Review
Environmental Sciences
Simon Schwarz, Daniela Gildemeister, Arne Hein, Patrick Schroeder, Jean Bachmann
Summary: Human pharmaceuticals undergo extensive environmental risk assessment before marketing approval, based on EU and German guidelines. An internal agency database contains effect data on approximately 300 active pharmaceutical ingredients, indicating potential for improvement in current assessment methods.
ENVIRONMENTAL SCIENCES EUROPE
(2021)
Article
Environmental Sciences
Luis A. Mendes, Angela Barreto, Joana Santos, Monica J. B. Amorim, Vera L. Maria
Summary: Plastics pollution, in combination with other contaminants, can have harmful effects on soil ecosystems, including decreased reproduction and survival of organisms.
Article
Environmental Sciences
Maria Antonopoulou, Margarita Dormousoglou, Alexandra Spyrou, Alexandra Aikaterini Dimitroulia, Dimitris Vlastos
Summary: This study investigated the toxic potential of the antidepressant Paroxetine (PRX) on aquatic organisms and human lymphocytes. The results showed that PRX caused toxic effects on aquatic organisms and induced cytotoxic and genotoxic effects in human lymphocytes.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Ma Jesus Garcia-Galan, Victor Matamoros, Enrica Uggetti, Ruben Diez-Montero, Joan Garcia
Summary: The study evaluated the efficiency of a new type of reactor in treating different types of pollutants, and indicated through risk assessment that it has minimal impact on the environment.
ENVIRONMENTAL RESEARCH
(2021)
Review
Environmental Sciences
Hongwei Luo, Chenyang Liu, Dongqin He, Jianqiang Sun, Jun Li, Xiangliang Pan
Summary: Microplastics are an emerging pollutant of global concern, and the additives within them may also have harmful effects on the environment. Through aging, these additives can be released from microplastics into the environment, increasing the ecotoxicological risk. Studying the functions and environmental behaviors of these additives helps to assess the environmental impact and potential risks of microplastics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Paolo Pastorino, Damia Barcelo
Summary: Microplastics (MPs) are recognized as emerging contaminants that pose a substantial threat to the environment, with adverse impacts extending across marine, freshwater, and terrestrial ecosystems. Despite advancements in understanding MP behavior, predicting exposure hotspots or scenarios remains challenging. While there is an increase in data on MP occurrence in various environments and species, there is a noticeable scarcity of experimental data on MP uptake, accumulation, and effects. This Virtual Special Issue received contributions from 11 countries, mainly focusing on the occurrence and effects of MPs on organisms, the presence of chemical additives in plastics, and review articles summarizing previous research on MPs.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Anna Ofrydopoulou, Eleni Evgenidou, Christina Nannou, Marlen Vasquez, Dimitra Lambropoulou
Summary: The study comprehensively investigated the phototransformation and ecotoxicity of a mixture of twelve pharmaceutically active compounds susceptible to photolysis. A total of 166 transformation products were identified, including twelve novel ones. The results demonstrated that photolysis of the target mixture leads to a decrease of the observed toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Didier Ramirez-Morales, Mario Masis-Mora, Wilson Beita-Sandi, Jose R. Montiel-Mora, Ericka Fernandez-Fernandez, Michael Mendez-Rivera, Victor Arias-Mora, Adrian Leiva-Salas, Laura Brenes-Alfaro, Carlos E. Rodriguez-Rodriguez
Summary: This study investigated the presence of pharmaceuticals in wastewater from swine farms and surrounding surface waters in a highland livestock production area of Costa Rica. Ten pharmaceutical molecules were detected in farm wastewater, with 57% of effluents displaying high hazard. Seven molecules were found in surface water, with most detections closer to human settlements than animal farms.
Article
Engineering, Environmental
Alan Rempel, Julia Pedo Gutkoski, Mateus Torres Nazari, Gabrielle Nadal Biolchi, Barbara Biduski, Helen Treichel, Luciane Maria Colla
Summary: This study evaluated the influence of emerging pollutants on the growth of microalgae and seed germination. The results showed that Scenedesmus obliquus was able to grow in all mixtures of pollutants, while Spirulina platensis experienced cell death in mixtures containing paracetamol. The culture medium of microalgae had toxic effects on seed germination, but by choosing the right microalgae strain, it is possible to use them for bioremediation and reduce the negative effects on seed germination.
