Article
Polymer Science
Monica Penas-Caballero, Enrico Chemello, Antonio Mattia Grande, Marianella Hernandez Santana, Raquel Verdejo, Miguel A. A. Lopez-Manchado
Summary: Self-healing materials offer a potential solution to the problem of damage to fibre-reinforced plastics (FRPs). By using poly(methyl methacrylate) (PMMA) as a self-healing agent, the study explores its effectiveness when blended with the matrix or applied as a coating to carbon fibres. The results show that blending strategy does not enable healing capacity, while coating the fibres with PMMA achieves up to 53% fracture toughness recovery.
Article
Medicine, Research & Experimental
Derek S. Frank, Prateek Prasad, Luca Iuzzolino, Luke Schenck
Summary: Amorphous solid dispersions (ASDs) are an effective formulation approach for improving the dissolution of hydrophobic pharmaceuticals. However, the application of weakly basic compounds in ASDs can be complicated due to their pH-dependent solubility. This study investigated the release mechanisms of ASDs containing weakly basic pharmaceuticals and compared their dissolution behavior with ASDs stabilized by acidic and neutral polymers. The results showed that the dissolution behavior of the ASDs was sensitive to the initial pH of the gastric media, and the use of a basic polymeric stabilizer had both benefits and liabilities for the release of weakly basic pharmaceuticals.
MOLECULAR PHARMACEUTICS
(2022)
Article
Pharmacology & Pharmacy
Nirali G. Patel, Sabrina Banella, Abu T. M. Serajuddin
Summary: Moisture sorption by different polymers used in amorphous solid dispersion (ASD) was investigated, and the effects of moisture on glass transition temperatures (Tg) of the polymers were determined. Among the polymers studied, Eudragit (R) EPO exhibited the least hygroscopicity, while the other three polymers absorbed more moisture. The apparent Tg of the polymers decreased with increasing moisture content, but remained higher than the usual storage temperature of ASD, indicating minimal impact on the physical stability of ASD.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Polymer Science
Roberto Lopez-Munoz, Raul Guillermo Lopez, Hened Saade, Angel Licea-Claverie, Francisco Javier Enriquez-Medrano, Graciela Morales, Daniel Grande
Summary: A drug-loaded electrospun mat has been found to have potential for cancer treatment after surgery. Using a semi-continuous heterophase polymerization method, a methacrylic copolymer called P(MMA-co-MAA) was synthesized as a carrier for the anticancer drug doxorubicin hydrochloride (DOX). Confocal microscopy images indicated that the copolymer was more effective at incorporating the drug than the ES100 nanofibers. The in-vitro release profiles showed that the synthesized copolymer had a lower release rate compared to the ES100 copolymer, suggesting its potential for sustained and prolonged drug release.
Article
Nanoscience & Nanotechnology
Bumjun Kim, Dawei Zhang, Madeleine S. Armstrong, Istvan Pelczer, Robert K. Prud'homme
Summary: This study investigates the use of methacrylate-based anionic copolymers (MACs) as stabilizers for nanoparticles and their impact on nanoparticle assembly. The size of the nanoparticles can be controlled by adjusting the degree of neutralization, ionic strength, total mass concentration, and the core-to-MAC ratio. The size of the nanoparticles is determined by the volume of hydrophilic domains on the surface relative to the volume of hydrophobic domains in the core. The results of this study are applicable to both high-molecular-weight polymers and small-molecule drugs.
