Review
Pharmacology & Pharmacy
Siu Kan Law, Yanping Wang, Xinchen Lu, Dawn Ching Tung Au, Wesley Yeuk Lung Chow, Albert Wing Nang Leung, Chuanshan Xu
Summary: Obesity is a global health threat and traditional Chinese medicine offers a potential solution, but there are still challenges that need to be addressed. Prodrugs could help overcome the deficiencies and provide insights for designing effective treatments for obesity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Run Jin, Aidan Kai Yeung Chan, Jingsong Wu, Tatia Mei Chun Lee
Summary: The review discusses the potential mechanisms and strategies for ameliorating age-related neurocognitive changes associated with inflammation, providing important insights for understanding the pathophysiological mechanisms of neurocognitive disorders and developing preventative measures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Angelica Varesi, Lucrezia Irene Maria Campagnoli, Annalisa Barbieri, Lorenzo Rossi, Giovanni Ricevuti, Ciro Esposito, Salvatore Chirumbolo, Nicoletta Marchesi, Alessia Pascale
Summary: Aging is a major risk factor for various diseases. Understanding the molecular mechanisms and discovering new therapies for aging-related diseases are crucial, as the population continues to age exponentially.
AGEING RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Darya V. Telegina, Oyuna S. Kozhevnikova, Anna K. Antonenko, Nataliya G. Kolosova
Summary: Age-related macular degeneration (AMD) is a complex neurodegenerative disease that often leads to irreversible blindness in the elderly. The pathogenesis of AMD, particularly its dry type, is not fully understood. In recent years, AMD has been increasingly detected in younger individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Luka Culig, Xixia Chu, Vilhelm A. Bohr
Summary: Adult neurogenesis is a potential target for extending cognitive healthspan, as aging is a major risk factor for neurodegenerative diseases. This review describes the role of adult neurogenesis in neurodegenerative diseases and discusses the molecular mechanisms involving key proteins. Interventions that increase neurogenesis and regulate aging research targets are summarized, and the outlook for restoring neurogenesis levels in elderly individuals and those with neurodegeneration is shared.
AGEING RESEARCH REVIEWS
(2022)
Review
Geriatrics & Gerontology
Michael R. Duggan, Anne Lu, Thomas C. Foster, Mathieu Wimmer, Vinay Parikh
Summary: Aging is a significant risk factor for cognitive decline, but the extent and underlying neurobiology can vary between individuals. Recent developments in analyzing exosomes have improved our understanding of the molecular and cellular mechanisms contributing to cognitive variation in aging. It holds promise for predicting cognitive trajectories and improving functional outcomes for the elderly.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Shan Shan Lei, Jie Su, Yang Zhang, Xiao Wen Huang, Xu Ping Wang, Min Cong Huang, Bo Li, Dan Shou
Summary: Polysaccharides from Chinese medicinal herbs exhibit anti-osteoporosis effects by balancing bone resorption and bone formation, particularly in the treatment of postmenopausal osteoporosis. These polysaccharides modulate various signaling pathways, such as the Wnt/beta-catenin signaling pathway, contributing to the improvement of bone homeostasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Vladimir Sukhorukov, Dmitry Voronkov, Tatiana Baranich, Natalia Mudzhiri, Alina Magnaeva, Sergey Illarioshkin
Summary: Aging is associated with cognitive decline due to accumulated damage to brain cells, with mitophagy playing a crucial role in managing mitochondrial quality and quantity. Mitophagy defects contribute to aging and age-related diseases, highlighting potential therapeutic targets for neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Mamta Rai, Michelle Curley, Zane Coleman, Fabio Demontis
Summary: Protein quality control is crucial for cellular homeostasis and health, with proteases playing a key role in this process. Proteases impact aging and age-related neurodegeneration by regulating various cellular functions and pathogenic protein degradation or generation.
Review
Biochemistry & Molecular Biology
Margarita-Elena Papandreou, Nektarios Tavernarakis
Summary: Progressive accumulation of damaged cellular constituents contributes to age-related diseases. Autophagy is the main catabolic process, which recycles cellular material in a multitude of tissues and organs. Autophagy is activated upon various stimuli and involves precise interactions between receptors or adaptors and substrates to maintain specificity and accuracy. Polymorphisms in genes regulating selective autophagy have been linked to aging and age-associated disorders, suggesting potential therapeutic interventions to alleviate cellular autophagic cargo burden and associated pathologies.