JOURNAL OF WATER PROCESS ENGINEERING
(2022)
Review
Environmental Sciences
Xinyu Wang, Tianshu Wu
Summary: This review provides a comprehensive and systematic analysis of the adverse effects of quantum dots (QDs) in different organisms based on recently available data. It found that QDs can cause toxicity in the environment and organisms and identified specific organs targeted by QDs. The review also discussed the cellular effects of QDs and highlighted the use of innovative technologies in risk assessment. By overcoming the limitations of previous reviews, this study provides new insights for the better application of QDs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Psychiatry
Julene Argaluza, Saioa Domingo-Echaburu, Gorka Orive, Juan Medrano, Rafael Hernandez, Unax Lertxundi
Summary: Drug pollution, especially concerning psychiatric drugs, poses a significant threat to the environment and human health. Wastewater is identified as a major source of drug contamination, with treatment plants ill-equipped to remove them effectively. Strategies to address this issue include promoting responsible medication use, developing more biodegradable pharmaceuticals, and improving coordination between health and environmental sciences.
WORLD JOURNAL OF PSYCHIATRY
(2021)
Article
Environmental Sciences
Astrid Solvag Nesse, Stine Goransson Aanrud, Jan Ludvig Lyche, Trine Sogn, Roland Kallenborn
Summary: Farms using sewage sludge and manure in plant production may contribute to the environmental release of antibiotics and the promotion of antibiotic resistance. The use of biogas digestates as soil fertilizers is increasing, but their potential for spreading pharmaceutical residues is largely unknown.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Environmental Sciences
Katarzyna Bethke, Klaudia Kropidlowska, Piotr Stepnowski, Magda Caban
Summary: An increase in temperature and acidification of water due to global warming have negative effects on aquatic organisms. Climate change also indirectly affects the toxicity of pollutants. However, there is limited knowledge on the effects of temperature, pH, and combined stressors on the toxicity of pharmaceuticals. This paper provides a summary of existing research and highlights the need for further investigation in the ecotoxicology of pharmaceuticals under climate change conditions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Environmental
Heinz-R. Koehler, Thomas Graeff, Mona Schweizer, Jasmin Blumhardt, Jasmin Burkhardt, Lisa Ehmann, Janine Hebel, Christoph Heid, Lone Kundy, Julia Kuttler, Miroslava Malusova, Friederike-Marie Moroff, Anne-Frida Schloesinger, Pia Schulze-Berge, Eleni I. Panagopoulou, Dimitrios E. Damalas, Nikolaos S. Thomaidis, Rita Triebskorn, Dirk Maletzki, Ute Kuehnen, Peter C. von der Ohe
Summary: Depending on the ambient pH, ionizable substances can exist in different proportions as neutral or charged forms, which may contribute to pH-dependent toxicity. In this study, the acute toxicity of 24 ionizable substances at various pH values on the embryonic development of zebrafish was determined. The results showed significant differences in LC50 values between pH5 and pH9 for some substances. Different models were created to calculate pH-dependent logD values as a measure of uptake, and it was found that both neutral and charged species were taken up by cells and exerted toxicity.
Article
Biochemical Research Methods
Kunyang Zhang, Kathrin Fenner
Summary: Researchers developed an automatic rule extraction tool called enviRule, which clusters biotransformation reactions into different groups based on reaction similarities and automatically extracts and generalizes rules for each group. Models trained with automatic rules outperformed those trained with manually curated rules by 30% in AUC scores for transformation product prediction. Additionally, automatic rules can be easily updated, highlighting enviRule's strengths in automated extraction of optimized reaction rules and updating.