ACS APPLIED NANO MATERIALS
(2022)
Article
Polymer Science
Guangchang Lian, Kaibo Hu, Meng Zhou, Ying Liu, Guofan Jin
Summary: In this study, curcumin and pyrimidine derivatives were successfully combined and encapsulated with different types of Eudragit((R)) for improving their solubility and optical properties. UV-vis and fluorescence tests were conducted to observe the optical properties of the complexes in human body fluid. The results showed that the emission wavelength of the complexes varied with pH value. TEM results demonstrated uniform wrapping of CP-2 compound by polymer materials, with moderate particle size that could be absorbed by cells. Molecular docking results indicated hydrogen bond as the main force between compounds and proteins. This study aims to provide new ideas for the development of antitumor fluorescent agents and gastrointestinal targeted drug delivery.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Dinesh Choudhury, Upadhyayula Suryanarayana Murty, Subham Banerjee
Summary: This study focused on extruding a brittle, tacky, cationic copolymer to prepare filament for 3D printing of hollow capsular devices. The printed capsules demonstrated soluble behavior in gastric fluid and prolonged swelling behavior in phosphate buffer solution, indicating potential applications for gastric and intestinal specific delayed drug delivery. Enteric coating of the printed capsules showed similar behavior to non-enteric capsules, suggesting a simple and effective process for delayed drug delivery.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nicole Fulopova, Sylvie Pavlokova, Ivan DeBono, David Vetchy, Ales Franc
Summary: Pharmaceutical technology offers options for protecting substances from acidic environments, but preparing small enteric batches suitable for clinical use is still an unsolved problem. This experiment offers a simple coating process of DRcaps(TM) capsules for small intestine administration and compares them to hard gelatin capsules.
Article
Pharmacology & Pharmacy
Keita Kondo, Sayaka Ohta, Toshiyuki Niwa
Summary: The aim of this study was to produce sustained-release tablets without using solvents or heating. By modifying the structure of the polymer particles using sodium lauryl sulfate, it was found that a surfactant ratio of 5% resulted in the most effective coating, while a ratio of 10% reduced the coating efficiency.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Ahmet Dogan Ergin, Zerrin Sezgin Bayindir, Arif Tanju Ozcelikay, Nilufer Yuksel
Summary: Nanoparticles-in-microparticles (NIMs) are a new drug delivery system that combines nano- and micro-sized drug carriers for improved drug bioavailability or targeted delivery. The study focused on a pectin nanoparticle based NIM formulation for colon targeted delivery of SAMe, showing advantages in delayed drug release and increased oral bioavailability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Chemistry, Applied
Anjana Dhar, Dhruba J. Haloi
Summary: PMMA-b-PEG-b-PMMA block copolymer was synthesized by ARGET-ATRP, and its structure was validated by FT-IR, NMR, and MALDI-TOF mass analysis. The results showed that the prepared block copolymer exhibited better thermal stability.
INDIAN JOURNAL OF CHEMICAL TECHNOLOGY
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
P. Mohamed Ashfaque, K. Abdul Wasi, K. Mohammed Rehan, J. Sathish Banarji, S. Mohammed Safiullah, K. Anver Basha
Summary: In this study, a copolymer was synthesized and its properties were enhanced by adding nanofillers. The polymer nanocomposites were extensively characterized and the optical characteristics and corrosion resistance were evaluated.
MATERIALS TODAY-PROCEEDINGS
(2022)
Article
Polymer Science
Dibyendu S. Bag, Shilpi Tiwari, Akansha Dixit, KM. Meenu
Summary: This paper investigates the microstructure and the influence of H-bonding on the thermal behavior of chiral copolymers. The results show that the increase in chiral unit content enhances the glass transition temperature, reaching an optimum value at around 25 mole% of chiral content, and then decreases with further increase in chiral content. The study also reveals that the secondary interaction, specifically H-bonding, plays a significant role in the thermal properties of these copolymers. The thermal degradation of the copolymers occurs in three stages, with the first and third stages associated with the chiral comonomer (R-NPEMAM) and the second stage indicating degradation due to the HEMA unit present in the copolymer chain.
JOURNAL OF POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jeyhun Hamidova, Lamia Kazimzadeh, Elnara Hasanova, Elkhan Isakov, Faig Mammadov, Nargiz Huseynova
Summary: The purpose of this work is to synthesize double copolymers and ternary copolymers as viscosity index improvers for lubricating oils. The synthesized copolymers were proved to have high viscosity-temperature depressant properties and thermal stability. Conditions for copolymerization and the compatibility of the copolymers with mineral and synthetic ester oils were also investigated.
CHEMISTRY AFRICA-A JOURNAL OF THE TUNISIAN CHEMICAL SOCIETY
(2023)
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)