fasting blood glucose and stroke risk was lower compared to the general population.
CLINICAL NUTRITION
(2021)
Article
Immunology
Tara E. Sutherland, Tovah N. Shaw, Rachel Lennon, Sarah E. Herrick, Dominik Rueckerl
Summary: Peritoneal dialysis initially benefits patients with chronic kidney disease, but long-term use may lead to significant pathology, increasing the risk of infection and inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Transplantation
Ines P. D. Costa, Nicolas Hautem, Gugliemo Schiano, Shinichi Uchida, Tomoya Nishino, Olivier Devuyst
Summary: The study reveals that AQP1 and AQP7 are abundantly expressed in the peritoneal membrane. While AQP1 facilitates water transport during peritoneal dialysis, the role of AQP7 in glycerol transport during fasting is unknown. The findings show that fasting increases the expression of AQP1 and AQP7 in the peritoneum, leading to structural and functional changes that improve fluid removal.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Ri Liu, Lishu Gao, Lu Guo, Wenqi Xu, Shouling Wu, Dehu Tian
Summary: This study investigates the impact of FPG variability on osteoporotic fractures in the community population. By analyzing participants from three consecutive surveys, it is found that increased FPG variability is associated with an increased risk of osteoporotic fractures.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Valeria Cernaro, Michela Calderone, Guido Gembillo, Vincenzo Calabrese, Chiara Casuscelli, Claudia Lo Re, Elisa Longhitano, Domenico Santoro
Summary: Hyperphosphatemia is a common complication in advanced chronic kidney disease and can lead to cardiovascular morbidity and mortality. This review focuses on the management of phosphatemia in uremic patients receiving peritoneal dialysis. The control of serum phosphate in peritoneal dialysis patients is influenced by various factors such as patient transporter characteristics, peritoneal dialysis modalities, prescriptions, and diet. There is a need for more clinical trials specifically designed for peritoneal dialysis patients to evaluate the effects of multiple therapeutic approaches on serum phosphate control and clinical outcomes.