Article
Toxicology
Linda Molander, Annika Hanberg, Christina Ruden, Marlene Agerstrand, Anna Beronius
JOURNAL OF APPLIED TOXICOLOGY
(2017)
Article
Environmental Sciences
Christina Ruden, Julie Adams, Marlene Agerstrand, Theo C. M. Brock, Veronique Poulsen, Christian E. Schlekat, James R. Wheeler, Tala R. Henry
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2017)
Article
Public, Environmental & Occupational Health
Vicki Stone, Martin Fuehr, Peter H. Feindt, Hans Bouwmeester, Igor Linkov, Stefania Sabella, Finbarr Murphy, Kilian Bizer, Lang Tran, Marlene Agerstrand, Carlos Fito, Torben Andersen, Diana Anderson, Enrico Bergamaschi, John W. Cherrie, Sue Cowan, Jean-Francois Dalemcourt, Michael Faure, Silke Gabbert, Agnieszka Gajewicz, Teresa F. Fernandes, Danail Hristozov, Helinor J. Johnston, Terry C. Lansdown, Stefan Linder, Hans J. P. Marvin, Martin Mullins, Kai Purnhagen, Tomasz Puzyn, Araceli Sanchez Jimenez, Janeck J. Scott-Fordsmand, George Streftaris, Martie van Tongeren, Nicolas H. Voelcker, George Voyiatzis, Spyros N. Yannopoulos, P. Marijn Poortvliet
Article
Toxicology
Marlene Agerstrand, Sofie Christiansen, Annika Hanberg, Christina Ruden, Lars Andersson, Sjur Andersen, Henrik Appelgren, Christine Bjorge, Ian Henning Clausen, Dag Markus Eide, Nanna B. Hartmann, Trine Husoy, Halldor Palmar Halldorsson, Marianne van der Hagen, Ellen Ingre-Khans, Adam David Lillicrap, Vibe Meister Beltoft, Anna-Karin Mork, Mari Murtomaa-Hautala, Elsa Nielsen, Kristin Olafsdottir, Jaana Palomaki, Hinni Papponen, Emilie Marie Reiler, Helene Stockmann-Juvala, Tiina Suutari, Henrik Tyle, Anna Beronius
JOURNAL OF APPLIED TOXICOLOGY
(2018)
Article
Biodiversity Conservation
Ellen Ingre-Khans, Marlene Agerstrand, Christina Ruden, Anna Beronius
HUMAN AND ECOLOGICAL RISK ASSESSMENT
(2020)
Article
Environmental Sciences
Ellen Ingre-Khans, Marlene Agerstrand, Anna Beronius, Christina Ruden
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2019)
Review
Environmental Sciences
Olwenn Martin, Julie Adams, Amy Beasley, Scott Belanger, Roger L. Breton, Theo C. M. Brock, Vito A. Buonsante, Malyka Galay Burgos, John Green, Patrick D. Guiney, Tilghman Hall, Mark Hanson, Meagan J. Harris, Tala R. Henry, Duane Huggett, Marion Junghans, Ryszard Laskowski, Gerd Maack, Caroline T. A. Moermond, Grace Panter, Anita Pease, Veronique Poulsen, Mike Roberts, Christina Ruden, Christian E. Schlekat, Ilse Schoeters, Keith R. Solomon, Jane Staveley, Bill Stubblefield, John P. Sumpter, Michael St J. Warne, Randall Wentsel, James R. Wheeler, Brian A. Wolff, Kunihiko Yamazaki, Holly Zahner, Marlene Agerstrand
ENVIRONMENT INTERNATIONAL
(2019)
Correction
Nanoscience & Nanotechnology