Article
Cell Biology
Silas A. Buck, Thomas Steinkellner, Despoina Aslanoglou, Michael Villeneuve, Sai H. Bhatte, Victoria C. Childers, Sophie A. Rubin, Briana R. De Miranda, Emma O'Leary, Elizabeth G. Neureiter, Keri J. Fogle, Michael J. Palladino, Ryan W. Logan, Jill R. Glausier, Kenneth N. Fish, David A. Lewis, J. Timothy Greenamyre, Brian D. McCabe, Claire E. J. Cheetham, Thomas S. Hnasko, Zachary Freyberg
Summary: The study revealed the impact of age and sex differences on dopamine neuron vulnerability, with males exhibiting greater decreases in neuron number and locomotion during aging, and dynamic changes in VGLUT expression in dopamine neurons possibly serving as a compensatory mechanism. Female fruit flies were found to possess higher levels of VGLUT expression in dopamine neurons compared to males, and diminishing VGLUT expression eliminated their greater resilience to neuron loss. Optimal control over VGLUT expression in dopamine neurons was identified as essential for neuron survival and a potential therapeutic target for age- and PD-related neurodegeneration.
Article
Neurosciences
Subhashini Brahadeeswaran, Narmadhaa Sivagurunathan, Latchoumycandane Calivarathan
Summary: Inflammasomes are important protein complexes in cells that play a critical role in maintaining homeostasis and responding to stimuli. Their activation leads to inflammation, cell death, and neuroinflammation, which are associated with aging and neurodegenerative diseases.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Consuelo Arias, Belgica Vasquez, Luis A. Salazar
Summary: Aging is linked to chronic low-grade systemic inflammation, and propolis, known for its antioxidant and anti-inflammatory properties, has the potential to alleviate age-induced changes in cartilage and osteoarthritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Young Gun Park, Yong Soo Park, In-Beom Kim
Summary: Age-related macular degeneration (AMD) is a complex disease characterized by neovascularization or geographic atrophy. The complement system plays a crucial role in AMD and has become a therapeutic target. Further research is needed to fully understand the mechanism of complement disease propagation in AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Sonali Nashine
Summary: This article discusses the contribution of aging to ocular diseases such as AMD, and introduces potential therapeutic candidates for AMD along with their known mechanisms of cytoprotection.
Article
Geriatrics & Gerontology
Liping Ai, Fan Yang, Jie Song, Yan Chen, Lingyun Xiao, Qiangqiang Wang, Liangyi Wang, Haifeng Li, Tao Lei, Zebo Huang
REJUVENATION RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Haifeng Li, Linnan Su, Sheng Chen, Libin Zhao, Hongyu Wang, Fei Ding, Hong Chen, Ruona Shi, Yulan Wang, Zebo Huang
Article
Geriatrics & Gerontology
Yahui Ding, Zhiyang Zhang, Zhongbao Yue, Liugang Ding, Yong Zhou, Zebo Huang, Hongliang Huang
REJUVENATION RESEARCH
(2019)
Article
Food Science & Technology
Kun-Ping Li, Min Yuan, Zhuo-Ru He, Qi Wu, Chu-Mei Zhang, Zhi-Li Lei, Xiang-Lu Rong, Zebo Huang, Jeremy E. Turnbull, Jiao Guo
MOLECULAR NUTRITION & FOOD RESEARCH
(2019)
Article
Geriatrics & Gerontology
Lingyun Xiao, Haifeng Li, Jing Tian, Nanxiang Jin, Ju Zhang, Fan Yang, Ling Zhou, Qiangqiang Wang, Zebo Huang
REJUVENATION RESEARCH
(2020)
Article
Plant Sciences
Wanwan Zhang, Yifang Wei, Xiaoxiao Cao, Kaixin Guo, Qiangqiang Wang, Xiaochun Xiao, Xufeng Zhai, Dingding Wang, Zebo Huang
Summary: The Crassostrea oyster peptide preparation COP3 has shown promising effects in increasing testosterone and cAMP levels in male mice, enhancing NOS activity in the penile region, and stimulating testosterone and NO production in Leydig-derived cells. Its upregulation of genes associated with sex hormone secretion pathways and a conserved steroidogenic enzyme suggests its potential in addressing erectile dysfunction.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Guohuan Zhong, Wenfeng Pan, Ziliang Huang, Kaixin Guo, Jingjing Hu, Peihua Liu, Sheng Chen, Yulan Wang, Liping Ai, Zebo Huang