Hon S. Leong, Kimberly S. Butler, C. Jeffrey Brinker, May Azzawi, Steve Conlan, Christine Dufes, Andrew Owen, Steve Rannard, Chris Scott, Chunying Chen, Marina A. Dobrovolskaia, Serguei V. Kozlov, Adriele Prina-Mello, Ruth Schmid, Peter Wick, Fanny Caputo, Patrick Boisseau, Rachael M. Crist, Scott E. McNeil, Bengt Fadeel, Lang Tran, Steffen Foss Hansen, Nanna B. Hartmann, Lauge P. W. Clausen, Lars M. Skjolding, Anders Baun, Marlene Agerstrand, Zhen Gu, Dimitrios A. Lamprou, Clare Hoskins, Leaf Huang, Wantong Song, Huiliang Cao, Xuanyong Liu, Klaus D. Jandt, Wen Jiang, Betty Y. S. Kim, Korin E. Wheeler, Andrew J. Chetwynd, Iseult Lynch, Sayed Moein Moghimi, Andre Nel, Tian Xia, Paul S. Weiss, Bruno Sarmento, Jose das Neves, Helder A. Santos, Luis Santos, Samir Mitragotri, Steve Little, Dan Peer, Mansoor M. Amiji, Maria Jose Alonso, Alke Petri-Fink, Sandor Balog, Aaron Lee, Barbara Drasler, Barbara Rothen-Rutishauser, Stefan Wilhelm, Handan Acar, Roger G. Harrison, Chuanbin Mao, Priyabrata Mukherjee, Rajagopal Ramesh, Lacey R. McNally, Sara Busatto, Joy Wolfram, Paolo Bergese, Mauro Ferrari, Ronnie H. Fang, Liangfang Zhang, Jie Zheng, Chuanqi Peng, Bujie Du, Mengxiao Yu, Danielle M. Charron, Gang Zheng, Chiara Pastore
NATURE NANOTECHNOLOGY
(2019)
Correction
Nanoscience & Nanotechnology
Hon S. Leong, Kimberly S. Butler, C. Jeffrey Brinker, May Azzawi, Steve Conlan, Christine Dufes, Andrew Owen, Steve Rannard, Chris Scott, Chunying Chen, Marina A. Dobrovolskaia, Serguei V. Kozlov, Adriele Prina-Mello, Ruth Schmid, Peter Wick, Fanny Caputo, Patrick Boisseau, Rachael M. Crist, Scott E. McNeil, Bengt Fadeel, Lang Tran, Steffen Foss Hansen, Nanna B. Hartmann, Lauge P. W. Clausen, Lars M. Skjolding, Anders Baun, Marlene Agerstrand, Zhen Gu, Dimitrios A. Lamprou, Clare Hoskins, Leaf Huang, Wantong Song, Huiliang Cao, Xuanyong Liu, Klaus D. Jandt, Wen Jiang, Betty Y. S. Kim, Korin E. Wheeler, Andrew J. Chetwynd, Iseult Lynch, Seyed Moein Moghimi, Andre Nel, Tian Xia, Paul S. Weiss, Bruno Sarmento, Jose das Neves, Helder A. Santos, Luis Santos, Samir Mitragotri, Steve Little, Dan Peer, Mansoor M. Amiji, Maria Jose Alonso, Alke Petri-Fink, Sandor Balog, Aaron Lee, Barbara Drasler, Barbara Rothen-Rutishauser, Stefan Wilhelm, Handan Acar, Roger G. Harrison, Chuanbin Mao, Priyabrata Mukherjee, Rajagopal Ramesh, Lacey R. McNally, Sara Busatto, Joy Wolfram, Paolo Bergese, Mauro Ferrari, Ronnie H. Fang, Liangfang Zhang, Jie Zheng, Chuanqi Peng, Bujie Du, Mengxiao Yu, Danielle M. Charron, Gang Zheng, Chiara Pastore
NATURE NANOTECHNOLOGY
(2019)
Letter
Nanoscience & Nanotechnology
Hon S. Leong, Kimberly S. Butler, C. Jeffrey Brinker, May Azzawi, Steve Conlan, Christine Dufes, Andrew Owen, Steve Rannard, Chris Scott, Chunying Chen, Marina A. Dobrovolskaia, Serguei V. Kozlov, Adriele Prina-Mello, Ruth Schmid, Peter Wick, Fanny Caputo, Patrick Boisseau, Rachael M. Crist, Scott E. McNeil, Bengt Fadeel, Lang Tran, Steffen Foss Hansen, Nanna B. Hartmann, Lauge P. W. Clausen, Lars M. Skjolding, Anders Baun, Marlene Agerstrand, Zhen Gu, Dimitrios A. Lamprou, Clare Hoskins, Leaf Huang, Wantong Song, Huiliang Cao, Xuanyong Liu, Klaus D. Jandt, Wen Jiang, Betty Y. S. Kim, Korin E. Wheeler, Andrew J. Chetwynd, Iseult Lynch, Sayed Moein Moghimi, Andre Nel, Tian Xia, Paul S. Weiss, Bruno Sarmento, Jose das Neves, Helder A. Santos, Luis Santos, Samir Mitragotri, Steve Little, Dan Peer, Mansoor M. Amiji, Maria Jose Alonso, Alke Petri-Fink, Sandor Balog, Aaron Lee, Barbara Drasler, Barbara Rothen-Rutishauser, Stefan Wilhelm, Handan Acar, Roger G. Harrison, Chuanbin Mao, Priyabrata Mukherjee, Rajagopal Ramesh, Lacey R. McNally, Sara Busatto, Joy Wolfram, Paolo Bergese, Mauro Ferrari, Ronnie H. Fang, Liangfang Zhang, Jie Zheng, Chuanqi Peng, Bujie Du, Mengxiao Yu, Danielle M. Charron, Gang Zheng, Chiara Pastore