Summary: This study revealed distinct physicochemical and biofunctional properties of N. sphaeroides polysaccharides during colony growth stages, with a significant decrease in high/low molecular weight ratio. Both polysaccharides and oligosaccharides demonstrated antioxidant activities, while only oligosaccharides showed neuroprotective effects, suggesting their potential as novel geroprotectors. Additionally, oligosaccharides were found to upregulate stress and proteostasis-associated genes in C. elegans.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Cell Biology
Meng Lu, Ajay Mishra, Chiara Boschetti, Jing Lin, Yushuang Liu, Hongliang Huang, Clemens F. Kaminski, Zebo Huang, Alan Tunnacliffe, Gabriele S. Kaminski Schierle
Summary: Sea cucumber peptides exhibit antioxidant activity, alleviating oxidative stress at both cellular and organism levels, and may be attractive as nutritional supplements for healthy ageing.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Integrative & Complementary Medicine
Sutticha Ruangchuay, Qiang-qiang Wang, Liang-yi Wang, Jing Lin, Yong-chao Wang, Guo-huan Zhong, Katesarin Maneenoon, Ze-bo Huang, Sasitorn Chusri
Summary: Supplementation with THP-R-SR012 decoction significantly increased the mean lifespan and reduced the oxidative damage to C. elegans under oxidative stress conditions. Furthermore, THP-R-SR012 supplementation slightly influenced the lifespan and the level of lipofuscin accumulation during adulthood. Antioxidant-related phytochemical constituents of THP-R-SR012 decoction were identified.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Chemistry, Applied
Dansi Huang, Chao Li, Qing Chen, Xing Xie, Xiong Fu, Chun Chen, Qiang Huang, Zebo Huang, Hao Dong
Summary: Rosa roxburghii Tratt pomace (RRTP) was extracted to obtain free and bound phenolic fractions, which showed dose-dependent scavenging of radicals and improved survival rates in paraquat-exposed nematodes by enhancing SOD and CAT activities. These results suggest RRTP as a good and cost-effective source of natural antioxidants.
Review
Food Science & Technology
Yuqing Wang, Kaixin Guo, Qiangqiang Wang, Guohuan Zhong, Wenjun Zhang, Yiyi Jiang, Xinliang Mao, Xiaomin Li, Zebo Huang
Summary: This article discusses the pros and cons of using Caenorhabditis elegans as a dietary model and provides an overview of its experimental strengths and recent advances in nutritional studies. It also reviews the current challenges and potential solutions for using C. elegans as a nutritional model, and outlines future perspectives for the development of chemically defined nematode food.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Editorial Material
Pharmacology & Pharmacy
Zebo Huang, Long Ma, Ajay Mishra, Jeremy E. Turnbull, Haijun Tu
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Peihua Liu, Jingjing Hu, Qiangqiang Wang, Jianhua Tan, Jian Wei, Hongbo Yang, Shuping Tang, Hongliang Huang, Yongdong Zou, Zebo Huang
Summary: This study aims to investigate the feasibility of isolating water-soluble biopolymers from seaweed hydrothermal waste and their potential applications. Efficient isolation of polymeric substances from Saccharina japonica blanching water was achieved, showing the coproduction potential of biopolymers from blanching wastewater. The resulting biopolymers were found to have polysaccharidic nature with distinct structural features and demonstrated compatibility and freshness when used in cosmetic creams.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Kaixin Guo, Linnan Su, Yongchao Wang, Huihui Liu, Jing Lin, Peng Cheng, Xiquan Yin, Ming Liang, Qiangqiang Wang, Zebo Huang
Article
Chemistry, Medicinal
Xuesong Yu, Dake Gao, Bing Qi, Xiaochun Xiao, Xufeng Zhai, Chung Wah Ma, Qiangqiang Wang, Zebo Huang
PHARMACOGNOSY MAGAZINE
(2018)