NATURE NANOTECHNOLOGY
(2019)
Article
Pharmacology & Pharmacy
Helena Ramstrom, Siv Martini, Johanna Borgendahl, Marlene Agerstrand, Gerd Larfars, Marie-Louise Ovesjo
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Environmental Sciences
Valeria Dulio, Jan Koschorreck, Bert van Bavel, Paul van den Brink, Juliane Hollender, John Munthe, Martin Schlabach, Reza Aalizadeh, Marlene Agerstrand, Lutz Ahrens, Ian Allan, Nikiforos Alygizakis, Damia Barcelo, Pernilla Bohlin-Nizzetto, Susanne Boutroup, Werner Brack, Adele Bressy, Jan H. Christensen, Lubos Cirka, Adrian Covaci, Anja Derksen, Genevieve Deviller, Milou M. L. Dingemans, Magnus Engwall, Despo Fatta-Kassinos, Pablo Gago-Ferrero, Flix Hernandez, Dorte Herzke, Klara Hilscherova, Henner Hollert, Marion Junghans, Barbara Kasprzyk-Hordern, Steffen Keiter, Stefan A. E. Kools, Anneli Kruve, Dimitra Lambropoulou, Marja Lamoree, Pim Leonards, Benjamin Lopez, Miren Lopez de Alda, Lian Lundy, Jarmila Makovinska, Ionan Marigomez, Jonathan W. Martin, Brendan McHugh, Ccile Miege, Simon O'Toole, Noora Perkola, Stefano Polesello, Leo Posthuma, Sara Rodriguez-Mozaz, Ivo Roessink, Pawel Rostkowski, Heinz Ruedel, Saer Samanipour, Tobias Schulze, Emma L. Schymanski, Manfred Sengl, Peter Tarabek, Dorien Ten Hulscher, Nikolaos Thomaidis, Anne Togola, Sara Valsecchi, Stefan van Leeuwen, Peter von der Ohe, Katrin Vorkamp, Branislav Vrana, Jaroslav Slobodnik
ENVIRONMENTAL SCIENCES EUROPE
(2020)
Article
Engineering, Environmental
Alex T. Ford, Marlene Agerstrand, Bryan W. Brooks, Joel Allen, Michael G. Bertram, Tomas Brodin, ZhiChao Dang, Sabine Duquesne, Rene Sahm, Frauke Hoffmann, Henner Hollert, Stefanie Jacob, Nils Kluever, James M. Lazorchak, Mariana Ledesma, Steven D. Melvin, Silvia Mohr, Stephanie Padilla, Gregory G. Pyle, Stefan Scholz, Minna Saaristo, Els Smit, Jeffery A. Steevens, Sanne van den Berg, Werner Kloas, Bob B. M. Wong, Michael Ziegler, Gerd Maack
Summary: Chemicals have long been acknowledged to impact human and wildlife behavior. Recent technological advancements have highlighted the adverse effects of contaminants on organismal behavior and ecological outcomes. Concerns about the lack of consideration of behavior in regulatory ecotoxicology have led to the exclusion of many studies from chemical risk assessments. A workshop with international representatives has resulted in consensus perspectives and recommendations to improve the integration of basic and translational sciences with regulatory practices.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Analytical
Marlene Agerstrand, Kathryn Arnold, Sigal Balshine, Tomas Brodin, Bryan W. Brooks, Gerd Maack, Erin S. McCallum, Greg Pyle, Minna Saaristo, Alex T. Ford
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2020)
Article
Toxicology
Ellen Ingre-Khans, Marlene Agerstrand, Anna Beronius, Christina Ruden
TOXICOLOGY RESEARCH
(2019)
